DK1511718T3 - N-acylaminobenzenderivater som selektive monoaminoxidase B-inhibitorer - Google Patents
N-acylaminobenzenderivater som selektive monoaminoxidase B-inhibitorerInfo
- Publication number
- DK1511718T3 DK1511718T3 DK03730080T DK03730080T DK1511718T3 DK 1511718 T3 DK1511718 T3 DK 1511718T3 DK 03730080 T DK03730080 T DK 03730080T DK 03730080 T DK03730080 T DK 03730080T DK 1511718 T3 DK1511718 T3 DK 1511718T3
- Authority
- DK
- Denmark
- Prior art keywords
- acylaminobenzene
- inhibitors
- derivatives
- monoamine oxidase
- selective monoamine
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
- C07C233/15—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
- C07C233/33—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C233/60—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/10—Hydrazines
- C07C243/12—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms
- C07C243/14—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms of a saturated carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
- C07C243/26—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C243/28—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of a saturated carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/23—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same unsaturated acyclic carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
- C07C255/25—Aminoacetonitriles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C07C323/41—Y being a hydrogen or an acyclic carbon atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02011639 | 2002-05-29 | ||
PCT/EP2003/005297 WO2003099763A1 (fr) | 2002-05-29 | 2003-05-20 | Derives de n-acylaminobenzene comme inhibiteurs de la monoamine oxydase b selectifs |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1511718T3 true DK1511718T3 (da) | 2009-06-22 |
Family
ID=29558293
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK03730080T DK1511718T3 (da) | 2002-05-29 | 2003-05-20 | N-acylaminobenzenderivater som selektive monoaminoxidase B-inhibitorer |
Country Status (36)
Country | Link |
---|---|
US (3) | US6762320B2 (fr) |
EP (1) | EP1511718B1 (fr) |
JP (1) | JP4223003B2 (fr) |
KR (1) | KR100706739B1 (fr) |
CN (1) | CN100482638C (fr) |
AR (1) | AR040133A1 (fr) |
AT (1) | ATE430726T1 (fr) |
AU (1) | AU2003240681B2 (fr) |
BR (1) | BR0311338A (fr) |
CA (1) | CA2486380C (fr) |
CY (1) | CY1109220T1 (fr) |
DE (1) | DE60327522D1 (fr) |
DK (1) | DK1511718T3 (fr) |
EA (1) | EA009372B1 (fr) |
ES (1) | ES2324214T3 (fr) |
GT (1) | GT200300119A (fr) |
HK (1) | HK1081529A1 (fr) |
HR (1) | HRP20041087B1 (fr) |
IL (1) | IL165055A0 (fr) |
MA (1) | MA27208A1 (fr) |
MX (1) | MXPA04011594A (fr) |
MY (1) | MY139027A (fr) |
NO (1) | NO329387B1 (fr) |
NZ (1) | NZ536538A (fr) |
PA (1) | PA8574401A1 (fr) |
PE (1) | PE20040520A1 (fr) |
PL (1) | PL212708B1 (fr) |
PT (1) | PT1511718E (fr) |
RS (1) | RS51642B (fr) |
SI (1) | SI1511718T1 (fr) |
TN (1) | TNSN04234A1 (fr) |
TW (2) | TWI331917B (fr) |
UA (1) | UA79284C2 (fr) |
UY (1) | UY27825A1 (fr) |
WO (1) | WO2003099763A1 (fr) |
ZA (1) | ZA200408965B (fr) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE430726T1 (de) * | 2002-05-29 | 2009-05-15 | Hoffmann La Roche | N-acylamino-benzyletherderivate als selektive inhibitoren der monoaminoxidase b |
EP1654247B1 (fr) * | 2003-07-21 | 2010-01-20 | Merck Serono SA | Alkynylaryl-carboxamides |
US20050089559A1 (en) * | 2003-10-23 | 2005-04-28 | Istvan Szelenyi | Combinations of potassium channel openers and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains |
AU2004283452A1 (en) * | 2003-10-23 | 2005-05-06 | F. Hoffmann-La Roche Ag | Benzazepine derivatives as MAO-B inhibitors |
EP1588704A1 (fr) * | 2004-04-22 | 2005-10-26 | Newron Pharmaceuticals S.p.A. | Dérivés d'alpha-aminoamides utiles dans le traitement de l'acroparesthésie nocturne et des troubles de toxicomanie |
UA89503C2 (uk) * | 2004-09-13 | 2010-02-10 | Х. Луннбек А/С | Заміщені похідні аніліну |
US7211573B2 (en) * | 2004-12-08 | 2007-05-01 | Hoffmann-La Roche Inc. | Malonamide derivatives |
WO2006089674A2 (fr) | 2005-02-25 | 2006-08-31 | F.Hoffmann-La Roche Ag | Comprimés présentant une dispersibilité de substance médicamenteuse améliorée |
WO2007008963A1 (fr) * | 2005-07-13 | 2007-01-18 | Jenrin Discovery | Inhibiteurs de la mao-b utiles pour traiter l'obésité |
US8722929B2 (en) * | 2006-10-10 | 2014-05-13 | Valeant Pharmaceuticals International | N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators |
US8563566B2 (en) * | 2007-08-01 | 2013-10-22 | Valeant Pharmaceuticals International | Naphthyridine derivatives as potassium channel modulators |
US7786146B2 (en) * | 2007-08-13 | 2010-08-31 | Valeant Pharmaceuticals International | Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators |
EP2310369A4 (fr) * | 2008-06-24 | 2014-02-19 | Valeant Pharmaceuticals Int | Dérivés de benzyloxy anilide utiles en tant que modulateurs du canal potassique |
US9006371B1 (en) * | 2010-09-28 | 2015-04-14 | United States Of America As Represented By The Secretary Of The Navy | Synthesis of oligomeric silsesquioxane monomers for high performance polymers |
IT1404729B1 (it) * | 2011-01-27 | 2013-11-29 | Univ Pisa | Inibitori altamente selettivi dell'attivita' di adams |
CA2826034A1 (fr) * | 2011-01-28 | 2012-08-02 | University Of Kentucky Research Foundation | Analogues de stilbene et procedes de traitement du cancer |
CN105237567B (zh) * | 2015-11-09 | 2017-09-29 | 河北工业大学 | 一种含芳甲基膦酸酯的制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1003753B (de) * | 1953-11-07 | 1957-03-07 | Dr Karl Kindler | Verfahren zur Herstellung von N-Dialkylaminoacylaminophenolaethern |
JPH05262718A (ja) * | 1992-03-23 | 1993-10-12 | Taisho Pharmaceut Co Ltd | 5−置換アミノ−2−フェノキシスルホンアニリド化合物 |
GB9313365D0 (en) * | 1993-06-29 | 1993-08-11 | Roussel Lab Ltd | Chemical compounds |
US5679715A (en) | 1995-06-07 | 1997-10-21 | Harris; Richard Y. | Method for treating multiple sclerosis |
EP0906090A1 (fr) | 1996-03-15 | 1999-04-07 | Somerset Pharmaceuticals, Inc. | Methode de prevention et de traitement de la neuropathie peripherique par administration de selegiline |
WO2001034172A2 (fr) | 1999-11-05 | 2001-05-17 | Vela Pharmaceuticals Inc. | Procedes et compositions pour traiter un syndrome d'insatisfaction |
ATE430726T1 (de) * | 2002-05-29 | 2009-05-15 | Hoffmann La Roche | N-acylamino-benzyletherderivate als selektive inhibitoren der monoaminoxidase b |
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2003
- 2003-05-20 AT AT03730080T patent/ATE430726T1/de active
- 2003-05-20 EP EP03730080A patent/EP1511718B1/fr not_active Expired - Lifetime
- 2003-05-20 NZ NZ536538A patent/NZ536538A/en not_active IP Right Cessation
- 2003-05-20 CA CA2486380A patent/CA2486380C/fr not_active Expired - Fee Related
- 2003-05-20 WO PCT/EP2003/005297 patent/WO2003099763A1/fr active Application Filing
- 2003-05-20 CN CNB038123932A patent/CN100482638C/zh not_active Expired - Fee Related
- 2003-05-20 SI SI200331610T patent/SI1511718T1/sl unknown
- 2003-05-20 AU AU2003240681A patent/AU2003240681B2/en not_active Ceased
- 2003-05-20 EA EA200401519A patent/EA009372B1/ru not_active IP Right Cessation
- 2003-05-20 DK DK03730080T patent/DK1511718T3/da active
- 2003-05-20 MX MXPA04011594A patent/MXPA04011594A/es active IP Right Grant
- 2003-05-20 JP JP2004507421A patent/JP4223003B2/ja not_active Expired - Fee Related
- 2003-05-20 PL PL375311A patent/PL212708B1/pl not_active IP Right Cessation
- 2003-05-20 ES ES03730080T patent/ES2324214T3/es not_active Expired - Lifetime
- 2003-05-20 DE DE60327522T patent/DE60327522D1/de not_active Expired - Lifetime
- 2003-05-20 PT PT03730080T patent/PT1511718E/pt unknown
- 2003-05-20 BR BR0311338-8A patent/BR0311338A/pt not_active IP Right Cessation
- 2003-05-21 KR KR1020047019240A patent/KR100706739B1/ko not_active IP Right Cessation
- 2003-05-21 RS YU101204A patent/RS51642B/en unknown
- 2003-05-21 UA UA20041210080A patent/UA79284C2/uk unknown
- 2003-05-26 PE PE2003000507A patent/PE20040520A1/es not_active Application Discontinuation
- 2003-05-26 TW TW092114175A patent/TWI331917B/zh not_active IP Right Cessation
- 2003-05-26 TW TW099119340A patent/TWI340641B/zh not_active IP Right Cessation
- 2003-05-26 PA PA20038574401A patent/PA8574401A1/es unknown
- 2003-05-27 US US10/445,580 patent/US6762320B2/en not_active Expired - Lifetime
- 2003-05-27 UY UY27825A patent/UY27825A1/es not_active Application Discontinuation
- 2003-05-28 GT GT200300119A patent/GT200300119A/es unknown
- 2003-05-28 MY MYPI20031959A patent/MY139027A/en unknown
- 2003-05-28 AR ARP030101862A patent/AR040133A1/es not_active Application Discontinuation
-
2004
- 2004-05-05 US US10/839,514 patent/US7053245B2/en not_active Expired - Fee Related
- 2004-11-04 NO NO20044806A patent/NO329387B1/no not_active IP Right Cessation
- 2004-11-04 IL IL16505504A patent/IL165055A0/xx not_active IP Right Cessation
- 2004-11-05 ZA ZA200408965A patent/ZA200408965B/en unknown
- 2004-11-18 HR HRP20041087AA patent/HRP20041087B1/hr not_active IP Right Cessation
- 2004-11-24 TN TNP2004000234A patent/TNSN04234A1/fr unknown
- 2004-11-26 MA MA27971A patent/MA27208A1/fr unknown
-
2005
- 2005-08-26 US US11/213,052 patent/US20050283019A1/en not_active Abandoned
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2006
- 2006-02-10 HK HK06101769.1A patent/HK1081529A1/xx not_active IP Right Cessation
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2009
- 2009-07-10 CY CY20091100728T patent/CY1109220T1/el unknown
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