TNSN03143A1 - Ligands de recepteurs de 5-ht et leurs utilisations . - Google Patents
Ligands de recepteurs de 5-ht et leurs utilisations .Info
- Publication number
- TNSN03143A1 TNSN03143A1 TNPCT/IB2002/002261A TNSN03143A TNSN03143A1 TN SN03143 A1 TNSN03143 A1 TN SN03143A1 TN SN03143 A TNSN03143 A TN SN03143A TN SN03143 A1 TNSN03143 A1 TN SN03143A1
- Authority
- TN
- Tunisia
- Prior art keywords
- receptor ligands
- receptors
- ligands
- animals
- activation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
LES COMPOSES DE FORMULE (IA) : QUI AGISSENT COMME DES LIGANDS DES RECEPTEURS 5-HT ET LEURS UTILISATIONS DANS LE TRAITEMENT DE MALADIES EN RAPPORT AVEC L'ACTIVATION DES RECEPTEURS 5-HT2 CHEZ DES ANIMAUX SONT DECRITS DANS LE PRESENT MEMOIRE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29995301P | 2001-06-21 | 2001-06-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
TNSN03143A1 true TNSN03143A1 (fr) | 2005-12-23 |
Family
ID=23157027
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TNPCT/IB2002/002261A TNSN03143A1 (fr) | 2001-06-21 | 2002-06-17 | Ligands de recepteurs de 5-ht et leurs utilisations . |
TNPCT/IB2002/002293A TNSN03142A1 (fr) | 2001-06-21 | 2002-06-17 | Ligands des recepteurs de 5-ht et leurs utilisations |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TNPCT/IB2002/002293A TNSN03142A1 (fr) | 2001-06-21 | 2002-06-17 | Ligands des recepteurs de 5-ht et leurs utilisations |
Country Status (39)
Country | Link |
---|---|
US (6) | US6825198B2 (fr) |
EP (2) | EP1401820A1 (fr) |
JP (2) | JP2004534823A (fr) |
KR (2) | KR20040010767A (fr) |
CN (2) | CN1745074A (fr) |
AP (1) | AP2002002561A0 (fr) |
AR (1) | AR036095A1 (fr) |
AU (1) | AU2002309173B2 (fr) |
BG (2) | BG108491A (fr) |
BR (2) | BR0210471A (fr) |
CA (2) | CA2450491A1 (fr) |
CR (1) | CR7168A (fr) |
CZ (2) | CZ20033508A3 (fr) |
DO (1) | DOP2002000412A (fr) |
EA (2) | EA200301213A1 (fr) |
EC (2) | ECSP034881A (fr) |
EE (2) | EE200400025A (fr) |
GE (1) | GEP20053655B (fr) |
GT (1) | GT200200120A (fr) |
HR (1) | HRP20031042A2 (fr) |
HU (2) | HUP0400249A3 (fr) |
IL (2) | IL158807A0 (fr) |
IS (2) | IS7040A (fr) |
MA (2) | MA27035A1 (fr) |
MX (2) | MXPA03011941A (fr) |
NO (2) | NO20035698L (fr) |
NZ (1) | NZ529542A (fr) |
OA (2) | OA12621A (fr) |
PA (1) | PA8548901A1 (fr) |
PE (1) | PE20030268A1 (fr) |
PL (2) | PL367777A1 (fr) |
SK (2) | SK15672003A3 (fr) |
SV (1) | SV2003001102A (fr) |
TN (2) | TNSN03143A1 (fr) |
UA (1) | UA74443C2 (fr) |
UY (1) | UY27343A1 (fr) |
WO (2) | WO2003000666A1 (fr) |
YU (1) | YU95303A (fr) |
ZA (2) | ZA200308843B (fr) |
Families Citing this family (111)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7732451B2 (en) * | 2001-08-10 | 2010-06-08 | Palatin Technologies, Inc. | Naphthalene-containing melanocortin receptor-specific small molecule |
US7456184B2 (en) * | 2003-05-01 | 2008-11-25 | Palatin Technologies Inc. | Melanocortin receptor-specific compounds |
JP2005504043A (ja) * | 2001-08-10 | 2005-02-10 | パラチン テクノロジーズ インク. | 生物学的に活性な金属ペプチド類のペプチド模倣体類 |
US7655658B2 (en) * | 2001-08-10 | 2010-02-02 | Palatin Technologies, Inc. | Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds |
US7718802B2 (en) | 2001-08-10 | 2010-05-18 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
US7354923B2 (en) * | 2001-08-10 | 2008-04-08 | Palatin Technologies, Inc. | Piperazine melanocortin-specific compounds |
US6953787B2 (en) | 2002-04-12 | 2005-10-11 | Arena Pharmaceuticals, Inc. | 5HT2C receptor modulators |
