PE87798A1 - Piridinas condensadas biciclicas - Google Patents
Piridinas condensadas biciclicasInfo
- Publication number
- PE87798A1 PE87798A1 PE1997000581A PE00058197A PE87798A1 PE 87798 A1 PE87798 A1 PE 87798A1 PE 1997000581 A PE1997000581 A PE 1997000581A PE 00058197 A PE00058197 A PE 00058197A PE 87798 A1 PE87798 A1 PE 87798A1
- Authority
- PE
- Peru
- Prior art keywords
- optionally
- cycloalkyl
- halogen
- formula
- alkylene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
SE REFIEREN A COMPUESTOS DE FORMULA (I), EN DONDE: "A" ES ARILO C6-C10 OPCIONALMENTE HASTA TRISUSTITUIDO, SIENDO DE PREFERENCIA FENILO SUSTITUIDO POR F; "D" ES -TR5 O ES -CR6R7R8, EN DONDE R5 Y R6 SON CICLOALQUILO C3-C8 O ARILO C6-C10, ENTRE OTROS, LOS CUALES SE ENCUENTRAN OPCIONALMENTE HASTA TRISUSTITUIDO CON CF3, TRIFLUORMETOXI O HALOGENO, ENTRE OTROS; "T" ES ALQUILENO C1-C10 O ALQUENILENO C1-C10 OPCIONALMENTE BISUSTITUIDO POR OH; R7 ES H O HALOGENO; R8 ES H, HALOGENO O AZIDO, ENTRE OTROS; O R7 Y R8 FORMAN JUNTO CON EL ATOMO DE C UN GRUPO CARBONILO; "E" ES CICLOALQUILO C3-C8 O ES ALQUILO LINEAL O RAMIFICADO C1-C8 OPCIONALMENTE SUSTITUIDO POR CICLOALQUILO C3-C8 O POR OH; R1 Y R2 FORMAN JUNTOS UNA CADENA DE ALQUILENO C1-C8, A LA QUE ESTA FUSIONADO UN FENILO, ESTANDO SUSTITUIDA POR CARBONILO, OR13 O UN RADICAL DE FORMULA (i), EN DONDE a ES 1; 2 o 3; R13 ES H, ALQUILO, ACILO, ALCOXICARBONILO O ES UN RESTO DE FORMULA SILILO. TAMBIEN SE REFIERE AL PROCEDIMIENTO DE PREPARACION DE (I), QUE COMPRENDE INTRODUCIR LOS SUSTITUYENTES "D" USANDO REACTIVOS ORGANOMETALICOS EN DISOLVENTES INERTES, EN EL SENTIDO DE UNA REACCION DE GRIGNARD O DE WITTING. LOS COMPUESTOS OBTENIDOS ACTUAN COMO INHIBIDORES DE LA PROTEINA DE TRANSFERENCIA COLESTEROL ESTER (PTCE), SIENDO UTILES EN EL TRATAMIENTO DE LA HIPERLIPOPROTEINEMIA Y LA ARTERIOESCLEROSIS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19627430A DE19627430A1 (de) | 1996-07-08 | 1996-07-08 | Bicyclisch kondensierte Pyridine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE87798A1 true PE87798A1 (es) | 1999-02-13 |
Family
ID=7799218
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1997000581A PE87798A1 (es) | 1996-07-08 | 1997-07-07 | Piridinas condensadas biciclicas |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6063788A (es) |
| EP (1) | EP0825185A1 (es) |
| JP (1) | JPH1067751A (es) |
| KR (1) | KR980009247A (es) |
| CN (1) | CN1172803A (es) |
| AR (1) | AR007716A1 (es) |
| AU (1) | AU722365B2 (es) |
| BG (1) | BG61972B1 (es) |
| BR (1) | BR9703886A (es) |
| CA (1) | CA2209609A1 (es) |
| CO (1) | CO4870759A1 (es) |
| CZ (1) | CZ214797A3 (es) |
| DE (1) | DE19627430A1 (es) |
| EE (1) | EE9700151A (es) |
| HN (1) | HN1997000082A (es) |
| HR (1) | HRP970331A2 (es) |
| HU (1) | HUP9701158A1 (es) |
| ID (1) | ID17659A (es) |
| IL (1) | IL121235A0 (es) |
| MA (1) | MA24261A1 (es) |
| NO (1) | NO308738B1 (es) |
| NZ (1) | NZ328260A (es) |
| PE (1) | PE87798A1 (es) |
| PL (1) | PL320954A1 (es) |
| SG (1) | SG46782A1 (es) |
| SK (1) | SK92697A3 (es) |
| TN (1) | TNSN97116A1 (es) |
| TR (1) | TR199700583A2 (es) |
