SU499806A3 - Способ получени производных пиперазина - Google Patents
Способ получени производных пиперазинаInfo
- Publication number
- SU499806A3 SU499806A3 SU1970164A SU1970164A SU499806A3 SU 499806 A3 SU499806 A3 SU 499806A3 SU 1970164 A SU1970164 A SU 1970164A SU 1970164 A SU1970164 A SU 1970164A SU 499806 A3 SU499806 A3 SU 499806A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- general formula
- piperazine derivatives
- producing piperazine
- compound
- phenol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Description
(54) СПОСОБ ПОЛУЧЕНИЯ ПЮИЗВОДНЫХ ПИПЕРАЗИНА
каталитическим гидрированием получают соединение формулы II, (т.пп. 180°С) Пример.
,
С,
«-v/o-ttH,)
HjC-:- СН,
14,2 г исходного фенола в этаноле с 12,6 г. N - 3 хлорпроЛил - N - 2 - метилфенилпиперазина в присутствии 3,1 г гидроокиси кали посредством кип чени превргйцают в вышеуказанное соединение (Т.ПЛ. 171° С). Выход - 87 %.
П р и м е р 2. Соединение формулы
О-(СНг), получают следующим образом:
14,2 г фенола формулы II в среде этанола, дри кип чении подвергают взаимодействию с 12,0г. N-2-xлopэтил-N-(2-метилфенил) - пицеразина в присутствии 3,1 г гидроокиси кали .
Выход - 61 %, Т.ПЛ. 152°С (основание.)
Точка плавлени : 152°С (основание).
Точка плавлени : 211°С (СНзЗОзН).
Claims (1)
- Формула изобоетени Способ получени производных пиперазина общей формулы Iо-ю«.)где R - атом водорода, низший алкил, п 2 ИЗ, или их солей: отличающий с тем, что фенол общей формулы IIОЛГott СИ,подвергают взаимодействию с соединением общей формулы III/ X-R.-N N-//Rгде X - атом галогена, R,- этил, пропил, R - имеет вьпиеуказанные значени ,в среде органического растворител в присутствии св зьшающего кислоту средства при кип че НИИ с последующим выделением целевого продук та в виде основани или соли известными приемами
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT492071A AT311956B (de) | 1971-06-07 | 1971-06-07 | Verfahren zur Herstellung neuer Phenylimidazolidinonderivate und ihrer Salze |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU499806A3 true SU499806A3 (ru) | 1976-01-15 |
Family
ID=3569889
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1970169A SU493067A3 (ru) | 1971-06-07 | 1972-05-31 | Способ получени фенилимидазолидинонов |
| SU1791532A SU453839A3 (ru) | 1971-06-07 | 1972-05-31 | Способ получения фенилимидазолидинонов |
| SU1970242A SU509228A3 (ru) | 1971-06-07 | 1973-11-14 | Способ получени производныхпиперазина |
| SU1970170A SU498907A3 (ru) | 1971-06-07 | 1973-11-14 | Способ получени фенилимидазолидинонов |
| SU1970168A SU503516A3 (ru) | 1971-06-07 | 1973-11-14 | Способ получени производных пиперазина |
| SU1970171A SU492085A3 (ru) | 1971-06-07 | 1973-11-14 | Способ получени фенилимидазолидинонов |
| SU1970167A SU505358A3 (ru) | 1971-06-07 | 1973-11-14 | Способ получени производных пиперазина |
| SU1970164A SU499806A3 (ru) | 1971-06-07 | 1973-11-14 | Способ получени производных пиперазина |
Family Applications Before (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1970169A SU493067A3 (ru) | 1971-06-07 | 1972-05-31 | Способ получени фенилимидазолидинонов |
| SU1791532A SU453839A3 (ru) | 1971-06-07 | 1972-05-31 | Способ получения фенилимидазолидинонов |
| SU1970242A SU509228A3 (ru) | 1971-06-07 | 1973-11-14 | Способ получени производныхпиперазина |
| SU1970170A SU498907A3 (ru) | 1971-06-07 | 1973-11-14 | Способ получени фенилимидазолидинонов |
| SU1970168A SU503516A3 (ru) | 1971-06-07 | 1973-11-14 | Способ получени производных пиперазина |
| SU1970171A SU492085A3 (ru) | 1971-06-07 | 1973-11-14 | Способ получени фенилимидазолидинонов |
| SU1970167A SU505358A3 (ru) | 1971-06-07 | 1973-11-14 | Способ получени производных пиперазина |
Country Status (20)
| Country | Link |
|---|---|
| AR (7) | AR200112A1 (ru) |
