CO5570698A2 - Nuevos compuestos de amida con accion antagonista de mch, y medicamentos que contienen estos compuestos - Google Patents
Nuevos compuestos de amida con accion antagonista de mch, y medicamentos que contienen estos compuestosInfo
- Publication number
- CO5570698A2 CO5570698A2 CO05051560A CO05051560A CO5570698A2 CO 5570698 A2 CO5570698 A2 CO 5570698A2 CO 05051560 A CO05051560 A CO 05051560A CO 05051560 A CO05051560 A CO 05051560A CO 5570698 A2 CO5570698 A2 CO 5570698A2
- Authority
- CO
- Colombia
- Prior art keywords
- replaced
- alkylene bridge
- compounds
- independently
- groups
- Prior art date
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- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07C2601/14—The ring being saturated
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Abstract
1.- Compuestos de amida de fórmula general Ien la cualR1, R2, de manera independiente entre sí, significan H, un grupo alquilo C1-8 o cicloalquilo C3-7 eventualmente sustituido con el radical R11, pudiendo un grupo -CH2- en la posición 3 o 4 de un grupo cicloalquilo de 5, 6 ó 7 eslabones, haber sido reemplazado por -O-, -S- ó N R13, o bien un radical fenilo o piridinilo eventualmente sustituido una o varias veces con el radical R12 y/o sustituido una vez con nitro, o bienR1 y R2 forman un puente de alquileno C2-8, en el cual - uno o dos grupos -CH2-, de manera independiente entre sí, pueden haber sido reemplazados por -CH=N- ó -CH=CH- y/o - uno o dos grupos -CH2-, de manera independiente entre sí, pueden haber sido reemplazados por -O-, -S-, -SO-, -(SO2)-, -C=N-O-R18, -CO-, -C(=CH2)- ó -NR13- de manera tal que los heteroátomos no estén unidos directamente entre sí,pudiendo haber sido reemplazados, en el puente de alqui-leno antes definido, uno o varios átomos de H por R14, ypudiendo estar sustituido el puente de alquileno antes definido con uno o dos grupos carbo- o heterocíclicos Cy, iguales o diferentes, de manera tal que la unión entre el puente de alquileno y el grupo Cy tiene lugar - a través de un enlace sencillo o doble, - a través de un átomo de C común, con formación de un sistema anular espirocíclico, - a través de dos átomos de C y/o de N comunes, contiguos, con formación de un sistema anular bicíclico condensado, o bien - a través de tres o más átomos de C y/o de N, con formación de un sistema anular puenteado,R3 significa H, alquilo C1-6, cicloalquilo C3-7 ó (cicloalquil C3-7)-(alquilo C1-4),X significa un puente de alquileno C1-8, en el cual - un grupo -CH2- puede haber sido reemplazado por -CH=CH- ó -C=C- y/o - uno o dos grupos -CH2-, de manera independiente entre sí, pueden haber sido reemplazados por -O-, -S-, -(SO)-, -(SO2)-, -CO- ó -NR4 - de manera tal que en cada caso no estén unidos directamente entre sí dos átomos de O, de S o de N, o bien un átomo de O con un átomo de S, ...
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Application Number | Priority Date | Filing Date | Title |
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DE10250743A DE10250743A1 (de) | 2002-10-31 | 2002-10-31 | Neue Amid-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
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CO5570698A2 true CO5570698A2 (es) | 2005-10-31 |
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EP (1) | EP1558567B1 (es) |
JP (1) | JP2006504761A (es) |
KR (1) | KR20050065654A (es) |
CN (1) | CN1708476A (es) |
AR (1) | AR041735A1 (es) |
AT (1) | ATE434601T1 (es) |
AU (1) | AU2003285306A1 (es) |
BR (1) | BR0315797A (es) |
CA (1) | CA2504207C (es) |
CO (1) | CO5570698A2 (es) |
DE (2) | DE10250743A1 (es) |
EA (1) | EA009040B1 (es) |
EC (1) | ECSP055765A (es) |
ES (1) | ES2327329T3 (es) |
HR (1) | HRP20050383A2 (es) |
MX (1) | MXPA05002865A (es) |
NO (1) | NO20050745L (es) |
PE (1) | PE20040785A1 (es) |
PL (1) | PL376256A1 (es) |
RS (1) | RS20050330A (es) |