US7226925B2 (en) | 2002-06-19 | 2007-06-05 | Biovitrum Ab | Compounds, their use and preparation |
CA2485537A1 (fr) | 2002-06-19 | 2003-12-31 | Biovitrum Ab | Nouveaux composes, leur utilisation et leur preparation |
EP1599468B1 (fr) | 2003-01-14 | 2007-10-03 | Arena Pharmaceuticals, Inc. | Derives aryles et heteroaryles tri-substitues en position 1,2,3 en tant que modulateurs de metabolisme et prophylaxie et traitement de troubles lies au metabolisme |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
AU2004207675B2 (en) * | 2003-01-29 | 2010-05-20 | Asterand Uk Acquisition Limited | EP4 receptor antagonists |
GEP20084341B (en) * | 2003-02-26 | 2008-03-25 | Sugen Inc | Aminoheteroaryl compounds as protein kinase inhibitors |
CL2004000826A1 (es) * | 2003-04-25 | 2005-03-04 | Pfizer | Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129 |
US20040235856A1 (en) * | 2003-04-25 | 2004-11-25 | Pfizer Inc | Treatment of incontinence |
US20080146583A1 (en) * | 2003-05-15 | 2008-06-19 | Pfizer Inc | Treatment of Incontinence |
US7968548B2 (en) | 2003-05-01 | 2011-06-28 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine compounds with diamine groups |
US7727990B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine and keto-piperazine compounds |
US7727991B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific single acyl piperazine compounds |
SI2332921T1 (sl) | 2003-06-17 | 2016-06-30 | Arena Pharmaceuticals, Inc. | 8-kloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzazapin hidroklorid |
CN1805939B (zh) | 2003-06-17 | 2010-10-13 | 艾尼纳制药公司 | 用于治疗5ht2c受体相关病症的苯并氮杂卓衍生物 |
US20070179155A1 (en) * | 2003-06-20 | 2007-08-02 | Brian Smith | N-phenyl-piperazine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases |
EP2287165A3 (fr) | 2003-07-14 | 2011-06-22 | Arena Pharmaceuticals, Inc. | Dérivés d'hétéroaryle et aryle fusionné en tant que modulateurs du métabolisme et prophylaxie et traitement des troubles associés |
US7390907B2 (en) | 2003-09-30 | 2008-06-24 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
US7476687B2 (en) | 2003-11-26 | 2009-01-13 | Alcon, Inc. | Substituted furo[2,3-g]indazoles for the treatment of glaucoma |
US7338972B1 (en) | 2003-12-15 | 2008-03-04 | Alcon, Inc. | Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma |
US20080194574A1 (en) * | 2003-12-16 | 2008-08-14 | Axxima Pharmaceuticals Ag | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases |
WO2005097127A2 (fr) | 2004-04-02 | 2005-10-20 | Merck & Co., Inc. | Methode destinee a traiter des hommes presentant des troubles metaboliques et anthropometriques |
US7709484B1 (en) | 2004-04-19 | 2010-05-04 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
DE602005011279D1 (de) * | 2004-06-04 | 2009-01-08 | Arena Pharm Inc | Substituierte aryl- und heteroarylderivate als modulatoren des stoffwechsels und für die prophylaxe und behandlung von damit in zusammenhang stehenden erkrankungen |
JP5173190B2 (ja) | 2004-08-25 | 2013-03-27 | 武田薬品工業株式会社 | 腹圧性尿失禁の予防・治療剤及びそのスクリーニング方法 |
US8114502B2 (en) * | 2004-09-02 | 2012-02-14 | 3M Innovative Properties Company | Substrates with multiple images |
EP2286838A3 (fr) * | 2004-11-01 | 2013-09-04 | Amylin Pharmaceuticals, LLC | Traitement de l'obésité et de maladies liés à l'obésité |
AU2005305036B2 (en) * | 2004-11-01 | 2011-03-10 | Amylin Pharmaceuticals, Llc | Treatment of obesity and related disorders |
US8394765B2 (en) | 2004-11-01 | 2013-03-12 | Amylin Pharmaceuticals Llc | Methods of treating obesity with two different anti-obesity agents |
