PE87798A1 - Piridinas condensadas biciclicas - Google Patents
Piridinas condensadas biciclicasInfo
- Publication number
- PE87798A1 PE87798A1 PE1997000581A PE00058197A PE87798A1 PE 87798 A1 PE87798 A1 PE 87798A1 PE 1997000581 A PE1997000581 A PE 1997000581A PE 00058197 A PE00058197 A PE 00058197A PE 87798 A1 PE87798 A1 PE 87798A1
- Authority
- PE
- Peru
- Prior art keywords
- optionally
- cycloalkyl
- halogen
- formula
- alkylene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIEREN A COMPUESTOS DE FORMULA (I), EN DONDE: "A" ES ARILO C6-C10 OPCIONALMENTE HASTA TRISUSTITUIDO, SIENDO DE PREFERENCIA FENILO SUSTITUIDO POR F; "D" ES -TR5 O ES -CR6R7R8, EN DONDE R5 Y R6 SON CICLOALQUILO C3-C8 O ARILO C6-C10, ENTRE OTROS, LOS CUALES SE ENCUENTRAN OPCIONALMENTE HASTA TRISUSTITUIDO CON CF3, TRIFLUORMETOXI O HALOGENO, ENTRE OTROS; "T" ES ALQUILENO C1-C10 O ALQUENILENO C1-C10 OPCIONALMENTE BISUSTITUIDO POR OH; R7 ES H O HALOGENO; R8 ES H, HALOGENO O AZIDO, ENTRE OTROS; O R7 Y R8 FORMAN JUNTO CON EL ATOMO DE C UN GRUPO CARBONILO; "E" ES CICLOALQUILO C3-C8 O ES ALQUILO LINEAL O RAMIFICADO C1-C8 OPCIONALMENTE SUSTITUIDO POR CICLOALQUILO C3-C8 O POR OH; R1 Y R2 FORMAN JUNTOS UNA CADENA DE ALQUILENO C1-C8, A LA QUE ESTA FUSIONADO UN FENILO, ESTANDO SUSTITUIDA POR CARBONILO, OR13 O UN RADICAL DE FORMULA (i), EN DONDE a ES 1; 2 o 3; R13 ES H, ALQUILO, ACILO, ALCOXICARBONILO O ES UN RESTO DE FORMULA SILILO. TAMBIEN SE REFIERE AL PROCEDIMIENTO DE PREPARACION DE (I), QUE COMPRENDE INTRODUCIR LOS SUSTITUYENTES "D" USANDO REACTIVOS ORGANOMETALICOS EN DISOLVENTES INERTES, EN EL SENTIDO DE UNA REACCION DE GRIGNARD O DE WITTING. LOS COMPUESTOS OBTENIDOS ACTUAN COMO INHIBIDORES DE LA PROTEINA DE TRANSFERENCIA COLESTEROL ESTER (PTCE), SIENDO UTILES EN EL TRATAMIENTO DE LA HIPERLIPOPROTEINEMIA Y LA ARTERIOESCLEROSIS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19627430A DE19627430A1 (de) | 1996-07-08 | 1996-07-08 | Bicyclisch kondensierte Pyridine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE87798A1 true PE87798A1 (es) | 1999-02-13 |
Family
ID=7799218
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1997000581A PE87798A1 (es) | 1996-07-08 | 1997-07-07 | Piridinas condensadas biciclicas |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6063788A (es) |
| EP (1) | EP0825185A1 (es) |
| JP (1) | JPH1067751A (es) |
| KR (1) | KR980009247A (es) |
| CN (1) | CN1172803A (es) |
| AR (1) | AR007716A1 (es) |
| AU (1) | AU722365B2 (es) |
| BG (1) | BG61972B1 (es) |
| BR (1) | BR9703886A (es) |
| CA (1) | CA2209609A1 (es) |
| CO (1) | CO4870759A1 (es) |
| CZ (1) | CZ214797A3 (es) |
| DE (1) | DE19627430A1 (es) |
| EE (1) | EE9700151A (es) |
| HN (1) | HN1997000082A (es) |
| HR (1) | HRP970331A2 (es) |
| HU (1) | HUP9701158A1 (es) |
| ID (1) | ID17659A (es) |
| IL (1) | IL121235A0 (es) |
| MA (1) | MA24261A1 (es) |
| NO (1) | NO308738B1 (es) |
| NZ (1) | NZ328260A (es) |
| PE (1) | PE87798A1 (es) |
| PL (1) | PL320954A1 (es) |
| SG (1) | SG46782A1 (es) |
| SK (1) | SK92697A3 (es) |
| TN (1) | TNSN97116A1 (es) |
| TR (1) | TR199700583A2 (es) |
