EP2310369A4 - Dérivés de benzyloxy anilide utiles en tant que modulateurs du canal potassique - Google Patents
Dérivés de benzyloxy anilide utiles en tant que modulateurs du canal potassiqueInfo
- Publication number
- EP2310369A4 EP2310369A4 EP09798525.3A EP09798525A EP2310369A4 EP 2310369 A4 EP2310369 A4 EP 2310369A4 EP 09798525 A EP09798525 A EP 09798525A EP 2310369 A4 EP2310369 A4 EP 2310369A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- benzyloxy
- potassium channel
- derivatives useful
- channel modulators
- anilide derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/26—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a saturated carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
- C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7530708P | 2008-06-24 | 2008-06-24 | |
PCT/US2009/048504 WO2010008894A1 (fr) | 2008-06-24 | 2009-06-24 | Dérivés de benzyloxy anilide utiles en tant que modulateurs du canal potassique |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2310369A1 EP2310369A1 (fr) | 2011-04-20 |
EP2310369A4 true EP2310369A4 (fr) | 2014-02-19 |
Family
ID=41448228
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP09798525.3A Withdrawn EP2310369A4 (fr) | 2008-06-24 | 2009-06-24 | Dérivés de benzyloxy anilide utiles en tant que modulateurs du canal potassique |
Country Status (7)
Country | Link |
---|---|
US (2) | US8188314B2 (fr) |
EP (1) | EP2310369A4 (fr) |
JP (1) | JP2011525538A (fr) |
AU (1) | AU2009271302A1 (fr) |
CA (1) | CA2728915A1 (fr) |
MX (1) | MX2010014461A (fr) |
WO (1) | WO2010008894A1 (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20150053257A (ko) * | 2012-04-30 | 2015-05-15 | 사이플루어 라이프 사이언시즈, 엘엘씨 | 플루오르화 2-아미노-4-(벤질아미노)페닐카르바메이트 유도체 |
CN103508943B (zh) * | 2012-06-29 | 2017-06-09 | 江苏先声药业有限公司 | 作为钾通道调节剂的化合物 |
Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS49426A (fr) * | 1972-04-15 | 1974-01-05 | ||
FR2395994A1 (fr) * | 1977-07-01 | 1979-01-26 | Merrell Toraude & Co | Nouveaux derives d'aminoacides a-acetyleniques et leur utilisation therapeutique |
US4539577A (en) * | 1983-09-30 | 1985-09-03 | Hodogaya Chemical Co., Ltd. | Heat sensitive record material |
WO1998011073A1 (fr) * | 1996-09-10 | 1998-03-19 | Pharmacia & Upjohn Company | 8-hydroxyquinoleines 7-substituees utilisees comme agents antiviraux |
JP2003026683A (ja) * | 2001-07-10 | 2003-01-29 | Sankyo Co Ltd | 新規ガランタミン類縁体 |
WO2003099763A1 (fr) * | 2002-05-29 | 2003-12-04 | F. Hoffmann-La Roche Ag | Derives de n-acylaminobenzene comme inhibiteurs de la monoamine oxydase b selectifs |
WO2004080377A2 (fr) * | 2003-03-11 | 2004-09-23 | Neurosearch A/S | Nouveaux composes modulant le canal kcnq et leur utilisation |
WO2005032493A2 (fr) * | 2003-10-07 | 2005-04-14 | Renovis, Inc. | Composes d'amides utilises en tant que ligands de canaux ioniques et utilisations correspondantes |
WO2005048948A2 (fr) * | 2003-11-13 | 2005-06-02 | Ambit Biosciences Corporation | Derives d'uree en tant que modulateurs de la kinase |
US20050182108A1 (en) * | 2004-02-13 | 2005-08-18 | Carson John R. | Hetero-substituted acetanilide derivatives as analgesic agents |