AR051946A1 (es) * | 2004-11-05 | 2007-02-21 | Wyeth Corp | Formulaciones de derivados de [1,4] diazepina [6,7,1-ij] quinolina |
EP1812424A4 (fr) | 2004-11-17 | 2009-07-08 | Miikana Therapeutics Inc | Inhibiteurs de kinase |
JPWO2006064780A1 (ja) * | 2004-12-14 | 2008-06-12 | 塩野義製薬株式会社 | 便秘治療剤 |
EP1838677B1 (fr) | 2004-12-21 | 2009-09-09 | Arena Pharmaceuticals, Inc. | Formes cristallines d'hydrochlorure de (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine |
EP2322162A1 (fr) * | 2004-12-23 | 2011-05-18 | Arena Pharmaceuticals, Inc. | Compositions comprenant des modulateurs des recepteurs 5HT2C et leur utilisation |
JP5186219B2 (ja) * | 2005-01-25 | 2013-04-17 | エピックス デラウェア, インコーポレイテッド | 置換アリールアミン化合物および5−ht6調節因子としてのその使用 |
MX2007012082A (es) * | 2005-03-31 | 2007-11-20 | Pfizer Prod Inc | Derivados de ciclopentapiridina y tetrahidroquinolina. |
US7594976B2 (en) * | 2005-05-13 | 2009-09-29 | 3M Innovative Properties Company | Methods of manufacturing substrates |
WO2007016361A2 (fr) | 2005-07-29 | 2007-02-08 | Concert Pharmaceuticals Inc. | Nouveaux composes pharmaceutiques |
WO2007041358A2 (fr) * | 2005-09-30 | 2007-04-12 | Miikana Therapeutics, Inc. | Composes pyrazole substitues |
EP1959955B1 (fr) * | 2005-12-05 | 2010-11-17 | Pfizer Products Inc. | Méthode de traitement d'une croissance cellulaire anormale |
AU2006323025B2 (en) * | 2005-12-05 | 2012-07-05 | Pfizer Products Inc. | Polymorphs of a c-Met/HGFR inhibitor |
WO2007075555A2 (fr) * | 2005-12-21 | 2007-07-05 | Schering Corporation | Combinaison d'un antagoniste/agoniste inverse de h3 et d'un moderateur de l'appetit |
JP5199997B2 (ja) | 2006-04-03 | 2013-05-15 | アリーナ ファーマシューティカルズ, インコーポレイテッド | 8−クロロ−1−メチル−2,3,4,5−テトラヒドロ−1h−3−ベンズアゼピンおよびこれに関連する中間体を調製するためのプロセス |
EP2018863B9 (fr) | 2006-05-16 | 2015-02-18 | Takeda Pharmaceutical Company Limited | Composé hétérocyclique fusionné et utilisation |
CA2652158A1 (fr) * | 2006-05-30 | 2007-12-06 | Matthias Heinrich Nettekoven | Derives de piperidinylpyrimidine |
KR20090029299A (ko) * | 2006-07-14 | 2009-03-20 | 화이자 프로덕츠 인코포레이티드 | (7s)-7-[(5-플루오로-2-메틸-벤질)옥시]-2-[(2r)-2-메틸피페라진-1-일]-6,7-다이하이드로-5h-사이클로펜타[b]피리딘의 타르트레이트 염 |
US7834017B2 (en) | 2006-08-11 | 2010-11-16 | Palatin Technologies, Inc. | Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents |
JP2010509392A (ja) | 2006-11-13 | 2010-03-25 | ファイザー・プロダクツ・インク | ジアリール、ジピリジニルおよびアリール−ピリジニル誘導体ならびにその使用 |
US8461161B2 (en) * | 2006-11-15 | 2013-06-11 | Ym Biosciences Australia Pty Ltd | Substituted pyrazines as inhibitors of kinase activity |
EP2099743B1 (fr) | 2006-12-05 | 2014-08-27 | Arena Pharmaceuticals, Inc. | Procédés de préparation de (r)-8-chloro-1-méthyl-2,3,4,5-tétrahydro-1h-3-benzazépine et intermédiaires de celle-ci |
MY154869A (en) | 2007-01-16 | 2015-08-14 | Ipintl Llc | Composition for treating metabolic syndrome |
US20080220104A1 (en) * | 2007-03-08 | 2008-09-11 | Cappello John V | Compositions for producing satiety |
CA2688161C (fr) | 2007-06-04 | 2020-10-20 | Kunwar Shailubhai | Agonistes de guanylase cyclase utiles pour le traitement de troubles gastro-intestinaux, d'inflammation, de cancer et d'autres troubles |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
US20090029992A1 (en) * | 2007-06-11 | 2009-01-29 | Agoston Gregory E | Substituted pyrazole compounds |
US20100266504A1 (en) | 2007-11-15 | 2010-10-21 | Takahiro Matsumoto | Condensed pyridine derivative and use thereof |
