ZA201102732B - Solid forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide - Google Patents

Solid forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide

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Publication number
ZA201102732B
ZA201102732B ZA2011/02732A ZA201102732A ZA201102732B ZA 201102732 B ZA201102732 B ZA 201102732B ZA 2011/02732 A ZA2011/02732 A ZA 2011/02732A ZA 201102732 A ZA201102732 A ZA 201102732A ZA 201102732 B ZA201102732 B ZA 201102732B
Authority
ZA
South Africa
Prior art keywords
trifluoromethyl
dihydroquinoline
heptan
azabicyclo
carboxamide
Prior art date
Application number
ZA2011/02732A
Inventor
Beili Zhang
Mariusz Krawiec
Martyn C Botfield
Peter D J Grootenhuis
Goor Frederick Van
Original Assignee
Vertex Pharmaceutical Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceutical Incorporated filed Critical Vertex Pharmaceutical Incorporated
Publication of ZA201102732B publication Critical patent/ZA201102732B/en

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
ZA2011/02732A 2008-10-23 2011-04-12 Solid forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide ZA201102732B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10781308P 2008-10-23 2008-10-23
PCT/US2009/061942 WO2010048573A1 (en) 2008-10-23 2009-10-23 Solid forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide

Publications (1)

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ZA201102732B true ZA201102732B (en) 2012-06-27

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ZA2011/02732A ZA201102732B (en) 2008-10-23 2011-04-12 Solid forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide

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US (2) US8436014B2 (en)
EP (1) EP2358680B1 (en)
JP (1) JP5645835B2 (en)
KR (1) KR20110074916A (en)
CN (1) CN102224141B (en)
AU (1) AU2009308241B2 (en)
BR (1) BRPI0920598A2 (en)
CA (1) CA2741178A1 (en)
CY (1) CY1114332T1 (en)
DK (1) DK2358680T3 (en)
ES (1) ES2406361T3 (en)
HK (1) HK1158650A1 (en)
HR (1) HRP20130536T1 (en)
IL (1) IL212308A0 (en)
MX (1) MX2011004374A (en)
NZ (1) NZ592504A (en)
PL (1) PL2358680T3 (en)
PT (1) PT2358680E (en)
RU (1) RU2518479C2 (en)
SM (1) SMT201300098B (en)
WO (1) WO2010048573A1 (en)
ZA (1) ZA201102732B (en)

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