TR199501421A2 - Amino gruplarini secici bir sekilde acillenmesi. - Google Patents

Amino gruplarini secici bir sekilde acillenmesi.

Info

Publication number
TR199501421A2
TR199501421A2 TR95/01421A TR9501421A TR199501421A2 TR 199501421 A2 TR199501421 A2 TR 199501421A2 TR 95/01421 A TR95/01421 A TR 95/01421A TR 9501421 A TR9501421 A TR 9501421A TR 199501421 A2 TR199501421 A2 TR 199501421A2
Authority
TR
Turkey
Prior art keywords
amino groups
selective opening
selective
opening
amino
Prior art date
Application number
TR95/01421A
Other languages
English (en)
Turkish (tr)
Inventor
Jeffrey Clayton Baker
Victor John Chen
Aidas Vladas Kriauciunas
Brian Alden Moser
Jose Michael Hanguier
Robert Theodore Shuman
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of TR199501421A2 publication Critical patent/TR199501421A2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
TR95/01421A 1994-11-17 1995-11-14 Amino gruplarini secici bir sekilde acillenmesi. TR199501421A2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/341,231 US5646242A (en) 1994-11-17 1994-11-17 Selective acylation of epsilon-amino groups

Publications (1)

Publication Number Publication Date
TR199501421A2 true TR199501421A2 (tr) 1996-06-21

Family

ID=23336740

Family Applications (1)

Application Number Title Priority Date Filing Date
TR95/01421A TR199501421A2 (tr) 1994-11-17 1995-11-14 Amino gruplarini secici bir sekilde acillenmesi.

Country Status (27)

Country Link
US (2) US5646242A (cg-RX-API-DMAC7.html)
EP (2) EP1227107A1 (cg-RX-API-DMAC7.html)
JP (1) JP4312828B2 (cg-RX-API-DMAC7.html)
CN (1) CN1171742A (cg-RX-API-DMAC7.html)
AR (1) AR003915A1 (cg-RX-API-DMAC7.html)
AT (1) ATE328902T1 (cg-RX-API-DMAC7.html)
AU (2) AU691066B2 (cg-RX-API-DMAC7.html)
BR (1) BR9509652A (cg-RX-API-DMAC7.html)
CA (1) CA2205061A1 (cg-RX-API-DMAC7.html)
CO (1) CO4520285A1 (cg-RX-API-DMAC7.html)
CZ (1) CZ287731B6 (cg-RX-API-DMAC7.html)
DE (1) DE69535031T2 (cg-RX-API-DMAC7.html)
DK (1) DK0712862T3 (cg-RX-API-DMAC7.html)
ES (1) ES2264124T3 (cg-RX-API-DMAC7.html)
HU (2) HU9903007D0 (cg-RX-API-DMAC7.html)
IL (1) IL115972A (cg-RX-API-DMAC7.html)
IN (1) IN179820B (cg-RX-API-DMAC7.html)
NO (1) NO972185L (cg-RX-API-DMAC7.html)
NZ (1) NZ297256A (cg-RX-API-DMAC7.html)
PL (1) PL320556A1 (cg-RX-API-DMAC7.html)
PT (1) PT712862E (cg-RX-API-DMAC7.html)
RU (1) RU2155773C2 (cg-RX-API-DMAC7.html)
SI (1) SI0712862T1 (cg-RX-API-DMAC7.html)
TR (1) TR199501421A2 (cg-RX-API-DMAC7.html)
WO (1) WO1996015803A1 (cg-RX-API-DMAC7.html)
YU (1) YU71495A (cg-RX-API-DMAC7.html)
ZA (1) ZA959680B (cg-RX-API-DMAC7.html)

Families Citing this family (76)

