UY25097A1 - Proceso para la produccion de heparina - Google Patents

Proceso para la produccion de heparina

Info

Publication number
UY25097A1
UY25097A1 UY25097A UY25097A UY25097A1 UY 25097 A1 UY25097 A1 UY 25097A1 UY 25097 A UY25097 A UY 25097A UY 25097 A UY25097 A UY 25097A UY 25097 A1 UY25097 A1 UY 25097A1
Authority
UY
Uruguay
Prior art keywords
heparin
room temperature
temperature
production
anticoagulant
Prior art date
Application number
UY25097A
Other languages
English (en)
Inventor
E A Houdenhoven F
L Sanders A
J J Zutphen P
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of UY25097A1 publication Critical patent/UY25097A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Abstract

Procedimiento simplificado para extracción de heparina desde tejido de mucosa animal. El método consta de una etapa de hidrólisis enzimática de la materia prima a temperatura ambiente, seguida por hidrólisis durante 6 horas a temperatura de 50-75 °C. El aumento de temperatura se obtiene fácilmente. La mezcla de digestión puede seguir siendo incubada mientras se enfría hasta la temperatura ambiente. La heparina se recupera desde una resina de intercambio aniónico presente en el hidrolizado de proteína. La heparina es un heteropolisacárido utilizado como agente anticoagulante y antitrombótico en el tratamiento y prevención de trombosis venosas.
UY25097A 1997-07-16 1998-07-16 Proceso para la produccion de heparina UY25097A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97202213 1997-07-16

Publications (1)

Publication Number Publication Date
UY25097A1 true UY25097A1 (es) 1999-01-11

Family

ID=8228564

Family Applications (1)

Application Number Title Priority Date Filing Date
UY25097A UY25097A1 (es) 1997-07-16 1998-07-16 Proceso para la produccion de heparina

Country Status (24)

Country Link
US (1) US6232093B1 (es)
EP (1) EP0996642B1 (es)
JP (1) JP4455680B2 (es)
KR (1) KR100515706B1 (es)
CN (1) CN1109048C (es)
AR (1) AR013223A1 (es)
AT (1) ATE315588T1 (es)
AU (1) AU739225B2 (es)
BR (1) BR9810881B1 (es)
CA (1) CA2294780C (es)
CZ (1) CZ299281B6 (es)
DE (1) DE69833205T2 (es)
DK (1) DK0996642T3 (es)
ES (1) ES2256954T3 (es)
HR (1) HRP980399B1 (es)
HU (1) HU225240B1 (es)
IL (1) IL133363A (es)
NO (1) NO320786B1 (es)
PL (1) PL195526B1 (es)
TR (1) TR200000086T2 (es)
TW (1) TW581814B (es)
UY (1) UY25097A1 (es)
WO (1) WO1999003893A1 (es)
ZA (1) ZA986289B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1518120A4 (en) * 2002-03-11 2008-08-13 Momenta Pharmaceuticals Inc ANALYSIS OF SULFATE POLYSACCHARIDES
BR0311904A (pt) 2002-06-19 2007-05-08 Can Technologies Inc composição de ração de animal compreendendo subproduto mucoso
US6933372B2 (en) * 2003-03-07 2005-08-23 Warner-Lambert Company Method to produce a solid form of heparin
CN100425624C (zh) * 2006-05-11 2008-10-15 中国农业大学 一种同步提取肝素钠和猪肠粘膜抗菌肽的方法
CN100439402C (zh) * 2006-10-12 2008-12-03 孙红 采用卵磷脂液膜分离法提取肝素的方法
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
WO2010110654A1 (en) * 2009-03-24 2010-09-30 Van Hessen Bv Method for preparation of heparin from mucosa
CN102791742B (zh) * 2010-01-19 2014-12-24 动量制药公司 评价肝素制剂
WO2012115952A1 (en) 2011-02-21 2012-08-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
KR101447123B1 (ko) 2014-02-27 2014-10-06 박상협 헤파린의 추출 방법
CN104086672A (zh) * 2014-06-10 2014-10-08 安徽申奥生物科技有限公司 一种粗品肝素钠的生产方法
HRP20231510T1 (hr) 2018-07-11 2024-03-01 Ajinomoto Co., Inc. Postupak enzimskog sulfuriliranja alkohola i amina uz pomoć bakterije iz porodice enterobacteriaceae
KR102180261B1 (ko) * 2019-03-19 2020-11-18 중앙대학교 산학협력단 돈육 부산물 유래 헤파린의 추출 방법
KR102104367B1 (ko) 2019-09-02 2020-04-24 팜앤바이오 주식회사 헤파린나트륨의 제조장치 및 제조방법
CN115028757A (zh) * 2022-06-29 2022-09-09 江苏麦德森制药有限公司 一种肝素钠的脱色方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH617963A5 (es) * 1973-10-05 1980-06-30 Derivati Organici Lab
HU177887B (en) * 1979-03-21 1982-01-28 Richter Gedeon Vegyeszet Process for preparing a raw material containing heparin
EP0421508B1 (en) * 1989-10-04 1993-12-15 Akzo Nobel N.V. Sulphated glycosaminoglycuronan with antithrombotic activity
WO1994012524A1 (en) * 1992-11-30 1994-06-09 Celsus, Inc. Protein hydrolysate derived from mucosal tissue

Also Published As

Publication number Publication date
US6232093B1 (en) 2001-05-15
WO1999003893A1 (en) 1999-01-28
ES2256954T3 (es) 2006-07-16
DE69833205D1 (de) 2006-04-06
HUP0003064A2 (hu) 2000-12-28
AU9071598A (en) 1999-02-10
ZA986289B (en) 1999-05-04
AU739225B2 (en) 2001-10-04
DK0996642T3 (da) 2006-05-08
BR9810881B1 (pt) 2009-01-13
HU225240B1 (en) 2006-08-28
CA2294780C (en) 2008-03-04
NO20000189L (no) 2000-03-14
HRP980399B1 (en) 2003-04-30
KR20010014387A (ko) 2001-02-26
NO320786B1 (no) 2006-01-30
CA2294780A1 (en) 1999-01-28
PL338007A1 (en) 2000-09-25
JP2002508805A (ja) 2002-03-19
PL195526B1 (pl) 2007-09-28
EP0996642B1 (en) 2006-01-11
HUP0003064A3 (en) 2003-01-28
KR100515706B1 (ko) 2005-09-15
IL133363A0 (en) 2001-04-30
EP0996642A1 (en) 2000-05-03
JP4455680B2 (ja) 2010-04-21
CN1109048C (zh) 2003-05-21
ATE315588T1 (de) 2006-02-15
CZ299281B6 (cs) 2008-06-04
DE69833205T2 (de) 2006-07-20
AR013223A1 (es) 2000-12-13
HRP980399A2 (en) 1999-04-30
CZ2000138A3 (cs) 2000-07-12
IL133363A (en) 2005-08-31
TR200000086T2 (tr) 2000-08-21
CN1264391A (zh) 2000-08-23
BR9810881A (pt) 2000-09-26
TW581814B (en) 2004-04-01
NO20000189D0 (no) 2000-01-14

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Legal Events

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VENC Patent expired

Effective date: 20180716