| YU (1) | YU28897A (es) |
| ZA (1) | ZA976021B (es) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6262277B1 (en) | 1994-09-13 | 2001-07-17 | G.D. Searle And Company | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
| US6268392B1 (en) | 1994-09-13 | 2001-07-31 | G. D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors |
| AU2157400A (en) | 1998-12-23 | 2000-07-31 | G.D. Searle & Co. | Combinations of cholesteryl ester transfer protein inhibitors and hmg coa reductase inhibitors for cardiovascular indications |
| DE69907960T2 (de) | 1998-12-23 | 2004-02-26 | G.D. Searle Llc, Chicago | Kombinationen von ileumgallensäuretransports inhibitoren und fibronsäure derivaten für kardiovaskuläre indikationen |
| JP2002533414A (ja) | 1998-12-23 | 2002-10-08 | ジー．ディー．サール エルエルシー | 心臓血管に適用するための回腸胆汁酸輸送阻害剤および胆汁酸隔離剤の組み合わせ |
| ES2200587T3 (es) | 1998-12-23 | 2004-03-01 | G.D. Searle Llc | Combinaciones de inhibidors del transporte de acidos biliares del ileon e inhibidores de la proteina de transferencia de colesteril ester para indicaciones cardiovasculares. |
| EA009466B1 (ru) | 1998-12-23 | 2007-12-28 | Джи.Ди. Сирл Ллс | Ингибитор белка, переносящего эфир холестерила |
| WO2000038721A1 (en) | 1998-12-23 | 2000-07-06 | G.D. Searle Llc | Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications |
| US6569905B1 (en) | 1998-12-23 | 2003-05-27 | G.D. Searle, Llc | Combinations of cholesteryl ester transfer protein inhibitors and bile acid sequestering agents for cardiovascular indications |
| US20010018446A1 (en) | 1999-09-23 | 2001-08-30 | G.D. Searle & Co. | Substituted N-Aliphatic-N-Aromatictertiary-Heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity |
| US6924313B1 (en) | 1999-09-23 | 2005-08-02 | Pfizer Inc. | Substituted tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity |
| US6683113B2 (en) * | 1999-09-23 | 2004-01-27 | Pharmacia Corporation | (R)-chiral halogenated substituted N,N-Bis-benzyl aminioalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity |
| EP1286984A2 (en) | 2000-03-10 | 2003-03-05 | Pharmacia Corporation | Method for the preparation of tetrahydrobenzothiepines |
| US20040219619A1 (en) * | 2000-07-21 | 2004-11-04 | Ester Fernandez-Salas | Methods of identifying compounds that alter toxin persistence and/or protease activity |
| US20050239782A1 (en) * | 2001-04-18 | 2005-10-27 | Heintzelman Geoffrey R | Arylindenopyridines and related therapeutic and prophylactic methods |
| US6958328B2 (en) | 2001-04-18 | 2005-10-25 | Ortho-Mcneil Pharmaceutical, Inc | Arylindenopyridines and related therapeutic and prophylactic methods |
| US6903109B2 (en) | 2001-04-18 | 2005-06-07 | Ortho-Muniel Pharmaceutical, Inc. | Arylindenopyridines and related therapeutic and prophylactic methods |
| EA006777B1 (ru) | 2001-06-22 | 2006-04-28 | Пфайзер Продактс Инк. | Фармацевтические композиции адсорбатов аморфного лекарственного средства |
| BR0210518A (pt) | 2001-06-22 | 2004-06-22 | Pfizer Prod Inc | Composições farmacêuticas de dispersões de drogas e polìmeros neutros |