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US6251856B1 (en) 1995-03-17 2001-06-26 Novo Nordisk A/S Insulin derivatives
US5631347A (en) * 1995-06-07 1997-05-20 Eli Lilly And Company Reducing gelation of a fatty acid-acylated protein
US6451970B1 (en) * 1996-02-21 2002-09-17 Novo Nordisk A/S Peptide derivatives
US5905140A (en) * 1996-07-11 1999-05-18 Novo Nordisk A/S, Novo Alle Selective acylation method
ATE278711T1 (de) * 1996-07-11 2004-10-15 Novo Nordisk As Verfahren zur selektiven acetylierung
US6444641B1 (en) 1997-10-24 2002-09-03 Eli Lilly Company Fatty acid-acylated insulin analogs
CA2306877A1 (en) * 1997-10-24 1999-05-06 Eli Lilly And Company Insoluble insulin compositions
US5981709A (en) * 1997-12-19 1999-11-09 Enzon, Inc. α-interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same
US5985263A (en) * 1997-12-19 1999-11-16 Enzon, Inc. Substantially pure histidine-linked protein polymer conjugates
US6451974B1 (en) 1999-03-17 2002-09-17 Novo Nordisk A/S Method of acylating peptides and novel acylating agents
AU4904800A (en) * 1999-05-27 2000-12-18 Robert Z-T. Luo Identification of compounds for modulating dimeric receptors
US7169889B1 (en) 1999-06-19 2007-01-30 Biocon Limited Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
WO2001085256A2 (en) * 2000-05-05 2001-11-15 Novo Nordisk A/S Critical illness neuropathy
US7316999B2 (en) 2000-06-02 2008-01-08 Novo Nordisk A/S Glucose dependent release of insulin from glucose sensing insulin derivatives
US20030054015A1 (en) * 2000-12-25 2003-03-20 Shinichiro Haze Sympathetic-activating perfume composition
US7060675B2 (en) * 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US6867183B2 (en) 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6713452B2 (en) 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6828305B2 (en) * 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7595172B2 (en) * 2001-07-24 2009-09-29 Novo Nordisk A/S Method for making acylated polypeptides
US20030082671A1 (en) 2001-07-24 2003-05-01 Thomas Hoeg-Jensen Method for making acylated polypeptides
KR20040019361A (ko) * 2001-07-24 2004-03-05 노보 노르디스크 에이/에스 아실화된 폴리펩티드의 제조 방법
AU2002355160A1 (en) * 2001-07-24 2003-02-17 Novo Nordisk A/S Method for making acylated polypeptides
US7312192B2 (en) * 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
SI1430082T1 (sl) 2001-09-07 2010-02-26 Biocon Ltd Postopki za sintetiziranje konjugatov inzulinski polipeptid-oligomer in konjugati proinzulinski polipeptid-oligomer in postopki za njihovo sintetiziranje
US7196059B2 (en) 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US6770625B2 (en) 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
US6913903B2 (en) 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7166571B2 (en) * 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
US20030199445A1 (en) * 2002-02-07 2003-10-23 Knudsen Lotte Bjerre Use of GLP-1 compound for treatment of critically ill patients
US7601688B2 (en) 2002-06-13 2009-10-13 Biocon Limited Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
CA2500123A1 (en) * 2002-09-25 2004-04-08 Novo Nordisk A/S Method for producing acylated peptides
US7273921B2 (en) 2002-09-25 2007-09-25 Novo Nordisk A/S Method for producing acylated peptides
EP2264065B1 (en) * 2003-08-05 2017-03-08 Novo Nordisk A/S Novel insulin derivatives
WO2005047508A1 (en) 2003-11-14 2005-05-26 Novo Nordisk A/S Processes for making acylated insulin
US7875700B2 (en) 2004-07-19 2011-01-25 Biocon Limited Cation complexes of insulin compound conjugates, formulation and uses thereof
CN101243190B (zh) 2005-08-16 2015-05-13 诺沃-诺迪斯克有限公司 制备成熟胰岛素多肽的方法
US20090074882A1 (en) 2005-12-28 2009-03-19 Novo Nordisk A/S Insulin compositions and method of making a composition
ATE482977T1 (de) * 2006-02-27 2010-10-15 Novo Nordisk As Insulinderivate
US8927015B2 (en) * 2006-04-12 2015-01-06 Emisphere Technologies, Inc. Formulations for delivering insulin
WO2008015099A2 (en) 2006-07-31 2008-02-07 Novo Nordisk A/S Pegylated, extended insulins
CN101541830A (zh) 2006-09-22 2009-09-23 诺沃-诺迪斯克有限公司 蛋白酶抗性的胰岛素类似物
WO2008037735A1 (en) 2006-09-27 2008-04-03 Novo Nordisk A/S Method for making maturated insulin polypeptides
EP2152245B1 (en) 2007-04-30 2015-12-02 Novo Nordisk A/S Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
US9034818B2 (en) 2007-06-13 2015-05-19 Novo Nordisk A/S Pharmaceutical formulations comprising an insulin derivative
MX2010003979A (es) 2007-10-16 2010-06-02 Biocon Ltd Composicion farmaceutica oralmente administrable y proceso para su preparacion.
WO2009112583A2 (en) 2008-03-14 2009-09-17 Novo Nordisk A/S Protease-stabilized insulin analogues
ES2611007T3 (es) 2008-03-18 2017-05-04 Novo Nordisk A/S Análogos de insulina acilada, estabilizados frente a proteasas
CN102149411A (zh) 2008-09-12 2011-08-10 诺沃—诺迪斯克有限公司 酰化肽或蛋白的方法
WO2010049488A1 (en) * 2008-10-30 2010-05-06 Novo Nordisk A/S Treating diabetes melitus using insulin injections with less than daily injection frequency
JP5422003B2 (ja) * 2009-02-20 2014-02-19 イプセン ファルマ ソシエテ パール アクシオン サンプリフィエ ３４位にプロリン置換を有する神経ペプチドｙの類似体
JP5892940B2 (ja) 2009-11-25 2016-03-23 アリスジェン ソシエテ アノニム クラウン化合物及び／又は対イオンと複合体化されたペプチドを含む粘膜送達組成物
BR112013010345A2 (pt) 2010-10-27 2017-07-25 Novo Nordisk As tratamento de diabetes melitus usando as injeções de insulina administradas com intervalos de variação da injeção
BR112014025132A2 (pt) 2012-04-11 2017-07-11 Novo Nordisk As formulações de insulina
WO2014177623A1 (en) 2013-04-30 2014-11-06 Novo Nordisk A/S Novel administration regime
EP3055325B1 (en) 2013-10-07 2018-01-03 Novo Nordisk A/S Novel derivative of an insulin analogue
FR3013049B1 (fr) 2013-11-14 2015-11-13 You-Ping Chan Analogue de l'insuline glargine
AR099569A1 (es) 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
CN104558097A (zh) * 2014-05-20 2015-04-29 广东东阳光药业有限公司 肽的酰化方法
CN105111305B (zh) * 2015-10-10 2018-12-14 山东阿华生物药业有限公司 酰化胰岛素的色谱纯化方法
CN105440125B (zh) * 2015-11-25 2019-09-24 华润昂德生物药业有限公司 地特胰岛素或其类似物的制备方法
KR102382489B1 (ko) 2016-05-05 2022-04-01 코덱시스, 인코포레이티드 페니실린 ｇ 아실라제
CN109922835B (zh) 2016-11-07 2023-08-04 诺和诺德股份有限公司 Peg化合物的dchbs活性酯及其用途
DK3821905T3 (da) 2016-12-16 2022-11-14 Novo Nordisk As Insulin indeholdende farmaceutiske sammensætninger
CN107602437A (zh) * 2017-08-09 2018-01-19 上海昂德生物科技有限公司 活化酯的制备方法
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin
WO2021009027A1 (en) 2019-07-12 2021-01-21 Novo Nordisk A/S High concentration insulin formulation
CN116874585B (zh) * 2023-09-06 2023-12-15 杭州湃肽生化科技有限公司 一种地特胰岛素的合成方法