WO2006022442A1 (fr) * | 2004-08-24 | 2006-03-02 | Santen Pharmaceutical Co., Ltd. | Nouveaux derives d’amides heterocycliques ayant une activite d’inhibition de la dihydroorotate deshydrogenase |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3995041A (en) * | 1975-10-30 | 1976-11-30 | Miles Laboratories, Inc. | Derivatives of 2-substituted-hydroxyanilino-hexahydro-2H-benzo[α]quinolizines |
JPS5953917B2 (ja) * | 1976-07-23 | 1984-12-27 | 武田薬品工業株式会社 | テトラヒドロイソフタルイミド誘導体およびその製造方法 |
FR2675504B1 (fr) * | 1991-04-16 | 1995-01-27 | Delalande Sa | Derives d'aryl-3 oxazolidinone, leur procede de preparation et leur application en therapeutique. |
IL111002A (en) * | 1993-09-22 | 1998-09-24 | Glaxo Group Ltd | History of piperidine, their preparation and the pharmaceutical preparations containing them |
EP0977743A1 (fr) * | 1997-04-25 | 2000-02-09 | Smithkline Beecham | Inhibiteurs de proteases |
GB0221246D0 (en) * | 2002-09-13 | 2002-10-23 | Astrazeneca Ab | Compounds |
AR043507A1 (es) * | 2003-03-14 | 2005-08-03 | Lundbeck & Co As H | Derivados de anilina sustituidos y composiciones farmaceuticas |
UA89503C2 (uk) * | 2004-09-13 | 2010-02-10 | Х. Луннбек А/С | Заміщені похідні аніліну |
JP2009256208A (ja) * | 2006-08-17 | 2009-11-05 | Dainippon Sumitomo Pharma Co Ltd | フタリド誘導体またはその薬学的に許容される塩 |
BRPI0716715B1 (pt) * | 2006-08-23 | 2021-07-06 | Xenon Pharmaceuticals, Inc | Derivados de 4-(n-azacicloalquil) anilidas como moduladores de canal de potássio, seus usos, produto, composição, comprimido e cápsula |
-
2009
- 2009-06-24 EP EP09798525.3A patent/EP2310369A4/fr not_active Withdrawn
- 2009-06-24 JP JP2011516617A patent/JP2011525538A/ja active Pending
- 2009-06-24 WO PCT/US2009/048504 patent/WO2010008894A1/fr active Application Filing
- 2009-06-24 US US12/491,055 patent/US8188314B2/en not_active Expired - Fee Related
- 2009-06-24 CA CA2728915A patent/CA2728915A1/fr not_active Abandoned
- 2009-06-24 AU AU2009271302A patent/AU2009271302A1/en not_active Abandoned
- 2009-06-24 MX MX2010014461A patent/MX2010014461A/es not_active Application Discontinuation
-
2012
- 2012-05-29 US US13/483,018 patent/US8492588B2/en not_active Expired - Fee Related
Patent Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS49426A (fr) * | 1972-04-15 | 1974-01-05 | ||
FR2395994A1 (fr) * | 1977-07-01 | 1979-01-26 | Merrell Toraude & Co | Nouveaux derives d'aminoacides a-acetyleniques et leur utilisation therapeutique |
US4539577A (en) * | 1983-09-30 | 1985-09-03 | Hodogaya Chemical Co., Ltd. | Heat sensitive record material |
WO1998011073A1 (fr) * | 1996-09-10 | 1998-03-19 | Pharmacia & Upjohn Company | 8-hydroxyquinoleines 7-substituees utilisees comme agents antiviraux |
JP2003026683A (ja) * | 2001-07-10 | 2003-01-29 | Sankyo Co Ltd | 新規ガランタミン類縁体 |
WO2003099763A1 (fr) * | 2002-05-29 | 2003-12-04 | F. Hoffmann-La Roche Ag | Derives de n-acylaminobenzene comme inhibiteurs de la monoamine oxydase b selectifs |
WO2004080377A2 (fr) * | 2003-03-11 | 2004-09-23 | Neurosearch A/S | Nouveaux composes modulant le canal kcnq et leur utilisation |
WO2005032493A2 (fr) * | 2003-10-07 | 2005-04-14 | Renovis, Inc. | Composes d'amides utilises en tant que ligands de canaux ioniques et utilisations correspondantes |