TW (1) | TW200412936A (es) |
UY (1) | UY28051A1 (es) |
WO (1) | WO2004039764A1 (es) |
ZA (1) | ZA200501164B (es) |
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JP2006076990A (ja) * | 2004-03-12 | 2006-03-23 | Bayer Cropscience Ag | 殺虫性ベンゼンジカルボキサミド類 |
DE102004017934A1 (de) | 2004-04-14 | 2005-11-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
US7524862B2 (en) | 2004-04-14 | 2009-04-28 | Boehringer Ingelheim International Gmbh | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds |
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WO2008069611A1 (en) * | 2006-12-08 | 2008-06-12 | Korea Research Institute Of Chemical Technology | N-phenylamide derivative, process for the preparation thereof, and composition for preventing or treating ischemic diseases comprising same |
WO2008071646A1 (en) | 2006-12-11 | 2008-06-19 | Boehringer Ingelheim International Gmbh | New pyridazine derivatives with mch antagonistic activity and medicaments comprising these compounds |
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CA2786314A1 (en) | 2010-02-25 | 2011-09-01 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
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WO2012008549A1 (ja) * | 2010-07-15 | 2012-01-19 | 武田薬品工業株式会社 | 複素環化合物 |
CN103476258B (zh) | 2011-02-25 | 2017-04-26 | 默沙东公司 | 用作抗糖尿病药剂的新的环状氮杂苯并咪唑衍生物 |
CN103874690B (zh) | 2011-07-29 | 2016-07-06 | 卡尔约药物治疗公司 | 含酰肼的核运输调节剂及其用途 |
PE20141003A1 (es) * | 2011-07-29 | 2014-09-02 | Karyopharm Therapeutics Inc | Moduladores del transporte nuclear y usos de los mismos |
AU2013240187A1 (en) | 2012-03-28 | 2014-10-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Salicylic acid derivatives useful as glucocerebrosidase activators |
LT3404027T (lt) | 2012-05-09 | 2020-07-10 | Biogen Ma Inc. | Branduolių transporto moduliatoriai ir jų panaudojimas |
JP2015525782A (ja) | 2012-08-02 | 2015-09-07 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | 抗糖尿病性三環式化合物 |
MX2015010935A (es) | 2013-02-22 | 2015-10-29 | Merck Sharp & Dohme | Compuestos biciclicos antidiabeticos. |
US9650375B2 (en) | 2013-03-14 | 2017-05-16 | Merck Sharp & Dohme Corp. | Indole derivatives useful as anti-diabetic agents |
US10202366B2 (en) | 2013-03-15 | 2019-02-12 | Karyopharm Therapeutics Inc. | Methods of promoting wound healing using CRM1 inhibitors |
MX365939B (es) | 2013-06-21 | 2019-06-19 | Karyopharm Therapeutics Inc | Moduladores del transporte nuclear y usos de los mismos. |
KR101662217B1 (ko) | 2013-06-27 | 2016-10-04 | 주식회사 엘지생명과학 | Gpr120 효능제로서의 바이아릴 유도체 |
WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
MX2017002013A (es) | 2014-08-15 | 2017-05-12 | Karyopharm Therapeutics Inc | Polimorfos de selinexor. |
CN105439914B (zh) * | 2014-09-17 | 2017-07-11 | 复旦大学 | 4‑氨酰基苯氧乙酰胺类化合物及其药物用途 |
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KR20040047935A (ko) * | 2001-10-25 | 2004-06-05 | 쉐링 코포레이션 | 비만 치료용 mch 길항제 |
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PL376256A1 (en) | 2005-12-27 |
ZA200501164B (en) | 2006-10-25 |
EA200500596A1 (ru) | 2005-12-29 |
CN1708476A (zh) | 2005-12-14 |
BR0315797A (pt) | 2005-09-13 |
UY28051A1 (es) | 2004-05-31 |
JP2006504761A (ja) | 2006-02-09 |
WO2004039764A1 (de) | 2004-05-13 |
PE20040785A1 (es) | 2004-12-23 |
NO20050745L (no) | 2005-05-23 |
EP1558567B1 (de) | 2009-06-24 |
AR041735A1 (es) | 2005-05-26 |
ES2327329T3 (es) | 2009-10-28 |
CA2504207C (en) | 2012-10-02 |
KR20050065654A (ko) | 2005-06-29 |
EP1558567A1 (de) | 2005-08-03 |
MXPA05002865A (es) | 2005-05-27 |
CA2504207A1 (en) | 2004-05-13 |
RS20050330A (en) | 2007-12-31 |
TW200412936A (en) | 2004-08-01 |
ECSP055765A (es) | 2005-07-06 |
AU2003285306A1 (en) | 2004-05-25 |
DE50311640D1 (de) | 2009-08-06 |
DE10250743A1 (de) | 2004-05-19 |
ATE434601T1 (de) | 2009-07-15 |
HRP20050383A2 (en) | 2006-08-31 |
EA009040B1 (ru) | 2007-10-26 |
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