SU591126A3 - Способ получени альбумина - Google Patents
Способ получени альбуминаInfo
- Publication number
- SU591126A3 SU591126A3 SU731938073A SU1938073A SU591126A3 SU 591126 A3 SU591126 A3 SU 591126A3 SU 731938073 A SU731938073 A SU 731938073A SU 1938073 A SU1938073 A SU 1938073A SU 591126 A3 SU591126 A3 SU 591126A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- albumin
- precipitate
- solution
- concentration
- proteins
- Prior art date
Links
- 102000009027 Albumins Human genes 0.000 title claims description 24
- 108010088751 Albumins Proteins 0.000 title claims description 24
- 238000000034 method Methods 0.000 title claims description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 40
- 239000002244 precipitate Substances 0.000 claims description 17
- 102000004169 proteins and genes Human genes 0.000 claims description 16
- 108090000623 proteins and genes Proteins 0.000 claims description 16
- 235000019441 ethanol Nutrition 0.000 claims description 14
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 claims description 11
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 10
- 102000001554 Hemoglobins Human genes 0.000 claims description 9
- 108010054147 Hemoglobins Proteins 0.000 claims description 9
- 239000012535 impurity Substances 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 230000000659 thermocoagulation Effects 0.000 claims description 7
- 229960005480 sodium caprylate Drugs 0.000 claims description 5
- BYKRNSHANADUFY-UHFFFAOYSA-M sodium octanoate Chemical compound [Na+].CCCCCCCC([O-])=O BYKRNSHANADUFY-UHFFFAOYSA-M 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 3
- 239000004215 Carbon black (E152) Substances 0.000 claims description 2
- 238000005119 centrifugation Methods 0.000 claims description 2
- 238000005352 clarification Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 229910052736 halogen Inorganic materials 0.000 claims description 2
- 150000002367 halogens Chemical class 0.000 claims description 2
- 229930195733 hydrocarbon Natural products 0.000 claims description 2
- 150000002430 hydrocarbons Chemical class 0.000 claims description 2
- 230000001376 precipitating effect Effects 0.000 claims description 2
- 239000000243 solution Substances 0.000 claims 14
- 102000004190 Enzymes Human genes 0.000 claims 5
- 108090000790 Enzymes Proteins 0.000 claims 5
- 239000000945 filler Substances 0.000 claims 4
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims 4
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims 3
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 3
- 210000002826 placenta Anatomy 0.000 claims 3
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 claims 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims 2
- 229960002446 octanoic acid Drugs 0.000 claims 2
- 229920000137 polyphosphoric acid Polymers 0.000 claims 2
- 229910002012 Aerosil® Inorganic materials 0.000 claims 1
- 102000006395 Globulins Human genes 0.000 claims 1
- 108010044091 Globulins Proteins 0.000 claims 1
- 102000008100 Human Serum Albumin Human genes 0.000 claims 1
- 108091006905 Human Serum Albumin Proteins 0.000 claims 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 claims 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 claims 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical compound [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 238000000502 dialysis Methods 0.000 claims 1
- 239000012153 distilled water Substances 0.000 claims 1
- 238000005516 engineering process Methods 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 150000008282 halocarbons Chemical class 0.000 claims 1
- 101150005467 lifO gene Proteins 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 101150015539 nlhH gene Proteins 0.000 claims 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-M octanoate Chemical compound CCCCCCCC([O-])=O WWZKQHOCKIZLMA-UHFFFAOYSA-M 0.000 claims 1
- 230000003169 placental effect Effects 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- 230000006920 protein precipitation Effects 0.000 claims 1
- 239000012460 protein solution Substances 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 239000011863 silicon-based powder Substances 0.000 claims 1
