TNSN04234A1 - Derives de n-acylaminobenzene comme inhibiteurs selectifs de la monoamine oxydase b - Google Patents
Derives de n-acylaminobenzene comme inhibiteurs selectifs de la monoamine oxydase bInfo
- Publication number
- TNSN04234A1 TNSN04234A1 TNP2004000234A TNSN04234A TNSN04234A1 TN SN04234 A1 TNSN04234 A1 TN SN04234A1 TN P2004000234 A TNP2004000234 A TN P2004000234A TN SN04234 A TNSN04234 A TN SN04234A TN SN04234 A1 TNSN04234 A1 TN SN04234A1
- Authority
- TN
- Tunisia
- Prior art keywords
- alkyl
- hydrogen
- alkoxy
- halogen
- derivatives
- Prior art date
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- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
- C07C233/15—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
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- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
- C07C233/33—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
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- C07C233/60—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
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- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
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- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/10—Hydrazines
- C07C243/12—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms
- C07C243/14—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms of a saturated carbon skeleton
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- C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
- C07C243/26—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C243/28—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of a saturated carbon skeleton
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
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- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/23—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same unsaturated acyclic carbon skeleton
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- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
- C07C255/25—Aminoacetonitriles
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- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C07C323/41—Y being a hydrogen or an acyclic carbon atom
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- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Rheumatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
L'invention concerne des dérivés de N-acylamino aryle de la formule générale (I); dans laquelle R1 représente halogène-(C1-C6)-alkyle; cyano; C1-C6-alcoxy ou halogène-(C1-C6)-alcoxy; R21; R22; R23 et R24 sont sélectionnés indépendamment les uns des autres dans le groupe formé d'hydrogène; de (C1-C6)-alkyle; d'halogène; d'halogène-(C1-C6)-alkyle; d'hydroxy; de C1-C6-alcoxy ou de CHO; R3 représente hydrogène ou C1-C3-alkyle; R4; R5 sont sélectionnés indépendamment l'un de l'autre dans le groupe formé d'hydrogène; de C1-C6-alkyle; de C1-C6-alcoxy ou de COO(C1-C6)alkyle; ou R4 et R5 forment ensemble avec l'atome C- auquel ils sont liés un noyau C3-C7-cycloalkyle; R6 représente CO-NR7R8; -COO(C1-C6)-alkyle; -CN; -NR2 ou NHC(O)R; R7 et R8 sont sélectionnés indépendamment l'un de l'autre dans le groupe formé d'hydrogène; de C1-C6-alkyle; de NH2 ou d'hydroxy; R représente hydrogène ou C1-C6-alkyle; n est un nombre représentant 0;1; 2 ou 3. X représente CHRO; -OCHR; -CH2S-; -SCH2-; -CH2CH2-; -CH=CH- ou C=C-. Elle concerne également des sels d'addition d'acide pharmaceutiquement actifs de ces dérivés. Ces composés de la formule générale (I) sont des inhibiteurs de la monoamine oxydase B sélectifs et sont par conséquent utiles dans le traitement de maladies liées aux inhibiteurs de la monoamine oxydase B; par exemple dans le traitement de la maladie d'Alzheimer ou de la démence sénile.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02011639 | 2002-05-29 | ||
