JPS54125656A - Halogen substituted mercaptoacylamino acids and their manufacture - Google Patents

Halogen substituted mercaptoacylamino acids and their manufacture

Info

Publication number
JPS54125656A
JPS54125656A JP2019979A JP2019979A JPS54125656A JP S54125656 A JPS54125656 A JP S54125656A JP 2019979 A JP2019979 A JP 2019979A JP 2019979 A JP2019979 A JP 2019979A JP S54125656 A JPS54125656 A JP S54125656A
Authority
JP
Japan
Prior art keywords
manufacture
halogen substituted
mercaptoacylamino acids
mercaptoacylamino
acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019979A
Other languages
English (en)
Other versions
JPH0134986B2 (ja
Inventor
Enjieru Ondetsutei Migeeru
Daburiyu Supureigu Piitaa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/939,147 external-priority patent/US4154935A/en
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of JPS54125656A publication Critical patent/JPS54125656A/ja
Publication of JPH0134986B2 publication Critical patent/JPH0134986B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
JP2019979A 1978-02-21 1979-02-21 Halogen substituted mercaptoacylamino acids and their manufacture Granted JPS54125656A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87903278A 1978-02-21 1978-02-21
US93914878A 1978-09-01 1978-09-01
US05/939,147 US4154935A (en) 1978-02-21 1978-09-01 Halogen substituted mercaptoacylamino acids

Publications (2)

Publication Number Publication Date
JPS54125656A true JPS54125656A (en) 1979-09-29
JPH0134986B2 JPH0134986B2 (ja) 1989-07-21

Family

ID=27420501

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019979A Granted JPS54125656A (en) 1978-02-21 1979-02-21 Halogen substituted mercaptoacylamino acids and their manufacture

Country Status (26)

Country Link
JP (1) JPS54125656A (ja)
AR (2) AR229152A1 (ja)
CA (1) CA1124723A (ja)
CH (1) CH639370A5 (ja)
CS (1) CS230562B2 (ja)
DD (1) DD141827A5 (ja)
DE (1) DE2906768A1 (ja)
DK (1) DK73379A (ja)
ES (3) ES477878A1 (ja)
FI (1) FI790593A (ja)
FR (1) FR2417499A1 (ja)
GB (1) GB2014987B (ja)
GR (1) GR82336B (ja)
HK (1) HK41383A (ja)
IE (1) IE47971B1 (ja)
IL (1) IL56662A0 (ja)
LU (1) LU80946A1 (ja)
NL (1) NL7901319A (ja)
NO (1) NO790568L (ja)
NZ (1) NZ189626A (ja)
PH (1) PH15381A (ja)
PL (1) PL118158B1 (ja)
PT (1) PT69254A (ja)
RO (1) RO77228A (ja)
SE (1) SE431643B (ja)
SU (1) SU882409A3 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005213165A (ja) * 2004-01-28 2005-08-11 Mitsui Chemicals Inc フルオロプロリン類の製造方法
JP2011121872A (ja) * 2009-12-08 2011-06-23 Central Glass Co Ltd 光学活性Ｎ−ｔｅｒｔ−ブトキシカルボニル−トランス−４−フルオロプロリンの精製方法

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1144930A (en) * 1978-08-11 1983-04-19 Miguel A. Ondetti Mercaptoacyl derivatives of substituted prolines
NL7809120A (nl) * 1978-09-07 1980-03-11 Oce Andeno B V Grubbenvorsterw Werkwijze voor de bereiding van proline-derivaten.
US4483861A (en) * 1978-10-31 1984-11-20 Santen Pharmaceutical Co., Ltd. Antihypertensive sulfur-containing compounds
CA1132985A (en) * 1978-12-22 1982-10-05 John Krapcho Ketal and thioketal derivatives of mercaptoacyl prolines
ZA802420B (en) * 1979-05-18 1981-04-29 Squibb & Sons Inc Aminoacyl derivatives of mercaptoacyl amino acids
US4288368A (en) * 1979-07-30 1981-09-08 E. R. Squibb & Sons, Inc. Dithioacylproline derivatives
AU542211B2 (en) * 1980-03-07 1985-02-14 Gruppo Lepetit S.P.A. Mercaptocycloalkyl carbonyl prolines

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU509899B2 (en) * 1976-02-13 1980-05-29 E.R. Squibb & Sons, Inc. Proline derivatives and related compounds

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005213165A (ja) * 2004-01-28 2005-08-11 Mitsui Chemicals Inc フルオロプロリン類の製造方法
JP2011121872A (ja) * 2009-12-08 2011-06-23 Central Glass Co Ltd 光学活性Ｎ−ｔｅｒｔ−ブトキシカルボニル−トランス−４−フルオロプロリンの精製方法

Also Published As

Publication number Publication date
PH15381A (en) 1982-12-17
RO77228A (ro) 1981-08-17
PT69254A (en) 1979-03-01
NO790568L (no) 1979-08-22
GB2014987A (en) 1979-09-05
PL118158B1 (en) 1981-09-30
NL7901319A (nl) 1979-08-23
AR228036A1 (es) 1983-01-14
PL213593A1 (ja) 1980-02-25
ES479833A1 (es) 1979-11-16
LU80946A1 (fr) 1979-06-18
ES479832A1 (es) 1979-11-16
DK73379A (da) 1979-08-22
SU882409A3 (ru) 1981-11-15
JPH0134986B2 (ja) 1989-07-21
AR229152A1 (es) 1983-06-30
CH639370A5 (fr) 1983-11-15
HK41383A (en) 1983-10-21
IE47971B1 (en) 1984-08-08
SE431643B (sv) 1984-02-20
GR82336B (ja) 1984-12-13
FI790593A (fi) 1979-08-22
ES477878A1 (es) 1980-03-01
IE790297L (en) 1979-08-21
DE2906768A1 (de) 1979-08-23
GB2014987B (en) 1982-11-03
FR2417499B1 (ja) 1982-06-04
FR2417499A1 (fr) 1979-09-14
IL56662A0 (en) 1979-05-31
CS230562B2 (en) 1984-08-13
NZ189626A (en) 1982-03-09
CA1124723A (en) 1982-06-01
SE7901510L (sv) 1979-08-22
DD141827A5 (de) 1980-05-21

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