MA28271A1 - Dérivés de benzènesulfonylamino-pyridine -2-yle et composés apparentés servant d'inhibiteurs de la 11-bêta- hydroxystéroïde-déshydrogénase de type 1(11-bêta-HSD-1)pour le traitement du diabète et de l'obésité - Google Patents
Dérivés de benzènesulfonylamino-pyridine -2-yle et composés apparentés servant d'inhibiteurs de la 11-bêta- hydroxystéroïde-déshydrogénase de type 1(11-bêta-HSD-1)pour le traitement du diabète et de l'obésitéInfo
- Publication number
- MA28271A1 MA28271A1 MA29114A MA29114A MA28271A1 MA 28271 A1 MA28271 A1 MA 28271A1 MA 29114 A MA29114 A MA 29114A MA 29114 A MA29114 A MA 29114A MA 28271 A1 MA28271 A1 MA 28271A1
- Authority
- MA
- Morocco
- Prior art keywords
- beta
- cr3r4
- hsd
- obesity
- diabetes
- Prior art date
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- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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Abstract
Dérivés de benzènesulfonylamino-pyridine-2-yle et composés apparentés servant d'inhibiteurs de la 11-bêta-hydroxystéroïde-déshydrogénase de type 1 (11-bêta-HSD-l) pour le traitement du diabète et de l'obésité La présente invention concerne des composés répondant à la formule (I), ou un de leurs sels pharmaceutiquement acceptables, dans laquelle : R1 est choisi dans le groupe consistant en des groupes alkyle en C1 à C6, - (CR3R4)t-(cycloalkyle en C3 à C12) , - (CR3R4)t(aryle en C6 à C12) et - ( CR3R4 ) t (hétéro-cyclyle tétra- à décagonal ; b et k sont choisis chacun indépendamment entre 1 et 2 ; j est choisi dans le groupe consistant en 0, 1 et 2 ; t, u, p, q et v sont choisis chacun indépendamment dans le groupe consistant en 0, 1, 2, 3, 4 et 5 ; T représente un groupe hétérocyclyle hexa- à décagonal contenant au moins un atome d'azote ; R2 est choisi dans le groupe consistant en H, des groupes alkyle en C1 à C6, - (CR3R4) t (cycloalkyle en C3 à C12) , - (CR3R4) t (aryle en C6 à C12) et - (CR3R4) t (hétérocyclyle tétra- à décagonal) ; chacun des groupes R3 et R4 est choisi indépendamment entre H et un groupe alkyle en Cx à C6, les atomes de carbone de T, R1, R2, R3 et R4 peuvent être chacun facultativement substitués avec 1 à 5 groupes R5 ; R5 est défini dans les revendications. Les composés de la présente invention sont des inhibiteurs de 11-(béta)-hsd-1 et il est considéré qu'ils sont utiles dans le traitement du diabète, de l'obésité, du glaucome, de 1'ostéoporose, de troubles cognitifs, de troubles immunitaires, de la dépression, de l'hypertension et de maladies métaboliques.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53118603P | 2003-12-19 | 2003-12-19 | |
US55692104P | 2004-03-26 | 2004-03-26 |
Publications (1)
Publication Number | Publication Date |
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MA28271A1 true MA28271A1 (fr) | 2006-11-01 |
Family
ID=34713786
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA29114A MA28271A1 (fr) | 2003-12-19 | 2006-06-19 | Dérivés de benzènesulfonylamino-pyridine -2-yle et composés apparentés servant d'inhibiteurs de la 11-bêta- hydroxystéroïde-déshydrogénase de type 1(11-bêta-HSD-1)pour le traitement du diabète et de l'obésité |
Country Status (24)
Country | Link |
---|---|
US (1) | US20050148631A1 (fr) |