US8822727B2 (en) * | 2008-03-04 | 2014-09-02 | Arena Pharmaceuticals, Inc. | Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine |
ES2522968T3 (es) | 2008-06-04 | 2014-11-19 | Synergy Pharmaceuticals Inc. | Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
CA2727684C (fr) | 2008-06-12 | 2017-01-31 | Janssen Pharmaceutica Nv | Modulateurs de diamino-pyridine, pyrimidine et pyridazine du recepteur de l'histamine h<sb>4</sb> |
WO2009154739A2 (fr) * | 2008-06-17 | 2009-12-23 | Duke University | Modulateurs du récepteur smoothened |
ES2624828T3 (es) | 2008-07-16 | 2017-07-17 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros |
WO2010047982A1 (fr) | 2008-10-22 | 2010-04-29 | Merck Sharp & Dohme Corp. | Nouveaux dérivés de benzimidazole cycliques utiles comme agents anti-diabétiques |
CA2741672A1 (fr) | 2008-10-31 | 2010-05-06 | Merck Sharp & Dohme Corp. | Nouveaux agents antidiabetiques utiles avec des derives de benzimidazole cycliques |
WO2010056717A1 (fr) | 2008-11-17 | 2010-05-20 | Merck Sharp & Dohme Corp. | Amines bicycliques substituées pour le traitement du diabète |
US8952197B2 (en) | 2009-06-18 | 2015-02-10 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 5-HT2C receptor agonists |
AR077223A1 (es) * | 2009-06-26 | 2011-08-10 | Sanofi Aventis | Sales de fumarato de un antagonista del receptor de histamina h3 |
WO2011011506A1 (fr) | 2009-07-23 | 2011-01-27 | Schering Corporation | Composés oxazépine spirocyclique en tant qu'inhibiteurs de la stéaroyl-coenzyme a delta-9 désaturase |
CA2768577A1 (fr) | 2009-07-23 | 2011-01-27 | Schering Corporation | Composes d?oxazepine benzofusionnes en tant qu?inhibiteurs de la coenzyme-stearoyle a delta-9 desaturase |
EP2510949A4 (fr) | 2009-12-11 | 2013-11-13 | Astellas Pharma Inc | Agent thérapeutique pour la fibromyalgie |
WO2011106273A1 (fr) | 2010-02-25 | 2011-09-01 | Merck Sharp & Dohme Corp. | Nouveaux dérivés benzimidazole cycliques utiles comme agents antidiabétiques |
EP2563764B1 (fr) | 2010-04-26 | 2015-02-25 | Merck Sharp & Dohme Corp. | Nouveaux inhibiteurs de spiropipéridine prolylcarboxypeptidase |
WO2011143057A1 (fr) | 2010-05-11 | 2011-11-17 | Merck Sharp & Dohme Corp. | Inhibiteurs inédits de la prolylcarboxypeptidase |
KR20130112848A (ko) | 2010-06-02 | 2013-10-14 | 아레나 파마슈티칼스, 인크. | 5-ht2c 수용체 아고니스트의 제조 방법 |
US9006268B2 (en) | 2010-06-11 | 2015-04-14 | Merck Sharp & Dohme Corp. | Prolylcarboxypeptidase inhibitors |
EP3613504A1 (fr) * | 2010-06-23 | 2020-02-26 | Johnson Matthey Public Limited Company | Complexes pi-allyl palladium et pi-allyl nickel et utilisation comme catalyseurs dans les reactions de couplage carbone-carbone et carbone-azote |
CA2808904A1 (fr) | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | Sels non hygroscopiques d'agonistes de 5-ht2c |
EP2611449A1 (fr) | 2010-09-01 | 2013-07-10 | Arena Pharmaceuticals, Inc. | Administration de lorcasérine à des individus présentant une insuffisance rénale |
SG188364A1 (en) | 2010-09-01 | 2013-04-30 | Arena Pharm Inc | Salts of lorcaserin with optically active acids |
EP3485878A1 (fr) | 2010-09-01 | 2019-05-22 | Arena Pharmaceuticals, Inc. | Formes posologiques à libération modifiée d'agonistes de 5-ht2c utiles pour la gestion du poids |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
AU2011305525B2 (en) | 2010-09-22 | 2016-08-18 | Arena Pharmaceuticals, Inc. | Modulators of the GPR119 receptor and the treatment of disorders related thereto |
