TR200000086T2 - Heparin üretimi için işlem. - Google Patents
Heparin üretimi için işlem.Info
- Publication number
- TR200000086T2 TR200000086T2 TR2000/00086T TR200000086T TR200000086T2 TR 200000086 T2 TR200000086 T2 TR 200000086T2 TR 2000/00086 T TR2000/00086 T TR 2000/00086T TR 200000086 T TR200000086 T TR 200000086T TR 200000086 T2 TR200000086 T2 TR 200000086T2
- Authority
- TR
- Turkey
- Prior art keywords
- heparin
- temperature
- hydrolysis
- ambient temperature
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
Bu bulus hayvan mukoza dokusundan heparin çikarilmasi için basitlestirilmis bir isleme iliskindir. Yöntem hammaddenin çevre sicakliginda enzimle hidrolizi, ardindan 50-75 C sicaklikta 6 saate kadar uzayan bir süre boyunca hidrolizi adimlarindan olusur. Sicaklikta yükselme kolay bir yolla elde edilir. Sindirim karisimi, çevre sicakligina sogurken ayrica kuluçkalanabilir. Heparin protein hidrolisat içinde mevcut anyon degistiriciden geri kazanilir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97202213 | 1997-07-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200000086T2 true TR200000086T2 (tr) | 2000-08-21 |
Family
ID=8228564
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2000/00086T TR200000086T2 (tr) | 1997-07-16 | 1998-07-09 | Heparin üretimi için işlem. |
Country Status (24)
Country | Link |
---|---|
US (1) | US6232093B1 (tr) |
EP (1) | EP0996642B1 (tr) |
JP (1) | JP4455680B2 (tr) |
KR (1) | KR100515706B1 (tr) |
CN (1) | CN1109048C (tr) |
AR (1) | AR013223A1 (tr) |
AT (1) | ATE315588T1 (tr) |
AU (1) | AU739225B2 (tr) |
BR (1) | BR9810881B1 (tr) |
CA (1) | CA2294780C (tr) |
CZ (1) | CZ299281B6 (tr) |
DE (1) | DE69833205T2 (tr) |
DK (1) | DK0996642T3 (tr) |
ES (1) | ES2256954T3 (tr) |
HR (1) | HRP980399B1 (tr) |
HU (1) | HU225240B1 (tr) |
IL (1) | IL133363A (tr) |
NO (1) | NO320786B1 (tr) |
PL (1) | PL195526B1 (tr) |
TR (1) | TR200000086T2 (tr) |
TW (1) | TW581814B (tr) |
UY (1) | UY25097A1 (tr) |
WO (1) | WO1999003893A1 (tr) |
ZA (1) | ZA986289B (tr) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7575886B2 (en) * | 2002-03-11 | 2009-08-18 | Momenta Pharmaceuticals, Inc. | Analysis of sulfated polysaccharides |
BR0311904A (pt) | 2002-06-19 | 2007-05-08 | Can Technologies Inc | composição de ração de animal compreendendo subproduto mucoso |
US6933372B2 (en) * | 2003-03-07 | 2005-08-23 | Warner-Lambert Company | Method to produce a solid form of heparin |
CN100425624C (zh) * | 2006-05-11 | 2008-10-15 | 中国农业大学 | 一种同步提取肝素钠和猪肠粘膜抗菌肽的方法 |
CN100439402C (zh) * | 2006-10-12 | 2008-12-03 | 孙红 | 采用卵磷脂液膜分离法提取肝素的方法 |
US9139876B1 (en) | 2007-05-03 | 2015-09-22 | Momenta Pharmacueticals, Inc. | Method of analyzing a preparation of a low molecular weight heparin |
WO2010110654A1 (en) * | 2009-03-24 | 2010-09-30 | Van Hessen Bv | Method for preparation of heparin from mucosa |
WO2011090948A1 (en) * | 2010-01-19 | 2011-07-28 | Momenta Pharmaceuticals, Inc. | Evaluating heparin preparations |
