WO1987004430A3 - Benzazepines fondues - Google Patents
Benzazepines fondues Download PDFInfo
- Publication number
- WO1987004430A3 WO1987004430A3 PCT/US1987/000042 US8700042W WO8704430A3 WO 1987004430 A3 WO1987004430 A3 WO 1987004430A3 US 8700042 W US8700042 W US 8700042W WO 8704430 A3 WO8704430 A3 WO 8704430A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fused benzazepines
- useful
- benzazepines
- fused
- hypertension
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE8787900939T DE3763928D1 (de) | 1986-01-16 | 1987-01-14 | Kondensierte benzazepine. |
JP62500944A JPH0681745B2 (ja) | 1986-01-16 | 1987-01-14 | 縮合ベンゾアゼピン |
HU87914A HU199805B (en) | 1986-01-16 | 1987-01-14 | Process for producing condensed benzazepine derivatives and pharmaceutical compositions comprising such compounds |
AT87900939T ATE54911T1 (de) | 1986-01-16 | 1987-01-14 | Kondensierte benzazepine. |
KR1019870700836A KR900007781B1 (ko) | 1986-01-16 | 1987-01-14 | 융합된 벤즈아제핀 |
DK479087A DK164161C (da) | 1986-01-16 | 1987-09-14 | Kondenserede benzazepiner, fremgangsmaade til fremstilling deraf, farmaceutiske praeparater indeholdende forbindelserne, fremgangsmaade til fremstilling af saadanne praeparater samt anvendelse af forbindelserne til fremstilling af farmaceutiske praeparater |
NO873874A NO172046C (no) | 1986-01-16 | 1987-09-15 | Analogifremgangsmaate for fremstilling av terapeutisk aktive, kondenserte benzazepiner |
FI874006A FI83512C (fi) | 1986-01-16 | 1987-09-15 | Foerfarande foer framstaellning av farmakologiskt vaerdefulla fusionerade bensazepinfoereningar. |
NO88883602A NO172047C (no) | 1986-01-16 | 1988-08-12 | Benzo(d)azepinderivater |
KR909072051A KR920000272B1 (en) | 1986-01-16 | 1990-09-15 | Fused benzazepines |
SG1286/92A SG128692G (en) | 1986-01-16 | 1992-12-17 | Fused benzazepines |
HK29493A HK29493A (en) | 1986-01-16 | 1993-03-25 | Fused benzazepines |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US82047186A | 1986-01-16 | 1986-01-16 | |
US820,471 | 1986-01-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1987004430A2 WO1987004430A2 (fr) | 1987-07-30 |
WO1987004430A3 true WO1987004430A3 (fr) | 1988-03-24 |
Family
ID=25230864
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1987/000042 WO1987004430A2 (fr) | 1986-01-16 | 1987-01-14 | Benzazepines fondues |
Country Status (19)
Country | Link |
---|---|
EP (2) | EP0254737B1 (fr) |
JP (1) | JPH0681745B2 (fr) |
KR (1) | KR900007781B1 (fr) |
AU (1) | AU588080B2 (fr) |
CA (1) | CA1333485C (fr) |
CS (1) | CS414091A3 (fr) |
DK (1) | DK164161C (fr) |
ES (1) | ES2031834T3 (fr) |
FI (1) | FI83512C (fr) |
GR (1) | GR3000994T3 (fr) |
HU (1) | HU199805B (fr) |
IE (1) | IE59651B1 (fr) |
IL (2) | IL81268A0 (fr) |
NZ (1) | NZ218953A (fr) |
OA (1) | OA08660A (fr) |
PT (1) | PT84109B (fr) |
SG (1) | SG128692G (fr) |
WO (1) | WO1987004430A2 (fr) |
ZA (1) | ZA87291B (fr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4973586A (en) | 1986-01-16 | 1990-11-27 | Schering Corporation | Fused benzazepines, compositions of, and medical use thereof |
ZA875183B (en) * | 1987-07-15 | 1988-04-08 | Schering Corporation | Fused benzazepines |
DK325188D0 (da) * | 1988-06-15 | 1988-06-15 | Novo Industri As | Hidtil ukendte benzazepinderivater |
US5091526A (en) * | 1988-07-29 | 1992-02-25 | Schering Corporation | Process for the enantiospecific synthesis of intermediates for hexahydro-benzo[d]-naphtho[2,1-b]azepines |
JPH03505735A (ja) * | 1988-07-29 | 1991-12-12 | シェリング・コーポレーション | ヘキサヒドロ―ベンゾ[d]―ナフト[2,1―b]アゼピンのための中間体の対掌体特異的合成のための方法 |
US5104814A (en) * | 1988-11-22 | 1992-04-14 | Schering Corporation | Assay kit and methods for neuroleptic drugs |
FR2642065B1 (fr) * | 1989-01-24 | 1991-05-24 | Lipha | Derives d'acides benzocycloalcenyl dihydroxy alcanoiques, procede de preparation et medicaments les contenant |
US5362728A (en) * | 1990-02-02 | 1994-11-08 | Schering Corporation | 4,5-bridged-2,3,4,5-tetrahydro-1H-3-benzazepine-7-ols and derivatives and compositions and methods employing such compounds |
US5461147A (en) * | 1993-09-27 | 1995-10-24 | Schering Corporation | Process for preparing benzazepine intermediates for the synthesis of D1 antagonists |