| YU (1) | YU28897A (es) |
| ZA (1) | ZA976021B (es) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
| US6268392B1 (en) | 1994-09-13 | 2001-07-31 | G. D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors |
| US6262277B1 (en) | 1994-09-13 | 2001-07-17 | G.D. Searle And Company | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| AU3103800A (en) | 1998-12-23 | 2000-07-31 | G.D. Searle Llc | Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acidderivatives for cardiovascular indications |
| EA004877B1 (ru) | 1998-12-23 | 2004-08-26 | Джи.Ди.Сирл Ллс | Сочетания ингибиторов транспорта желчных кислот в подвздошной кишке и агентов, секвестрирующих желчные кислоты, для сердечно-сосудистых показаний |
| AU2157400A (en) | 1998-12-23 | 2000-07-31 | G.D. Searle & Co. | Combinations of cholesteryl ester transfer protein inhibitors and hmg coa reductase inhibitors for cardiovascular indications |
| US6458850B1 (en) | 1998-12-23 | 2002-10-01 | G.D. Searle, Llc | Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications |
| BR9916486A (pt) | 1998-12-23 | 2002-02-05 | Searle Llc | Combinações de inibidores do transporte de ácidos biliares no ìleo e inibidores da proteìna de transferência do ester colesteril para indicações cardiovasculares |
| DK1140189T3 (da) | 1998-12-23 | 2003-09-15 | Searle Llc | Kombinationer af ileal galdesyre-transportinhibitorer og fibrinsyrederivater til cardiovaskulære indikationer |
| AU2157500A (en) | 1998-12-23 | 2000-07-31 | G.D. Searle Llc | Combinations of cholesteryl ester transfer protein inhibitors and bile acid sequestering agents for cardiovascular indications |
| US20010018446A1 (en) | 1999-09-23 | 2001-08-30 | G.D. Searle & Co. | Substituted N-Aliphatic-N-Aromatictertiary-Heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity |
| US6544974B2 (en) | 1999-09-23 | 2003-04-08 | G.D. Searle & Co. | (R)-chiral halogenated substituted fused heterocyclic amino compounds useful for inhibiting cholesteryl ester transfer protein activity |
| US6924313B1 (en) | 1999-09-23 | 2005-08-02 | Pfizer Inc. | Substituted tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity |
| EP1286984A2 (en) | 2000-03-10 | 2003-03-05 | Pharmacia Corporation | Method for the preparation of tetrahydrobenzothiepines |
| US20040219619A1 (en) * | 2000-07-21 | 2004-11-04 | Ester Fernandez-Salas | Methods of identifying compounds that alter toxin persistence and/or protease activity |
| US6958328B2 (en) * | 2001-04-18 | 2005-10-25 | Ortho-Mcneil Pharmaceutical, Inc | Arylindenopyridines and related therapeutic and prophylactic methods |
| US20050239782A1 (en) * | 2001-04-18 | 2005-10-27 | Heintzelman Geoffrey R | Arylindenopyridines and related therapeutic and prophylactic methods |
| US6903109B2 (en) * | 2001-04-18 | 2005-06-07 | Ortho-Muniel Pharmaceutical, Inc. | Arylindenopyridines and related therapeutic and prophylactic methods |
| MXPA03011784A (es) | 2001-06-22 | 2004-04-02 | Pfizer Prod Inc | Composiciones farmaceuticas de dispersiones de farmacos y polimeros neutros. |
