TNSN99054A1 - Procede pour alkyler des sulfonamides a encombrement sterique - Google Patents
Procede pour alkyler des sulfonamides a encombrement steriqueInfo
- Publication number
- TNSN99054A1 TNSN99054A1 TNTNSN99054A TNSN99054A TNSN99054A1 TN SN99054 A1 TNSN99054 A1 TN SN99054A1 TN TNSN99054 A TNTNSN99054 A TN TNSN99054A TN SN99054 A TNSN99054 A TN SN99054A TN SN99054 A1 TNSN99054 A1 TN SN99054A1
- Authority
- TN
- Tunisia
- Prior art keywords
- alkyling
- sulfonamides
- sterically
- bulk
- sterically bulk
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 150000003456 sulfonamides Chemical class 0.000 title abstract 2
- 229940124530 sulfonamide Drugs 0.000 title 1
- 102000002274 Matrix Metalloproteinases Human genes 0.000 abstract 1
- 108010000684 Matrix Metalloproteinases Proteins 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Virology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Psychology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Obesity (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8131098P | 1998-04-10 | 1998-04-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TNSN99054A1 true TNSN99054A1 (fr) | 2005-11-10 |
Family
ID=22163376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TNTNSN99054A TNSN99054A1 (fr) | 1998-04-10 | 1999-04-07 | Procede pour alkyler des sulfonamides a encombrement sterique |
Country Status (47)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6458822B2 (en) | 2000-03-13 | 2002-10-01 | Pfizer Inc. | 2-oxo-imidazolidine-4-carboxylic acid hydroxamide compounds that inhibit matrix metalloproteinases |
| EP1134207A1 (en) * | 2000-03-15 | 2001-09-19 | Pfizer Products Inc. | Process for preparing resorcinol derivatives |
| US6548667B2 (en) | 2000-04-07 | 2003-04-15 | Samsung Electronics Co. Ltd. | Sulfonamide derivative as a matrix metalloproteinase inhibitor |
| US20020073441A1 (en) | 2000-12-13 | 2002-06-13 | Ross Brian D. | Compositions and methods for detecting proteolytic activity |
| US6844373B2 (en) * | 2002-05-28 | 2005-01-18 | Alcatel | Composition comprising fluorinated, radiation-curable dyes for surface energy control |
| JP2006516548A (ja) | 2002-12-30 | 2006-07-06 | アンジオテック インターナショナル アクツィエン ゲゼルシャフト | 迅速ゲル化ポリマー組成物からの薬物送達法 |
| ITFI20040174A1 (it) * | 2004-08-03 | 2004-11-03 | Protera S R L | Derivati arilsolfonammidici dell'acido idrossammico ad azione inibitoria di metalloproteinasi |
| ITBO20050005U1 (it) * | 2005-01-31 | 2006-08-01 | Ali Spa | Distributore di bevande ghiacciate e simili |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU523636A3 (ru) * | 1973-06-18 | 1976-07-30 | Стауффер Кемикал Компани (Фирма) | Способ получени сульфоксидных или сульфоновых производных тиокарбаматов |
| ZA794723B (en) | 1978-09-11 | 1980-08-27 | Univ Miami | Anti-hypertensive agents |
| GB9000725D0 (en) | 1990-01-12 | 1990-03-14 | Pfizer Ltd | Therapeutic agents |
| US5506242A (en) | 1993-01-06 | 1996-04-09 | Ciba-Geigy Corporation | Arylsufonamido-substituted hydroxamic acids |
| US5863949A (en) * | 1995-03-08 | 1999-01-26 | Pfizer Inc | Arylsulfonylamino hydroxamic acid derivatives |
| JP2000501423A (ja) * | 1996-08-23 | 2000-02-08 | ファイザー インク． | アリールスルホニルアミノヒドロキサム酸誘導体 |
| NZ336840A (en) | 1997-02-03 | 2001-01-26 | Pfizer Prod Inc | Arylsulfonylamino hydroxamic acid derivatives useful in the treatment of tumor necrosis factor and matrix metalloproteinase mediated diseases |
| ATE217863T1 (de) | 1997-08-08 | 2002-06-15 | Pfizer Prod Inc | Arylsulfonylaminohydroxamsäurederivate |
| CA2299355C (en) | 1997-08-08 | 2005-09-27 | Pfizer Products Inc. | Aryloxyarylsulfonylamino hydroxamic acid derivatives |