WO2005048948A2 (fr) * | 2003-11-13 | 2005-06-02 | Ambit Biosciences Corporation | Derives d'uree en tant que modulateurs de la kinase |
US20050182108A1 (en) * | 2004-02-13 | 2005-08-18 | Carson John R. | Hetero-substituted acetanilide derivatives as analgesic agents |
WO2006022442A1 (fr) * | 2004-08-24 | 2006-03-02 | Santen Pharmaceutical Co., Ltd. | Nouveaux derives d’amides heterocycliques ayant une activite d’inhibition de la dihydroorotate deshydrogenase |
Non-Patent Citations (18)
Title |
---|
ALONSO-ALIJA C ET AL: "A convenient synthesis of 4-alkoxy- and 4-hydroxy-2,6-difluoroanilines", TETRAHEDRON LETTERS, PERGAMON, GB, vol. 45, no. 1, 1 January 2004 (2004-01-01), pages 95 - 98, XP004621820, ISSN: 0040-4039, DOI: 10.1016/J.TETLET.2003.10.109 * |
ARMOUR D R ET AL: "Tetrazole NK1 receptor antagonists: the identification of an exceptionally potent orally active antiemetic compound", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, GB, vol. 6, no. 9, 7 May 1996 (1996-05-07), pages 1015 - 1020, XP004134899, ISSN: 0960-894X, DOI: 10.1016/0960-894X(96)00163-1 * |
CHU-BIAO XUE ET AL: "Rational design, synthesis and structure-Activity relationships of a cyclic succinate series of TNF-[alpha] converting enzyme inhibitors. Part 1: lead identification", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, no. 24, 1 December 2003 (2003-12-01), pages 4293 - 4297, XP055095063, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2003.09.056 * |
D KEGLEVIC ET AL: "The synthesis of 3,5-disubstituted indoles by cyclization under mild conditions", CROATICA CHEMICA ACTA, 1 January 1961 (1961-01-01), pages 83 - 88, XP055095526, Retrieved from the Internet <URL:http://chemistry.mdma.ch/hiveboard/rhodium/pdf/keglevic1961.pdf> [retrieved on 20140109] * |
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP055095511, retrieved from STN accession no. 71709-17-6 Database accession no. 91:211044 * |
EHRHARDT J-D ET AL: "STRUCTURE ACTIVITY RELATIONSHIPS IN A SERIES OF 2,6-DICHLORO ANALOGS OF LIDOCAINE//RELATIONS STRUCTURE-ACTIVITE DANS UNE SERIE D'ANALOGUE 2,6-DICHLORES DE LA LIDOCAINE", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 13, no. 3, 1 May 1978 (1978-05-01), pages 235 - 240, XP009018741, ISSN: 0223-5234 * |
IAN CALDER ET AL: "Synthesis and Reactions of Some para -Substituted N-Hydroxyacetanilides", AUSTRALIAN JOURNAL OF CHEMISTRY, vol. 32, no. 6, 1 January 1979 (1979-01-01), pages 1301 - 1306, XP055095511, ISSN: 0004-9425, DOI: 10.1071/CH9791301 * |
LUKAS A ET AL: "STUDIEN UEBER LOKALANAESTHETIKA. XXX BASISCHE 4-AROXY- UND 4-ARALKOXY-2, 6-DIMETHYLACETANILIDE", ACTA FACULTATIS PHARMACEUTICAE BOHEMOSLOVENICAE, UNIVERZITA KOMENSKEHO. FARMACEUTICKA FAKULTA, BRATISLAVA, SK, vol. 12, 1 January 1966 (1966-01-01), pages 189 - 202, XP001155535, ISSN: 0303-2639 * |
LUKAS A ET AL: "STUDIES ON LOCAL ANAESTHETICS. XLII. BASIC PHENOXY- AND BENZYLOCYACYLTOLUIDINES", CESKOSLOVENSKA FARMACIE, CZECH MEDICAL SOCIETY, PRAGUE, CZ, vol. 21, no. 6, 1 January 1972 (1972-01-01), pages 273 - 275, XP009018758, ISSN: 0009-0530 * |
