SU496719A3 - Способ получени производных допамина - Google Patents
Способ получени производных допаминаInfo
- Publication number
- SU496719A3 SU496719A3 SU1908277A SU1908277A SU496719A3 SU 496719 A3 SU496719 A3 SU 496719A3 SU 1908277 A SU1908277 A SU 1908277A SU 1908277 A SU1908277 A SU 1908277A SU 496719 A3 SU496719 A3 SU 496719A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- solution
- mixture
- dopamine derivatives
- residue
- preparing dopamine
- Prior art date
Links
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical class NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 title description 7
- 238000000034 method Methods 0.000 title description 5
- 239000000243 solution Substances 0.000 description 12
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 10
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 4
- -1 ethyl ethyl Chemical group 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000011541 reaction mixture Substances 0.000 description 4
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 239000007795 chemical reaction product Substances 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 229960000583 acetic acid Drugs 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- UORVGPXVDQYIDP-UHFFFAOYSA-N borane Chemical compound B UORVGPXVDQYIDP-UHFFFAOYSA-N 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 229960003638 dopamine Drugs 0.000 description 2
- 239000012362 glacial acetic acid Substances 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 125000004203 4-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 241000790917 Dioxys <bee> Species 0.000 description 1
- 229910052770 Uranium Inorganic materials 0.000 description 1
- 238000005903 acid hydrolysis reaction Methods 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 229910000085 borane Inorganic materials 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 125000005805 dimethoxy phenyl group Chemical group 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
- 239000012442 inert solvent Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- GPKUICFDWYEPTK-UHFFFAOYSA-N methoxycyclohexatriene Chemical group COC1=CC=C=C[CH]1 GPKUICFDWYEPTK-UHFFFAOYSA-N 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- QUSNBJAOOMFDIB-UHFFFAOYSA-N monoethyl amine Natural products CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- 150000004672 propanoic acids Chemical class 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24346672A | 1972-04-12 | 1972-04-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU496719A3 true SU496719A3 (ru) | 1975-12-25 |
Family
ID=22918877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1908277A SU496719A3 (ru) | 1972-04-12 | 1973-04-11 | Способ получени производных допамина |
Country Status (31)
| Country | Link |
|---|---|
| JP (2) | JPS5825656B2 (OSRAM) |
| KR (1) | KR790000113B1 (OSRAM) |
| AR (1) | AR203822A1 (OSRAM) |
| AT (1) | AT323719B (OSRAM) |
| AU (1) | AU472734B2 (OSRAM) |
| BE (1) | BE798051A (OSRAM) |
| BG (1) | BG23001A3 (OSRAM) |
| CA (1) | CA1018188A (OSRAM) |
| CH (2) | CH569691A5 (OSRAM) |
| CS (2) | CS190448B2 (OSRAM) |
| CY (1) | CY963A (OSRAM) |
| DD (1) | DD107670B3 (OSRAM) |
| DE (1) | DE2317710C2 (OSRAM) |
| DK (1) | DK142750C (OSRAM) |
| ES (1) | ES413639A1 (OSRAM) |
| FR (1) | FR2182947B1 (OSRAM) |
| GB (1) | GB1392674A (OSRAM) |
| HK (1) | HK50178A (OSRAM) |
| HU (2) | HU167597B (OSRAM) |
| IE (1) | IE37511B1 (OSRAM) |
| IL (1) | IL42016A (OSRAM) |
| KE (1) | KE2870A (OSRAM) |
| MY (1) | MY7800381A (OSRAM) |
| NL (1) | NL174459C (OSRAM) |
| PH (1) | PH11041A (OSRAM) |
| PL (2) | PL90695B1 (OSRAM) |
| RO (2) | RO70892A (OSRAM) |
| SE (1) | SE399064B (OSRAM) |
| SU (1) | SU496719A3 (OSRAM) |
| YU (2) | YU36483B (OSRAM) |
| ZA (1) | ZA732136B (OSRAM) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH585693A5 (OSRAM) * | 1974-02-08 | 1977-03-15 | Ciba Geigy Ag | |
| US4342692A (en) * | 1980-10-20 | 1982-08-03 | Usv Pharmaceutical Corporation | Pyrrolidines |
| ES8702355A1 (es) * | 1981-07-22 | 1985-07-01 | Syntex Inc | Procedimiento para la preparacion de antidepresivos reguladores del sistema cardiovascular a base de pirrolidina sustituida |
| JPS6061523A (ja) * | 1983-09-16 | 1985-04-09 | Shionogi & Co Ltd | 経口用ドブタミン製剤 |
