HRP20050383A2 - Novel amide compounds with mch antagonistic effect and medicaments comprising said compounds - Google Patents

Novel amide compounds with mch antagonistic effect and medicaments comprising said compounds

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Publication number
HRP20050383A2
HRP20050383A2 HR20050383A HRP20050383A HRP20050383A2 HR P20050383 A2 HRP20050383 A2 HR P20050383A2 HR 20050383 A HR20050383 A HR 20050383A HR P20050383 A HRP20050383 A HR P20050383A HR P20050383 A2 HRP20050383 A2 HR P20050383A2
Authority
HR
Croatia
Prior art keywords
compounds
medicaments
antagonistic effect
novel amide
amide compounds
Prior art date
Application number
HR20050383A
Other languages
Croatian (hr)
Inventor
Stenkamp Dirk
Georg M�ller Stephan
Arndt Kirsten
Lustenberger Philipp
J�rgen Roth Gerald
Richard Hermann Lotz Ralf
Rudolf Klaus
Lenter Martin
Lehmann-Lintz Thorsten
Wieland Heike-Andrea
Original Assignee
Boehringer Ingelheim Pharma Gmbh & Co.Kg.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma Gmbh & Co.Kg. filed Critical Boehringer Ingelheim Pharma Gmbh & Co.Kg.
Publication of HRP20050383A2 publication Critical patent/HRP20050383A2/en

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
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    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/29—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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Abstract

Predloženi izum odnosi se na amidne spojeve opće formule Iu kojoj skupine i ostaci A, B, b, W, X, Y, Z, R1, R2 i R3 imaju značenja data u zahtjevu 1.Izum se odnosi, nadalje, na lijekove koji sadrže najmanje jedan amid prema izumu. Zbog njihovog antagonističkog djelovanja prema MCH receptoru, lijekovi prema izumu su prikladni za liječenje metaboličkih poremećaja i/ili poremećaja prehrane, posebnodebljine, bulimije, anoreksije, hiperfagije i dijabetesa.The present invention relates to amide compounds of general formula I in which groups and residues A, B, b, W, X, Y, Z, R 1, R 2 and R 3 have the meanings given in claim 1. The invention further relates to medicaments containing at least one amide according to the invention. Due to their MCH receptor antagonist activity, the drugs according to the invention are suitable for the treatment of metabolic disorders and / or eating disorders, in particular obesity, bulimia, anorexia, hyperphagia and diabetes.

HR20050383A 2002-10-31 2005-04-29 Novel amide compounds with mch antagonistic effect and medicaments comprising said compounds HRP20050383A2 (en)

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