EP (1) | EP1696915A1 (fr) |
JP (1) | JP2007514731A (fr) |
KR (1) | KR20060101772A (fr) |
AP (1) | AP2006003633A0 (fr) |
AR (1) | AR046767A1 (fr) |
AU (1) | AU2004305321A1 (fr) |
BR (1) | BRPI0417687A (fr) |
CA (1) | CA2549651A1 (fr) |
DO (1) | DOP2004001052A (fr) |
EA (1) | EA200600990A1 (fr) |
EC (1) | ECSP066653A (fr) |
IL (1) | IL175949A0 (fr) |
IS (1) | IS8473A (fr) |
MA (1) | MA28271A1 (fr) |
MX (1) | MXPA06007077A (fr) |
NL (1) | NL1027811C2 (fr) |
NO (1) | NO20063298L (fr) |
OA (1) | OA13344A (fr) |
PA (1) | PA8620301A1 (fr) |
PE (1) | PE20050864A1 (fr) |
TW (1) | TW200530185A (fr) |
UY (1) | UY28674A1 (fr) |
WO (1) | WO2005060963A1 (fr) |
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-
2004
- 2004-12-06 AU AU2004305321A patent/AU2004305321A1/en not_active Abandoned
- 2004-12-06 KR KR1020067012036A patent/KR20060101772A/ko not_active Application Discontinuation
- 2004-12-06 JP JP2006544581A patent/JP2007514731A/ja active Pending
- 2004-12-06 MX MXPA06007077A patent/MXPA06007077A/es not_active Application Discontinuation
- 2004-12-06 BR BRPI0417687-1A patent/BRPI0417687A/pt not_active IP Right Cessation
- 2004-12-06 EA EA200600990A patent/EA200600990A1/ru unknown
- 2004-12-06 EP EP04801352A patent/EP1696915A1/fr not_active Withdrawn
- 2004-12-06 AP AP2006003633A patent/AP2006003633A0/xx unknown
- 2004-12-06 WO PCT/IB2004/004056 patent/WO2005060963A1/fr not_active Application Discontinuation
- 2004-12-06 OA OA1200600201A patent/OA13344A/en unknown
- 2004-12-06 CA CA002549651A patent/CA2549651A1/fr not_active Abandoned
- 2004-12-10 PE PE2004001240A patent/PE20050864A1/es not_active Application Discontinuation
- 2004-12-15 AR ARP040104669A patent/AR046767A1/es unknown
- 2004-12-16 DO DO2004001052A patent/DOP2004001052A/es unknown
- 2004-12-16 UY UY28674A patent/UY28674A1/es not_active Application Discontinuation
- 2004-12-17 PA PA20048620301A patent/PA8620301A1/es unknown
- 2004-12-17 TW TW093139461A patent/TW200530185A/zh unknown
- 2004-12-17 US US11/016,152 patent/US20050148631A1/en not_active Abandoned
- 2004-12-17 NL NL1027811A patent/NL1027811C2/nl not_active IP Right Cessation
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- 2006-05-18 IS IS8473A patent/IS8473A/is unknown
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Also Published As
Publication number | Publication date |
---|---|
UY28674A1 (es) | 2005-07-29 |
IL175949A0 (en) | 2006-10-05 |
JP2007514731A (ja) | 2007-06-07 |
PE20050864A1 (es) | 2005-10-31 |
TW200530185A (en) | 2005-09-16 |
PA8620301A1 (es) | 2005-08-04 |
MXPA06007077A (es) | 2006-08-23 |
IS8473A (is) | 2006-05-18 |
ECSP066653A (es) | 2006-10-25 |
AP2006003633A0 (en) | 2006-06-30 |
WO2005060963A8 (fr) | 2005-12-01 |
DOP2004001052A (es) | 2005-06-30 |
OA13344A (en) | 2007-04-13 |
EP1696915A1 (fr) | 2006-09-06 |
NL1027811C2 (nl) | 2006-03-06 |
WO2005060963A1 (fr) | 2005-07-07 |
US20050148631A1 (en) | 2005-07-07 |
BRPI0417687A (pt) | 2007-04-03 |
NL1027811A1 (nl) | 2005-06-21 |
EA200600990A1 (ru) | 2006-10-27 |
AU2004305321A1 (en) | 2005-07-07 |
NO20063298L (no) | 2006-09-14 |
AR046767A1 (es) | 2005-12-21 |
CA2549651A1 (fr) | 2005-07-07 |
KR20060101772A (ko) | 2006-09-26 |
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