| AT (1) | AT311956B (ru) |
| AU (1) | AU473287B2 (ru) |
| BE (1) | BE784475A (ru) |
| BG (1) | BG22822A3 (ru) |
| CA (1) | CA1011336A (ru) |
| CH (7) | CH573425A5 (ru) |
| DD (1) | DD101403A5 (ru) |
| DE (1) | DE2223751A1 (ru) |
| ES (1) | ES403542A1 (ru) |
| FR (1) | FR2140492B1 (ru) |
| GB (1) | GB1391491A (ru) |
| HU (1) | HU165493B (ru) |
| IE (1) | IE37812B1 (ru) |
| IL (1) | IL39620A (ru) |
| NL (1) | NL7207701A (ru) |
| NO (1) | NO136841C (ru) |
| SE (1) | SE392902B (ru) |
| SU (8) | SU493067A3 (ru) |
| ZA (1) | ZA723840B (ru) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19822678A1 (de) * | 1998-05-20 | 1999-11-25 | Bayer Ag | Substituierte 1,3-Diaza-2-(thi)oxo-cycloalkane |
| CA2568609A1 (en) * | 2003-05-28 | 2004-12-09 | Imotep Inc. | Haloethyl urea compounds and their use to attenuate, inhibit or prevent non-cancerous pathogenic cellular proliferation and diseases associated therewith |
| CA2568607A1 (en) * | 2003-05-28 | 2004-12-09 | Imotep Inc. | Haloethyl urea compounds and the use thereof to attenuate, inhibit or prevent cancer cell migration |
| RU2497810C1 (ru) * | 2012-06-28 | 2013-11-10 | Общество с ограниченной ответственностью "Объединенный центр исследований и разработок" | Способ получения n,n-диарилзамещенных 2-трихлорометилимидазолидинов |
-
1971
- 1971-06-07 AT AT492071A patent/AT311956B/de not_active IP Right Cessation
-
1972
- 1972-05-16 DE DE19722223751 patent/DE2223751A1/de active Pending
- 1972-05-31 SU SU1970169A patent/SU493067A3/ru active
- 1972-05-31 SU SU1791532A patent/SU453839A3/ru active
- 1972-06-05 CA CA143,854A patent/CA1011336A/en not_active Expired
- 1972-06-05 BG BG20655A patent/BG22822A3/xx unknown
- 1972-06-06 CH CH840072A patent/CH573425A5/xx not_active IP Right Cessation
- 1972-06-06 CH CH1507475A patent/CH589644A5/xx not_active IP Right Cessation
- 1972-06-06 BE BE784475A patent/BE784475A/xx unknown
- 1972-06-06 FR FR7220319A patent/FR2140492B1/fr not_active Expired
- 1972-06-06 CH CH1507675A patent/CH589646A5/xx not_active IP Right Cessation
- 1972-06-06 CH CH1507575A patent/CH589645A5/xx not_active IP Right Cessation
- 1972-06-06 CH CH1507275A patent/CH591475A5/xx not_active IP Right Cessation
- 1972-06-06 NO NO2007/72A patent/NO136841C/no unknown
- 1972-06-06 HU HUBO1379A patent/HU165493B/hu unknown
- 1972-06-06 CH CH1507375A patent/CH590269A5/xx not_active IP Right Cessation
- 1972-06-06 AU AU43129/72A patent/AU473287B2/en not_active Expired
- 1972-06-06 CH CH1507175A patent/CH583729A5/xx not_active IP Right Cessation
- 1972-06-06 SE SE7207420A patent/SE392902B/xx unknown
- 1972-06-06 ZA ZA723840A patent/ZA723840B/xx unknown
- 1972-06-06 IL IL39620A patent/IL39620A/en unknown
- 1972-06-06 DD DD163478A patent/DD101403A5/xx unknown
- 1972-06-06 ES ES403542A patent/ES403542A1/es not_active Expired
- 1972-06-07 AR AR242433A patent/AR200112A1/es active
- 1972-06-07 NL NL7207701A patent/NL7207701A/xx unknown
- 1972-06-07 IE IE791/72A patent/IE37812B1/xx unknown
- 1972-06-07 GB GB2662372A patent/GB1391491A/en not_active Expired
-
1973
- 1973-01-01 AR AR249758A patent/AR205522A1/es active
- 1973-01-01 AR AR249754A patent/AR207109A1/es active
- 1973-08-24 AR AR249757A patent/AR200139A1/es active
- 1973-08-24 AR AR249753A patent/AR203017A1/es active
- 1973-08-24 AR AR249755A patent/AR202904A1/es active
- 1973-08-24 AR AR249752A patent/AR202903A1/es active
- 1973-11-14 SU SU1970242A patent/SU509228A3/ru active
- 1973-11-14 SU SU1970170A patent/SU498907A3/ru active
- 1973-11-14 SU SU1970168A patent/SU503516A3/ru active
- 1973-11-14 SU SU1970171A patent/SU492085A3/ru active
- 1973-11-14 SU SU1970167A patent/SU505358A3/ru active
- 1973-11-14 SU SU1970164A patent/SU499806A3/ru active
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