| KR100759635B1 (ko) | 2001-06-22 | 2007-09-17 | 화이자 프로덕츠 인코포레이티드 | 비정질 약물의 흡착체의 약학 조성물 |
| BR0213501A (pt) | 2001-11-02 | 2004-08-24 | Searle Llc | Compostos de benzotiepina mono- e di-fluorada como inibidores de transporte de ácido biliar co-dependente de sódio apical (asbt) e captação de taurocolato |
| MXPA04006255A (es) | 2002-01-17 | 2004-09-27 | Pharmacia Corp | Compuestos novedosos de alquil/aril hidroxi o ceto tiepina como inhibidores del transporte del acido biliar codependiente del sodio apical y la captacion de taurocolato. |
| DE60320940D1 (de) * | 2002-02-01 | 2008-06-26 | Pfizer Prod Inc | Pharmazeutische zusammensetzungen amorpher dispersionen von wirkstoffen und lipophiler mikrophasenbildender materialien |
| US20040127510A1 (en) | 2002-04-16 | 2004-07-01 | Heintzelman Geoffrey R. | Arylindenopyridines and arylindenopyrimidines and related therapeutic and prophylactic methods |
| CL2004001884A1 (es) | 2003-08-04 | 2005-06-03 | Pfizer Prod Inc | Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros. |
| JP2007501218A (ja) * | 2003-08-04 | 2007-01-25 | ファイザー・プロダクツ・インク | 非晶質薬物の吸着物および親油性ミクロ相形成物質の医薬組成物 |
| KR20070087197A (ko) | 2003-09-26 | 2007-08-27 | 니뽄 다바코 산교 가부시키가이샤 | 잔여 리포프로테인 생산 저해 방법 |
| WO2005037796A1 (en) | 2003-10-08 | 2005-04-28 | Eli Lilly And Company | Compounds and methods for treating dyslipidemia |
| BRPI0508966A (pt) | 2004-03-26 | 2007-08-21 | Lilly Co Eli | composto, composição farmacêutica, e, uso de um composto |
| MX2007007188A (es) * | 2004-12-18 | 2007-08-14 | Bayer Healthcare Ag | Derivados de tetrahidroquinolina sustituidos en 4 con cicloalquilo y su uso como medicamentos. |
| EP1844078B1 (en) | 2005-02-03 | 2016-09-28 | Bend Research, Inc | Pharmaceutical compositions with enhanced performance |
| RU2008119687A (ru) | 2005-10-21 | 2009-11-27 | Новартис АГ (CH) | Комбинации органических соединений |
| DE102006012548A1 (de) * | 2006-03-18 | 2007-09-20 | Bayer Healthcare Ag | Substituierte Chromanol-Derivate und ihre Verwendung |
| PA8801401A1 (es) * | 2007-10-25 | 2009-05-15 | Janssen Pharmaceutica Nv | Arilindenopirimidinas y su uso como adenosina a2a |
| WO2012027331A1 (en) | 2010-08-27 | 2012-03-01 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5169857A (en) * | 1988-01-20 | 1992-12-08 | Bayer Aktiengesellschaft | 7-(polysubstituted pyridyl)-hept-6-endates useful for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis |
| GB8626344D0 (en) * | 1986-11-04 | 1986-12-03 | Zyma Sa | Bicyclic compounds |
| NO177005C (no) * | 1988-01-20 | 1995-07-05 | Bayer Ag | Analogifremgangsmåte for fremstilling av substituerte pyridiner, samt mellomprodukter til bruk ved fremstillingen |
| IE892088L (en) * | 1988-07-12 | 1990-01-12 | William Henry Deryk Morris | Quinoline derivatives, their production and use |
| NZ237097A (en) * | 1990-02-26 | 1993-12-23 | Squibb & Sons Inc | Pyridine derivatives substituted in the 3-position by a phosphinic moiety. |
| JPH059179A (ja) * | 1990-09-27 | 1993-01-19 | Takeda Chem Ind Ltd | 複素環化合物、その製造法及びａｃａｔ阻害剤 |
-
1996
- 1996-07-08 DE DE19627430A patent/DE19627430A1/de not_active Withdrawn
-
1997
