SMT201300098B - Forme solide di N-(4-(7-azabiciclo[2.2.1]eptan-7-il)-2-(trifluorometil)fenil-4-osso-5-trifluorometil)-1,4-diidrochinolina-3-carbossammide - Google Patents
Forme solide di N-(4-(7-azabiciclo[2.2.1]eptan-7-il)-2-(trifluorometil)fenil-4-osso-5-trifluorometil)-1,4-diidrochinolina-3-carbossammideInfo
- Publication number
- SMT201300098B SMT201300098B SM201300098T SM201300098T SMT201300098B SM T201300098 B SMT201300098 B SM T201300098B SM 201300098 T SM201300098 T SM 201300098T SM 201300098 T SM201300098 T SM 201300098T SM T201300098 B SMT201300098 B SM T201300098B
- Authority
- SM
- San Marino
- Prior art keywords
- trifluoromethyl
- dihydroquinoline
- heptan
- azabicyclo
- carboxamide
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- Medicinal Chemistry (AREA)
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10781308P | 2008-10-23 | 2008-10-23 | |
PCT/US2009/061942 WO2010048573A1 (en) | 2008-10-23 | 2009-10-23 | Solid forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide |
Publications (1)
Publication Number | Publication Date |
---|---|
SMT201300098B true SMT201300098B (it) | 2013-11-08 |
Family
ID=41460125
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SM201300098T SMT201300098B (it) | 2008-10-23 | 2013-09-06 | Forme solide di N-(4-(7-azabiciclo[2.2.1]eptan-7-il)-2-(trifluorometil)fenil-4-osso-5-trifluorometil)-1,4-diidrochinolina-3-carbossammide |
Country Status (22)
Country | Link |
---|---|
US (2) | US8436014B2 (hr) |
EP (1) | EP2358680B1 (hr) |
JP (1) | JP5645835B2 (hr) |
KR (1) | KR20110074916A (hr) |
CN (1) | CN102224141B (hr) |
AU (1) | AU2009308241B2 (hr) |
BR (1) | BRPI0920598A2 (hr) |
CA (1) | CA2741178A1 (hr) |
CY (1) | CY1114332T1 (hr) |
DK (1) | DK2358680T3 (hr) |
ES (1) | ES2406361T3 (hr) |
HK (1) | HK1158650A1 (hr) |
HR (1) | HRP20130536T1 (hr) |
IL (1) | IL212308A0 (hr) |
MX (1) | MX2011004374A (hr) |
NZ (1) | NZ592504A (hr) |
PL (1) | PL2358680T3 (hr) |
PT (1) | PT2358680E (hr) |
RU (1) | RU2518479C2 (hr) |
SM (1) | SMT201300098B (hr) |
WO (1) | WO2010048573A1 (hr) |
ZA (1) | ZA201102732B (hr) |
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US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
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CN1898221A (zh) | 2003-09-06 | 2007-01-17 | 沃泰克斯药物股份有限公司 | Atp-结合弹夹转运蛋白的调控剂 |
ZA200604578B (en) * | 2003-11-14 | 2008-05-28 | Vertex Pharma | Thiazoles and oxazoles.useful as modulators of ATP Binding cassette transporters |
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CA2635760C (en) * | 2005-12-28 | 2014-07-15 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters |
ES2790700T3 (es) | 2005-12-28 | 2020-10-28 | Vertex Pharma | Composiciones farmacéuticas de la forma amorfa de N-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-dihidro-4-oxoquinolin-3-carboxamida |
US7671221B2 (en) * | 2005-12-28 | 2010-03-02 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
US10022352B2 (en) | 2006-04-07 | 2018-07-17 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
US7645789B2 (en) * | 2006-04-07 | 2010-01-12 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
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US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
JP5497633B2 (ja) | 2007-05-09 | 2014-05-21 | バーテックス ファーマシューティカルズ インコーポレイテッド | Cftrのモジュレーター |
