SU882409A3 - Способ получени галоидзамещенных меркаптоациламинокислот - Google Patents

Способ получени галоидзамещенных меркаптоациламинокислот Download PDF

Info

Publication number
SU882409A3
SU882409A3 SU802878653A SU2878653A SU882409A3 SU 882409 A3 SU882409 A3 SU 882409A3 SU 802878653 A SU802878653 A SU 802878653A SU 2878653 A SU2878653 A SU 2878653A SU 882409 A3 SU882409 A3 SU 882409A3
Authority
SU
USSR - Soviet Union
Prior art keywords
halogen
hydrogen
proline
ethyl acetate
substituted
Prior art date
Application number
SU802878653A
Other languages
English (en)
Russian (ru)
Inventor
Анджел Ондетти Мигуел
Витни Спрейг Питер
Original Assignee
Е.Р. Сквибб Энд Санз, Инк (Фирма)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/939,147 external-priority patent/US4154935A/en
Application filed by Е.Р. Сквибб Энд Санз, Инк (Фирма) filed Critical Е.Р. Сквибб Энд Санз, Инк (Фирма)
Application granted granted Critical
Publication of SU882409A3 publication Critical patent/SU882409A3/ru

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00Thiocarboxylic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
SU802878653A 1978-02-21 1980-02-04 Способ получени галоидзамещенных меркаптоациламинокислот SU882409A3 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87903278A 1978-02-21 1978-02-21
US93914878A 1978-09-01 1978-09-01
US05/939,147 US4154935A (en) 1978-02-21 1978-09-01 Halogen substituted mercaptoacylamino acids

Publications (1)

Publication Number Publication Date
SU882409A3 true SU882409A3 (ru) 1981-11-15

Family

ID=27420501

Family Applications (1)

Application Number Title Priority Date Filing Date
SU802878653A SU882409A3 (ru) 1978-02-21 1980-02-04 Способ получени галоидзамещенных меркаптоациламинокислот

Country Status (26)

Country Link
JP (1) JPS54125656A (ja)
AR (2) AR229152A1 (ja)
CA (1) CA1124723A (ja)
CH (1) CH639370A5 (ja)
CS (1) CS230562B2 (ja)
DD (1) DD141827A5 (ja)
DE (1) DE2906768A1 (ja)
DK (1) DK73379A (ja)
ES (3) ES477878A1 (ja)
FI (1) FI790593A (ja)
FR (1) FR2417499A1 (ja)
GB (1) GB2014987B (ja)
GR (1) GR82336B (ja)
HK (1) HK41383A (ja)
IE (1) IE47971B1 (ja)
IL (1) IL56662A0 (ja)
LU (1) LU80946A1 (ja)
NL (1) NL7901319A (ja)
NO (1) NO790568L (ja)
NZ (1) NZ189626A (ja)
PH (1) PH15381A (ja)
PL (1) PL118158B1 (ja)
PT (1) PT69254A (ja)
RO (1) RO77228A (ja)
SE (1) SE431643B (ja)
SU (1) SU882409A3 (ja)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1144930A (en) * 1978-08-11 1983-04-19 Miguel A. Ondetti Mercaptoacyl derivatives of substituted prolines
NL7809120A (nl) * 1978-09-07 1980-03-11 Oce Andeno B V Grubbenvorsterw Werkwijze voor de bereiding van proline-derivaten.
US4483861A (en) * 1978-10-31 1984-11-20 Santen Pharmaceutical Co., Ltd. Antihypertensive sulfur-containing compounds
CA1132985A (en) * 1978-12-22 1982-10-05 John Krapcho Ketal and thioketal derivatives of mercaptoacyl prolines
ZA802420B (en) * 1979-05-18 1981-04-29 Squibb & Sons Inc Aminoacyl derivatives of mercaptoacyl amino acids
US4288368A (en) * 1979-07-30 1981-09-08 E. R. Squibb & Sons, Inc. Dithioacylproline derivatives
AU542211B2 (en) * 1980-03-07 1985-02-14 Gruppo Lepetit S.P.A. Mercaptocycloalkyl carbonyl prolines
JP2005213165A (ja) * 2004-01-28 2005-08-11 Mitsui Chemicals Inc フルオロプロリン類の製造方法
JP2011121872A (ja) * 2009-12-08 2011-06-23 Central Glass Co Ltd 光学活性N−tert−ブトキシカルボニル−トランス−4−フルオロプロリンの精製方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU509899B2 (en) * 1976-02-13 1980-05-29 E.R. Squibb & Sons, Inc. Proline derivatives and related compounds

