SU856383A3 - Способ получени производных 1-(N-пиперидино)фталазина или их солей - Google Patents

Способ получени производных 1-(N-пиперидино)фталазина или их солей Download PDF

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Publication number
SU856383A3
SU856383A3 SU782624349A SU2624349A SU856383A3 SU 856383 A3 SU856383 A3 SU 856383A3 SU 782624349 A SU782624349 A SU 782624349A SU 2624349 A SU2624349 A SU 2624349A SU 856383 A3 SU856383 A3 SU 856383A3
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SU
USSR - Soviet Union
Prior art keywords
alkyl
general formula
hydrogen atom
compound
group
Prior art date
Application number
SU782624349A
Other languages
English (en)
Russian (ru)
Inventor
Фрейзер Кэмпбелл Саймон
Кристофер Данилевич Джон
Гарт Эванс Энтони
Лесли Хэм Аллан
Original Assignee
Пфаизер Корпорейшн (Фирма)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Пфаизер Корпорейшн (Фирма) filed Critical Пфаизер Корпорейшн (Фирма)
Application granted granted Critical
Publication of SU856383A3 publication Critical patent/SU856383A3/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SU782624349A 1977-06-03 1978-06-02 Способ получени производных 1-(N-пиперидино)фталазина или их солей SU856383A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2358277 1977-06-03

Publications (1)

Publication Number Publication Date
SU856383A3 true SU856383A3 (ru) 1981-08-15

Family

ID=10198020

Family Applications (2)

Application Number Title Priority Date Filing Date
SU782624349A SU856383A3 (ru) 1977-06-03 1978-06-02 Способ получени производных 1-(N-пиперидино)фталазина или их солей
SU792777649A SU862826A3 (ru) 1977-06-03 1979-06-18 Способ получени производных фталазина или их солей с фармацевтически приемлемыми кислотами

Family Applications After (1)

Application Number Title Priority Date Filing Date
SU792777649A SU862826A3 (ru) 1977-06-03 1979-06-18 Способ получени производных фталазина или их солей с фармацевтически приемлемыми кислотами

Country Status (29)

Country Link
US (1) US4289772A (enExample)
JP (1) JPS5416488A (enExample)
AR (2) AR222013A1 (enExample)
AT (2) AT362792B (enExample)
AU (1) AU505373B1 (enExample)
BE (1) BE867727A (enExample)
CA (1) CA1111850A (enExample)
DD (1) DD137355A5 (enExample)
DE (1) DE2824064A1 (enExample)
DK (1) DK248078A (enExample)
EG (1) EG13527A (enExample)
ES (4) ES470470A1 (enExample)
FI (1) FI781753A7 (enExample)
FR (1) FR2392986A1 (enExample)
GB (1) GB2000136B (enExample)
GR (1) GR74402B (enExample)
HU (1) HU179745B (enExample)
IL (1) IL54842A (enExample)
IN (3) IN148482B (enExample)
IT (1) IT1094944B (enExample)
LU (1) LU79761A1 (enExample)
NL (1) NL7806016A (enExample)
NO (1) NO781935L (enExample)
NZ (1) NZ187453A (enExample)
PL (3) PL116437B1 (enExample)
PT (1) PT68126A (enExample)
SE (1) SE7806519L (enExample)
SU (2) SU856383A3 (enExample)
ZA (1) ZA783183B (enExample)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4370328A (en) * 1977-11-03 1983-01-25 Pfizer Inc. Cardiac stimulant 1-(3- or 4-substituted piperidino)phthalazines
IL59619A0 (en) * 1979-03-28 1980-06-30 Pfizer Phthalazine derivatives,their preparation and pharmaceutical compositions containing them
ES499716A0 (es) * 1980-03-01 1982-05-01 Wyeth John & Brother Ltd Un procedimiento para la preparacion de nuevos derivados de piperidina
GB8320958D0 (en) * 1983-08-03 1983-09-07 Pfizer Ltd Quinazoline cardiac stimulants
US5001125A (en) * 1984-03-26 1991-03-19 Janssen Pharmaceutica N.V. Anti-virally active pyridazinamines
US4882354A (en) * 1987-12-16 1989-11-21 Norwich Eaton Pharmaceuticals, Inc. N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents
JP3169188B2 (ja) * 1991-01-31 2001-05-21 杏林製薬株式会社 カルバミン酸誘導体及びその製造方法
US5300515A (en) * 1991-01-31 1994-04-05 Kyorin Pharmaceutical Co., Ltd. Carbamic acid derivatives and method for preparing the same
EP0621267A1 (en) * 1993-04-07 1994-10-26 Shell Internationale Researchmaatschappij B.V. Spiropiperidine derivatives and their use as fungicides
AU5772196A (en) * 1995-05-19 1996-11-29 Chiroscience Limited 3,4-disubstituted-phenylsulphonamides and their therapeutic use
NZ333354A (en) * 1996-08-20 2000-05-26 Eisai Co Ltd Fused pyridazine compounds for erectile dysfunction
US20030186963A1 (en) 2001-09-14 2003-10-02 Dorwald Florencio Zaragoza Substituted piperidines
US20040224986A1 (en) * 2002-08-16 2004-11-11 Bart De Corte Piperidinyl targeting compounds that selectively bind integrins
DE60335118D1 (de) * 2002-08-16 2011-01-05 Janssen Pharmaceutica Nv Piperidinylverbindungen, die selektiv an integrine binden
US20060019975A1 (en) * 2004-07-23 2006-01-26 Pfizer Inc Novel piperidyl derivatives of quinazoline and isoquinoline
TW200630337A (en) 2004-10-14 2006-09-01 Euro Celtique Sa Piperidinyl compounds and the use thereof
EP1928437A2 (en) 2005-08-26 2008-06-11 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
EP2377530A3 (en) 2005-10-21 2012-06-20 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
JP2009513672A (ja) 2005-10-31 2009-04-02 ブレインセルス，インコーポレイティド 神経発生のｇａｂａ受容体媒介調節
BRPI0707223A2 (pt) * 2006-01-27 2011-04-26 Pfizer Prod Inc compostos de derivados de aminoftalazina
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US8247442B2 (en) 2006-03-29 2012-08-21 Purdue Pharma L.P. Benzenesulfonamide compounds and their use
TW200812963A (en) 2006-04-13 2008-03-16 Euro Celtique Sa Benzenesulfonamide compounds and the use thereof
US8791264B2 (en) 2006-04-13 2014-07-29 Purdue Pharma L.P. Benzenesulfonamide compounds and their use as blockers of calcium channels
MX2008014320A (es) 2006-05-09 2009-03-25 Braincells Inc Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
EP2021000A2 (en) 2006-05-09 2009-02-11 Braincells, Inc. Neurogenesis by modulating angiotensin
EP1903037A1 (de) * 2006-09-07 2008-03-26 Bayer Schering Pharma Aktiengesellschaft 1-(Het)aryl-3-[hetaryl-piperidin-4-yl]-thioharnstoffe als Modulatoren des EP2-Rezeptors
EP1900731A1 (de) * 2006-09-07 2008-03-19 Bayer Schering Pharma Aktiengesellschaft N-(1-Phthalazin-1-yl-piperidin-4-yl)-amide als EP2-Rezeptor Modulatoren
JP2010502722A (ja) 2006-09-08 2010-01-28 ブレインセルス，インコーポレイティド ４−アシルアミノピリジン誘導体を含む組み合わせ
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2008124118A1 (en) 2007-04-09 2008-10-16 Purdue Pharma L.P. Benzenesulfonyl compounds and the use therof
AU2008285718A1 (en) 2007-08-07 2009-02-12 F. Hoffmann-La Roche Ag Pyrrolidine aryl-ether as NK3 receptor antagonists
EP2190815B1 (en) 2007-08-22 2011-08-10 F. Hoffmann-La Roche AG Pyrrolidine aryl-ether as nk3 receptor antagonists
CA2699464A1 (en) * 2007-09-14 2009-03-19 F. Hoffmann-La Roche Ag Piperidine derivatives as nk3 receptor antagonists
US8765736B2 (en) 2007-09-28 2014-07-01 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
AR077014A1 (es) * 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use
EP4229828A4 (en) 2020-10-13 2024-08-28 Endeavor Biomedicines, Inc. METHODS OF TREATMENT OF FIBROSIS
CN113087654B (zh) * 2021-04-15 2022-12-23 苏州昊帆生物股份有限公司 哌啶-4-丁胺的制备方法
WO2025188802A1 (en) 2024-03-05 2025-09-12 Endeavor Biomedicines, Inc. Methods of improving lung function

