ATE425169T1 - Heterotricyclyl-6-alkylidenpeneme als beta- lactamaseinhibitoren - Google Patents

Heterotricyclyl-6-alkylidenpeneme als beta- lactamaseinhibitoren

Info

Publication number
ATE425169T1
ATE425169T1 AT03733911T AT03733911T ATE425169T1 AT E425169 T1 ATE425169 T1 AT E425169T1 AT 03733911 T AT03733911 T AT 03733911T AT 03733911 T AT03733911 T AT 03733911T AT E425169 T1 ATE425169 T1 AT E425169T1
Authority
AT
Austria
Prior art keywords
heterotricyclyl
penems
alkylide
beta
lactamase inhibitors
Prior art date
Application number
AT03733911T
Other languages
English (en)
Inventor
Aranapakam Venkatesan
Tarek Mansour
Takao Abe
Ado Mihira
Atul Agarwal
Hideki Ushirogochi
Yansong Gu
Satoshi Tamai
Fuk-Wah Sum
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Application granted granted Critical
Publication of ATE425169T1 publication Critical patent/ATE425169T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/881—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hydrogen atom or an unsubstituted hydrocarbon radical, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT03733911T 2002-05-01 2003-04-30 Heterotricyclyl-6-alkylidenpeneme als beta- lactamaseinhibitoren ATE425169T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37705102P 2002-05-01 2002-05-01

Publications (1)

Publication Number Publication Date
ATE425169T1 true ATE425169T1 (de) 2009-03-15

Family

ID=29401436

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03733911T ATE425169T1 (de) 2002-05-01 2003-04-30 Heterotricyclyl-6-alkylidenpeneme als beta- lactamaseinhibitoren

Country Status (23)

Country Link
US (3) US7018997B2 (de)
EP (1) EP1499622B1 (de)
JP (1) JP4472515B2 (de)
KR (1) KR20050007366A (de)
CN (1) CN100506825C (de)
AR (1) AR039475A1 (de)
AT (1) ATE425169T1 (de)
AU (1) AU2003239325B8 (de)
BR (1) BR0309878A (de)
CA (1) CA2483562C (de)
DE (1) DE60326562D1 (de)
DK (1) DK1499622T3 (de)
EC (1) ECSP045405A (de)
ES (1) ES2322951T3 (de)
IL (1) IL164898A0 (de)
MX (1) MXPA04010662A (de)
NO (1) NO20044550L (de)
NZ (1) NZ536181A (de)
RU (1) RU2004135086A (de)
TW (1) TW200404809A (de)
UA (1) UA78312C2 (de)
WO (1) WO2003093280A1 (de)
ZA (1) ZA200409691B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR039774A1 (es) * 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
US20040132708A1 (en) * 2002-05-01 2004-07-08 Wyeth Process for preparing 6-alkylidene penem derivatives
AR039475A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
AR039476A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp Proceso para preparar derivados de 6-alquiliden penem
TW200716104A (en) * 2005-06-01 2007-05-01 Wyeth Corp Tricyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
TW200716102A (en) * 2005-06-01 2007-05-01 Wyeth Corp Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
WO2007027323A2 (en) * 2005-07-27 2007-03-08 Wyeth TRICYCLIC 6-ALKYLIDENE-PENEM β-LACTAMASE INHIBITORS AND β-LACTAM ANTIBIOTIC COMBINATION: A BROAD SPECTRUM ANTIBIOTIC
KR20080032637A (ko) * 2005-07-27 2008-04-15 와이어쓰 이환식 6-알킬리덴-페넴 β-락타마제 저해제 및 β-락탐항생제 조합: 광범위 항생제
GT200600380A (es) * 2005-08-24 2007-03-29 Proceso para la preparacion de inhibidores de beta-lactamasa
US20100063023A1 (en) * 2008-09-10 2010-03-11 Wyeth Bicyclic and Tricyclic Substituted 6-Methylidene Carbapenems as Broad Spectrum Beta-Lactamase Inhibitors
US20110288063A1 (en) * 2010-05-19 2011-11-24 Naeja Pharmaceutical Inc. Novel fused bridged bicyclic heteroaryl substituted 6-alkylidene penems as potent beta-lactamase inhibitors
PE20240776A1 (es) 2021-07-15 2024-04-17 Genentech Inc Compuestos terapeuticos y procedimientos

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AR039475A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
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WO2007027323A2 (en) * 2005-07-27 2007-03-08 Wyeth TRICYCLIC 6-ALKYLIDENE-PENEM β-LACTAMASE INHIBITORS AND β-LACTAM ANTIBIOTIC COMBINATION: A BROAD SPECTRUM ANTIBIOTIC
KR20080032637A (ko) * 2005-07-27 2008-04-15 와이어쓰 이환식 6-알킬리덴-페넴 β-락타마제 저해제 및 β-락탐항생제 조합: 광범위 항생제

Also Published As

Publication number Publication date
BR0309878A (pt) 2005-04-19
CA2483562A1 (en) 2003-11-13
ECSP045405A (es) 2005-01-03
DE60326562D1 (de) 2009-04-23
UA78312C2 (en) 2007-03-15
AR039475A1 (es) 2005-02-23
ES2322951T3 (es) 2009-07-02
US20080318921A1 (en) 2008-12-25
JP4472515B2 (ja) 2010-06-02
AU2003239325B8 (en) 2009-06-18
NZ536181A (en) 2007-06-29
CN1649882A (zh) 2005-08-03
IL164898A0 (en) 2005-12-18
US7018997B2 (en) 2006-03-28
WO2003093280A1 (en) 2003-11-13
KR20050007366A (ko) 2005-01-17
EP1499622A1 (de) 2005-01-26
JP2005533018A (ja) 2005-11-04
DK1499622T3 (da) 2009-06-08
NO20044550L (no) 2005-01-28
US7691842B2 (en) 2010-04-06
TW200404809A (en) 2004-04-01
MXPA04010662A (es) 2005-01-25
CA2483562C (en) 2011-06-21
RU2004135086A (ru) 2005-05-10
EP1499622B1 (de) 2009-03-11
AU2003239325A1 (en) 2003-11-17
AU2003239325B2 (en) 2009-04-23
US20060074064A1 (en) 2006-04-06
US20040043978A1 (en) 2004-03-04
ZA200409691B (en) 2009-09-30
CN100506825C (zh) 2009-07-01

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