Also Published As

Publication number Publication date
AR229152A1 (es) 1983-06-30
PL213593A1 (ja) 1980-02-25
CS230562B2 (en) 1984-08-13
PT69254A (en) 1979-03-01
DK73379A (da) 1979-08-22
AR228036A1 (es) 1983-01-14
NL7901319A (nl) 1979-08-23
NO790568L (no) 1979-08-22
IL56662A0 (en) 1979-05-31
IE790297L (en) 1979-08-21
PL118158B1 (en) 1981-09-30
FR2417499A1 (fr) 1979-09-14
JPS54125656A (en) 1979-09-29
FI790593A (fi) 1979-08-22
JPH0134986B2 (ja) 1989-07-21
NZ189626A (en) 1982-03-09
ES479833A1 (es) 1979-11-16
ES477878A1 (es) 1980-03-01
HK41383A (en) 1983-10-21
IE47971B1 (en) 1984-08-08
CH639370A5 (fr) 1983-11-15
DE2906768A1 (de) 1979-08-23
GB2014987A (en) 1979-09-05
LU80946A1 (fr) 1979-06-18
ES479832A1 (es) 1979-11-16
SE431643B (sv) 1984-02-20
SE7901510L (sv) 1979-08-22
PH15381A (en) 1982-12-17
CA1124723A (en) 1982-06-01
DD141827A5 (de) 1980-05-21
RO77228A (ro) 1981-08-17
GR82336B (ja) 1984-12-13
GB2014987B (en) 1982-11-03
FR2417499B1 (ja) 1982-06-04

Similar Documents

Publication Publication Date Title
US4154935A (en) Halogen substituted mercaptoacylamino acids
CA1124725A (en) Alkanoyl-thio-acyl derivatives of dehydrocyclicimino acids
SU850001A3 (ru) Способ получени производных пролина
Kataoka et al. Studies of unusual amino acids and their peptides. VI. The synthese and the optical resolutions of. BETA.-methylphenylalanine and its dipeptide present in bottromycin.
JPH0655757B2 (ja) N−アルキル化ジペプチドおよびそれらのエステルの製造法
EP0053021B1 (en) Process for 5-aroylation of 1,2-dihydro-3h-pyrrolo(1,2-a)pyrrole-1-carboxylic esters and nitriles
SU882409A3 (ru) Способ получени галоидзамещенных меркаптоациламинокислот
US4297282A (en) Resolution of mercaptopropionic acids
SU837319A3 (ru) Способ получени оптических изомеров -(2-бЕНзгидРилэТил)- -(1-фЕНилэТил)-АМиНА или иХ СОлЕй
US4977264A (en) Process for the production of 4,5-dichloro-6-ethylpyrimidine
IE63654B1 (en) Process for the preparation of quinolonecarboxylic acids
IL95949A (en) Process for the preparation of L-) - 3 pyroglutamil (- L-thiolidine-4-carboxylic acid and its history
DK152208B (da) Analogifremgangsmaade til fremstilling af 2-phenylamino-phenyleddikesyreamider eller farmaceutisk acceptable salte deraf
US4048168A (en) Process for preparing 1-polyhaloalkyl-3,4-dihydro-2-(1H)-quinazolinones
US3299095A (en) 1-benzyl tetramic acid derivatives
JPH0737440B2 (ja) スルホニウム化合物の製造方法
US4292431A (en) Process for the production of hydroxymethylimidazoles
US5252747A (en) Chiral quinolone intermediates
US4411836A (en) Racemization of an α-methyl-β-acylthiopropionic acid
US3598856A (en) T-alkyl pentachlorophenyl carbonate
GB2036723A (en) Mercaptoacylpiperazine carboxylic acid compounds
EP0705240B1 (en) Novel processes for preparing (s)-4-amino-hepta-5,6-dienoic acid and intermediates thereof
US4889929A (en) Preparation of 1'-ethoxycarbonyl-oxyethyl esters of penicillins
US3308132A (en) 6, 8-dithiooctanoyl amides and intermediates
CA1055951A (en) Process for preparing 1-ethyl-2-/2'-methoxy-5'-sulphonamidobenzoyl/-aminomethylpyrrolidine and its salts