TNSN97116A1 - Pyridines bicycliques condensees - Google Patents
Pyridines bicycliques condenseesInfo
- Publication number
- TNSN97116A1 TNSN97116A1 TNTNSN97116A TNSN97116A TNSN97116A1 TN SN97116 A1 TNSN97116 A1 TN SN97116A1 TN TNSN97116 A TNTNSN97116 A TN TNSN97116A TN SN97116 A TNSN97116 A TN SN97116A TN SN97116 A1 TNSN97116 A1 TN SN97116A1
- Authority
- TN
- Tunisia
- Prior art keywords
- pyridines
- condensed bicyclic
- condensed
- medicinal products
- bicyclic pyridines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
LES PYRIDINES BICYCLIQUES CONDENSEES SONT PREPAREES PAR INTRODUCTION DE LA CHAINE LATERALE APPROPRIEE PAR REACTION DES ALDEHYDES CORRESPONDANTES A L'AIDE DE REACTIFS DE GRIGNARD. LES PYRIDINES BICYCIQUES CONDENSEES CONVIENNENT COMME COMPOSES ACTIFS DANS DES MEDICAMENTS, EN PARTICULIER DES MEDICAMENTS POUR LE TRAITEMENT DE L'ATHEROSCLEROSE
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19627430A DE19627430A1 (de) | 1996-07-08 | 1996-07-08 | Bicyclisch kondensierte Pyridine |
Publications (1)
Publication Number | Publication Date |
---|---|
TNSN97116A1 true TNSN97116A1 (fr) | 2005-03-15 |
Family
ID=7799218
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TNTNSN97116A TNSN97116A1 (fr) | 1996-07-08 | 1997-07-07 | Pyridines bicycliques condensees |
Country Status (30)
Country | Link |
---|---|
US (1) | US6063788A (fr) |
EP (1) | EP0825185A1 (fr) |
JP (1) | JPH1067751A (fr) |
KR (1) | KR980009247A (fr) |
CN (1) | CN1172803A (fr) |
AR (1) | AR007716A1 (fr) |
AU (1) | AU722365B2 (fr) |
BG (1) | BG61972B1 (fr) |
BR (1) | BR9703886A (fr) |
CA (1) | CA2209609A1 (fr) |
CO (1) | CO4870759A1 (fr) |
CZ (1) | CZ214797A3 (fr) |
DE (1) | DE19627430A1 (fr) |
EE (1) | EE9700151A (fr) |
HN (1) | HN1997000082A (fr) |
HR (1) | HRP970331A2 (fr) |
HU (1) | HUP9701158A1 (fr) |
ID (1) | ID17659A (fr) |
IL (1) | IL121235A0 (fr) |
MA (1) | MA24261A1 (fr) |
NO (1) | NO308738B1 (fr) |
NZ (1) | NZ328260A (fr) |
PE (1) | PE87798A1 (fr) |
PL (1) | PL320954A1 (fr) |
SG (1) | SG46782A1 (fr) |
SK (1) | SK92697A3 (fr) |
TN (1) | TNSN97116A1 (fr) |
TR (1) | TR199700583A2 (fr) |
YU (1) | YU28897A (fr) |
ZA (1) | ZA976021B (fr) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6268392B1 (en) | 1994-09-13 | 2001-07-31 | G. D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors |
US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
US6262277B1 (en) | 1994-09-13 | 2001-07-17 | G.D. Searle And Company | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
MXPA01006470A (es) | 1998-12-23 | 2003-06-06 | Searle Llc | Combinaciones de inhibidores de transporte de acido biliar ileal y agentes de secuentro de acido biliar para indicaciones cardiovasculares. |
ES2200587T3 (es) | 1998-12-23 | 2004-03-01 | G.D. Searle Llc | Combinaciones de inhibidors del transporte de acidos biliares del ileon e inhibidores de la proteina de transferencia de colesteril ester para indicaciones cardiovasculares. |