| US6740663B2 (en) | 2001-11-02 | 2004-05-25 | G.D. Searle, Llc | Mono- and di-fluorinated benzothiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (ASBT) and taurocholate uptake |
| US6852753B2 (en) | 2002-01-17 | 2005-02-08 | Pharmacia Corporation | Alkyl/aryl hydroxy or keto thiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (ASBT) and taurocholate uptake |
| EP1469832B2 (en) * | 2002-02-01 | 2016-10-26 | Bend Research, Inc. | Pharmaceutical compositions of amorphous dispersions of drugs and lipophilic microphase-forming materials |
| US20040127510A1 (en) * | 2002-04-16 | 2004-07-01 | Heintzelman Geoffrey R. | Arylindenopyridines and arylindenopyrimidines and related therapeutic and prophylactic methods |
| CL2004001884A1 (es) | 2003-08-04 | 2005-06-03 | Pfizer Prod Inc | Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros. |
| CA2532931A1 (en) * | 2003-08-04 | 2005-02-10 | Pfizer Products Inc. | Pharmaceutical compositions of adsorbates of amorphous drugs and lipophilic microphase-forming materials |
| EP1670446A2 (en) | 2003-09-26 | 2006-06-21 | Japan Tobacco Inc. | Method of inhibiting remnant lipoprotein production |
| MXPA06003927A (es) | 2003-10-08 | 2008-02-07 | Lilly Co Eli | Compuestos y metodos para tratar dislipidemia. |
| US20070208003A1 (en) | 2004-03-26 | 2007-09-06 | Bell Michael G | Compounds and methods for treating dyslipidemia |
| SI1828137T1 (sl) * | 2004-12-18 | 2012-08-31 | Bayer Pharma AG | 4-cikloalkil-substituirani derivati tetrahidrokinolina in njihova uporaba kot zdravila |
| EP1844078B1 (en) | 2005-02-03 | 2016-09-28 | Bend Research, Inc | Pharmaceutical compositions with enhanced performance |
| WO2007048027A2 (en) | 2005-10-21 | 2007-04-26 | Novartis Ag | Combination of a renin-inhibitor and an anti-dyslipidemic agent and/or an antiobesity agent |
| DE102006012548A1 (de) * | 2006-03-18 | 2007-09-20 | Bayer Healthcare Ag | Substituierte Chromanol-Derivate und ihre Verwendung |
| PA8801401A1 (es) * | 2007-10-25 | 2009-05-15 | Janssen Pharmaceutica Nv | Arilindenopirimidinas y su uso como adenosina a2a |
| US20130156720A1 (en) | 2010-08-27 | 2013-06-20 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5169857A (en) * | 1988-01-20 | 1992-12-08 | Bayer Aktiengesellschaft | 7-(polysubstituted pyridyl)-hept-6-endates useful for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis |
| GB8626344D0 (en) * | 1986-11-04 | 1986-12-03 | Zyma Sa | Bicyclic compounds |
| NO177005C (no) * | 1988-01-20 | 1995-07-05 | Bayer Ag | Analogifremgangsmåte for fremstilling av substituerte pyridiner, samt mellomprodukter til bruk ved fremstillingen |
| IE892088L (en) * | 1988-07-12 | 1990-01-12 | William Henry Deryk Morris | Quinoline derivatives, their production and use |
| ZA911046B (en) * | 1990-02-26 | 1992-10-28 | Squibb & Sons Inc | Quinoline and pyridine anchors for hmg-coa reductase inhibitors |
| JPH059179A (ja) * | 1990-09-27 | 1993-01-19 | Takeda Chem Ind Ltd | 複素環化合物、その製造法及びａｃａｔ阻害剤 |
-
1996
- 1996-07-08 DE DE19627430A patent/DE19627430A1/de not_active Withdrawn
-
1997
- 1997-06-16 HN HN1997000082A patent/HN1997000082A/es unknown
