TR199700470A2 - Sildenafilin haz�rlanmas� i�in proses. - Google Patents

Sildenafilin haz�rlanmas� i�in proses.

Info

Publication number
TR199700470A2
TR199700470A2 TR97/00470A TR9700470A TR199700470A2 TR 199700470 A2 TR199700470 A2 TR 199700470A2 TR 97/00470 A TR97/00470 A TR 97/00470A TR 9700470 A TR9700470 A TR 9700470A TR 199700470 A2 TR199700470 A2 TR 199700470A2
Authority
TR
Turkey
Prior art keywords
sildenafilin
rlanmas
haz
compound
formula
Prior art date
Application number
TR97/00470A
Other languages
English (en)
Turkish (tr)
Inventor
James Dunn Peter
Shaw Wood Albert
Original Assignee
Pfizer Research And Development Company N.V./S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10795332&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TR199700470(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Research And Development Company N.V./S.A. filed Critical Pfizer Research And Development Company N.V./S.A.
Publication of TR199700470A2 publication Critical patent/TR199700470A2/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26Sulfur atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
TR97/00470A 1996-06-14 1997-06-05 Sildenafilin haz�rlanmas� i�in proses. TR199700470A2 (xx)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9612514.1A GB9612514D0 (en) 1996-06-14 1996-06-14 Novel process

Publications (1)

Publication Number Publication Date
TR199700470A2 true TR199700470A2 (xx) 1998-01-21

Family

ID=10795332

Family Applications (1)

Application Number Title Priority Date Filing Date
TR97/00470A TR199700470A2 (xx) 1996-06-14 1997-06-05 Sildenafilin haz�rlanmas� i�in proses.

Country Status (47)

Country Link
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TN (1) TNSN97102A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TR (1) TR199700470A2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
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US6821978B2 (en) 2000-09-19 2004-11-23 Schering Corporation Xanthine phosphodiesterase V inhibitors
CN1127506C (zh) * 2001-06-29 2003-11-12 刘宝顺 一种治疗阳痿的新化合物
CN1315835C (zh) * 2001-08-28 2007-05-16 先灵公司 多环鸟嘌呤磷酸二酯酶v抑制剂
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DE10232113A1 (de) 2002-07-16 2004-01-29 Bayer Ag Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
CN100374441C (zh) 2003-06-06 2008-03-12 天津倍方科技发展有限公司 二氢吡咯[2,3-d]嘧啶-4-酮衍生物,其制备方法及其制药用途
CN100360531C (zh) * 2003-12-18 2008-01-09 中国人民解放军军事医学科学院放射与辐射医学研究所 用于预防或治疗阳萎和性冷淡的新吡唑并嘧啶类化合物
EP1779852A3 (en) * 2004-01-05 2007-05-09 Teva Pharmaceutical Industries Ltd. Processes for the production of sildenafil base and citrate salt
ES2300979T3 (es) 2004-01-05 2008-06-16 Teva Pharmaceutical Industries Ltd. Procedimiento para la produccion de sildenafilo base y de su sal citrato.
DE102005009240A1 (de) 2005-03-01 2006-09-07 Bayer Healthcare Ag Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften
CN101563348B (zh) * 2006-12-21 2011-08-24 上海特化医药科技有限公司 西地那非的制备方法及其中间体
ES2310144B1 (es) 2007-06-15 2010-01-12 Galenicum Health, S.L. Intermedios para la preparacion de un inhibidor de la fosfodiesterasa tipo 5.
BRPI0823356A2 (pt) 2008-12-12 2015-06-16 Rhein Siegfried Sa De Cv Composição de liberação pulsátil de sildenafil e processo para prepará-la
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CN102993205B (zh) * 2012-12-27 2015-04-15 华润赛科药业有限责任公司 一种高收率制备高纯度西地那非游离碱的纯化方法
CN103044330B (zh) * 2013-01-14 2018-11-13 常州亚邦制药有限公司 西地那非中间体4-氨基-1-甲基-3-正丙基吡唑-5-甲酰胺的绿色合成新工艺
CN105085526B (zh) * 2014-05-15 2017-08-01 重庆圣华曦药业股份有限公司 一种改进的西地那非制备方法
CN105753870B (zh) * 2016-04-01 2018-05-22 重庆康刻尔制药有限公司 一种西地那非杂质f及其制备方法和应用
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil
CN105837578A (zh) * 2016-04-05 2016-08-10 重庆康刻尔制药有限公司 一种西地那非杂质d的合成方法
EP3522920A2 (en) 2016-10-10 2019-08-14 Transgene SA Immunotherapeutic product and mdsc modulator combination therapy
CN113493459B (zh) * 2020-04-07 2022-12-13 广州白云山医药集团股份有限公司白云山制药总厂 Pde5抑制剂化合物及其制备方法和应用
CN112961160A (zh) * 2021-03-05 2021-06-15 遂成药业股份有限公司 一种西地那非的改良合成工艺
CN113754612B (zh) * 2021-10-26 2023-09-26 山东安舜制药有限公司 一种西地那非中间体的制备方法
CN119874665B (zh) * 2025-01-16 2025-10-17 常州大学 一种hi催化制备2-苯基苯并-1,3-硫氧杂环己二烯-4-酮的方法