AU3103800A (en) | 1998-12-23 | 2000-07-31 | G.D. Searle Llc | Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acidderivatives for cardiovascular indications |
EP1340509A1 (fr) | 1998-12-23 | 2003-09-03 | G.D. Searle LLC. | Combinaisons d'inhibiteurs de la protéine de transfert de l'ester de cholestéryle et de dérivés de l'acide fibrique utilisées dans le cadre de troubles cardio-vasculaires |
HUP0104793A2 (en) | 1998-12-23 | 2002-06-29 | Searle Llc | Combinations of ileal bile acid transport inhibitors and fibric acid derivatives for cardiovascular indications |
WO2000038722A1 (fr) | 1998-12-23 | 2000-07-06 | G.D. Searle & Co. | COMBINAISONS D'INHIBITEURS DE LA PROTEINE DE TRANSFERT DE L'ESTER DE CHOLESTERYLE ET D'INHIBITEURS DE LA HMG CoA-REDUCTASE UTILISEES DANS LE CADRE DE TROUBLES CARDIO-VASCULAIRES |
WO2000038723A1 (fr) | 1998-12-23 | 2000-07-06 | G.D. Searle Llc | Combinaisons d'inhibiteurs de la proteine de transfert de l'ester de cholesteryle et d'agents sequestrants de l'acide biliaire, utilisees dans le cadre de toubles cardio-vasculaires |
US6924313B1 (en) | 1999-09-23 | 2005-08-02 | Pfizer Inc. | Substituted tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity |
US6723752B2 (en) | 1999-09-23 | 2004-04-20 | Pharmacia Corporation | (R)-chiral halogenated substituted n-benzyl-n-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity |
US20010018446A1 (en) | 1999-09-23 | 2001-08-30 | G.D. Searle & Co. | Substituted N-Aliphatic-N-Aromatictertiary-Heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity |
EP1286984A2 (fr) | 2000-03-10 | 2003-03-05 | Pharmacia Corporation | Procede de preparation de tetrahydrobenzothiepines |
US20040219619A1 (en) * | 2000-07-21 | 2004-11-04 | Ester Fernandez-Salas | Methods of identifying compounds that alter toxin persistence and/or protease activity |
US6958328B2 (en) | 2001-04-18 | 2005-10-25 | Ortho-Mcneil Pharmaceutical, Inc | Arylindenopyridines and related therapeutic and prophylactic methods |
US20050239782A1 (en) * | 2001-04-18 | 2005-10-27 | Heintzelman Geoffrey R | Arylindenopyridines and related therapeutic and prophylactic methods |
US6903109B2 (en) | 2001-04-18 | 2005-06-07 | Ortho-Muniel Pharmaceutical, Inc. | Arylindenopyridines and related therapeutic and prophylactic methods |
ES2333645T3 (es) | 2001-06-22 | 2010-02-25 | Bend Research, Inc. | Composiciones farmaceuticas de dispersiones de medicamentos y polimeros neutros. |
OA12625A (en) | 2001-06-22 | 2006-06-12 | Pfizer Prod Inc | Pharmaceutical compositions of adsorbates of amorphous drug. |
WO2003040127A1 (fr) | 2001-11-02 | 2003-05-15 | G.D. Searle Llc | Composes benzothiepine mono- et di-fluores en tant qu'inhibiteurs du transport d'acides biliaires a co-dependance sodique apicale (asbt) et de reprise de taurocholate |
CA2471639A1 (fr) | 2002-01-17 | 2003-07-31 | Pharmacia Corporation | Nouveaux composes d'alkyl/aryl hydroxy ou cetothiepine servant d'inhibiteurs du transport des acides biliaires de type ileal et de l'absorption de taurocholate |
