TR199700583A2 - Bisiklik-kaynasik piridinler. - Google Patents

Bisiklik-kaynasik piridinler.

Info

Publication number
TR199700583A2
TR199700583A2 TR97/00583A TR9700583A TR199700583A2 TR 199700583 A2 TR199700583 A2 TR 199700583A2 TR 97/00583 A TR97/00583 A TR 97/00583A TR 9700583 A TR9700583 A TR 9700583A TR 199700583 A2 TR199700583 A2 TR 199700583A2
Authority
TR
Turkey
Prior art keywords
pyridines
bicyclic
sourced
boiling
witting
Prior art date
Application number
TR97/00583A
Other languages
English (en)
Inventor
Brandes Arndt
Logers Michael
Schmidt Gunter
Angerbauer Rolf
Schmeck Carsten
Bremm Klaus-Dieter
Bischoff Hilmar
Schmidt Delf
Schuhmacher Joachim
Original Assignee
Bayer Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Aktiengesellschaft filed Critical Bayer Aktiengesellschaft
Publication of TR199700583A2 publication Critical patent/TR199700583A2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Bisiklik-kaynasik piridinler, Witting veya Grignard reaktiflerinin yardimiyla tekabül eden aldehidleri reaksiyona sokarak uygun yan zinciri moleküle dahil etmek suretiyle hazirlanirlar. Bisiklik kaynasik piridinler, ilaç içinde aktif bilesikler olarak kullanim için uygundurlar.
TR97/00583A 1996-07-08 1997-07-04 Bisiklik-kaynasik piridinler. TR199700583A2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19627430A DE19627430A1 (de) 1996-07-08 1996-07-08 Bicyclisch kondensierte Pyridine

Publications (1)

Publication Number Publication Date
TR199700583A2 true TR199700583A2 (tr) 1998-01-21

Family

ID=7799218

Family Applications (1)

Application Number Title Priority Date Filing Date
TR97/00583A TR199700583A2 (tr) 1996-07-08 1997-07-04 Bisiklik-kaynasik piridinler.

Country Status (30)

Country Link
US (1) US6063788A (tr)
EP (1) EP0825185A1 (tr)
JP (1) JPH1067751A (tr)
KR (1) KR980009247A (tr)
CN (1) CN1172803A (tr)
AR (1) AR007716A1 (tr)
AU (1) AU722365B2 (tr)
BG (1) BG61972B1 (tr)
BR (1) BR9703886A (tr)
CA (1) CA2209609A1 (tr)
CO (1) CO4870759A1 (tr)
CZ (1) CZ214797A3 (tr)
DE (1) DE19627430A1 (tr)
EE (1) EE9700151A (tr)
HN (1) HN1997000082A (tr)
HR (1) HRP970331A2 (tr)
HU (1) HUP9701158A1 (tr)
ID (1) ID17659A (tr)
IL (1) IL121235A0 (tr)
MA (1) MA24261A1 (tr)
NO (1) NO308738B1 (tr)
NZ (1) NZ328260A (tr)
PE (1) PE87798A1 (tr)
PL (1) PL320954A1 (tr)
SG (1) SG46782A1 (tr)
SK (1) SK92697A3 (tr)
TN (1) TNSN97116A1 (tr)
TR (1) TR199700583A2 (tr)
YU (1) YU28897A (tr)
ZA (1) ZA976021B (tr)

Families Citing this family (35)