LUKAS A ET AL: "STUDIES ON LOCAL ANESTHETICS. XXXVII. BASIC PHENOXY- AND BENZYLOXYACYLTOLUIDINES", ACTA FACULTATIS PHARMACEUTICAE UNIVERSITATIS COMENIANAE, COMENIUS UNIV., BRATISLAVA, CZ, vol. 28, 1 January 1975 (1975-01-01), pages 91 - 114, XP001155612, ISSN: 0301-2298 * |
MODESTO DE CANDIA ET AL: "Fluorinated Benzyloxyphenyl Piperidine-4-carboxamides with Dual Function against Thrombosis: Inhibitors of Factor Xa and Platelet Aggregation", JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, no. 4, 26 February 2009 (2009-02-26), pages 1018 - 1028, XP055095066, ISSN: 0022-2623, DOI: 10.1021/jm801141f * |
NOEL A. POWELL ET AL: "Practical Synthesis of 1-Aryl-6-(hydroxymethyl)-2-ketopiperazines via a 6- exo Amide-Epoxide Cyclization", ORGANIC LETTERS, vol. 6, no. 22, 1 October 2004 (2004-10-01), pages 4069 - 4072, XP055095204, ISSN: 1523-7060, DOI: 10.1021/ol048235t * |
See also references of WO2010008894A1 * |
SHINOBU ITOH ET AL: "Synthesis, Physicochemical Properties, and Amine-Oxidation Reaction of Indolequinone Derivatives as Model Compounds of Novel Organic Cofactor TTQ of Amine Dehydrogenases", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 62, no. 17, 1 August 1997 (1997-08-01), pages 5898 - 5907, XP055095062, ISSN: 0022-3263, DOI: 10.1021/jo970716l * |
TRIVEDI J P ET AL: "POTENTIAL LOCAL ANAESTHETICS: SYNTHESIS OF BENZYLOXY-ACETANILIDES AND PROPIONANILIDES", INDIAN JOURNAL OF APPLIED CHEMISTRY, INDIAN CHEMICAL SOCIETY, CALCUTTA, IN, vol. 30, no. 3/04, 1 January 1967 (1967-01-01), pages 91, XP009018747, ISSN: 0019-5065 * |
WOLFGANG WIEGREBE ET AL: "Synthese des (+)-S-Hydroxy-2.3-dimethoxy-9.11.12.13.13a.14- hexahydro-dibenzo[f,h]pyrrolo[ 1 2-b]isochinolins", LIEBIGS ANN. CHEM., 1 January 1970 (1970-01-01), pages 125 - 140, XP055095056, Retrieved from the Internet <URL:http://onlinelibrary.wiley.com/store/10.1002/jlac.19707330114/asset/19707330114_ftp.pdf?v=1&t=hq58qtq9&s=d19583f2b50bfd27b56d0ef90727512cd68587a2> [retrieved on 20140107], DOI: 10.1002/jlac.19707330114 * |
WU Y-J ET AL: "RECENT DEVELOPMENTS ON KCNQ POTASSIUM CHANNEL OPENERS", CURRENT MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBLISHERS, vol. 12, no. 4, 1 January 2005 (2005-01-01), pages 453 - 460, XP009049808, ISSN: 0929-8673 * |
XIONG ET AL: "Activation of Kv7 (KCNQ) voltage-gated potassium channels by synthetic compounds", TRENDS IN PHARMACOLOGICAL SCIENCES, ELSEVIER, HAYWARTH, GB, vol. 29, no. 2, 18 January 2008 (2008-01-18), pages 99 - 107, XP022460445, ISSN: 0165-6147 * |
Also Published As
Publication number | Publication date |
---|---|
EP2310369A1 (fr) | 2011-04-20 |
AU2009271302A1 (en) | 2010-01-21 |
MX2010014461A (es) | 2011-04-28 |
US8492588B2 (en) | 2013-07-23 |
CA2728915A1 (fr) | 2010-01-21 |
US8188314B2 (en) | 2012-05-29 |
JP2011525538A (ja) | 2011-09-22 |
WO2010008894A1 (fr) | 2010-01-21 |
US20120329869A1 (en) | 2012-12-27 |
US20090326059A1 (en) | 2009-12-31 |
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Ipc: C07C 233/26 20060101ALI20140115BHEP Ipc: C07C 233/25 20060101ALI20140115BHEP Ipc: A61K 31/472 20060101ALI20140115BHEP Ipc: C07D 213/30 20060101AFI20140115BHEP Ipc: C07C 271/28 20060101ALI20140115BHEP |
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