ATE455772T1 - Alkinylarylcarbonsäureamide - Google Patents
AlkinylarylcarbonsäureamideInfo
- Publication number
- ATE455772T1 ATE455772T1 AT04766274T AT04766274T ATE455772T1 AT E455772 T1 ATE455772 T1 AT E455772T1 AT 04766274 T AT04766274 T AT 04766274T AT 04766274 T AT04766274 T AT 04766274T AT E455772 T1 ATE455772 T1 AT E455772T1
- Authority
- AT
- Austria
- Prior art keywords
- alkynyl
- alkyl
- aryl
- carboxy
- group
- Prior art date
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
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- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
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EP03102235 | 2003-07-21 | ||
US51799303P | 2003-11-06 | 2003-11-06 | |
PCT/EP2004/051557 WO2005012280A1 (en) | 2003-07-21 | 2004-07-20 | Alkynyl aryl carboxamides |
Publications (1)
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ATE455772T1 true ATE455772T1 (de) | 2010-02-15 |
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AT04766274T ATE455772T1 (de) | 2003-07-21 | 2004-07-20 | Alkinylarylcarbonsäureamide |
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US (1) | US7589232B2 (de) |
EP (1) | EP1654247B1 (de) |
JP (1) | JP5198768B2 (de) |
AT (1) | ATE455772T1 (de) |
AU (1) | AU2004261400A1 (de) |
CA (1) | CA2527861A1 (de) |
ES (1) | ES2337150T3 (de) |
WO (1) | WO2005012280A1 (de) |
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PT1656139E (pt) * | 2003-07-21 | 2011-11-04 | Merck Serono Sa | Arildicarboxamidas |
AU2005231980B2 (en) * | 2004-04-07 | 2011-09-08 | Merck Serono Sa | 1,1'-(1,2-ethynediyl)bis-benzene derivatives as PTP 1-B inhibitors |
US7713973B2 (en) | 2004-10-15 | 2010-05-11 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
WO2007009959A1 (en) * | 2005-07-15 | 2007-01-25 | Laboratoires Serono S.A. | Glepp-1 inhibitors in the treatment of autoimmune and/or inflammatory disorders |
ITRM20050389A1 (it) | 2005-07-22 | 2007-01-23 | Giuliani Spa | Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico. |
ITRM20050390A1 (it) * | 2005-07-22 | 2007-01-23 | Giuliani Spa | Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico. |
US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
MX2008012404A (es) * | 2006-03-28 | 2008-10-09 | Novartis Ag | Derivados de amida y su aplicacion para el tratamiento de enfermedades relacionadas con proteina-g. |
WO2007117465A2 (en) | 2006-03-31 | 2007-10-18 | Abbott Laboratories | Indazole compounds |
GEP20135728B (en) | 2006-10-09 | 2013-01-25 | Takeda Pharmaceuticals Co | Kinase inhibitors |
UA107562C2 (uk) | 2008-12-05 | 2015-01-26 | Спосіб лікування псоріазу | |
JP5715070B2 (ja) | 2009-02-16 | 2015-05-07 | ノグラ ファーマ リミテッド | アルキルアミド化合物およびその使用 |
CN103561573A (zh) | 2011-04-26 | 2014-02-05 | 印第安纳大学研究与技术公司 | 酪氨酸磷酸酶及其在调节参与结核分枝杆菌之病理学的酶的活性中的用途 |
CA2864059C (en) | 2012-02-09 | 2020-04-28 | Nogra Pharma Limited | Methods of treating fibrosis |
MX2014012652A (es) | 2012-04-18 | 2014-11-25 | Nogra Pharma Ltd | Metodo de tratamiento de la intolerancia a la lactosa. |
WO2015155738A2 (en) | 2014-04-09 | 2015-10-15 | Christopher Rudd | Use of gsk-3 inhibitors or activators which modulate pd-1 or t-bet expression to modulate t cell immunity |
AU2020217884A1 (en) | 2019-02-08 | 2021-08-12 | Nogra Pharma Limited | Process of making 3-(4'-aminophenyl)-2-methoxypropionic acid, and analogs and intermediates thereof |
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JP3827530B2 (ja) | 1998-12-16 | 2006-09-27 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 置換アリール誘導体及び置換ヘテロアリール誘導体、それらの調製及び薬物としてのそれらの使用 |
WO2000053801A1 (en) * | 1999-03-08 | 2000-09-14 | Merck Frosst Canada & Co. | Intact cell assay for protein tyrosine phosphatases |
WO2002018321A2 (en) | 2000-08-29 | 2002-03-07 | Abbott Laboratories | Amino(oxo)acetic acid protein tyrosine phosphatase inhibitors |
BR0307394A (pt) * | 2002-01-29 | 2004-11-09 | Applied Research Systems | Derivados de metileno amida substituìda como moduladores de proteìnas tirosinas fosfatases (ptps), uso de um derivado de metileno amida substituìda, composição farmacêutica contendo pelo menos um derivado de metileno amida substituìda e método de preparação de um derivado de metileno amida substituìda |
PL212708B1 (pl) * | 2002-05-29 | 2012-11-30 | Hoffmann La Roche | Pochodne N-acyloaminobenzenu, sposób ich wytwarzania, lek zawierajacy te pochodne i zastosowanie pochodnych N-acyloaminobenzenu |
PT1656139E (pt) * | 2003-07-21 | 2011-11-04 | Merck Serono Sa | Arildicarboxamidas |
EA011811B1 (ru) | 2004-02-27 | 2009-06-30 | Лаборатуар Сероно Са | Применение производных метиленамида при лечении сердечно-сосудистых нарушений |
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2004
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- 2004-07-20 AU AU2004261400A patent/AU2004261400A1/en not_active Abandoned
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- 2004-07-20 EP EP04766274A patent/EP1654247B1/de active Active
- 2004-07-20 AT AT04766274T patent/ATE455772T1/de not_active IP Right Cessation
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- 2004-07-20 CA CA002527861A patent/CA2527861A1/en not_active Abandoned
- 2004-07-20 JP JP2006520835A patent/JP5198768B2/ja not_active Expired - Fee Related
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CA2527861A1 (en) | 2005-02-10 |
ES2337150T3 (es) | 2010-04-21 |
JP2006528156A (ja) | 2006-12-14 |
JP5198768B2 (ja) | 2013-05-15 |
WO2005012280A1 (en) | 2005-02-10 |
US20070105913A1 (en) | 2007-05-10 |
EP1654247A1 (de) | 2006-05-10 |
AU2004261400A1 (en) | 2005-02-10 |
EP1654247B1 (de) | 2010-01-20 |
US7589232B2 (en) | 2009-09-15 |
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