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US6262277B1 (en) 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
PT1140185E (pt) 1998-12-23 2003-10-31 Searle Llc Combinacoes de inibidores de proteina de transferencia de ester de colesterilo com agentes sequestrantes de acido biliar para indicacoes cardiovasculares
ES2201827T3 (es) 1998-12-23 2004-03-16 G.D. Searle Llc Combinaciones de inhibidores de la proteina de transferencia de ester de colesterilo y de derivados de acido fibrico para indicaciones cardiovasculares.
EP1140184B1 (en) 1998-12-23 2003-06-04 G.D. Searle LLC. Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications
DK1140190T3 (da) 1998-12-23 2002-12-23 Searle Llc Kombinationer af ileumgaldesyretransport-inhibitorer og galdesyre-sekvestreringsmidler til cardiovaskulære indikatorer
CZ20012342A3 (cs) 1998-12-23 2001-12-12 G. D. Searle Llc Kombinace inhibitorů transportu ľlučové kyseliny v ileu a derivátů kyseliny fibrové pro kardiovaskulární indikace
US6462091B1 (en) 1998-12-23 2002-10-08 G.D. Searle & Co. Combinations of cholesteryl ester transfer protein inhibitors and HMG coA reductase inhibitors for cardiovascular indications
WO2000038726A1 (en) 1998-12-23 2000-07-06 G.D. Searle Llc Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications
US20010018446A1 (en) 1999-09-23 2001-08-30 G.D. Searle & Co. Substituted N-Aliphatic-N-Aromatictertiary-Heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
US6924313B1 (en) 1999-09-23 2005-08-02 Pfizer Inc. Substituted tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
US6683113B2 (en) * 1999-09-23 2004-01-27 Pharmacia Corporation (R)-chiral halogenated substituted N,N-Bis-benzyl aminioalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
JP2003528830A (ja) 2000-03-10 2003-09-30 ファルマシア・コーポレーション テトラヒドロベンゾチエピン類の製造方法
US20040219619A1 (en) * 2000-07-21 2004-11-04 Ester Fernandez-Salas Methods of identifying compounds that alter toxin persistence and/or protease activity
US20050239782A1 (en) * 2001-04-18 2005-10-27 Heintzelman Geoffrey R Arylindenopyridines and related therapeutic and prophylactic methods
US6903109B2 (en) 2001-04-18 2005-06-07 Ortho-Muniel Pharmaceutical, Inc. Arylindenopyridines and related therapeutic and prophylactic methods
US6958328B2 (en) * 2001-04-18 2005-10-25 Ortho-Mcneil Pharmaceutical, Inc Arylindenopyridines and related therapeutic and prophylactic methods
DE60233874D1 (de) 2001-06-22 2009-11-12 Pfizer Prod Inc Pharmazeutische zusammensetzungen enthaltend dispersionen aus arzneistoffen und neutralen polymeren
BR0210519A (pt) 2001-06-22 2004-06-22 Pfizer Prod Inc Composições farmacêuticas de adsorvatos de fármaco amorfo
WO2003040127A1 (en) 2001-11-02 2003-05-15 G.D. Searle Llc Novel mono- and di-fluorinated benzothiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (asbt) and taurocholate uptake
US6852753B2 (en) 2002-01-17 2005-02-08 Pharmacia Corporation Alkyl/aryl hydroxy or keto thiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (ASBT) and taurocholate uptake
BR0307344A (pt) * 2002-02-01 2004-12-14 Pfizer Prod Inc Composições farmacêuticas de dispersões amorfas de fármacos e materiais formadores de microfase lipofìlica
US20040127510A1 (en) 2002-04-16 2004-07-01 Heintzelman Geoffrey R. Arylindenopyridines and arylindenopyrimidines and related therapeutic and prophylactic methods
WO2005011635A2 (en) 2003-08-04 2005-02-10 Pfizer Products Inc. Pharmaceutical compositions of adsorbates of amorphous drugs and lipophilic microphase-forming materials
CL2004001884A1 (es) 2003-08-04 2005-06-03 Pfizer Prod Inc Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros.
WO2005030185A2 (en) * 2003-09-26 2005-04-07 Japan Tobacco Inc. Method of inhibiting remnant lipoprotein production
KR20060085675A (ko) 2003-10-08 2006-07-27 일라이 릴리 앤드 캄파니 이상지혈증 치료를 위한 화합물 및 방법
PT1732933E (pt) 2004-03-26 2008-10-20 Lilly Co Eli Compostos para o tratamento da dislipidémia
AU2005315770B2 (en) * 2004-12-18 2011-12-08 Bayer Schering Pharma Aktiengesellschaft 4-cycloalkyl-substituted tetrahydrochinoline derivatives and use thereof as medicaments
EP2548894A1 (en) 2005-02-03 2013-01-23 Bend Research, Inc. Pharmaceutical compositions with enhanced performance
WO2007048027A2 (en) 2005-10-21 2007-04-26 Novartis Ag Combination of a renin-inhibitor and an anti-dyslipidemic agent and/or an antiobesity agent
DE102006012548A1 (de) * 2006-03-18 2007-09-20 Bayer Healthcare Ag Substituierte Chromanol-Derivate und ihre Verwendung
PA8801401A1 (es) * 2007-10-25 2009-05-15 Janssen Pharmaceutica Nv Arilindenopirimidinas y su uso como adenosina a2a
WO2012027331A1 (en) 2010-08-27 2012-03-01 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5169857A (en) * 1988-01-20 1992-12-08 Bayer Aktiengesellschaft 7-(polysubstituted pyridyl)-hept-6-endates useful for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis
GB8626344D0 (en) * 1986-11-04 1986-12-03 Zyma Sa Bicyclic compounds
NO177005C (no) * 1988-01-20 1995-07-05 Bayer Ag Analogifremgangsmåte for fremstilling av substituerte pyridiner, samt mellomprodukter til bruk ved fremstillingen
IE892088L (en) * 1988-07-12 1990-01-12 William Henry Deryk Morris Quinoline derivatives, their production and use
ZA911046B (en) * 1990-02-26 1992-10-28 Squibb & Sons Inc Quinoline and pyridine anchors for hmg-coa reductase inhibitors
JPH059179A (ja) * 1990-09-27 1993-01-19 Takeda Chem Ind Ltd 複素環化合物、その製造法及びａｃａｔ阻害剤

Also Published As

Publication number Publication date
EP0825185A1 (de) 1998-02-25
HRP970331A2 (en) 1998-08-31
US6063788A (en) 2000-05-16
CO4870759A1 (es) 1999-12-27
CA2209609A1 (en) 1998-01-08
BG101746A (en) 1998-03-31
NO973144L (no) 1998-01-09
SG46782A1 (en) 1998-02-20
BR9703886A (pt) 1998-11-03
NZ328260A (en) 1998-09-24
HU9701158D0 (en) 1997-09-29
KR980009247A (ko) 1998-04-30
CN1172803A (zh) 1998-02-11
SK92697A3 (en) 1998-02-04
HN1997000082A (es) 1997-12-26
DE19627430A1 (de) 1998-01-15
YU28897A (sh) 2000-03-21
BG61972B1 (bg) 1998-11-30
AU2844897A (en) 1998-01-15
JPH1067751A (ja) 1998-03-10
EE9700151A (et) 1998-02-16
AR007716A1 (es) 1999-11-10
AU722365B2 (en) 2000-08-03
PL320954A1 (en) 1998-01-19
MA24261A1 (fr) 1998-04-01
NO973144D0 (no) 1997-07-07
ID17659A (id) 1998-01-15
PE87798A1 (es) 1999-02-13
HUP9701158A1 (hu) 1999-09-28
IL121235A0 (en) 1998-01-04
ZA976021B (en) 1998-02-02
CZ214797A3 (cs) 1998-01-14
TNSN97116A1 (fr) 2005-03-15
NO308738B1 (no) 2000-10-23

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