PCT/EP2003/005297 WO2003099763A1 (fr) | 2002-05-29 | 2003-05-20 | Derives de n-acylaminobenzene comme inhibiteurs de la monoamine oxydase b selectifs |
Publications (1)
Publication Number | Publication Date |
---|---|
TNSN04234A1 true TNSN04234A1 (fr) | 2007-03-12 |
Family
ID=29558293
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TNP2004000234A TNSN04234A1 (fr) | 2002-05-29 | 2004-11-24 | Derives de n-acylaminobenzene comme inhibiteurs selectifs de la monoamine oxydase b |
Country Status (36)
Country | Link |
---|---|
US (3) | US6762320B2 (fr) |
EP (1) | EP1511718B1 (fr) |
JP (1) | JP4223003B2 (fr) |
KR (1) | KR100706739B1 (fr) |
CN (1) | CN100482638C (fr) |
AR (1) | AR040133A1 (fr) |
AT (1) | ATE430726T1 (fr) |
AU (1) | AU2003240681B2 (fr) |
BR (1) | BR0311338A (fr) |
CA (1) | CA2486380C (fr) |
CY (1) | CY1109220T1 (fr) |
DE (1) | DE60327522D1 (fr) |
DK (1) | DK1511718T3 (fr) |
EA (1) | EA009372B1 (fr) |
ES (1) | ES2324214T3 (fr) |
GT (1) | GT200300119A (fr) |
HK (1) | HK1081529A1 (fr) |
HR (1) | HRP20041087B1 (fr) |
IL (1) | IL165055A0 (fr) |
MA (1) | MA27208A1 (fr) |
MX (1) | MXPA04011594A (fr) |
MY (1) | MY139027A (fr) |
NO (1) | NO329387B1 (fr) |
NZ (1) | NZ536538A (fr) |
PA (1) | PA8574401A1 (fr) |
PE (1) | PE20040520A1 (fr) |
PL (1) | PL212708B1 (fr) |
PT (1) | PT1511718E (fr) |
RS (1) | RS51642B (fr) |
SI (1) | SI1511718T1 (fr) |
TN (1) | TNSN04234A1 (fr) |
TW (2) | TWI340641B (fr) |
UA (1) | UA79284C2 (fr) |
UY (1) | UY27825A1 (fr) |
WO (1) | WO2003099763A1 (fr) |
ZA (1) | ZA200408965B (fr) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI1511718T1 (sl) * | 2002-05-29 | 2009-08-31 | Hoffmann La Roche | Derivati n-acilaminobenzena kot selektivni inhibitorji monoaminske oksidaze b |
ATE455772T1 (de) * | 2003-07-21 | 2010-02-15 | Merck Serono Sa | Alkinylarylcarbonsäureamide |
US7799832B2 (en) * | 2003-10-23 | 2010-09-21 | Valeant Pharmaceuticals North America | Combinations of retigabine and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains |
EP1680127B1 (fr) * | 2003-10-23 | 2008-10-15 | F. Hoffmann-La Roche Ag | Derives de benzazepine utiles comme inhibiteurs de mao-b |
EP1588704A1 (fr) * | 2004-04-22 | 2005-10-26 | Newron Pharmaceuticals S.p.A. | Dérivés d'alpha-aminoamides utiles dans le traitement de l'acroparesthésie nocturne et des troubles de toxicomanie |
UA89503C2 (uk) * | 2004-09-13 | 2010-02-10 | Х. Луннбек А/С | Заміщені похідні аніліну |
US7211573B2 (en) * | 2004-12-08 | 2007-05-01 | Hoffmann-La Roche Inc. | Malonamide derivatives |
CN101128189A (zh) | 2005-02-25 | 2008-02-20 | 弗·哈夫曼-拉罗切有限公司 | 药物物质分散性改善的片剂 |
WO2007008963A1 (fr) * | 2005-07-13 | 2007-01-18 | Jenrin Discovery | Inhibiteurs de la mao-b utiles pour traiter l'obésité |
US8722929B2 (en) * | 2006-10-10 | 2014-05-13 | Valeant Pharmaceuticals International | N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators |
US8563566B2 (en) * | 2007-08-01 | 2013-10-22 | Valeant Pharmaceuticals International | Naphthyridine derivatives as potassium channel modulators |
US7786146B2 (en) * | 2007-08-13 | 2010-08-31 | Valeant Pharmaceuticals International | Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators |
CA2728915A1 (fr) * | 2008-06-24 | 2010-01-21 | Valeant Pharmaceuticals International | Derives de benzyloxy anilide utiles en tant que modulateurs du canal potassique |
US9006371B1 (en) * | 2010-09-28 | 2015-04-14 | United States Of America As Represented By The Secretary Of The Navy | Synthesis of oligomeric silsesquioxane monomers for high performance polymers |
IT1404729B1 (it) * | 2011-01-27 | 2013-11-29 | Univ Pisa | Inibitori altamente selettivi dell'attivita' di adams |
CN110015962B (zh) | 2011-01-28 | 2022-03-15 | 肯塔基大学研究基金会 | 茋类似物和治疗癌症的方法 |
CN105237567B (zh) * | 2015-11-09 | 2017-09-29 | 河北工业大学 | 一种含芳甲基膦酸酯的制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1003753B (de) * | 1953-11-07 | 1957-03-07 | Dr Karl Kindler | Verfahren zur Herstellung von N-Dialkylaminoacylaminophenolaethern |
