DK1499622T3 - Meterotricyclyl-6-alkylidenpenemer som beta-lactamaseinhibitorer - Google Patents

Meterotricyclyl-6-alkylidenpenemer som beta-lactamaseinhibitorer

Info

Publication number
DK1499622T3
DK1499622T3 DK03733911T DK03733911T DK1499622T3 DK 1499622 T3 DK1499622 T3 DK 1499622T3 DK 03733911 T DK03733911 T DK 03733911T DK 03733911 T DK03733911 T DK 03733911T DK 1499622 T3 DK1499622 T3 DK 1499622T3
Authority
DK
Denmark
Prior art keywords
meterotricyclyl
penes
alkylidene
beta
lactamase inhibitors
Prior art date
Application number
DK03733911T
Other languages
English (en)
Inventor
Aranapakam Mudumbai Venkatesan
Tarek Suhayl Mansour
Takao Abe
Ado Mihira
Atul Agarwal
Hideki Ushirogochi
Yansong Gu
Satoshi Tamai
Fuk-Wah Sum
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Application granted granted Critical
Publication of DK1499622T3 publication Critical patent/DK1499622T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/881—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hydrogen atom or an unsubstituted hydrocarbon radical, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
DK03733911T 2002-05-01 2003-04-30 Meterotricyclyl-6-alkylidenpenemer som beta-lactamaseinhibitorer DK1499622T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37705102P 2002-05-01 2002-05-01
PCT/US2003/013451 WO2003093280A1 (en) 2002-05-01 2003-04-30 Heterotricyclyl 6-alkylidene-penems as βετα-lactamase inhibitors

Publications (1)

Publication Number Publication Date
DK1499622T3 true DK1499622T3 (da) 2009-06-08

Family

ID=29401436

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03733911T DK1499622T3 (da) 2002-05-01 2003-04-30 Meterotricyclyl-6-alkylidenpenemer som beta-lactamaseinhibitorer

Country Status (23)

Country Link
US (3) US7018997B2 (da)
EP (1) EP1499622B1 (da)
JP (1) JP4472515B2 (da)
KR (1) KR20050007366A (da)
CN (1) CN100506825C (da)
AR (1) AR039475A1 (da)
AT (1) ATE425169T1 (da)
AU (1) AU2003239325B8 (da)
BR (1) BR0309878A (da)
CA (1) CA2483562C (da)
DE (1) DE60326562D1 (da)
DK (1) DK1499622T3 (da)
EC (1) ECSP045405A (da)
ES (1) ES2322951T3 (da)
IL (1) IL164898A0 (da)
MX (1) MXPA04010662A (da)
NO (1) NO20044550L (da)
NZ (1) NZ536181A (da)
RU (1) RU2004135086A (da)
TW (1) TW200404809A (da)
UA (1) UA78312C2 (da)
WO (1) WO2003093280A1 (da)
ZA (1) ZA200409691B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040132708A1 (en) * 2002-05-01 2004-07-08 Wyeth Process for preparing 6-alkylidene penem derivatives
AR039475A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
AR039774A1 (es) 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
AR039476A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp Proceso para preparar derivados de 6-alquiliden penem
TW200716104A (en) * 2005-06-01 2007-05-01 Wyeth Corp Tricyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
TW200716102A (en) * 2005-06-01 2007-05-01 Wyeth Corp Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
MX2008001083A (es) * 2005-07-27 2008-03-19 Wyeth Corp Inhibidores de 6-alquiliden-penem b-lactamasa triciclicos y combinacion de antibioticos de beta-lactama: un antibiotico de amplio espectro.
AU2006275940A1 (en) * 2005-07-27 2007-02-08 Wyeth Bicyclic 6-alkylidene-penem beta-lactamase inhibitors and beta-lactam antibiotic combination: a broad spectrum antibiotic
GT200600380A (es) * 2005-08-24 2007-03-29 Proceso para la preparacion de inhibidores de beta-lactamasa
US20100063023A1 (en) * 2008-09-10 2010-03-11 Wyeth Bicyclic and Tricyclic Substituted 6-Methylidene Carbapenems as Broad Spectrum Beta-Lactamase Inhibitors
US20110288063A1 (en) * 2010-05-19 2011-11-24 Naeja Pharmaceutical Inc. Novel fused bridged bicyclic heteroaryl substituted 6-alkylidene penems as potent beta-lactamase inhibitors
WO2023287793A1 (en) * 2021-07-15 2023-01-19 Genentech, Inc. Therapeutic compounds and methods

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Also Published As

Publication number Publication date
CN1649882A (zh) 2005-08-03
MXPA04010662A (es) 2005-01-25
JP4472515B2 (ja) 2010-06-02
JP2005533018A (ja) 2005-11-04
ATE425169T1 (de) 2009-03-15
CN100506825C (zh) 2009-07-01
NO20044550L (no) 2005-01-28
AU2003239325A1 (en) 2003-11-17
US20080318921A1 (en) 2008-12-25
IL164898A0 (en) 2005-12-18
EP1499622A1 (en) 2005-01-26
CA2483562C (en) 2011-06-21
BR0309878A (pt) 2005-04-19
ZA200409691B (en) 2009-09-30
US20040043978A1 (en) 2004-03-04
US7691842B2 (en) 2010-04-06
RU2004135086A (ru) 2005-05-10
AU2003239325B2 (en) 2009-04-23
ECSP045405A (es) 2005-01-03
AR039475A1 (es) 2005-02-23
AU2003239325B8 (en) 2009-06-18
US7018997B2 (en) 2006-03-28
DE60326562D1 (de) 2009-04-23
TW200404809A (en) 2004-04-01
EP1499622B1 (en) 2009-03-11
US20060074064A1 (en) 2006-04-06
KR20050007366A (ko) 2005-01-17
ES2322951T3 (es) 2009-07-02
CA2483562A1 (en) 2003-11-13
NZ536181A (en) 2007-06-29
UA78312C2 (en) 2007-03-15
WO2003093280A1 (en) 2003-11-13

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ITPS20030009U1 (it) Progetto tapascia
DE602004014762D1 (de) Proteasehemmer