SU679142A3 - Способ получени производных 2н-пиран-2,6(3н)-диона или их солей - Google Patents
Способ получени производных 2н-пиран-2,6(3н)-диона или их солейInfo
- Publication number
- SU679142A3 SU679142A3 SU762424502A SU2424502A SU679142A3 SU 679142 A3 SU679142 A3 SU 679142A3 SU 762424502 A SU762424502 A SU 762424502A SU 2424502 A SU2424502 A SU 2424502A SU 679142 A3 SU679142 A3 SU 679142A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- pyran
- salts
- producing
- dione derivatives
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Description
I
.Изобретение относнтс к способу получени овых соединений - производных 2Н-пиран-2, (ЗН)-диона формулы
О СН,
ОН
II он 1 //
он
. г
л
(iHj-d
110.
-.
их солеи.
Эти соединени обладают ценными биологически активными свойствами.
Способ основан на известной в органической химии реакции взаимодействи амина с ацетилпроизводным П.
Предлагаемый способ заключаетс в том, что 3,5-диацетил-4,6-диокси-2Н-пиран-2-он подвергают взаимодействию с нитроанилином формулы
ОН
11,1
КО 2
в среде инертного органического растворител
при TCNmepatype кипени реакцнонноу среды, и полученное нитропроизводное формуль
О
II он
II
ТЬ
,C-NH C.
Hi
0 о каталитически гидрируют с последушидам выделением целевого продукта в свободном виде или в виде соли.
Предпочтительно в качестве инептпого органического растворител используют метанол и в качестве катализатора гидрщювани предпочтительно используют палладий на угле.
Пример . К 1,3 г (0,0195 моль) 4-амино2-нитрофенола добавл ют в кип щий с обратным холодильником раствор 4,1 г (0,0195 моль) 3,5-дицетил-4;6-диокси-2Н-пнран-2-она в мета толе и смесь кип т т с обратным хололильииком около 2 ч. После фильтровани реакционной смеси получают 5-ацетил-4-окси-3- 1-(3-нигро-4- 1ксифениламино )эти:1иде1 1-2Н-пир1т-:.6(ЗН)-днон, т. пл. 236-237°С (с разложением). 4.1 г (О.ОП.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/637,428 US4025642A (en) | 1975-12-03 | 1975-12-03 | Substituted 2H-pyran-2, 6(3H)-dione derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU679142A3 true SU679142A3 (ru) | 1979-08-05 |
Family
ID=24555892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU762424502A SU679142A3 (ru) | 1975-12-03 | 1976-12-02 | Способ получени производных 2н-пиран-2,6(3н)-диона или их солей |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US4025642A (ru) |
| JP (2) | JPS5911594B2 (ru) |
| AT (1) | AT348522B (ru) |
| AU (1) | AU501748B2 (ru) |
| BE (1) | BE848352A (ru) |
| CA (1) | CA1070319A (ru) |
| CH (1) | CH624400A5 (ru) |
| DD (1) | DD127642A5 (ru) |
| DE (1) | DE2649855A1 (ru) |
| DK (1) | DK489776A (ru) |
| ES (1) | ES453883A1 (ru) |
| FI (1) | FI60864C (ru) |
| FR (1) | FR2333503A1 (ru) |
| GB (1) | GB1565813A (ru) |
| GR (1) | GR62008B (ru) |
| HU (1) | HU176158B (ru) |
| IE (1) | IE44268B1 (ru) |
| IL (1) | IL50786A (ru) |
| LU (1) | LU76301A1 (ru) |
| MX (1) | MX4457E (ru) |
| NL (1) | NL175995C (ru) |
| NO (1) | NO145059C (ru) |
| PH (1) | PH12397A (ru) |
| PT (1) | PT65811B (ru) |
| SE (1) | SE426489B (ru) |
| SU (1) | SU679142A3 (ru) |
| ZA (1) | ZA766279B (ru) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4165365A (en) * | 1977-04-29 | 1979-08-21 | Smithkline Corporation | Substituted 2H-pyran-2,6(3H)-dione derivatives |
| US4160021A (en) * | 1977-05-23 | 1979-07-03 | Smithkline Corporation | Substituted 2H-pyran-2,6(3H)-dione derivatives |
| DE4419622A1 (de) | 1994-06-03 | 1995-12-07 | Cassella Ag | Monoazofarbstoffe, ihre Herstellung und Verwendung |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3864493A (en) * | 1967-08-17 | 1975-02-04 | Fisons Ltd Felixstowe | Compositions and methods for the prevention of asthmatic symptoms |
| GB1223690A (en) * | 1967-10-17 | 1971-03-03 | Fisons Pharmaceuticals Ltd | Substituted chromon-2-carboxylic acids |
| US3885038A (en) * | 1971-08-23 | 1975-05-20 | Syntex Inc | Method of using substituted xanthone carboxylic acid |
| BE790802A (fr) * | 1971-11-04 | 1973-04-30 | Takeda Chemical Industries Ltd | Nouveaux derives de chromone et leur fabrication |
| US3849446A (en) * | 1972-01-17 | 1974-11-19 | Warner Lambert Co | Chromone-3-carboxylic acids |