JPH05262718A (ja) * | 1992-03-23 | 1993-10-12 | Taisho Pharmaceut Co Ltd | 5−置換アミノ−2−フェノキシスルホンアニリド化合物 |
GB9313365D0 (en) * | 1993-06-29 | 1993-08-11 | Roussel Lab Ltd | Chemical compounds |
US5679715A (en) | 1995-06-07 | 1997-10-21 | Harris; Richard Y. | Method for treating multiple sclerosis |
CN1116870C (zh) | 1996-03-15 | 2003-08-06 | 萨默塞特药品有限公司 | 司立吉林在制备用于预防或治疗外周神经病的药物中的应用 |
WO2001034172A2 (fr) | 1999-11-05 | 2001-05-17 | Vela Pharmaceuticals Inc. | Procedes et compositions pour traiter un syndrome d'insatisfaction |
SI1511718T1 (sl) * | 2002-05-29 | 2009-08-31 | Hoffmann La Roche | Derivati n-acilaminobenzena kot selektivni inhibitorji monoaminske oksidaze b |
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2003
- 2003-05-20 SI SI200331610T patent/SI1511718T1/sl unknown
- 2003-05-20 DE DE60327522T patent/DE60327522D1/de not_active Expired - Lifetime
- 2003-05-20 JP JP2004507421A patent/JP4223003B2/ja not_active Expired - Fee Related
- 2003-05-20 ES ES03730080T patent/ES2324214T3/es not_active Expired - Lifetime
- 2003-05-20 NZ NZ536538A patent/NZ536538A/en not_active IP Right Cessation
- 2003-05-20 PL PL375311A patent/PL212708B1/pl not_active IP Right Cessation
- 2003-05-20 CN CNB038123932A patent/CN100482638C/zh not_active Expired - Fee Related
- 2003-05-20 PT PT03730080T patent/PT1511718E/pt unknown
- 2003-05-20 MX MXPA04011594A patent/MXPA04011594A/es active IP Right Grant
- 2003-05-20 AU AU2003240681A patent/AU2003240681B2/en not_active Ceased
- 2003-05-20 AT AT03730080T patent/ATE430726T1/de active
- 2003-05-20 BR BR0311338-8A patent/BR0311338A/pt not_active IP Right Cessation
- 2003-05-20 WO PCT/EP2003/005297 patent/WO2003099763A1/fr active Application Filing
- 2003-05-20 EP EP03730080A patent/EP1511718B1/fr not_active Expired - Lifetime
- 2003-05-20 CA CA2486380A patent/CA2486380C/fr not_active Expired - Fee Related
- 2003-05-20 EA EA200401519A patent/EA009372B1/ru not_active IP Right Cessation
- 2003-05-20 DK DK03730080T patent/DK1511718T3/da active
- 2003-05-21 KR KR1020047019240A patent/KR100706739B1/ko not_active IP Right Cessation
- 2003-05-21 RS YU101204A patent/RS51642B/en unknown
- 2003-05-21 UA UA20041210080A patent/UA79284C2/uk unknown
- 2003-05-26 TW TW099119340A patent/TWI340641B/zh not_active IP Right Cessation
- 2003-05-26 TW TW092114175A patent/TWI331917B/zh not_active IP Right Cessation
- 2003-05-26 PA PA20038574401A patent/PA8574401A1/es unknown
- 2003-05-26 PE PE2003000507A patent/PE20040520A1/es not_active Application Discontinuation
- 2003-05-27 US US10/445,580 patent/US6762320B2/en not_active Expired - Lifetime
- 2003-05-27 UY UY27825A patent/UY27825A1/es not_active Application Discontinuation
- 2003-05-28 MY MYPI20031959A patent/MY139027A/en unknown
- 2003-05-28 AR ARP030101862A patent/AR040133A1/es not_active Application Discontinuation
- 2003-05-28 GT GT200300119A patent/GT200300119A/es unknown
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2004
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- 2004-11-04 IL IL16505504A patent/IL165055A0/xx not_active IP Right Cessation
- 2004-11-04 NO NO20044806A patent/NO329387B1/no not_active IP Right Cessation
- 2004-11-05 ZA ZA200408965A patent/ZA200408965B/en unknown
- 2004-11-18 HR HRP20041087AA patent/HRP20041087B1/hr not_active IP Right Cessation
- 2004-11-24 TN TNP2004000234A patent/TNSN04234A1/fr unknown
- 2004-11-26 MA MA27971A patent/MA27208A1/fr unknown
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2005
- 2005-08-26 US US11/213,052 patent/US20050283019A1/en not_active Abandoned
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2006
- 2006-02-10 HK HK06101769.1A patent/HK1081529A1/xx not_active IP Right Cessation
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2009
- 2009-07-10 CY CY20091100728T patent/CY1109220T1/el unknown
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