- 1997-06-16 HN HN1997000082A patent/HN1997000082A/es unknown
- 1997-06-17 HR HR19627430.3A patent/HRP970331A2/hr not_active Application Discontinuation
- 1997-06-18 SG SG1997002082A patent/SG46782A1/en unknown
- 1997-06-25 EP EP97110360A patent/EP0825185A1/de not_active Withdrawn
- 1997-06-27 US US08/883,067 patent/US6063788A/en not_active Expired - Fee Related
- 1997-07-02 AR ARP970102972A patent/AR007716A1/es not_active Application Discontinuation
- 1997-07-03 AU AU28448/97A patent/AU722365B2/en not_active Ceased
- 1997-07-04 BG BG101746A patent/BG61972B1/bg unknown
- 1997-07-04 TR TR97/00583A patent/TR199700583A2/xx unknown
- 1997-07-04 ID IDP972332A patent/ID17659A/id unknown
- 1997-07-04 NZ NZ328260A patent/NZ328260A/en unknown
- 1997-07-04 PL PL97320954A patent/PL320954A1/xx unknown
- 1997-07-04 IL IL12123597A patent/IL121235A0/xx unknown
- 1997-07-04 CA CA002209609A patent/CA2209609A1/en not_active Abandoned
- 1997-07-07 HU HU9701158A patent/HUP9701158A1/hu unknown
- 1997-07-07 MA MA24705A patent/MA24261A1/fr unknown
- 1997-07-07 TN TNTNSN97116A patent/TNSN97116A1/fr unknown
- 1997-07-07 SK SK926-97A patent/SK92697A3/sk unknown
- 1997-07-07 ZA ZA9706021A patent/ZA976021B/xx unknown
- 1997-07-07 CZ CZ972147A patent/CZ214797A3/cs unknown
- 1997-07-07 KR KR1019970031342A patent/KR980009247A/ko not_active Withdrawn
- 1997-07-07 CO CO97037764A patent/CO4870759A1/es unknown
- 1997-07-07 JP JP9195235A patent/JPH1067751A/ja active Pending
- 1997-07-07 NO NO973144A patent/NO308738B1/no not_active IP Right Cessation
- 1997-07-07 PE PE1997000581A patent/PE87798A1/es not_active Application Discontinuation
- 1997-07-08 BR BR9703886A patent/BR9703886A/pt active Search and Examination
- 1997-07-08 YU YU28897A patent/YU28897A/sh unknown
- 1997-07-08 EE EE9700151A patent/EE9700151A/xx unknown
- 1997-07-08 CN CN97114558A patent/CN1172803A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NO973144L (no) | 1998-01-09 |
| NZ328260A (en) | 1998-09-24 |
| JPH1067751A (ja) | 1998-03-10 |
| ID17659A (id) | 1998-01-15 |
| AU2844897A (en) | 1998-01-15 |
| TR199700583A2 (xx) | 1998-01-21 |
| PL320954A1 (en) | 1998-01-19 |
| EE9700151A (et) | 1998-02-16 |
| CZ214797A3 (cs) | 1998-01-14 |
| IL121235A0 (en) | 1998-01-04 |
| BG101746A (en) | 1998-03-31 |
| US6063788A (en) | 2000-05-16 |
| HU9701158D0 (en) | 1997-09-29 |
| SG46782A1 (en) | 1998-02-20 |
| BR9703886A (pt) | 1998-11-03 |
| YU28897A (sh) | 2000-03-21 |
| CN1172803A (zh) | 1998-02-11 |
| KR980009247A (ko) | 1998-04-30 |
| TNSN97116A1 (fr) | 2005-03-15 |
| HRP970331A2 (en) | 1998-08-31 |
| HUP9701158A1 (hu) | 1999-09-28 |
| SK92697A3 (en) | 1998-02-04 |
| CO4870759A1 (es) | 1999-12-27 |
| DE19627430A1 (de) | 1998-01-15 |
| ZA976021B (en) | 1998-02-02 |
| CA2209609A1 (en) | 1998-01-08 |
| AU722365B2 (en) | 2000-08-03 |
| NO308738B1 (no) | 2000-10-23 |
| NO973144D0 (no) | 1997-07-07 |
| HN1997000082A (es) | 1997-12-26 |
| MA24261A1 (fr) | 1998-04-01 |
| AR007716A1 (es) | 1999-11-10 |
| EP0825185A1 (de) | 1998-02-25 |
| BG61972B1 (bg) | 1998-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |