CO5570698A2 - Nuevos compuestos de amida con accion antagonista de mch, y medicamentos que contienen estos compuestos - Google Patents

Nuevos compuestos de amida con accion antagonista de mch, y medicamentos que contienen estos compuestos

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Publication number
CO5570698A2
CO5570698A2 CO05051560A CO05051560A CO5570698A2 CO 5570698 A2 CO5570698 A2 CO 5570698A2 CO 05051560 A CO05051560 A CO 05051560A CO 05051560 A CO05051560 A CO 05051560A CO 5570698 A2 CO5570698 A2 CO 5570698A2
Authority
CO
Colombia
Prior art keywords
replaced
alkylene bridge
compounds
independently
groups
Prior art date
Application number
CO05051560A
Other languages
English (en)
Inventor
Stephan Georg Muller
Roth Gerald Jurgen
Rudolf Klaus
Lehmann-Lint Throsten
Martin Lenter
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of CO5570698A2 publication Critical patent/CO5570698A2/es

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Abstract

1.- Compuestos de amida de fórmula general Ien la cualR1, R2, de manera independiente entre sí, significan H, un grupo alquilo C1-8 o cicloalquilo C3-7 eventualmente sustituido con el radical R11, pudiendo un grupo -CH2- en la posición 3 o 4 de un grupo cicloalquilo de 5, 6 ó 7 eslabones, haber sido reemplazado por -O-, -S- ó N R13, o bien un radical fenilo o piridinilo eventualmente sustituido una o varias veces con el radical R12 y/o sustituido una vez con nitro, o bienR1 y R2 forman un puente de alquileno C2-8, en el cual - uno o dos grupos -CH2-, de manera independiente entre sí, pueden haber sido reemplazados por -CH=N- ó -CH=CH- y/o - uno o dos grupos -CH2-, de manera independiente entre sí, pueden haber sido reemplazados por -O-, -S-, -SO-, -(SO2)-, -C=N-O-R18, -CO-, -C(=CH2)- ó -NR13- de manera tal que los heteroátomos no estén unidos directamente entre sí,pudiendo haber sido reemplazados, en el puente de alqui-leno antes definido, uno o varios átomos de H por R14, ypudiendo estar sustituido el puente de alquileno antes definido con uno o dos grupos carbo- o heterocíclicos Cy, iguales o diferentes, de manera tal que la unión entre el puente de alquileno y el grupo Cy tiene lugar - a través de un enlace sencillo o doble, - a través de un átomo de C común, con formación de un sistema anular espirocíclico, - a través de dos átomos de C y/o de N comunes, contiguos, con formación de un sistema anular bicíclico condensado, o bien - a través de tres o más átomos de C y/o de N, con formación de un sistema anular puenteado,R3 significa H, alquilo C1-6, cicloalquilo C3-7 ó (cicloalquil C3-7)-(alquilo C1-4),X significa un puente de alquileno C1-8, en el cual - un grupo -CH2- puede haber sido reemplazado por -CH=CH- ó -C=C- y/o - uno o dos grupos -CH2-, de manera independiente entre sí, pueden haber sido reemplazados por -O-, -S-, -(SO)-, -(SO2)-, -CO- ó -NR4 - de manera tal que en cada caso no estén unidos directamente entre sí dos átomos de O, de S o de N, o bien un átomo de O con un átomo de S, ...
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