- 239000010802 sludge Substances 0.000 claims 1
- 229910000029 sodium carbonate Inorganic materials 0.000 claims 1
- 230000001954 sterilising effect Effects 0.000 claims 1
- 238000004659 sterilization and disinfection Methods 0.000 claims 1
- 239000011550 stock solution Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 102000007562 Serum Albumin Human genes 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- -1 caprylate ion Chemical class 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
- Y10S530/83—Plasma; serum
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/85—Reproductive organs or embryos
- Y10S530/851—Placenta; amniotic fluid
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7224311A FR2190437B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1972-07-05 | 1972-07-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU591126A3 true SU591126A3 (ru) | 1978-01-30 |
Family
ID=9101388
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU731938073A SU591126A3 (ru) | 1972-07-05 | 1973-04-04 | Способ получени альбумина |
Country Status (17)
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2415079C3 (de) * | 1974-03-28 | 1980-02-14 | Plasmesco Ag, Zug (Schweiz) | Verfahren zum Isolieren von Albumin aus Blutplasma |
| US4075197A (en) * | 1976-09-20 | 1978-02-21 | Monsanto Company | Serum albumin production |
| DK25877A (da) * | 1977-01-21 | 1978-08-15 | Nordisk Insulinlab | Fremgangsmaade til udvinding af renset albumin fra blodplasma |
| US4197238A (en) * | 1977-04-12 | 1980-04-08 | The Green Cross Corporation | Method of preparation of human albumin using polyethylene glycol |
| US4164496A (en) * | 1978-08-23 | 1979-08-14 | American National Red Cross | Preparation of albumin using PEG and EDTA |
| US4228154A (en) * | 1979-02-26 | 1980-10-14 | Armour Pharmaceutical Company | Purification of plasma albumin by ion exchange chromatography |
| US4222934A (en) * | 1979-04-12 | 1980-09-16 | American National Red Cross | Preparation of albumin using ethanol |
| US4440679A (en) * | 1980-03-05 | 1984-04-03 | Cutter Laboratories, Inc. | Pasteurized therapeutically active protein compositions |
| DE3344656A1 (de) * | 1983-12-09 | 1985-06-13 | Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München | Verfahren zur herstellung einer serumproteinloesung |
| JPS6152702U (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1984-09-12 | 1986-04-09 | ||
| JPS62294621A (ja) * | 1986-06-13 | 1987-12-22 | Green Cross Corp:The | アルブミンの回収方法 |
| US4841023A (en) * | 1986-06-25 | 1989-06-20 | New York Blood Center, Inc. | Inactivation of viruses in labile protein-containing compositions using fatty acids |
| US4791191A (en) * | 1987-11-12 | 1988-12-13 | Plasmatech Corporation | Depyrogenation of clinical albumin |
| FR2632308B1 (fr) * | 1988-06-07 | 1991-08-16 | Fondation Nale Transfusion San | Procede et installation de fractionnement en continu de proteines vegetales animales ou humaines |
| JPH0253505U (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1988-10-12 | 1990-04-18 | ||
| US5277818A (en) * | 1988-10-31 | 1994-01-11 | The Green Cross Corporation | Albumin preparation and process for preparing the same |
| FR2648048B1 (fr) * | 1989-06-08 | 1994-06-03 | Lille Transfusion Sanguine | Procede de preparation de solutions d'albumine purifiee |
| JPH0671434B2 (ja) * | 1989-09-18 | 1994-09-14 | 株式会社ミドリ十字 | ヒト血清アルブミンの製造方法 |
| US5250663A (en) * | 1990-04-19 | 1993-10-05 | Miles Inc. | Preparing essentially monomeric normal human serum albumin |
| US5440018A (en) * | 1992-05-20 | 1995-08-08 | The Green Cross Corporation | Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same |
| US5521287A (en) * | 1992-05-20 | 1996-05-28 | The Green Cross Corporation | Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same |
| US5728553A (en) * | 1992-09-23 | 1998-03-17 | Delta Biotechnology Limited | High purity albumin and method of producing |
| US5561115A (en) | 1994-08-10 | 1996-10-01 | Bayer Corporation | Low temperature albumin fractionation using sodium caprylate as a partitioning agent |
