BR0315797A - Compostos de amida com eficácia antagonista de mch, e medicamentos que contêm esses compostos - Google Patents

Compostos de amida com eficácia antagonista de mch, e medicamentos que contêm esses compostos

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Publication number
BR0315797A
BR0315797A BR0315797-0A BR0315797A BR0315797A BR 0315797 A BR0315797 A BR 0315797A BR 0315797 A BR0315797 A BR 0315797A BR 0315797 A BR0315797 A BR 0315797A
Authority
BR
Brazil
Prior art keywords
compounds
drugs containing
amide compounds
mch antagonist
amide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
BR0315797-0A
Other languages
English (en)
Inventor
Dirk Stenkamp
Stephan Georg Mueler
Kirsten Arndt
Philipp Lustenberger
Gerald Juergen Roth
Ralf R H Lotz
Klaus Rudolf
Martin Lenter
Thorsten Lehmann-Lintz
Heike-Andrea Wieland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH Co KG
Original Assignee
Boehringer Ingelheim Pharma GmbH Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH Co KG filed Critical Boehringer Ingelheim Pharma GmbH Co KG
Publication of BR0315797A publication Critical patent/BR0315797A/pt
Expired - Fee Related legal-status Critical Current

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
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    • C07C233/00—Carboxylic acid amides
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    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/29—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
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Abstract

"COMPOSTOS DE AMIDA COM EFICáCIA ANTAGONISTA DE MCH, E MEDICAMENTOS QUE CONTêM ESSES COMPOSTOS". A presente invenção refere-se a compostos de amida de fórmula geral (I) na qual os grupos e radicais A, B, b, W, X, 1, Z, R¬ 1¬, R¬ 2¬ e R¬ 3¬ apresentam os significados indicados na reivindicação 1. Além disso a invenção refere-se a um medicamento contendo pelo menos uma amida de acordo com a invenção. Devido à atividade antagonística do receptor de MCH, os medicamentos de acordo com a invenção são apropriados para tratamento de perturbações metabólicas e/ou perturbações alimentares, particularmente da obesidade, bulimia, anorexia, hiperfagia e diabete.
BR0315797-0A 2002-10-31 2003-10-28 Compostos de amida com eficácia antagonista de mch, e medicamentos que contêm esses compostos Expired - Fee Related BR0315797A (pt)

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DE10250743A DE10250743A1 (de) 2002-10-31 2002-10-31 Neue Amid-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel
PCT/EP2003/011933 WO2004039764A1 (de) 2002-10-31 2003-10-28 Neue amid-verbindungen mit mch-antagonistischer wirkung und diese verbindungen enthaltende arzneimittel

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