CN101827593B (zh) | 2007-08-24 | 2013-07-24 | 沃泰克斯药物股份有限公司 | 用于治疗(特别是)囊性纤维化的异噻唑并吡啶酮 |
AU2008310734B2 (en) | 2007-10-10 | 2014-06-05 | Parion Sciences, Inc. | Delivering osmolytes by nasal cannula |
CA2705562C (en) | 2007-11-16 | 2016-05-17 | Vertex Pharmaceuticals Incorporated | Isoquinoline modulators of atp-binding cassette transporters |
CA2708146A1 (en) * | 2007-12-07 | 2009-06-18 | Vertex Pharmaceuticals Incorporated | Formulations of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid |
US20100036130A1 (en) | 2007-12-07 | 2010-02-11 | Vertex Pharmaceuticals Incorporated | Processes for producing cycloalkylcarboxamido-pyridine benzoic acids |
AU2008335440B2 (en) | 2007-12-07 | 2013-11-07 | Vertex Pharmaceuticals Incorporated | Processes for producing cycloalkylcarboxamido-pyridine benzoic acids |
WO2009073757A1 (en) | 2007-12-07 | 2009-06-11 | Vertex Pharmaceuticals Incorporated | Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3] dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid |
US8299099B2 (en) | 2008-02-28 | 2012-10-30 | Vertex Pharmaceuticals Incorporated | Heteroaryl derivatives as CFTR modulators |
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BRPI0919930A2 (pt) | 2008-10-23 | 2016-02-16 | Vertex Pharma | moduladores de regulador de condutância transmembrana de fibrose cística |
US20110257223A1 (en) * | 2008-10-23 | 2011-10-20 | Vertex Pharmaceuticals Incorporated | Modulators of Cystic Fibrosis Transmembrane Conductance Regulator |
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RU2568608C2 (ru) * | 2009-10-23 | 2015-11-20 | Вертекс Фармасьютикалз Инкорпорейтед | Твердые формы n-(4-(7-азабицикло[2.2.1]гептан-7-ил)-2-(трифторметил)фенил)-4-оксо-5-(трифторметил)-1,4-дигидрохинолин-3-карбоксамида |
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PL2555754T3 (pl) | 2010-04-07 | 2016-09-30 | Formy stałe kwasu 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-ilo)cyklopropanokarboksyamido)-3-metylopirydyn-2-ylo)benzoesowego | |
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US9035072B2 (en) | 2010-04-22 | 2015-05-19 | Vertex Pharmaceuticals Incorporated | Process of producing cycloalkylcarboxamido-indole compounds |
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HK1158650A1 (en) | 2012-09-07 |
HRP20130536T1 (en) | 2013-07-31 |
US20140113933A9 (en) | 2014-04-24 |
AU2009308241B2 (en) | 2016-01-07 |
BRPI0920598A2 (pt) | 2015-12-29 |
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CN102224141A (zh) | 2011-10-19 |
AU2009308241A1 (en) | 2010-04-29 |
JP5645835B2 (ja) | 2014-12-24 |
EP2358680A1 (en) | 2011-08-24 |
WO2010048573A1 (en) | 2010-04-29 |
US20100130547A1 (en) | 2010-05-27 |
JP2012506868A (ja) | 2012-03-22 |
RU2518479C2 (ru) | 2014-06-10 |
EP2358680B1 (en) | 2013-03-20 |
PL2358680T3 (pl) | 2013-08-30 |
ES2406361T3 (es) | 2013-06-06 |
MX2011004374A (es) | 2011-05-23 |
CY1114332T1 (el) | 2016-08-31 |
NZ592504A (en) | 2013-04-26 |
DK2358680T3 (da) | 2013-06-24 |
RU2011120327A (ru) | 2012-11-27 |
CA2741178A1 (en) | 2010-04-29 |
PT2358680E (pt) | 2013-05-14 |
CN102224141B (zh) | 2014-10-08 |
KR20110074916A (ko) | 2011-07-04 |
ZA201102732B (en) | 2012-06-27 |
US8436014B2 (en) | 2013-05-07 |
IL212308A0 (en) | 2011-06-30 |
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