EP1469832B2 (fr) | 2002-02-01 | 2016-10-26 | Bend Research, Inc. | Compositions pharmaceutiques de dispersions amorphes de medicaments et materiaux formant des microphases lipophiles |
US20040127510A1 (en) | 2002-04-16 | 2004-07-01 | Heintzelman Geoffrey R. | Arylindenopyridines and arylindenopyrimidines and related therapeutic and prophylactic methods |
CL2004001884A1 (es) | 2003-08-04 | 2005-06-03 | Pfizer Prod Inc | Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros. |
CA2532931A1 (fr) * | 2003-08-04 | 2005-02-10 | Pfizer Products Inc. | Compositions pharmaceutiques a base d'adsorbats de medicaments amorphes et de produits aptes a former des microphases lipophiles |
EP1670446A2 (fr) * | 2003-09-26 | 2006-06-21 | Japan Tobacco Inc. | Procede pour inhiber la production de lipoproteines restantes |
SI1670768T1 (sl) | 2003-10-08 | 2010-01-29 | Lilly Co Eli | Spojine in metode za zdravljenje dislipidemije |
EP1735320B1 (fr) | 2004-03-26 | 2009-06-17 | Eli Lilly And Company | Composes et procedes permettant de traiter la dyslipidemie |
BRPI0519602A2 (pt) * | 2004-12-18 | 2009-02-25 | Bayer Healthcare Ag | derivados de tetrahidroquinolina substituÍdos com 4-cicloalquila e seu uso como medicamento |
WO2006082518A1 (fr) | 2005-02-03 | 2006-08-10 | Pfizer Products Inc. | Compositions pharmaceutiques a efficacite amelioree |
CA2625416A1 (fr) | 2005-10-21 | 2007-04-26 | Novartis Ag | Combinaison de composes organiques |
DE102006012548A1 (de) * | 2006-03-18 | 2007-09-20 | Bayer Healthcare Ag | Substituierte Chromanol-Derivate und ihre Verwendung |
PA8801401A1 (es) * | 2007-10-25 | 2009-05-15 | Janssen Pharmaceutica Nv | Arilindenopirimidinas y su uso como adenosina a2a |
WO2012027331A1 (fr) | 2010-08-27 | 2012-03-01 | Ironwood Pharmaceuticals, Inc. | Compositions et procédés pour traiter ou prévenir un syndrome métabolique et des maladies et troubles associés |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5169857A (en) * | 1988-01-20 | 1992-12-08 | Bayer Aktiengesellschaft | 7-(polysubstituted pyridyl)-hept-6-endates useful for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis |
GB8626344D0 (en) * | 1986-11-04 | 1986-12-03 | Zyma Sa | Bicyclic compounds |
NO177005C (no) * | 1988-01-20 | 1995-07-05 | Bayer Ag | Analogifremgangsmåte for fremstilling av substituerte pyridiner, samt mellomprodukter til bruk ved fremstillingen |
IE892088L (en) * | 1988-07-12 | 1990-01-12 | William Henry Deryk Morris | Quinoline derivatives, their production and use |
ZA911046B (en) * | 1990-02-26 | 1992-10-28 | Squibb & Sons Inc | Quinoline and pyridine anchors for hmg-coa reductase inhibitors |
JPH059179A (ja) * | 1990-09-27 | 1993-01-19 | Takeda Chem Ind Ltd | 複素環化合物、その製造法及びacat阻害剤 |
-
1996
- 1996-07-08 DE DE19627430A patent/DE19627430A1/de not_active Withdrawn
-
1997
- 1997-06-16 HN HN1997000082A patent/HN1997000082A/es unknown