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Also Published As

Publication number Publication date
DK0712862T3 (da) 2006-09-25
NO972185D0 (no) 1997-05-13
MX9703506A (es) 1997-07-31
HU9903007D0 (en) 1999-11-29
JPH10509176A (ja) 1998-09-08
EP0712862A3 (en) 1998-03-04
RU2155773C2 (ru) 2000-09-10
DE69535031T2 (de) 2006-12-28
DE69535031D1 (de) 2006-07-20
EP0712862B1 (en) 2006-06-07
PT712862E (pt) 2006-08-31
JP4312828B2 (ja) 2009-08-12
AU4237296A (en) 1996-06-17
AU720820B2 (en) 2000-06-15
EP0712862A2 (en) 1996-05-22
CZ287731B6 (en) 2001-01-17
CZ145697A3 (en) 1997-12-17
WO1996015803A1 (en) 1996-05-30
AU7885498A (en) 1998-11-05
HUT77737A (hu) 1998-07-28
ATE328902T1 (de) 2006-06-15
US5646242A (en) 1997-07-08
ZA959680B (en) 1997-05-14
YU71495A (sh) 1998-09-18
CN1171742A (zh) 1998-01-28
CA2205061A1 (en) 1996-05-30
ES2264124T3 (es) 2006-12-16
BR9509652A (pt) 1997-09-16
NZ297256A (en) 2000-01-28
HU217585B (hu) 2000-02-28
SI0712862T1 (sl) 2006-10-31
CO4520285A1 (es) 1997-10-15
USRE37971E1 (en) 2003-01-28
EP1227107A1 (en) 2002-07-31
IN179820B (cg-RX-API-DMAC7.html) 1997-12-13
HK1014007A1 (en) 1999-09-17
IL115972A (en) 2000-09-28
NO972185L (no) 1997-05-13
IL115972A0 (en) 1996-01-31
AR003915A1 (es) 1998-09-30
PL320556A1 (en) 1997-10-13
AU691066B2 (en) 1998-05-07

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