EA025380B1 (ru) | 2011-02-25 | 2016-12-30 | Мерк Шарп Энд Домэ Корп. | Новые циклические производные азабензимидазола, используемые в качестве антидиабетических агентов |
KR101671341B1 (ko) * | 2011-02-25 | 2016-11-01 | 주식회사유한양행 | 다이아미노피리미딘 유도체 및 그의 제조방법 |
BR112014028006A2 (pt) * | 2012-05-30 | 2017-06-27 | Hoffmann La Roche | heterociclos de pirrolidino |
KR20150036245A (ko) | 2012-08-02 | 2015-04-07 | 머크 샤프 앤드 돔 코포레이션 | 항당뇨병 트리시클릭 화합물 |
RU2674670C1 (ru) | 2012-10-09 | 2018-12-12 | Арена Фармасьютикалз, Инк. | Способ коррекции массы тела |
CN109568319A (zh) | 2013-01-10 | 2019-04-05 | 普尔莫凯恩股份有限公司 | 非选择性激酶抑制剂 |
RU2015140066A (ru) | 2013-02-22 | 2017-03-30 | Мерк Шарп И Доум Корп. | Противодиабетические бициклические соединения |
WO2014139388A1 (fr) | 2013-03-14 | 2014-09-18 | Merck Sharp & Dohme Corp. | Nouveaux dérivés d'indole utiles en tant qu'agents antidiabétiques |
EP2970384A1 (fr) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonistes de la guanylate cyclase et leurs utilisations |
US9486494B2 (en) | 2013-03-15 | 2016-11-08 | Synergy Pharmaceuticals, Inc. | Compositions useful for the treatment of gastrointestinal disorders |
JP6606491B2 (ja) | 2013-06-05 | 2019-11-13 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼcの超高純度アゴニスト、その作成および使用方法 |
WO2015051496A1 (fr) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Composés tricycliques antidiabétiques |
US9925184B2 (en) | 2013-10-11 | 2018-03-27 | Pulmokine, Inc. | Spray-dry formulations |
WO2015066344A1 (fr) | 2013-11-01 | 2015-05-07 | Arena Pharmaceuticals, Inc. | Agonistes du récepteur 5-ht2c et compositions et procédés d'utilisation |
CN116850181A (zh) | 2015-01-06 | 2023-10-10 | 艾尼纳制药公司 | 治疗与s1p1受体有关的病症的方法 |
ES2929526T3 (es) | 2015-06-22 | 2022-11-29 | Arena Pharm Inc | Sal cristalina de L-arginina del ácido (R)-2-(7-(4-ciclopentil-3-(trifluorometil)benciloxi)-1,2,3,4-tetrahidrociclo-penta[b]indol-3-il)acético para su uso en trastornos asociados al receptor S1P1 |
US10231966B2 (en) | 2016-10-27 | 2019-03-19 | Pulmokine, Inc. | Combination therapy for treating pulmonary hypertension |
US11072602B2 (en) | 2016-12-06 | 2021-07-27 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
US10968232B2 (en) | 2016-12-20 | 2021-04-06 | Merck Sharp & Dohme Corp. | Antidiabetic spirochroman compounds |
MA47504A (fr) | 2017-02-16 | 2019-12-25 | Arena Pharm Inc | Composés et méthodes de traitement de l'angiocholite biliaire primitive |
US20210052600A1 (en) | 2017-12-27 | 2021-02-25 | Takeda Pharmaceutical Company Limited | Therapeutic agents for stress urinary incontinence and incotinence of feces |
KR20210141968A (ko) * | 2019-03-07 | 2021-11-23 | 아보멘티스 엘엘씨 | 비-환각/정신병유사 투여량 및 제형으로 투여되는 신경 가소성 작용을 갖는 물질을 포함하는 조성물 및 사용 방법 |
CN111704582B (zh) * | 2020-06-23 | 2021-06-11 | 杭州煌森生物科技有限公司 | 一种法匹拉韦及其衍生物的制备方法 |
CN115618396B (zh) * | 2022-11-28 | 2023-04-07 | 云账户技术(天津)有限公司 | 一种数据的加密方法及装置 |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL127996C (fr) * | 1963-11-19 | |||
US3980781A (en) * | 1966-03-31 | 1976-09-14 | Imperial Chemical Industries Limited | Fungicidal composition and method containing 2-amino-pyrimidines |
GB1165283A (en) * | 1967-01-17 | 1969-09-24 | Science Union & Cie | New Purine Derivatives and processes for prepararing them |
FR2281117A2 (fr) | 1974-08-09 | 1976-03-05 | Ugine Kuhlmann | Nouvelles piperazino-pyrimidines utilisables comme medicaments |
US4166852A (en) * | 1974-08-09 | 1979-09-04 | Produits Chimiques Ugine Kuhlmann | Piperazino-pyrimidines and their use as spasmolytic agents |