| ZA881076B (en) * | 1987-02-24 | 1989-10-25 | Lilly Co Eli | Dobutamine salts |
| JPH0383364U (OSRAM) * | 1989-12-18 | 1991-08-23 | ||
| WO1992020645A1 (en) * | 1991-05-20 | 1992-11-26 | Tsumura & Co. | Phellodendrine analogs and allergy type iv suppressor containing the same as active ingredient |
| ATE155125T1 (de) * | 1993-04-13 | 1997-07-15 | Duphar Int Res | Herstellung von dobutamin verbindungen |
| EP0620208B1 (en) * | 1993-04-13 | 1997-07-09 | Duphar International Research B.V | Production of dobutamine compounds |
| JP4667870B2 (ja) | 2002-10-03 | 2011-04-13 | ノヴァレメッド リミテッド | 自己免疫疾患、免疫−アレルギー疾患及び臓器又は組織移植拒絶反応の治療において使用する新規な化合物 |
| JP4939396B2 (ja) * | 2004-03-26 | 2012-05-23 | ノヴァレメッド リミテッド | Ａｉｄｓ及び他のウイルス性疾患及びｈｉｖ関連感染症の改善又はその治療用化合物及びそのような化合物を含む組成物、そのような疾患及び感染症の治療方法及びそのような化合物及び組成物の製造方法 |
| GB0804213D0 (en) | 2008-03-06 | 2008-04-16 | New Era Biotech Ltd | A method of printing or preventing pain |
| CN102595884B (zh) | 2009-07-31 | 2014-12-03 | 考格尼申治疗股份有限公司 | 认知衰退的抑制剂 |
| US8802734B2 (en) | 2009-09-09 | 2014-08-12 | Novaremed Limited | Method of treating or preventing pain |
| EP2747759A4 (en) * | 2011-08-25 | 2015-05-13 | Cognition Therapeutics Inc | COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES |
| DK3498692T3 (da) | 2014-01-31 | 2022-05-16 | Cognition Therapeutics Inc | Isoindolin-sammensætninger og fremgangsmåder til behandling af neurodegenerativ sygdom og makulær degeneration |
| BR112019023851A2 (pt) | 2017-05-15 | 2020-08-18 | Cognition Therapeutics, Inc. | compostos, suas composições farmacêuticas e métodos para tratamento de doenças neurodegenerativas |
| CN114524734B (zh) * | 2021-12-27 | 2024-04-26 | 嘉实（湖南）医药科技有限公司 | 一种盐酸多巴酚丁胺的制备方法 |
| CN117326958B (zh) * | 2023-09-21 | 2025-07-11 | 锦州奥鸿药业有限责任公司 | 一种高纯度盐酸多巴酚丁胺的制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2276619A (en) * | 1942-03-17 | N-phentlaliphatic-dihtoroxyphentnl |
-
1973
- 1973-03-28 ZA ZA732136A patent/ZA732136B/xx unknown
- 1973-04-09 CY CY963A patent/CY963A/xx unknown
- 1973-04-09 GB GB1683573A patent/GB1392674A/en not_active Expired
- 1973-04-09 DE DE2317710A patent/DE2317710C2/de not_active Expired
- 1973-04-10 SE SE7305032A patent/SE399064B/xx unknown
- 1973-04-10 FR FR7312845A patent/FR2182947B1/fr not_active Expired
- 1973-04-10 IE IE563/73A patent/IE37511B1/xx unknown
- 1973-04-11 KR KR7300573A patent/KR790000113B1/ko not_active Expired
- 1973-04-11 BG BG023268A patent/BG23001A3/xx unknown
- 1973-04-11 SU SU1908277A patent/SU496719A3/ru active
- 1973-04-11 NL NLAANVRAGE7305097,A patent/NL174459C/xx not_active IP Right Cessation
- 1973-04-11 CA CA168,428A patent/CA1018188A/en not_active Expired
- 1973-04-11 CH CH517473A patent/CH569691A5/xx not_active IP Right Cessation
- 1973-04-11 YU YU00976/73A patent/YU36483B/xx unknown
- 1973-04-11 CH CH1112475A patent/CH580563A5/xx not_active IP Right Cessation
- 1973-04-11 BE BE1004956A patent/BE798051A/xx not_active IP Right Cessation
- 1973-04-11 AU AU54385/73A patent/AU472734B2/en not_active Expired
- 1973-04-11 DK DK196773A patent/DK142750C/da not_active IP Right Cessation
- 1973-04-11 AT AT318773A patent/AT323719B/de not_active IP Right Cessation
- 1973-04-12 HU HUEI552A patent/HU167597B/hu unknown
- 1973-04-12 JP JP48041750A patent/JPS5825656B2/ja not_active Expired
- 1973-04-12 PL PL1973161874A patent/PL90695B1/pl unknown
- 1973-04-12 AR AR247523A patent/AR203822A1/es active
- 1973-04-12 PH PH14508A patent/PH11041A/en unknown
- 1973-04-12 IL IL42016A patent/IL42016A/en unknown
- 1973-04-12 PL PL1973183808A patent/PL94207B1/pl unknown
- 1973-04-12 RO RO7383749A patent/RO70892A/ro unknown
- 1973-04-12 DD DD73170118A patent/DD107670B3/de unknown
- 1973-04-12 CS CS77171A patent/CS190448B2/cs unknown
- 1973-04-12 RO RO7374457A patent/RO65105A/ro unknown
- 1973-04-12 ES ES413639A patent/ES413639A1/es not_active Expired
- 1973-04-12 CS CS732601A patent/CS190406B2/cs unknown
- 1973-04-12 HU HUEI469A patent/HU166213B/hu unknown
-
1978
- 1978-08-10 KE KE2870A patent/KE2870A/xx unknown
- 1978-09-07 HK HK501/78A patent/HK50178A/xx unknown
- 1978-12-30 MY MY381/78A patent/MY7800381A/xx unknown
-
1979
- 1979-12-28 YU YU3212/79A patent/YU37113B/xx unknown
-
1982
- 1982-08-27 JP JP57149025A patent/JPS58131945A/ja active Granted
Also Published As
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