US5461148A (en) * | 1993-09-27 | 1995-10-24 | Schering Corporation | Process for preparing benzazepine intermediates for the synthesis of D1 antagonists |
US5463051A (en) * | 1993-09-27 | 1995-10-31 | Schering Corporation | Process for preparing benzazepine intermediates for the synthesis of D1 antagonists |
AR027687A1 (es) * | 2000-03-22 | 2003-04-09 | Yakult Honsha Kk | Procedimiento para preparar camptotecina |
AU2003217676B2 (en) | 2002-02-22 | 2009-06-11 | Takeda Pharmaceutical Company Limited | Active agent delivery systems and methods for protecting and administering active agents |
CN1688584A (zh) * | 2002-08-29 | 2005-10-26 | 先灵公司 | 治疗肥胖和中枢神经系统疾病的选择性d1/d5受体拮抗剂 |
JP2006526021A (ja) * | 2003-05-22 | 2006-11-16 | シェーリング コーポレイション | 肥満およびcns障害を治療する選択的d1/d5レセプタアンタゴニストとしての5h−ベンゾ[d]ナフト[2,1−b]アゼピン誘導体 |
WO2008156707A1 (fr) | 2007-06-15 | 2008-12-24 | University Of Florida Research Foundation | Composés thérapeutiques |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3393192A (en) * | 1965-04-26 | 1968-07-16 | Schering Corp | Novel benzazepines |
GB1221324A (en) * | 1967-02-17 | 1971-02-03 | Geigy Ag J R | New processes for the production of benzazepine derivatives |
FR2137626A1 (en) * | 1971-05-10 | 1972-12-29 | Hoffmann La Roche | 6-(benzazepine-6-yl) benzoic acid salts-intermediates for - rheadan alkaloids |
US3939165A (en) * | 1974-11-14 | 1976-02-17 | Morton-Norwich Products, Inc. | 5,6,6A,6B,7,8-Hexahydrobenz[a]phenanthridine hydrochloride |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1118688A (en) | 1967-02-17 | 1968-07-03 | Scherico Ltd | Novel benzazepines and process for making same |
US3609138A (en) | 1967-12-22 | 1971-09-28 | Ciba Geigy Corp | 1-aryl-3-benzazepines |
US4011319A (en) | 1975-07-02 | 1977-03-08 | Smithkline Corporation | Pharmaceutical compositions and methods involving benzazepine derivatives |
US4284555A (en) | 1979-04-27 | 1981-08-18 | Schering Corporation | 7-Chloro-8(substituted amino carbonyloxy)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines |
US4477378A (en) | 1980-02-05 | 1984-10-16 | Schering Corp. | Esters of substituted 8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines |
-
1987
- 1987-01-14 KR KR1019870700836A patent/KR900007781B1/ko not_active IP Right Cessation
- 1987-01-14 EP EP87900939A patent/EP0254737B1/fr not_active Expired - Lifetime
- 1987-01-14 WO PCT/US1987/000042 patent/WO1987004430A2/fr active IP Right Grant
- 1987-01-14 HU HU87914A patent/HU199805B/hu not_active IP Right Cessation
- 1987-01-14 JP JP62500944A patent/JPH0681745B2/ja not_active Expired - Lifetime
- 1987-01-14 AU AU68920/87A patent/AU588080B2/en not_active Ceased
- 1987-01-15 ZA ZA87291A patent/ZA87291B/xx unknown
- 1987-01-15 ES ES198787100446T patent/ES2031834T3/es not_active Expired - Lifetime
- 1987-01-15 IL IL81268A patent/IL81268A0/xx not_active IP Right Cessation
- 1987-01-15 EP EP87100446A patent/EP0230270B1/fr not_active Expired - Lifetime
- 1987-01-15 NZ NZ218953A patent/NZ218953A/xx unknown
- 1987-01-15 PT PT84109A patent/PT84109B/pt not_active IP Right Cessation
- 1987-01-15 CA CA000527422A patent/CA1333485C/fr not_active Expired - Fee Related
- 1987-01-15 IL IL103007A patent/IL103007A/xx not_active IP Right Cessation
- 1987-01-20 IE IE11287A patent/IE59651B1/en not_active IP Right Cessation
- 1987-09-14 DK DK479087A patent/DK164161C/da not_active IP Right Cessation
- 1987-09-15 OA OA59194A patent/OA08660A/xx unknown
- 1987-09-15 FI FI874006A patent/FI83512C/fi not_active IP Right Cessation
-
1990
- 1990-10-29 GR GR90400833T patent/GR3000994T3/el unknown
-
1991
- 1991-12-30 CS CS914140A patent/CS414091A3/cs unknown
-
1992
- 1992-12-17 SG SG1286/92A patent/SG128692G/en unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3393192A (en) * | 1965-04-26 | 1968-07-16 | Schering Corp | Novel benzazepines |
GB1221324A (en) * | 1967-02-17 | 1971-02-03 | Geigy Ag J R | New processes for the production of benzazepine derivatives |
FR2137626A1 (en) * | 1971-05-10 | 1972-12-29 | Hoffmann La Roche | 6-(benzazepine-6-yl) benzoic acid salts-intermediates for - rheadan alkaloids |
US3939165A (en) * | 1974-11-14 | 1976-02-17 | Morton-Norwich Products, Inc. | 5,6,6A,6B,7,8-Hexahydrobenz[a]phenanthridine hydrochloride |
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