TR200000086T2 - Heparin üretimi için işlem. - Google Patents

Heparin üretimi için işlem.

Info

Publication number
TR200000086T2
TR200000086T2 TR2000/00086T TR200000086T TR200000086T2 TR 200000086 T2 TR200000086 T2 TR 200000086T2 TR 2000/00086 T TR2000/00086 T TR 2000/00086T TR 200000086 T TR200000086 T TR 200000086T TR 200000086 T2 TR200000086 T2 TR 200000086T2
Authority
TR
Turkey
Prior art keywords
heparin
temperature
hydrolysis
ambient temperature
production
Prior art date
Application number
TR2000/00086T
Other languages
English (en)
Inventor
Egbert Abraham Van Houdenhoven Francois
Lambertus Maria Sanders Adrianus
Johannes Josephus Van Zutphen Petrus
Original Assignee
Akzo Nobel N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel N.V. filed Critical Akzo Nobel N.V.
Publication of TR200000086T2 publication Critical patent/TR200000086T2/tr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/04Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Bu bulus hayvan mukoza dokusundan heparin çikarilmasi için basitlestirilmis bir isleme iliskindir. Yöntem hammaddenin çevre sicakliginda enzimle hidrolizi, ardindan 50-75 C sicaklikta 6 saate kadar uzayan bir süre boyunca hidrolizi adimlarindan olusur. Sicaklikta yükselme kolay bir yolla elde edilir. Sindirim karisimi, çevre sicakligina sogurken ayrica kuluçkalanabilir. Heparin protein hidrolisat içinde mevcut anyon degistiriciden geri kazanilir.
TR2000/00086T 1997-07-16 1998-07-09 Heparin üretimi için işlem. TR200000086T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97202213 1997-07-16

Publications (1)

Publication Number Publication Date
TR200000086T2 true TR200000086T2 (tr) 2000-08-21

Family

ID=8228564

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/00086T TR200000086T2 (tr) 1997-07-16 1998-07-09 Heparin üretimi için işlem.

Country Status (24)

Country Link
US (1) US6232093B1 (tr)
EP (1) EP0996642B1 (tr)
JP (1) JP4455680B2 (tr)
KR (1) KR100515706B1 (tr)
CN (1) CN1109048C (tr)
AR (1) AR013223A1 (tr)
AT (1) ATE315588T1 (tr)
AU (1) AU739225B2 (tr)
BR (1) BR9810881B1 (tr)
CA (1) CA2294780C (tr)
CZ (1) CZ299281B6 (tr)
DE (1) DE69833205T2 (tr)
DK (1) DK0996642T3 (tr)
ES (1) ES2256954T3 (tr)
HR (1) HRP980399B1 (tr)
HU (1) HU225240B1 (tr)
IL (1) IL133363A (tr)
NO (1) NO320786B1 (tr)
PL (1) PL195526B1 (tr)
TR (1) TR200000086T2 (tr)
TW (1) TW581814B (tr)
UY (1) UY25097A1 (tr)
WO (1) WO1999003893A1 (tr)
ZA (1) ZA986289B (tr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7575886B2 (en) * 2002-03-11 2009-08-18 Momenta Pharmaceuticals, Inc. Analysis of sulfated polysaccharides
BR0311904A (pt) 2002-06-19 2007-05-08 Can Technologies Inc composição de ração de animal compreendendo subproduto mucoso
US6933372B2 (en) * 2003-03-07 2005-08-23 Warner-Lambert Company Method to produce a solid form of heparin
CN100425624C (zh) * 2006-05-11 2008-10-15 中国农业大学 一种同步提取肝素钠和猪肠粘膜抗菌肽的方法
CN100439402C (zh) * 2006-10-12 2008-12-03 孙红 采用卵磷脂液膜分离法提取肝素的方法
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
WO2010110654A1 (en) * 2009-03-24 2010-09-30 Van Hessen Bv Method for preparation of heparin from mucosa
WO2011090948A1 (en) * 2010-01-19 2011-07-28 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
WO2012115952A1 (en) 2011-02-21 2012-08-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
KR101447123B1 (ko) 2014-02-27 2014-10-06 박상협 헤파린의 추출 방법
CN104086672A (zh) * 2014-06-10 2014-10-08 安徽申奥生物科技有限公司 一种粗品肝素钠的生产方法
EP3821025B1 (en) 2018-07-11 2023-09-20 Ajinomoto Co., Inc. Method for enzymatic sulfurylation of alcohols and amines using bacterium of the family enterobacteriaceae
KR102180261B1 (ko) * 2019-03-19 2020-11-18 중앙대학교 산학협력단 돈육 부산물 유래 헤파린의 추출 방법
KR102104367B1 (ko) 2019-09-02 2020-04-24 팜앤바이오 주식회사 헤파린나트륨의 제조장치 및 제조방법
CN115028757A (zh) * 2022-06-29 2022-09-09 江苏麦德森制药有限公司 一种肝素钠的脱色方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH617963A5 (tr) * 1973-10-05 1980-06-30 Derivati Organici Lab
HU177887B (en) * 1979-03-21 1982-01-28 Richter Gedeon Vegyeszet Process for preparing a raw material containing heparin
DE69005251T2 (de) * 1989-10-04 1994-05-05 Akzo Nv Sulfatierte Glykosaminoglykuronane mit antithrombotischer Wirkung.
AU5681094A (en) * 1992-11-30 1994-06-22 Celsus, Inc. Protein hydrolysate derived from mucosal tissue

Also Published As

Publication number Publication date
DE69833205D1 (de) 2006-04-06
CZ299281B6 (cs) 2008-06-04
NO320786B1 (no) 2006-01-30
NO20000189D0 (no) 2000-01-14
CN1264391A (zh) 2000-08-23
TW581814B (en) 2004-04-01
BR9810881B1 (pt) 2009-01-13
HU225240B1 (en) 2006-08-28
ZA986289B (en) 1999-05-04
PL338007A1 (en) 2000-09-25
JP4455680B2 (ja) 2010-04-21
KR100515706B1 (ko) 2005-09-15
IL133363A0 (en) 2001-04-30
PL195526B1 (pl) 2007-09-28
ATE315588T1 (de) 2006-02-15
DK0996642T3 (da) 2006-05-08
CA2294780A1 (en) 1999-01-28
HRP980399A2 (en) 1999-04-30
UY25097A1 (es) 1999-01-11
EP0996642A1 (en) 2000-05-03
ES2256954T3 (es) 2006-07-16
AR013223A1 (es) 2000-12-13
HRP980399B1 (en) 2003-04-30
DE69833205T2 (de) 2006-07-20
HUP0003064A3 (en) 2003-01-28
US6232093B1 (en) 2001-05-15
BR9810881A (pt) 2000-09-26
CA2294780C (en) 2008-03-04
IL133363A (en) 2005-08-31
WO1999003893A1 (en) 1999-01-28
CN1109048C (zh) 2003-05-21
JP2002508805A (ja) 2002-03-19
KR20010014387A (ko) 2001-02-26
EP0996642B1 (en) 2006-01-11
HUP0003064A2 (hu) 2000-12-28
AU739225B2 (en) 2001-10-04
NO20000189L (no) 2000-03-14
AU9071598A (en) 1999-02-10
CZ2000138A3 (cs) 2000-07-12

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