| US3883653A (en) * | 1972-10-24 | 1975-05-13 | Pfizer | Method of preventing asthmatic symptoms |
| US3879544A (en) * | 1973-05-09 | 1975-04-22 | Carter Wallace | Method for suppressing histamine release |
-
1975
- 1975-12-03 US US05/637,428 patent/US4025642A/en not_active Expired - Lifetime
-
1976
- 1976-10-21 ZA ZA766279A patent/ZA766279B/xx unknown
- 1976-10-27 IL IL50786A patent/IL50786A/xx unknown
- 1976-10-29 DE DE19762649855 patent/DE2649855A1/de active Granted
- 1976-10-29 DK DK489776A patent/DK489776A/da not_active Application Discontinuation
- 1976-11-01 NO NO763717A patent/NO145059C/no unknown
- 1976-11-02 CA CA264,674A patent/CA1070319A/en not_active Expired
- 1976-11-04 SE SE7612288A patent/SE426489B/xx unknown
- 1976-11-04 JP JP51134001A patent/JPS5911594B2/ja not_active Expired
- 1976-11-05 DD DD195634A patent/DD127642A5/xx unknown
- 1976-11-09 PT PT65811A patent/PT65811B/pt unknown
- 1976-11-15 AT AT849676A patent/AT348522B/de not_active IP Right Cessation
- 1976-11-16 BE BE172366A patent/BE848352A/xx not_active IP Right Cessation
- 1976-11-17 NL NLAANVRAGE7612770,A patent/NL175995C/xx not_active IP Right Cessation
- 1976-11-19 FI FI763325A patent/FI60864C/fi not_active IP Right Cessation
- 1976-11-26 PH PH19170A patent/PH12397A/en unknown
- 1976-11-30 FR FR7636077A patent/FR2333503A1/fr active Granted
- 1976-11-30 HU HU76SI1554A patent/HU176158B/hu unknown
- 1976-12-01 GB GB50051/76A patent/GB1565813A/en not_active Expired
- 1976-12-01 LU LU76301A patent/LU76301A1/xx unknown
- 1976-12-01 IE IE2636/76A patent/IE44268B1/en unknown
- 1976-12-02 CH CH1522276A patent/CH624400A5/de not_active IP Right Cessation
- 1976-12-02 SU SU762424502A patent/SU679142A3/ru active
- 1976-12-02 ES ES453883A patent/ES453883A1/es not_active Expired
- 1976-12-03 GR GR52311A patent/GR62008B/el unknown
- 1976-12-03 MX MX765188U patent/MX4457E/es unknown
- 1976-12-03 AU AU20250/76A patent/AU501748B2/en not_active Expired
-
1981
- 1981-05-12 JP JP56072876A patent/JPS5943953B2/ja not_active Expired
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US3652671A (en) | Process for making a cationic methacrylamide | |
| SU679142A3 (ru) | Способ получени производных 2н-пиран-2,6(3н)-диона или их солей | |
| HUT49866A (en) | Composition suitable for hindering deposits developing during polymerization and process for producing the phenothiazine derivative active component | |
| CA1042917A (en) | Method for racemization of optically active amines | |
| US3499032A (en) | Hydroxyl-,mercapto-,and amino-substituted aminimides | |
| US2973361A (en) | Triethylenediamine hydrazinium compounds | |
| DE824635C (de) | Verfahren zur Herstellung von N-Carboanhydriden | |
| SU499806A3 (ru) | Способ получени производных пиперазина | |
| SU1074405A3 (ru) | Способ получени производных уразола | |
| DE2453365A1 (de) | Verfahren zur herstellung von n-trimethylsilylacetamid | |
| CN113105354B (zh) | 一种无催化剂制备n-(4-羟基-3-甲氧基苄基)壬酰胺的方法 | |
| Kato et al. | Studies on ketene and its derivatives. 98. 1, 1-Dichloro-5-oxo-4-oxaspiro [2.3] hexane. Synthesis and reactions | |
| SU588919A3 (ru) | Способ получени производных 5,5,7,7-тетраметилфуро(3,4-е)асиммтриазина | |
| US3704248A (en) | Zearalenone reduction | |
| SU505366A3 (ru) | Способ получени -/гетероарилметилдезокси-норморфинов или-норкодеинов | |
| SU765268A1 (ru) | 3,4-Дигидропирроло-(1,2-а) пиразин в качестве промежуточного продукта дл синтеза физиологически активных соединений и способ его получени | |
| SU1525151A1 (ru) | Способ получени 1-аминопирролидина | |
| DE19853558A1 (de) | Verfahren zur Herstellung von 2,3-Dihydroindolen (Indolinen), neuartige 2,3-Dihydroindole sowie deren Verwendung | |
| US5378333A (en) | Halogenated polycarboxycubanes | |
| JPS6351153B2 (ru) | ||
| SU598871A1 (ru) | Способ получени гидрохлорида метиламиноацетопирокатехина | |
| RU1768595C (ru) | 2-(2 @ -Гидроксифенил)амино-3,4,6-трихлор-5-цианопиридин, обладающий антиокислительной активностью при термоокислительной деструкции углеводородов и способ его получени | |
| SU520351A1 (ru) | Способ плучени азометинов | |
| JPS5686184A (en) | Novel mitomycin c derivative | |
| SU1699995A1 (ru) | Способ получени метиламинов |