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Also Published As

Publication number Publication date
EA199700061A1 (ru) 1997-12-30
CN1168376A (zh) 1997-12-24
ZA975259B (en) 1997-12-15
AU697684B2 (en) 1998-10-15
SK283894B6 (sk) 2004-04-06
DZ2247A1 (fr) 2002-12-18
EP0812845A1 (en) 1997-12-17
HRP970326B1 (en) 2000-10-31
ES2201397T3 (es) 2004-03-16
RS49653B (sr) 2007-09-21
DE69723846D1 (de) 2003-09-04
US6066735A (en) 2000-05-23
UA27085C2 (uk) 2000-02-28
SK283893B6 (sk) 2004-04-06
KR980002051A (ko) 1998-03-30
RS49924B (sr) 2008-09-29
SA97180124B1 (ar) 2006-02-08
YU25497A (sh) 1998-12-23
IL121000A0 (en) 1997-11-20
IL125411A0 (en) 1999-03-12
EG24123A (en) 2008-07-06
HUP9701048A2 (hu) 1998-12-28
IN187319B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2002-03-23
BG101569A (en) 1998-01-30
NO306115B1 (no) 1999-09-20
CA2207694A1 (en) 1997-12-14
CN1282740A (zh) 2001-02-07
ATE182150T1 (de) 1999-07-15
DE69700321D1 (de) 1999-08-19
IL121000A (en) 2000-02-29
AP717A (en) 1999-01-04
SI0812845T1 (en) 1999-12-31
NO972481L (no) 1997-12-15
AU2487897A (en) 1997-12-18
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NO304551B1 (no) 1999-01-11
IS6634A (is) 2002-11-25
NZ328084A (en) 1998-08-26
CZ181197A3 (cs) 1998-03-18
SA97180124A (ar) 2005-12-03
DK0916675T3 (da) 2003-10-27
AR003401A1 (es) 1998-08-05
CZ290942B6 (cs) 2002-11-13
DK0812845T3 (da) 1999-11-29
HN1997000072A (es) 1997-12-26
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JP3058863B2 (ja) 2000-07-04
SG50024A1 (en) 1998-06-15
PT916675E (pt) 2003-11-28
BR9703580A (pt) 1998-11-10
IN187317B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2002-03-23
NO985064D0 (no) 1998-10-30
MA24205A1 (fr) 1997-12-31
NO972481D0 (no) 1997-05-30
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JP2866841B2 (ja) 1999-03-08
PL189333B1 (pl) 2005-07-29
RS20060484A (sr) 2007-04-10
US5955611A (en) 1999-09-21
BG62554B1 (bg) 2000-02-29
EP0916675A2 (en) 1999-05-19
IN187318B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2002-03-23
IN187350B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2002-03-30
CO4780028A1 (es) 1999-05-26
SK283896B6 (sk) 2004-04-06
OA10426A (en) 2001-12-07
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EA000102B1 (ru) 1998-08-27
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IS1922B (is) 2004-03-15
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IN187320B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2002-03-23
HRP970326A2 (en) 1998-06-30
SK74397A3 (en) 1998-06-03
SK283895B6 (sk) 2004-04-06
JPH11171879A (ja) 1999-06-29
SI0916675T1 (en) 2003-12-31
IL125411A (en) 2000-02-29
PE20011303A1 (es) 2001-12-25
DE69700321T2 (de) 1999-11-04
EP0916675A3 (en) 1999-07-14
PL320555A1 (en) 1997-12-22
TNSN97102A1 (fr) 2005-03-15
CA2207694C (en) 1999-11-23
HK1033459A1 (en) 2001-08-31
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DE69723846T2 (de) 2004-03-04

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