WO2012115952A1 (en) | 2011-02-21 | 2012-08-30 | Momenta Pharmaceuticals, Inc. | Evaluating heparin preparations |
KR101447123B1 (ko) | 2014-02-27 | 2014-10-06 | 박상협 | 헤파린의 추출 방법 |
CN104086672A (zh) * | 2014-06-10 | 2014-10-08 | 安徽申奥生物科技有限公司 | 一种粗品肝素钠的生产方法 |
EP3821025B1 (en) | 2018-07-11 | 2023-09-20 | Ajinomoto Co., Inc. | Method for enzymatic sulfurylation of alcohols and amines using bacterium of the family enterobacteriaceae |
KR102180261B1 (ko) * | 2019-03-19 | 2020-11-18 | 중앙대학교 산학협력단 | 돈육 부산물 유래 헤파린의 추출 방법 |
KR102104367B1 (ko) | 2019-09-02 | 2020-04-24 | 팜앤바이오 주식회사 | 헤파린나트륨의 제조장치 및 제조방법 |
CN115028757A (zh) * | 2022-06-29 | 2022-09-09 | 江苏麦德森制药有限公司 | 一种肝素钠的脱色方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH617963A5 (tr) * | 1973-10-05 | 1980-06-30 | Derivati Organici Lab | |
HU177887B (en) * | 1979-03-21 | 1982-01-28 | Richter Gedeon Vegyeszet | Process for preparing a raw material containing heparin |
DE69005251T2 (de) * | 1989-10-04 | 1994-05-05 | Akzo Nv | Sulfatierte Glykosaminoglykuronane mit antithrombotischer Wirkung. |
AU5681094A (en) * | 1992-11-30 | 1994-06-22 | Celsus, Inc. | Protein hydrolysate derived from mucosal tissue |
-
1998
- 1998-07-09 CA CA2294780A patent/CA2294780C/en not_active Expired - Lifetime
- 1998-07-09 KR KR10-1999-7012554A patent/KR100515706B1/ko not_active IP Right Cessation
- 1998-07-09 DE DE69833205T patent/DE69833205T2/de not_active Expired - Lifetime
- 1998-07-09 CZ CZ20000138A patent/CZ299281B6/cs not_active IP Right Cessation
- 1998-07-09 BR BRPI9810881-6A patent/BR9810881B1/pt not_active IP Right Cessation
- 1998-07-09 TR TR2000/00086T patent/TR200000086T2/tr unknown
- 1998-07-09 WO PCT/EP1998/004939 patent/WO1999003893A1/en active IP Right Grant
- 1998-07-09 AT AT98942666T patent/ATE315588T1/de active
- 1998-07-09 US US09/462,223 patent/US6232093B1/en not_active Expired - Lifetime
- 1998-07-09 DK DK98942666T patent/DK0996642T3/da active
- 1998-07-09 EP EP98942666A patent/EP0996642B1/en not_active Expired - Lifetime
- 1998-07-09 PL PL98338007A patent/PL195526B1/pl unknown
- 1998-07-09 ES ES98942666T patent/ES2256954T3/es not_active Expired - Lifetime
- 1998-07-09 JP JP50645999A patent/JP4455680B2/ja not_active Expired - Lifetime
- 1998-07-09 CN CN98807195A patent/CN1109048C/zh not_active Expired - Lifetime
- 1998-07-09 IL IL13336398A patent/IL133363A/xx not_active IP Right Cessation
- 1998-07-09 AU AU90715/98A patent/AU739225B2/en not_active Expired
- 1998-07-09 HU HU0003064A patent/HU225240B1/hu unknown
- 1998-07-15 ZA ZA986289A patent/ZA986289B/xx unknown
- 1998-07-16 TW TW087111617A patent/TW581814B/zh not_active IP Right Cessation
- 1998-07-16 UY UY25097A patent/UY25097A1/es not_active IP Right Cessation
- 1998-07-16 AR ARP980103468A patent/AR013223A1/es active IP Right Grant
- 1998-07-16 HR HR980399A patent/HRP980399B1/xx not_active IP Right Cessation
-
2000
- 2000-01-14 NO NO20000189A patent/NO320786B1/no not_active IP Right Cessation
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