DK143899C (da) * | 1975-04-21 | 1982-04-13 | Merck & Co Inc | Analogifremgangsmaade til fremstilling af piperazinylpyrazinderivater |
US4081542A (en) * | 1975-04-21 | 1978-03-28 | Merck & Co., Inc. | Piperazinylpyrazines |
FR2311776A1 (fr) * | 1975-05-23 | 1976-12-17 | Sogeras | Diamino-2,4 bromo-5 chloro-6 pyrimidines et procede pour leur preparation |
FI70411C (fi) * | 1980-12-29 | 1986-09-19 | Pfizer | Foerfarande foer framstaellning av nya antihypertensiva 4-amino-6,7-dimetoxi-2-piperazinokinazolin derivat |
HU206337B (en) * | 1988-12-29 | 1992-10-28 | Mitsui Petrochemical Ind | Process for producing pyrimidine derivatives and pharmaceutical compositions |
DE3905364A1 (de) * | 1989-02-22 | 1990-08-23 | Hoechst Ag | Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als tool |
GB9012592D0 (en) | 1990-06-06 | 1990-07-25 | Smithkline Beecham Intercredit | Compounds |
JPH0665203A (ja) * | 1992-06-25 | 1994-03-08 | Elf Sanofi | ピペラジンのヘテロ環誘導体 |
WO1994007867A1 (fr) * | 1992-09-28 | 1994-04-14 | Pfizer Inc. | Pyrimidines substituees pour le controle des complications diabetiques |
RU2153494C2 (ru) * | 1993-10-12 | 2000-07-27 | Дзе Дюпон Мерк Фармасьютикал Компани | 1-n-алкил-n-арилпиримидинамины, способ лечения заболеваний, фармацевтическая композиция |
BR9407799A (pt) * | 1993-10-12 | 1997-05-06 | Du Pont Merck Pharma | Composição de matéria método de tratamento e composição farmaceutica |
US5419301A (en) * | 1994-04-14 | 1995-05-30 | Ford Motor Company | Adaptive control of camless valvetrain |
EP0826674A4 (fr) | 1995-04-03 | 1998-07-08 | Sumitomo Pharma | Nouveaux derives de pyrimidine efficaces en tant que medicament psychotrope et leur procede de fabrication |
US5795905A (en) | 1995-06-06 | 1998-08-18 | Neurocrine Biosciences, Inc. | CRF receptor antagonists and methods relating thereto |
DE69711965T2 (de) * | 1996-02-29 | 2003-01-23 | Pfizer | Verwendung von Sorbitol-Dehydrogenase-Inhibitoren zum Reduzieren von Ischämie-assozierten Gewebeschäden |
US6326368B1 (en) * | 1996-03-27 | 2001-12-04 | Dupont Pharmaceuticals Company | Aryloxy- and arylthiosubstituted pyrimidines and triazines and derivatives thereof |
TW440563B (en) * | 1996-05-23 | 2001-06-16 | Hoffmann La Roche | Aryl pyrimidine derivatives and a pharmaceutical composition thereof |
KR100239800B1 (ko) * | 1996-11-28 | 2000-03-02 | 손경식 | 4,5-디아미노 피리미딘 유도체 및 이의 제조방법 |
DE19710435A1 (de) * | 1997-03-13 | 1998-09-17 | Hoechst Ag | Verwendung von Pyrimidinderivaten zur Prävention von Krebs allein oder in Kombination mit anderen therapeutischen Maßnahmen |
US6440965B1 (en) * | 1997-10-15 | 2002-08-27 | Krenitsky Pharmaceuticals, Inc. | Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system |
WO2000028993A1 (fr) | 1998-11-19 | 2000-05-25 | Nortran Pharmaceuticals, Inc. | Ligands de serotonine en tant que composes favorisant l'erection |
GB9902047D0 (en) | 1999-01-29 | 1999-03-17 | Cerebrus Ltd | Chemical compounds XI |
DE60024986T2 (de) | 1999-05-21 | 2006-07-27 | Biovitrum Ab | Pyrazinyl-piperazin-verbindungen, ihre anwendung und herstellung |
SE0002754D0 (sv) | 2000-07-21 | 2000-07-21 | Pharmacia & Upjohn Ab | New pharmaceutical combination formulation and method of treatment with the combination |
PL360982A1 (en) | 2000-11-20 | 2004-09-20 | Biovitrum Ab | Piperazinylpyrazines compounds as antagonists of serotonin 5-ht2 receptor |
NZ525700A (en) * | 2000-11-20 | 2004-12-24 | Biovitrum Ab | Piperazinylpyrazine compounds as agonist or antagonist of serotonin 5HT-2 receptor |