- 1997-06-17 HR HR19627430.3A patent/HRP970331A2/hr not_active Application Discontinuation
- 1997-06-18 SG SG1997002082A patent/SG46782A1/en unknown
- 1997-06-25 EP EP97110360A patent/EP0825185A1/de not_active Withdrawn
- 1997-06-27 US US08/883,067 patent/US6063788A/en not_active Expired - Fee Related
- 1997-07-02 AR ARP970102972A patent/AR007716A1/es not_active Application Discontinuation
- 1997-07-03 AU AU28448/97A patent/AU722365B2/en not_active Ceased
- 1997-07-04 PL PL97320954A patent/PL320954A1/xx unknown
- 1997-07-04 IL IL12123597A patent/IL121235A0/xx unknown
- 1997-07-04 CA CA002209609A patent/CA2209609A1/en not_active Abandoned
- 1997-07-04 ID IDP972332A patent/ID17659A/id unknown
- 1997-07-04 NZ NZ328260A patent/NZ328260A/en unknown
- 1997-07-04 BG BG101746A patent/BG61972B1/bg unknown
- 1997-07-04 TR TR97/00583A patent/TR199700583A2/xx unknown
- 1997-07-07 CZ CZ972147A patent/CZ214797A3/cs unknown
- 1997-07-07 NO NO973144A patent/NO308738B1/no not_active IP Right Cessation
- 1997-07-07 ZA ZA9706021A patent/ZA976021B/xx unknown
- 1997-07-07 CO CO97037764A patent/CO4870759A1/es unknown
- 1997-07-07 TN TNTNSN97116A patent/TNSN97116A1/fr unknown
- 1997-07-07 HU HU9701158A patent/HUP9701158A1/hu unknown
- 1997-07-07 KR KR1019970031342A patent/KR980009247A/ko not_active Application Discontinuation
- 1997-07-07 JP JP9195235A patent/JPH1067751A/ja active Pending
- 1997-07-07 MA MA24705A patent/MA24261A1/fr unknown
- 1997-07-07 SK SK926-97A patent/SK92697A3/sk unknown
- 1997-07-07 PE PE1997000581A patent/PE87798A1/es not_active Application Discontinuation
- 1997-07-08 EE EE9700151A patent/EE9700151A/xx unknown
- 1997-07-08 BR BR9703886A patent/BR9703886A/pt active Search and Examination
- 1997-07-08 CN CN97114558A patent/CN1172803A/zh active Pending
- 1997-07-08 YU YU28897A patent/YU28897A/sh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL320954A1 (en) | 1998-01-19 |
| ID17659A (id) | 1998-01-15 |
| CN1172803A (zh) | 1998-02-11 |
| IL121235A0 (en) | 1998-01-04 |
| SG46782A1 (en) | 1998-02-20 |
| YU28897A (sh) | 2000-03-21 |
| NO308738B1 (no) | 2000-10-23 |
| HUP9701158A1 (hu) | 1999-09-28 |
| BR9703886A (pt) | 1998-11-03 |
| NZ328260A (en) | 1998-09-24 |
| AR007716A1 (es) | 1999-11-10 |
| BG61972B1 (bg) | 1998-11-30 |
| DE19627430A1 (de) | 1998-01-15 |
| HRP970331A2 (en) | 1998-08-31 |
| HU9701158D0 (en) | 1997-09-29 |
| SK92697A3 (en) | 1998-02-04 |
| EE9700151A (et) | 1998-02-16 |
| AU722365B2 (en) | 2000-08-03 |
| CA2209609A1 (en) | 1998-01-08 |
| MA24261A1 (fr) | 1998-04-01 |
| TNSN97116A1 (fr) | 2005-03-15 |
| BG101746A (en) | 1998-03-31 |
| JPH1067751A (ja) | 1998-03-10 |
| ZA976021B (en) | 1998-02-02 |
| NO973144D0 (no) | 1997-07-07 |
| CO4870759A1 (es) | 1999-12-27 |
| CZ214797A3 (cs) | 1998-01-14 |
| AU2844897A (en) | 1998-01-15 |
| KR980009247A (ko) | 1998-04-30 |
| HN1997000082A (es) | 1997-12-26 |
| NO973144L (no) | 1998-01-09 |
| US6063788A (en) | 2000-05-16 |
| EP0825185A1 (de) | 1998-02-25 |
| TR199700583A2 (xx) | 1998-01-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |