AR046767A1 - Inhibidores heterociclil amino de 11-beta-hidroxiesteroide deshidrogenasa tipo 1 - Google Patents

Inhibidores heterociclil amino de 11-beta-hidroxiesteroide deshidrogenasa tipo 1

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Publication number
AR046767A1
AR046767A1 ARP040104669A ARP040104669A AR046767A1 AR 046767 A1 AR046767 A1 AR 046767A1 AR P040104669 A ARP040104669 A AR P040104669A AR P040104669 A ARP040104669 A AR P040104669A AR 046767 A1 AR046767 A1 AR 046767A1
Authority
AR
Argentina
Prior art keywords
alkyl
cr10r11
group
aryl
heterocycle
Prior art date
Application number
ARP040104669A
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English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of AR046767A1 publication Critical patent/AR046767A1/es

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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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Abstract

El presente se refiere a composiciones farmacéutica que comprenden los compuestos de fórmula (1) y a métodos para tratar una condición que está mediada por la modulación de 11-beta-hsd-1, método que comprende administrar a un mamífero una cantidad eficaz de un compuesto de fórmula (1). Reivindicación 1: Un compuesto de fórmula (1), en el que: R1 se selecciona del grupo que consiste en (C1-6) alquilo,-(CR3R4)t(C3-12)cicloalquilo, -(CR3R4)t(C6-12)arilo, y un heterociclo -(CR3R4)t de 4-10 miembros; b y k se seleccionan cada uno de manera independiente de 1 y 2; j se selecciona del grupo que consiste en 0, 1 y 2; t, u p, q y v se seleccionan cada uno de manera independiente del grupo que consiste en 0, 1, 2, 3, 4, y 5; T es un heterociclo de 6-10 miembros que contiene al menos un átomo de nitrógeno; R2 se selecciona del grupo que consiste en H, (C1-6) alquilo, -(CR3R4)t(C3-12)cicloalquilo, -(CR3R4)t(C6-12)arilo, y un heterociclo -(CR3R4)t de 4-10 miembros; R3 y R4 se seleccionan cada uno, de manera independiente, de H y (C1-6) alquilo; los átomos de carbono de T, R1, R2, R3 y R4 pueden estar cada uno sustituidos, de manera opcional, con 1 a 5 grupos R5; cada grupo R5 se selecciona, de manera independiente, del grupo que consiste en halo, ciano, nitro, -CF3, -CHF2, -CH2F, trifluorometoxi, azido, hidroxi, (C1-6) alcoxi, (C1-6) alquilo, (C2-6) alquenilo, (C2-6) alquinilo, -(C=O)R6, -(C=O)-O-R6, -O-(C=O)-R7, -(C=O)-NR7, -NR8(C=O)-R9, -(C=O)-NR8R9, -NR8R9, - NR8OR9, -S(O)kNR8R9, -S(O)j(C1-6)alquilo, -O-SO2-R9, -NR8-S(O)k-R9, -(CR10R11)v(C6-12)arilo, heterociclo-(CR10R11)v de 4-10 miembros; -(CR10R11)q(C=O)(CR10R11)v(C6-12)arilo, heterociclo-(CR10R11)q(C=O)(CR10R11)v de 4-10 miembros, - (CR10R11)vO(CR10R11)q(C6-12)arilo, heterociclo-(CR10R11)vO(CR10R11)q de 4-10 miembros, -(CR10R11)qS(O)j(CR10R11)v(C6-12)arilo, y heterociclo-(CR10R11)qS(O)j(CR10R11)v de 4-10 miembros; cualquier 1 ó 2 átomos de carbono de cualquier heterociclo de 4- 10 miembros de los grupos R6 anteriores está sustituido, de manera opcional, con un oxo(=O); cualquier átomo de carbono de cualquier (C1-6) alquilo, de cualquier (C6-12) arilo y de cualquier heterociclo de 4-10 miembros de los grupos R5 anteriores está sustituido, de manera opcional, con 1 a 3 sustituyentes seleccionados de manera independiente de halo, ciano, nitro, -CF3, -CFH2, -CF2H, trifluorometoxi, azido, -OR12, -C(=O)-R12, -(C=O)-O-R13, -O-(C=O)-R13, -NR13(C=O)-R14, -(C=O)-NR15R16, - NR17R18, -NR14OR15, (C1-6) alquilo, (C2-6) alquenilo, (C2-6) alquinilo, -(CR16R17)u(C6-12)arilo, y heterociclo-(CR16R17)u de 4-10 miembros; cada grupo R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, y R17 se selecciona, de manera independiente, del grupo que consiste en H, (C1-6) alquilo, -(C=O)N(C1-6)alquilo, -(CR18R19)p(C6-12)arilo, y un heterociclo-(CR18R19)p de 4-10 miembros; cualquier 1 ó 2 átomos de carbono del heterociclo de 4-10 miembros de cada uno de los mencionados grupos R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, y R17 está sustituido, de manera opcional, con un oxo(=O); cualquier átomo de carbono de cualquier (C1-6) alquilo, de cualquier (C6-12) arilo, y de cualquier heterociclo de 4-10 miembros de los grupos R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, y R17 anteriores está sustituido, de manera opcional, con 1 a 3 sustituyentes, seleccionados de manera independiente, del grupo que consiste en halo, ciano, nitro, -NR21R22, -CF3, -CHF2, -CH2F, trifluorometoxi, (C1-6) alquilo, (C2-6) alquenilo, (C2-6) alquinilo, hidroxi, y (C1-6) alcoxi; cada grupo R18, R19, R20, R21 y R22 se selecciona, de manera independiente, de H y -(C1-6)alquilo; y en el que cualquiera de los sustituyentes mencionados más arriba que comprenden un grupo -(CH)3(metilo), -CH2(metileno), o -CH(metino) que no está unido a un grupo halo, -SO o -SO2 o un átomo de N, O o S presenta, de manera opcional, en dicho grupo un sustituyente seleccionado de manera independiente del grupo que consiste en hidroxi, halo, (C1-6) alquilo, (C1-6) alcoxi, -NH2, -NH(C1-6)(alquilo) y -N((C1-6)(alquilo))2; o una sal o solvato de éste aceptable desde un punto de vista farmacéutico.
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Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7880001B2 (en) 2004-04-29 2011-02-01 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
US8415354B2 (en) 2004-04-29 2013-04-09 Abbott Laboratories Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
US20100222316A1 (en) 2004-04-29 2010-09-02 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
TWI350168B (en) 2004-05-07 2011-10-11 Incyte Corp Amido compounds and their use as pharmaceuticals
EP1758580A4 (en) 2004-06-24 2008-01-16 Incyte Corp N-SUBSTITUTED PIPERIDINE AND ITS USE AS A MEDICAMENT
CN101027286B (zh) * 2004-09-29 2011-05-25 霍夫曼-拉罗奇有限公司 作为11b-HSD1抑制剂的吲唑酮衍生物
BRPI0516454A (pt) * 2004-10-04 2008-09-02 Hoffmann La Roche compostos, processo para a preparação de um composto, composição farmacêutica que o compreende, sua utilização, método para o tratamento e profilaxia de enfermidades, e de diabetes do tipo ii
EP1659113A1 (en) * 2004-11-08 2006-05-24 Evotec AG Inhibitors of 11beta-hydroxy steroid dehydrogenase type 1 (11beta-HSD1)
US20090192198A1 (en) 2005-01-05 2009-07-30 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
US8198331B2 (en) 2005-01-05 2012-06-12 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
KR101302627B1 (ko) 2005-01-05 2013-09-10 아비에 인코포레이티드 11-베타-하이드록시스테로이드 데하이드로게나제 타입 1 효소의 억제제
US7511175B2 (en) 2005-01-05 2009-03-31 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
WO2006095822A1 (ja) * 2005-03-11 2006-09-14 Ono Pharmaceutical Co., Ltd. スルホンアミド化合物およびその医薬
JP5140577B2 (ja) 2005-03-31 2013-02-06 タケダ カリフォルニア インコーポレイテッド ヒドロキシステロイドデヒドロゲナーゼ阻害剤
WO2006106423A2 (en) * 2005-04-07 2006-10-12 Pfizer Inc. Amino sulfonyl derivatives as inhibitors of human 11-.beta.-hydrosysteroid dehydrogenase
US20060235028A1 (en) * 2005-04-14 2006-10-19 Li James J Inhibitors of 11-beta hydroxysteroid dehydrogenase type I
MX2007016319A (es) 2005-06-16 2008-03-10 Pfizer Derivados de n-(piridin-2-il)-sulfonamida.
EP1922068A4 (en) * 2005-08-16 2010-08-11 Icagen Inc INHIBITORS OF VOLTAGE-CONTROLLED SODIUM CHANNELS
US7622492B2 (en) 2005-08-31 2009-11-24 Hoffmann-La Roche Inc. Pyrazolones as inhibitors of 11β-hydroxysteroid dehydrogenase
ATE551333T1 (de) 2005-10-12 2012-04-15 Vertex Pharma Biphenylderivate als modulatoren von spannungsabhängigen ionenkanälen
BRPI0619446A2 (pt) 2005-12-05 2011-10-04 Incyte Corp compostos de lactama, suas composições e método de modulação da atividade de 11bhsd1
US20090018118A1 (en) * 2005-12-29 2009-01-15 Uros Urleb Heterocyclic compounds
WO2007084314A2 (en) 2006-01-12 2007-07-26 Incyte Corporation MODULATORS OF 11-ß HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME
US7645773B2 (en) 2006-01-18 2010-01-12 Hoffmann-La Roche Inc. Thiazoles as inhibitors of 11β-hydroxysteroid dehydrogenase
BRPI0707408A2 (pt) * 2006-01-31 2011-05-03 Incyte Corp compostos de amido e seu uso como produtos farmacêuticos
US20090170898A1 (en) * 2006-03-31 2009-07-02 Malena Bengtsson Sulphonamide Derivatives as Modulators of the Glucocorticoid Receptor
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
WO2007137066A2 (en) 2006-05-17 2007-11-29 Incyte Corporation HETEROCYCLIC INHIBITORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE I AND METHODS OF USING THE SAME
TW200827346A (en) 2006-11-03 2008-07-01 Astrazeneca Ab Chemical compounds
TW200829578A (en) 2006-11-23 2008-07-16 Astrazeneca Ab Chemical compounds 537
CN102838532A (zh) * 2006-11-24 2012-12-26 Ac免疫有限公司 用于治疗与淀粉样物质或淀粉样蛋白有关的疾病的吡唑胺和噻唑胺衍生物
JO2754B1 (en) 2006-12-21 2014-03-15 استرازينكا ايه بي Amylendazoleil derivatives for the treatment of glucocorticoid-mediated disorders
TW200836719A (en) 2007-02-12 2008-09-16 Astrazeneca Ab Chemical compounds
GB0705400D0 (en) 2007-03-21 2007-05-02 Univ Aberdeen Therapeutic compounds andm their use
CL2008001839A1 (es) 2007-06-21 2009-01-16 Incyte Holdings Corp Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades.
JP5736098B2 (ja) 2007-08-21 2015-06-17 アッヴィ・インコーポレイテッド 中枢神経系障害を治療するための医薬組成物
SA109300309B1 (ar) 2008-05-20 2013-01-22 باير شيرنج فارما ايه جي مشتقات فينيل وبنزو داي أوكسينيل إندازول بها استبدال
GB0817207D0 (en) 2008-09-19 2008-10-29 Pimco 2664 Ltd therapeutic apsac compounds and their use
GB0817208D0 (en) 2008-09-19 2008-10-29 Pimco 2664 Ltd Therapeutic apsap compounds and their use
ES2350077B1 (es) 2009-06-04 2011-11-04 Laboratorios Salvat, S.A. Compuestos inhibidores de 11beta-hidroxiesteroide deshidrogenasa de tipo 1.
DE102010033690A1 (de) * 2010-08-06 2012-02-09 Saltigo Gmbh Verfahren zur Herstellung vom Aminoarylalkylverbindungen
UA112418C2 (uk) * 2010-09-07 2016-09-12 Астеллас Фарма Інк. Терапевтичний болезаспокійливий засіб
US9233946B2 (en) 2010-09-17 2016-01-12 Kancera Ab Sulfonamide compounds
JPWO2012124744A1 (ja) * 2011-03-14 2014-07-24 大正製薬株式会社 含窒素縮合複素環化合物
CA2859586C (en) * 2011-12-22 2020-03-31 Kancera Ab Bisarylsulfonamides useful in the treatment of inflammation and cancer
US10000449B2 (en) 2011-12-22 2018-06-19 Kancera Ab Bisarylsulfonamides useful in the treatment of inflammation and cancer
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia
TW201512171A (zh) 2013-04-19 2015-04-01 Pfizer Ltd 化學化合物
GB201311361D0 (en) 2013-06-26 2013-08-14 Pimco 2664 Ltd Compounds and their therapeutic use
US20160168132A1 (en) * 2013-07-31 2016-06-16 Minoryx Therapeutics S.L. Di(hetero)arylamides and sulfonamides, methods for their preparation and therapeutic uses thereof
EP2940022B1 (en) * 2014-04-30 2020-09-02 Masarykova Univerzita Furopyridines as inhibitors of protein kinases
US10005733B2 (en) 2014-12-17 2018-06-26 Pimco 2664 Limited N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and N-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)-benzenesulfonamide compounds and their therapeutic use
EP3235813A1 (en) 2016-04-19 2017-10-25 Cidqo 2012, S.L. Aza-tetra-cyclo derivatives
WO2019136025A1 (en) 2018-01-02 2019-07-11 Seal Rock Therapeutics, Inc. Ask1 inhibitor compounds and uses thereof
EP4054570A1 (en) * 2019-11-05 2022-09-14 Dermira, Inc Mrgprx2 antagonists and uses thereof

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE167473T1 (de) * 1990-08-20 1998-07-15 Eisai Co Ltd Sulfonamid-derivate
DE4041780A1 (de) * 1990-12-24 1992-06-25 Boehringer Mannheim Gmbh Neue amine, verfahren zu ihrer herstellung, sowie diese verbindungen enthaltende arzneimittel
SE9103397D0 (sv) * 1991-11-18 1991-11-18 Kabi Pharmacia Ab Nya substituerade salicylsyror
GB9504854D0 (en) * 1994-03-31 1995-04-26 Zeneca Ltd Nitrogen derivatives
GB9409618D0 (en) * 1994-05-13 1994-07-06 Zeneca Ltd Pyridine derivatives
AU5772296A (en) * 1995-05-19 1996-11-29 Chiroscience Limited 3,4-disubstituted-phenylsulphonamides and their therapeutic use
US5939451A (en) * 1996-06-28 1999-08-17 Hoffmann-La Roche Inc. Use of sulfonamides
GB9805520D0 (en) * 1998-03-17 1998-05-13 Zeneca Ltd Chemical compounds
JP4327915B2 (ja) * 1998-03-30 2009-09-09 株式会社デ・ウエスタン・セラピテクス研究所 スルフォンアミド誘導体
ATE344237T1 (de) * 1999-09-04 2006-11-15 Astrazeneca Ab Hydroxyacetamidobenzolsulfonamidderivate
US6506754B1 (en) * 2000-04-14 2003-01-14 Corvas International, Inc. Non-covalent thrombin inhibitors
SE0001899D0 (sv) * 2000-05-22 2000-05-22 Pharmacia & Upjohn Ab New compounds
PL370111A1 (en) * 2001-11-22 2005-05-16 Biovitrum Ab Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
US7094792B2 (en) * 2001-11-22 2006-08-22 Biovitrum Ab Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
EP2399903A1 (en) * 2002-05-24 2011-12-28 Millennium Pharmaceuticals, Inc. Ccr9 inhibitors and methods of use thereof
WO2004056744A1 (en) * 2002-12-23 2004-07-08 Janssen Pharmaceutica N.V. Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors
WO2004103980A1 (en) * 2003-05-21 2004-12-02 Biovitrum Ab Inhibitors of 11-beta-hydroxy steroid dehydrogenase type i

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