SE0004245D0 (sv) * | 2000-11-20 | 2000-11-20 | Pharmacia Ab | Novel compounds and their use |
-
2002
- 2002-05-28 US US10/156,884 patent/US6825198B2/en not_active Expired - Fee Related
- 2002-06-05 DO DO2002000412A patent/DOP2002000412A/es unknown
- 2002-06-05 US US10/163,881 patent/US6894050B2/en not_active Expired - Fee Related
- 2002-06-14 GT GT200200120A patent/GT200200120A/es unknown
- 2002-06-17 EP EP02735869A patent/EP1401820A1/fr not_active Withdrawn
- 2002-06-17 KR KR10-2003-7016704A patent/KR20040010767A/ko not_active Application Discontinuation
- 2002-06-17 OA OA1200300319A patent/OA12621A/en unknown
- 2002-06-17 MX MXPA03011941A patent/MXPA03011941A/es unknown
- 2002-06-17 IL IL15880702A patent/IL158807A0/xx unknown
- 2002-06-17 TN TNPCT/IB2002/002261A patent/TNSN03143A1/fr unknown
- 2002-06-17 YU YU95303A patent/YU95303A/sh unknown
- 2002-06-17 GE GE5389A patent/GEP20053655B/en unknown
- 2002-06-17 OA OA1200300330A patent/OA12629A/en unknown
- 2002-06-17 EP EP02735853A patent/EP1401819A1/fr not_active Withdrawn
- 2002-06-17 HU HU0400249A patent/HUP0400249A3/hu unknown
- 2002-06-17 WO PCT/IB2002/002293 patent/WO2003000666A1/fr not_active Application Discontinuation
- 2002-06-17 EA EA200301213A patent/EA200301213A1/ru unknown
- 2002-06-17 PL PL02367777A patent/PL367777A1/xx not_active Application Discontinuation
- 2002-06-17 KR KR1020037016699A patent/KR100566854B1/ko not_active IP Right Cessation
- 2002-06-17 CN CNA028125541A patent/CN1745074A/zh active Pending
- 2002-06-17 UA UA20031211976A patent/UA74443C2/uk unknown
- 2002-06-17 CZ CZ20033508A patent/CZ20033508A3/cs unknown
- 2002-06-17 AU AU2002309173A patent/AU2002309173B2/en not_active Ceased
- 2002-06-17 CZ CZ20033431A patent/CZ20033431A3/cs unknown
- 2002-06-17 EE EEP200400025A patent/EE200400025A/xx unknown
- 2002-06-17 WO PCT/IB2002/002261 patent/WO2003000663A1/fr active IP Right Grant
- 2002-06-17 SK SK1567-2003A patent/SK15672003A3/sk unknown
- 2002-06-17 NZ NZ529542A patent/NZ529542A/en unknown
- 2002-06-17 MX MXPA03011940A patent/MXPA03011940A/es active IP Right Grant
- 2002-06-17 TN TNPCT/IB2002/002293A patent/TNSN03142A1/fr unknown
- 2002-06-17 IL IL15880802A patent/IL158808A0/xx unknown
- 2002-06-17 CA CA002450491A patent/CA2450491A1/fr not_active Abandoned
- 2002-06-17 JP JP2003507068A patent/JP2004534823A/ja not_active Withdrawn
- 2002-06-17 SK SK1571-2003A patent/SK15712003A3/sk not_active Application Discontinuation
- 2002-06-17 BR BR0210471-7A patent/BR0210471A/pt not_active IP Right Cessation
- 2002-06-17 HU HU0400251A patent/HUP0400251A3/hu unknown
- 2002-06-17 EA EA200301215A patent/EA007183B1/ru not_active IP Right Cessation
- 2002-06-17 BR BR0210503-9A patent/BR0210503A/pt not_active IP Right Cessation
- 2002-06-17 JP JP2003507071A patent/JP2005501821A/ja not_active Abandoned
- 2002-06-17 CN CNA028137345A patent/CN1630645A/zh active Pending
- 2002-06-17 CA CA002455292A patent/CA2455292A1/fr not_active Abandoned
- 2002-06-17 EE EEP200400026A patent/EE200400026A/xx unknown
- 2002-06-17 PL PL02367746A patent/PL367746A1/xx not_active Application Discontinuation
- 2002-06-19 PE PE2002000529A patent/PE20030268A1/es not_active Application Discontinuation
- 2002-06-19 AR ARP020102299A patent/AR036095A1/es unknown
- 2002-06-20 UY UY27343A patent/UY27343A1/es not_active Application Discontinuation
- 2002-06-20 SV SV2002001102A patent/SV2003001102A/es not_active Application Discontinuation
- 2002-06-20 AP APAP/P/2002/002561A patent/AP2002002561A0/en unknown
