PL320556A1 - Selective acylation of amino groups - Google Patents

Selective acylation of amino groups

Info

Publication number
PL320556A1
PL320556A1 PL95320556A PL32055695A PL320556A1 PL 320556 A1 PL320556 A1 PL 320556A1 PL 95320556 A PL95320556 A PL 95320556A PL 32055695 A PL32055695 A PL 32055695A PL 320556 A1 PL320556 A1 PL 320556A1
Authority
PL
Poland
Prior art keywords
amino groups
selective acylation
acylation
selective
amino
Prior art date
Application number
PL95320556A
Other languages
English (en)
Inventor
Jeffrey Clayton Baker
Victor John Chen
Jose Michael Hanquier
Aidas Vladas Kriauciunas
Brian Allen Moser
Robert Theodore Shuman
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PL320556A1 publication Critical patent/PL320556A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PL95320556A 1994-11-17 1995-11-14 Selective acylation of amino groups PL320556A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/341,231 US5646242A (en) 1994-11-17 1994-11-17 Selective acylation of epsilon-amino groups
PCT/US1995/014872 WO1996015803A1 (en) 1994-11-17 1995-11-14 SELECTIVE ACYLATION OF ε-AMINO GROUPS

Publications (1)

Publication Number Publication Date
PL320556A1 true PL320556A1 (en) 1997-10-13

Family

ID=23336740

Family Applications (1)

Application Number Title Priority Date Filing Date
PL95320556A PL320556A1 (en) 1994-11-17 1995-11-14 Selective acylation of amino groups

Country Status (27)

Country Link
US (2) US5646242A (cg-RX-API-DMAC7.html)
EP (2) EP1227107A1 (cg-RX-API-DMAC7.html)
JP (1) JP4312828B2 (cg-RX-API-DMAC7.html)
CN (1) CN1171742A (cg-RX-API-DMAC7.html)
AR (1) AR003915A1 (cg-RX-API-DMAC7.html)
AT (1) ATE328902T1 (cg-RX-API-DMAC7.html)
AU (2) AU691066B2 (cg-RX-API-DMAC7.html)
BR (1) BR9509652A (cg-RX-API-DMAC7.html)
CA (1) CA2205061A1 (cg-RX-API-DMAC7.html)
CO (1) CO4520285A1 (cg-RX-API-DMAC7.html)
CZ (1) CZ287731B6 (cg-RX-API-DMAC7.html)
DE (1) DE69535031T2 (cg-RX-API-DMAC7.html)
DK (1) DK0712862T3 (cg-RX-API-DMAC7.html)
ES (1) ES2264124T3 (cg-RX-API-DMAC7.html)
HU (2) HU9903007D0 (cg-RX-API-DMAC7.html)
IL (1) IL115972A (cg-RX-API-DMAC7.html)
IN (1) IN179820B (cg-RX-API-DMAC7.html)
NO (1) NO972185L (cg-RX-API-DMAC7.html)
NZ (1) NZ297256A (cg-RX-API-DMAC7.html)
PL (1) PL320556A1 (cg-RX-API-DMAC7.html)
PT (1) PT712862E (cg-RX-API-DMAC7.html)
RU (1) RU2155773C2 (cg-RX-API-DMAC7.html)
SI (1) SI0712862T1 (cg-RX-API-DMAC7.html)
TR (1) TR199501421A2 (cg-RX-API-DMAC7.html)
WO (1) WO1996015803A1 (cg-RX-API-DMAC7.html)
YU (1) YU71495A (cg-RX-API-DMAC7.html)
ZA (1) ZA959680B (cg-RX-API-DMAC7.html)

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US7196059B2 (en) 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
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US6913903B2 (en) 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
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US20030199445A1 (en) * 2002-02-07 2003-10-23 Knudsen Lotte Bjerre Use of GLP-1 compound for treatment of critically ill patients
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KR101131783B1 (ko) * 2002-09-25 2012-03-30 노보 노르디스크 에이/에스 아실화된 펩타이드의 제조방법
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ES2561208T3 (es) 2008-09-12 2016-02-25 Novo Nordisk A/S Método de acilación de un péptido o una proteína
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KR101396951B1 (ko) * 2009-02-20 2014-06-27 입센 파마 에스.에이.에스 34번 위치에 프롤린 치환이 있는 뉴로펩타이드 ｙ의 유사체
CA2782056C (en) 2009-11-25 2021-03-09 Arisgen Sa Mucosal delivery of peptides
JP6049625B2 (ja) 2010-10-27 2016-12-21 ノヴォ ノルディスク アー／エス 様々な注射間隔を用いて施されるインスリン注射を使用する、真性糖尿病の治療
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CN104558097A (zh) * 2014-05-20 2015-04-29 广东东阳光药业有限公司 肽的酰化方法
CN105111305B (zh) * 2015-10-10 2018-12-14 山东阿华生物药业有限公司 酰化胰岛素的色谱纯化方法
CN105440125B (zh) * 2015-11-25 2019-09-24 华润昂德生物药业有限公司 地特胰岛素或其类似物的制备方法
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Also Published As

Publication number Publication date
JPH10509176A (ja) 1998-09-08
CZ145697A3 (en) 1997-12-17
JP4312828B2 (ja) 2009-08-12
ES2264124T3 (es) 2006-12-16
EP0712862B1 (en) 2006-06-07
PT712862E (pt) 2006-08-31
EP0712862A2 (en) 1996-05-22
AU720820B2 (en) 2000-06-15
SI0712862T1 (sl) 2006-10-31
DE69535031T2 (de) 2006-12-28
IN179820B (cg-RX-API-DMAC7.html) 1997-12-13
CA2205061A1 (en) 1996-05-30
EP0712862A3 (en) 1998-03-04
MX9703506A (es) 1997-07-31
IL115972A (en) 2000-09-28
ATE328902T1 (de) 2006-06-15
RU2155773C2 (ru) 2000-09-10
CN1171742A (zh) 1998-01-28
NZ297256A (en) 2000-01-28
DE69535031D1 (de) 2006-07-20
EP1227107A1 (en) 2002-07-31
AU4237296A (en) 1996-06-17
HU217585B (hu) 2000-02-28
AU691066B2 (en) 1998-05-07
IL115972A0 (en) 1996-01-31
HUT77737A (hu) 1998-07-28
HU9903007D0 (en) 1999-11-29
TR199501421A2 (tr) 1996-06-21
NO972185D0 (no) 1997-05-13
CZ287731B6 (en) 2001-01-17
AR003915A1 (es) 1998-09-30
HK1014007A1 (en) 1999-09-17
DK0712862T3 (da) 2006-09-25
WO1996015803A1 (en) 1996-05-30
YU71495A (sh) 1998-09-18
CO4520285A1 (es) 1997-10-15
USRE37971E1 (en) 2003-01-28
BR9509652A (pt) 1997-09-16
NO972185L (no) 1997-05-13
ZA959680B (en) 1997-05-14
AU7885498A (en) 1998-11-05
US5646242A (en) 1997-07-08

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