| US6955917B2 (en) * | 1997-06-20 | 2005-10-18 | Bayer Healthcare Llc | Chromatographic method for high yield purification and viral inactivation of antibodies |
| US5886154A (en) | 1997-06-20 | 1999-03-23 | Lebing; Wytold R. | Chromatographic method for high yield purification and viral inactivation of antibodies |
| RU2140287C1 (ru) * | 1998-08-25 | 1999-10-27 | Государственное унитарное предприятие "Иммунопрепарат" | Способ получения альбумина |
| GB9902000D0 (en) | 1999-01-30 | 1999-03-17 | Delta Biotechnology Ltd | Process |
| JP4935242B2 (ja) * | 2006-08-24 | 2012-05-23 | ニプロ株式会社 | 脂肪酸を含有するｓ−ニトロソタンパク質とその製法 |
| CA3058234A1 (en) * | 2017-03-16 | 2018-09-20 | Therapure Biopharma Inc. | Method for purification of albumin |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2390074A (en) * | 1942-02-09 | 1945-12-04 | Research Corp | Protein product and process |
| US2705230A (en) * | 1949-09-23 | 1955-03-29 | Allen F Reid | Method of purifying albumin |
| US2770616A (en) * | 1951-01-29 | 1956-11-13 | Protein Foundation Inc | Fractionation of proteinaceous materials in blood plasma and liver tissue |
| US2765299A (en) * | 1952-06-27 | 1956-10-02 | Armour & Co | Recovery of serum albumin |
| US2761810A (en) * | 1954-07-22 | 1956-09-04 | Ortho Pharma Corp | Preparation of blood fraction for use in rh testing procedures |
| US2958628A (en) * | 1957-02-21 | 1960-11-01 | Cutter Lab | Heat treatable plasma protein product and method of preparation |
| US3100737A (en) * | 1958-02-05 | 1963-08-13 | Auerswald Wilhelm | Method of preparing a plasma protein solution free of active hepatitis virus and product produced thereby |
| US3497492A (en) * | 1968-04-02 | 1970-02-24 | American Cyanamid Co | Preparation of placental albumin |
| JPS5220524B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1968-11-02 | 1977-06-04 |
-
1972
- 1972-07-05 FR FR7224311A patent/FR2190437B1/fr not_active Expired
-
1973
- 1973-04-04 SU SU731938073A patent/SU591126A3/ru active
- 1973-07-03 US US05/376,204 patent/US3992367A/en not_active Expired - Lifetime
- 1973-07-03 LU LU67931A patent/LU67931A1/xx unknown
- 1973-07-03 DE DE2333883A patent/DE2333883C3/de not_active Expired
- 1973-07-04 BE BE133092A patent/BE801888A/xx not_active IP Right Cessation
- 1973-07-04 DK DK371873AA patent/DK134425B/da not_active IP Right Cessation
- 1973-07-04 NO NO2749/73A patent/NO140579C/no unknown
- 1973-07-04 CA CA175,571A patent/CA1028320A/en not_active Expired
- 1973-07-04 GB GB3179273A patent/GB1441751A/en not_active Expired
- 1973-07-04 SE SE7309451A patent/SE421997B/xx unknown
- 1973-07-04 AR AR248915A patent/AR195041A1/es active
- 1973-07-04 NL NLAANVRAGE7309361,A patent/NL179874C/xx not_active IP Right Cessation
- 1973-07-05 BR BR5002/73A patent/BR7305002D0/pt unknown
- 1973-07-05 RO RO7375353A patent/RO64629A/ro unknown
- 1973-07-05 JP JP7611873A patent/JPS5312965B2/ja not_active Expired
- 1973-07-05 ES ES416597A patent/ES416597A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| BR7305002D0 (pt) | 1974-08-15 |
| AR195041A1 (es) | 1973-08-30 |
| DE2333883B2 (de) | 1982-09-16 |
| ES416597A1 (es) | 1976-03-01 |
| RO64629A (fr) | 1979-02-15 |
| NL7309361A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-01-08 |
| FR2190437B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-08-08 |
| GB1441751A (en) | 1976-07-07 |
| DE2333883C3 (de) | 1983-05-11 |
| NL179874C (nl) | 1986-12-01 |
| SE421997B (sv) | 1982-02-15 |
| CA1028320A (en) | 1978-03-21 |
| NO140579C (no) | 1979-10-03 |
| NL179874B (nl) | 1986-07-01 |
| FR2190437A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-02-01 |
| JPS4985219A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-08-15 |
| LU67931A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-04-11 |
| DK134425C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1977-04-12 |
| BE801888A (fr) | 1974-01-04 |
| DK134425B (da) | 1976-11-08 |
| NO140579B (no) | 1979-06-25 |
| US3992367A (en) | 1976-11-16 |
| JPS5312965B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1978-05-06 |
| DE2333883A1 (de) | 1974-01-31 |
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