- 2002-06-21 PA PA20028548901A patent/PA8548901A1/es unknown
-
2003
- 2003-11-13 ZA ZA200308843A patent/ZA200308843B/en unknown
- 2003-11-13 ZA ZA200308842A patent/ZA200308842B/en unknown
- 2003-11-17 IS IS7040A patent/IS7040A/is unknown
- 2003-11-17 IS IS7041A patent/IS7041A/is unknown
- 2003-11-25 CR CR7168A patent/CR7168A/es not_active Application Discontinuation
- 2003-12-08 EC EC2003004881A patent/ECSP034881A/es unknown
- 2003-12-09 EC EC2003004884A patent/ECSP034884A/es unknown
- 2003-12-10 MA MA27431A patent/MA27035A1/fr unknown
- 2003-12-10 MA MA27432A patent/MA27036A1/fr unknown
- 2003-12-16 HR HR20031042A patent/HRP20031042A2/hr not_active Application Discontinuation
- 2003-12-19 NO NO20035698A patent/NO20035698L/no not_active Application Discontinuation
- 2003-12-19 NO NO20035697A patent/NO20035697D0/no not_active Application Discontinuation
- 2003-12-22 BG BG108491A patent/BG108491A/xx unknown
- 2003-12-22 BG BG108495A patent/BG108495A/xx unknown
-
2004
- 2004-08-19 US US10/922,058 patent/US20050090503A1/en not_active Abandoned
- 2004-08-19 US US10/922,198 patent/US20050020604A1/en not_active Abandoned
- 2004-09-16 US US10/942,345 patent/US6995159B2/en not_active Expired - Fee Related
- 2004-09-16 US US10/942,346 patent/US20050054656A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TNSN03143A1 (fr) | Ligands de recepteurs de 5-ht et leurs utilisations . | |
TNSN05121A1 (fr) | Purines et leurs utilisations comme ligands des recepteurs de cannabinoides | |
TNSN05190A1 (fr) | DERIVES DE PYRAZOLO [1,5-a][1,3,5] TRIAZINE SERVANT DE LIGANDS DES RECEPTEURS DE CANNABINOIDES | |
MA28681B1 (fr) | 3-aminocyclopentanecarboxamides utiles comme modulateurs de récepteurs de chimiokines | |
MA28680B1 (fr) | 3-aminocyclopentanecarboxamides utiles comme modulateurs de récepteurs de chimiokines | |
TNSN07367A1 (fr) | Derives de cyclopentapyridine et tetrahydroquinoleine | |
MA27767A1 (fr) | Ligands des recepteurs de cannabinoides et leurs utilisations | |
MA30077B1 (fr) | 3-aminocyclopentanecarboxamides servant de modulateurs de recepteurs de chimiokines | |
CA2515596A1 (fr) | Ligands du recepteur cannabinoide et leurs utilisations | |
MA27853A1 (fr) | LIGANDS DES RECEPTEURS DE CANNABINOiDES ET LEURS UTILISATIONS | |
MA33155B1 (fr) | Composes organiques et leurs utilisations | |
MA29692B1 (fr) | Derives de la xanthine en tant qu'agonistes selectifs du hm74a | |
TNSN01019A1 (fr) | Pyrimidinecarboxamides utiles comme inhibiteurs d'iso-ezymes pde4, et compositions les contenant | |
MA31767B1 (fr) | Composes organiques et leurs utilisations | |
TR200102021T2 (tr) | TWEAK ve TWEAK reseptörü antagonistleri ve bunların imünolojik bozuklukların iyileştirilmesi için kullanımları | |
HRP20040684A2 (en) | 2,4-pyrimidinediamine compounds and their uses | |
MA27766A1 (fr) | Ligands de recepteurs de cannabinoides et leurs utilisations | |
TNSN02011A1 (fr) | Derives de pyrimidine bicycliques nouveaux, inhibiteurs de mmp, et compositions les contenant | |
TNSN01012A1 (fr) | Derives amines de dihydro-1, 3,5-triazine et leurs applications en therapeutique | |
ATE262277T1 (de) | Wasser-dispergierbare agrochemische zusammensetzungen | |
MA30485B1 (fr) | Aminothiazoles et leurs utilisations | |
ATE439363T1 (de) | Imidazo 2,1-b -1,3,4-thiadiazole sulfonamides | |
TR200103638T2 (tr) | IL-8 Reseptör antagonistleri | |
BR0108867A (pt) | Antagonistas de receptor il-8 | |
TR199900730T2 (xx) | S�v� alendronat form�lasyonlar� |