- 1997-06-17 HR HR19627430.3A patent/HRP970331A2/hr not_active Application Discontinuation
- 1997-06-18 SG SG1997002082A patent/SG46782A1/en unknown
- 1997-06-25 EP EP97110360A patent/EP0825185A1/fr not_active Withdrawn
- 1997-06-27 US US08/883,067 patent/US6063788A/en not_active Expired - Fee Related
- 1997-07-02 AR ARP970102972A patent/AR007716A1/es not_active Application Discontinuation
- 1997-07-03 AU AU28448/97A patent/AU722365B2/en not_active Ceased
- 1997-07-04 CA CA002209609A patent/CA2209609A1/fr not_active Abandoned
- 1997-07-04 BG BG101746A patent/BG61972B1/bg unknown
- 1997-07-04 PL PL97320954A patent/PL320954A1/xx unknown
- 1997-07-04 TR TR97/00583A patent/TR199700583A2/xx unknown
- 1997-07-04 ID IDP972332A patent/ID17659A/id unknown
- 1997-07-04 NZ NZ328260A patent/NZ328260A/en unknown
- 1997-07-04 IL IL12123597A patent/IL121235A0/xx unknown
- 1997-07-07 NO NO973144A patent/NO308738B1/no not_active IP Right Cessation
- 1997-07-07 CO CO97037764A patent/CO4870759A1/es unknown
- 1997-07-07 TN TNTNSN97116A patent/TNSN97116A1/fr unknown
- 1997-07-07 MA MA24705A patent/MA24261A1/fr unknown
- 1997-07-07 CZ CZ972147A patent/CZ214797A3/cs unknown
- 1997-07-07 KR KR1019970031342A patent/KR980009247A/ko not_active Application Discontinuation
- 1997-07-07 JP JP9195235A patent/JPH1067751A/ja active Pending
- 1997-07-07 PE PE1997000581A patent/PE87798A1/es not_active Application Discontinuation
- 1997-07-07 ZA ZA9706021A patent/ZA976021B/xx unknown
- 1997-07-07 HU HU9701158A patent/HUP9701158A1/hu unknown
- 1997-07-07 SK SK926-97A patent/SK92697A3/sk unknown
- 1997-07-08 CN CN97114558A patent/CN1172803A/zh active Pending
- 1997-07-08 YU YU28897A patent/YU28897A/sh unknown
- 1997-07-08 BR BR9703886A patent/BR9703886A/pt active Search and Examination
- 1997-07-08 EE EE9700151A patent/EE9700151A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
TR199700583A2 (xx) | 1998-01-21 |
BG101746A (en) | 1998-03-31 |
NZ328260A (en) | 1998-09-24 |
NO973144D0 (no) | 1997-07-07 |
YU28897A (sh) | 2000-03-21 |
SG46782A1 (en) | 1998-02-20 |
CO4870759A1 (es) | 1999-12-27 |
JPH1067751A (ja) | 1998-03-10 |
CA2209609A1 (fr) | 1998-01-08 |
HU9701158D0 (en) | 1997-09-29 |
ID17659A (id) | 1998-01-15 |
EE9700151A (et) | 1998-02-16 |
KR980009247A (ko) | 1998-04-30 |
AU2844897A (en) | 1998-01-15 |
BG61972B1 (bg) | 1998-11-30 |
IL121235A0 (en) | 1998-01-04 |
BR9703886A (pt) | 1998-11-03 |
DE19627430A1 (de) | 1998-01-15 |
HN1997000082A (es) | 1997-12-26 |
HRP970331A2 (en) | 1998-08-31 |
CN1172803A (zh) | 1998-02-11 |
SK92697A3 (en) | 1998-02-04 |
EP0825185A1 (fr) | 1998-02-25 |
AR007716A1 (es) | 1999-11-10 |
ZA976021B (en) | 1998-02-02 |
NO308738B1 (no) | 2000-10-23 |
PL320954A1 (en) | 1998-01-19 |
CZ214797A3 (cs) | 1998-01-14 |
MA24261A1 (fr) | 1998-04-01 |
NO973144L (no) | 1998-01-09 |
US6063788A (en) | 2000-05-16 |
HUP9701158A1 (hu) | 1999-09-28 |
PE87798A1 (es) | 1999-02-13 |
AU722365B2 (en) | 2000-08-03 |
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