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1094044A (en) * 1965-07-12 1967-12-06 Vantorex Ltd Phthalazine derivatives
GB1199768A (en) 1966-10-31 1970-07-22 Pfizer & Co C Nitrogen Heterocycles and process for their preparation
GB1293565A (en) * 1969-05-03 1972-10-18 Aspro Nicholas Ltd Aminophthalazines and pharmaceutical compositions thereof
GB1460389A (en) 1974-07-25 1977-01-06 Pfizer Ltd 4-substituted quinazoline cardiac stimulants

Also Published As

Publication number Publication date
IL54842A0 (en) 1978-08-31
IL54842A (en) 1982-01-31
AU505373B1 (en) 1979-11-15
PL113208B1 (en) 1980-11-29
ES470470A1 (es) 1979-09-01
PT68126A (en) 1978-07-01
LU79761A1 (fr) 1980-01-22
AT363096B (de) 1981-07-10
IN149550B (enExample) 1982-01-16
DE2824064A1 (de) 1978-12-14
ATA305080A (de) 1980-12-15
IN148482B (enExample) 1981-03-07
SU862826A3 (ru) 1981-09-07
SE7806519L (sv) 1978-12-04
GR74402B (enExample) 1984-06-28
IN149973B (enExample) 1982-06-19
JPS5538351B2 (enExample) 1980-10-03
CA1111850A (en) 1981-11-03
GB2000136A (en) 1979-01-04
PL207337A1 (pl) 1979-06-04
AT362792B (de) 1981-06-10
FI781753A7 (fi) 1978-12-04
AR223999A1 (es) 1981-10-15
US4289772A (en) 1981-09-15
NO781935L (no) 1978-12-05
FR2392986A1 (fr) 1978-12-29
PL116437B1 (en) 1981-06-30
JPS5416488A (en) 1979-02-07
IT1094944B (it) 1985-08-10
AR222013A1 (es) 1981-04-15
DK248078A (da) 1978-12-04
FR2392986B1 (enExample) 1982-07-16
ZA783183B (en) 1979-06-27
GB2000136B (en) 1982-01-06
BE867727A (fr) 1978-12-01
DD137355A5 (de) 1979-08-29
IT7824106A0 (it) 1978-06-01
ES478200A1 (es) 1980-01-01
PL116420B1 (en) 1981-06-30
ES478201A1 (es) 1980-02-01
ES478199A1 (es) 1980-01-16
ATA400878A (de) 1980-11-15
NZ187453A (en) 1980-12-19
NL7806016A (nl) 1978-12-05
HU179745B (en) 1982-12-28
EG13527A (en) 1981-12-31

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