| PA8469401A1 (es) | 1998-04-10 | 2000-05-24 | Pfizer Prod Inc | Derivados biciclicos del acido hidroxamico |
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1999
- 1999-03-24 PA PA19998469601A patent/PA8469601A1/es unknown
- 1999-03-25 ES ES99302287T patent/ES2163316T3/es not_active Expired - Lifetime
- 1999-03-25 DK DK99302287T patent/DK0949245T3/da active
- 1999-03-25 GT GT199900047A patent/GT199900047A/es unknown
- 1999-03-25 DE DE69900321T patent/DE69900321T2/de not_active Expired - Fee Related
- 1999-03-25 EP EP99302287A patent/EP0949245B1/en not_active Expired - Lifetime
- 1999-03-25 PT PT99302287T patent/PT949245E/pt unknown
- 1999-03-25 IL IL12916899A patent/IL129168A/xx not_active IP Right Cessation
- 1999-03-25 AT AT99302287T patent/ATE206392T1/de not_active IP Right Cessation
- 1999-04-01 OA OA9900073A patent/OA11030A/en unknown
- 1999-04-05 ID IDP990304D patent/ID23244A/id unknown
- 1999-04-06 PE PE1999000277A patent/PE20000417A1/es not_active Application Discontinuation
- 1999-04-06 IS IS5018A patent/IS5018A/is unknown
- 1999-04-07 TW TW088105541A patent/TW520354B/zh not_active IP Right Cessation
- 1999-04-07 KR KR1019990011957A patent/KR100357660B1/ko not_active Expired - Fee Related
- 1999-04-07 MA MA25530A patent/MA24833A1/fr unknown
- 1999-04-07 DZ DZ990055A patent/DZ2754A1/xx active
- 1999-04-07 SK SK453-99A patent/SK45399A3/sk unknown
- 1999-04-07 IN IN522DE1999 patent/IN192485B/en unknown
- 1999-04-07 TN TNTNSN99054A patent/TNSN99054A1/fr unknown
- 1999-04-08 AP APAP/P/1999/001506A patent/AP1095A/en active
- 1999-04-08 EG EG37499A patent/EG21985A/xx active
- 1999-04-08 SG SG1999001651A patent/SG75167A1/en unknown
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- 1999-04-09 ID IDW20002031A patent/ID27208A/id unknown
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- 1999-04-09 NZ NZ335105A patent/NZ335105A/xx unknown
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- 1999-04-09 UA UA99042034A patent/UA57039C2/uk unknown
- 1999-04-09 HU HU0101465A patent/HUP0101465A3/hu unknown
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- 1999-04-09 RU RU2000125555/04A patent/RU2197479C2/ru not_active IP Right Cessation
- 1999-04-09 EA EA199900277A patent/EA002277B1/ru not_active IP Right Cessation
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- 1999-04-09 ZA ZA9902627A patent/ZA992627B/xx unknown
- 1999-04-09 US US09/290,022 patent/US6229025B1/en not_active Expired - Fee Related
- 1999-04-09 US US09/289,454 patent/US6114568A/en not_active Expired - Fee Related
- 1999-04-09 PL PL99332451A patent/PL332451A1/xx unknown
- 1999-04-09 HU HU9901043A patent/HUP9901043A1/hu unknown
- 1999-04-09 ES ES99917394T patent/ES2234253T3/es not_active Expired - Lifetime
- 1999-04-09 KR KR10-2000-7011232A patent/KR100377718B1/ko not_active Expired - Fee Related
- 1999-04-09 WO PCT/US1999/007858 patent/WO1999052862A1/en active IP Right Grant
- 1999-04-09 AU AU23691/99A patent/AU755004B2/en not_active Ceased
- 1999-04-09 BG BG103320A patent/BG63665B1/bg unknown
- 1999-04-09 HN HN1999000043A patent/HN1999000043A/es unknown
- 1999-04-12 CO CO99021411A patent/CO4810299A1/es unknown
- 1999-04-12 JP JP10387399A patent/JP3540959B2/ja not_active Expired - Fee Related
- 1999-04-12 UY UY25469A patent/UY25469A1/es unknown
- 1999-05-05 SA SA99200089A patent/SA99200089A/ar unknown
-
2000
- 2000-08-25 CN CN00126476A patent/CN1288885A/zh active Pending
- 2000-10-02 ZA ZA200005370A patent/ZA200005370B/en unknown
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