TNSN96072A1 - N-(indole -2-carbonyl)-glycinamides substitues, procede pour leur preparation et compositions les contenant - Google Patents

N-(indole -2-carbonyl)-glycinamides substitues, procede pour leur preparation et compositions les contenant

Info

Publication number
TNSN96072A1
TNSN96072A1 TNTNSN96072A TNSN96072A TNSN96072A1 TN SN96072 A1 TNSN96072 A1 TN SN96072A1 TN TNSN96072 A TNTNSN96072 A TN TNSN96072A TN SN96072 A TNSN96072 A TN SN96072A TN SN96072 A1 TNSN96072 A1 TN SN96072A1
Authority
TN
Tunisia
Prior art keywords
preparation
compositions containing
indole
glycinamides
carbonyl
Prior art date
Application number
TNTNSN96072A
Other languages
English (en)
Inventor
Bernard Hulin
Judith Lee Treadway
William Holt Martin
Dennis Jay Hoover
Douglas Phillips
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of TNSN96072A1 publication Critical patent/TNSN96072A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

L'INVENTION CONCERNE CERTAINS INDOLE-2- CARBOXAMIDES DE FORMULE I ..............DANS LAQUELLE LA LIGNE DISCONTINUE EST UNE LIAISON FACULTATIVE, ET A, R1 à R11 REPRESENTENT DIVERS SUBSTITUANTS. L'INVENTION CONCERNE EGALEMENT UN PROCEDE DE PREPARATION DE CES COMPOSES. APPLICATION : UTILISATION DE COMPOSITIONS PHARMACEUTIQUES RENFERMANT CES COMPOSES POUR LE TRAITEMENT DU DIABETE, DE L'HYPERGLYCEMIE, DE L'HYPERCHOLESTEROLEMIE, DE L'HYPERTENSION, DE L'HYPERINSULINEMIE, DE L'HYPERLIPIDEMIE, DE L'ATHEROSCLEROSE ET DE L'ISCHEMIE MYOCARDIQUE.
TNTNSN96072A 1995-06-06 1996-05-17 N-(indole -2-carbonyl)-glycinamides substitues, procede pour leur preparation et compositions les contenant TNSN96072A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB1995/000442 WO1996039384A1 (fr) 1995-06-06 1995-06-06 (indole-2-carbonyl-)-glycinamides substitues en n et leurs derives, servant d'inhibiteurs de la glycogene phosphorylase

Publications (1)

Publication Number Publication Date
TNSN96072A1 true TNSN96072A1 (fr) 2005-03-15

Family

ID=11004338

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN96072A TNSN96072A1 (fr) 1995-06-06 1996-05-17 N-(indole -2-carbonyl)-glycinamides substitues, procede pour leur preparation et compositions les contenant

Country Status (37)

Country Link
US (1) US6107329A (fr)
EP (1) EP0832065B1 (fr)
JP (1) JP3314938B2 (fr)
KR (1) KR100191992B1 (fr)
CN (2) CN1142492A (fr)
AP (1) AP623A (fr)
AR (1) AR003955A1 (fr)
AT (1) ATE206702T1 (fr)
AU (1) AU701465B2 (fr)
BG (1) BG100547A (fr)
BR (1) BR9602542A (fr)
CA (2) CA2224062C (fr)
CO (1) CO4700440A1 (fr)
CZ (1) CZ157396A3 (fr)
DE (1) DE69523182T2 (fr)
DK (1) DK0832065T3 (fr)
FI (1) FI974436A (fr)
HR (1) HRP960244A2 (fr)
HU (1) HUP9601475A2 (fr)
IL (1) IL118029A0 (fr)
IS (1) IS4341A (fr)
LV (1) LV11613B (fr)
MA (1) MA23866A1 (fr)
MX (1) MX9709875A (fr)
NO (2) NO306398B1 (fr)
NZ (1) NZ286460A (fr)
OA (1) OA10581A (fr)
PL (1) PL314561A1 (fr)
RU (1) RU2143424C1 (fr)
SG (1) SG44947A1 (fr)
SI (1) SI9600177A (fr)
SK (1) SK69996A3 (fr)
TN (1) TNSN96072A1 (fr)
TR (1) TR199600456A2 (fr)
TW (1) TW346485B (fr)
WO (1) WO1996039384A1 (fr)
YU (1) YU34896A (fr)

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LV11613A (lv) 1996-12-20
TW346485B (en) 1998-12-01
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JP3314938B2 (ja) 2002-08-19
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