EP2297140A4 - Novel 1,2,4 oxadiazole compounds and methods of use thereof - Google Patents

Novel 1,2,4 oxadiazole compounds and methods of use thereof

Info

Publication number
EP2297140A4
EP2297140A4 EP08770247A EP08770247A EP2297140A4 EP 2297140 A4 EP2297140 A4 EP 2297140A4 EP 08770247 A EP08770247 A EP 08770247A EP 08770247 A EP08770247 A EP 08770247A EP 2297140 A4 EP2297140 A4 EP 2297140A4
Authority
EP
European Patent Office
Prior art keywords
novel
methods
oxadiazole compounds
oxadiazole
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08770247A
Other languages
German (de)
French (fr)
Other versions
EP2297140A1 (en
Inventor
Jianguo Ji
Chih-Hung Lee
Kevin B Sippy
Tao Li
Murali Gopalakrishnan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of EP2297140A1 publication Critical patent/EP2297140A1/en
Publication of EP2297140A4 publication Critical patent/EP2297140A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
EP08770247A 2008-06-06 2008-06-06 Novel 1,2,4 oxadiazole compounds and methods of use thereof Withdrawn EP2297140A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2008/066002 WO2009148452A1 (en) 2008-06-06 2008-06-06 Novel 1,2,4 oxadiazole compounds and methods of use thereof

Publications (2)

Publication Number Publication Date
EP2297140A1 EP2297140A1 (en) 2011-03-23
EP2297140A4 true EP2297140A4 (en) 2012-05-02

Family

ID=41398367

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08770247A Withdrawn EP2297140A4 (en) 2008-06-06 2008-06-06 Novel 1,2,4 oxadiazole compounds and methods of use thereof

Country Status (6)

Country Link
EP (1) EP2297140A4 (en)
JP (1) JP2011522818A (en)
CN (1) CN102089297A (en)
CA (1) CA2725573A1 (en)
MX (1) MX2010013399A (en)
WO (1) WO2009148452A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8580842B2 (en) 2003-09-30 2013-11-12 Abbott Gmbh & Co. Kg Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
US20080167286A1 (en) 2006-12-12 2008-07-10 Abbott Laboratories Pharmaceutical compositions and their methods of use
US8486979B2 (en) 2006-12-12 2013-07-16 Abbvie Inc. 1,2,4 oxadiazole compounds and methods of use thereof
UY30846A1 (en) 2006-12-30 2008-07-31 Abbott Gmbh & Amp OXINDOL DERIVATIVES REPLACED, MEDICINES THAT UNDERSTAND AND USE THEMSELVES
US8703774B2 (en) 2007-12-07 2014-04-22 AbbVie Deutschland GmbH & Co. KG Carbamate-substituted oxindole derivatives and use thereof for the treatment of vasopressin-dependent diseases
BRPI0820668A2 (en) 2007-12-07 2017-08-22 Abbott Gmbh & Co Kg 5-HALOGEN SUBSTITUTED OXINDOL DERIVATIVES AND THEIR USE TO TREAT VASOPRESSIN DEPENDENT DISEASES
JP5701607B2 (en) 2007-12-07 2015-04-15 アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー Amidomethyl-substituted oxindole derivatives and their use in the treatment of vasopressin-dependent diseases
JP5645217B2 (en) 2007-12-07 2014-12-24 アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー 5,6-disubstituted oxindole derivatives and their use to treat vasopressin-dependent diseases
US9040568B2 (en) 2009-05-29 2015-05-26 Abbvie Inc. Pharmaceutical compositions for the treatment of pain
PT2588197E (en) * 2010-07-02 2015-02-09 Gilead Sciences Inc Fused heterocyclic compounds as ion channel modulators
CN103270029B (en) * 2010-10-22 2016-01-20 拜耳知识产权有限责任公司 As the heterogeneous ring compound of agricultural chemicals
TWI510480B (en) 2011-05-10 2015-12-01 Gilead Sciences Inc Fused heterocyclic compounds as ion channel modulators
TWI549944B (en) 2011-07-01 2016-09-21 吉李德科學股份有限公司 Fused heterocyclic compounds as ion channel modulators
NO3175985T3 (en) 2011-07-01 2018-04-28
CN104144925A (en) * 2011-10-17 2014-11-12 拜耳知识产权有限责任公司 Substituted oxadiazolyl pyridinones and oxadiazolyl pyridazinones as hif inhibitors
UA114915C2 (en) 2012-07-02 2017-08-28 Монсанто Текнолоджи Ллс Processes for the preparation of 3,5-disubstituted-1,2,4-oxadiazoles
CN106316885B (en) * 2015-07-03 2019-02-12 普济生物科技（台州）有限公司 A kind of preparation method of 3- [5- (2- fluorophenyl) -1,2,4- oxadiazoles -3- base] benzoic acid
KR20200020781A (en) 2017-06-14 2020-02-26 트레베나, 인코포레이티드. Compounds for modulating S1P1 activity and methods of using the same
RU2671563C1 (en) * 2017-11-13 2018-11-02 Федеральное государственное бюджетное учреждение науки Южный научный центр Российской академии наук 2-phenyl-5-(3,4,5-triethoxyphenyl)-1,3,4-oxadiazole with luminescent activity
EP4061352A4 (en) 2019-11-19 2024-02-28 Trevena Inc Compounds and methods of preparing compounds s1p1 modulators
CN111138376A (en) * 2019-12-24 2020-05-12 中山大学 3, 5-disubstituted phenyl-1, 2, 4-oxadiazole derivative and preparation method and application thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4022901A (en) * 1975-03-05 1977-05-10 E. R. Squibb & Sons, Inc. 3-Pyridinyl-5-isothiocyanophenyl oxadiazoles
US4122257A (en) * 1976-06-04 1978-10-24 Hoechst Aktiengesellschaft Benzofuran-oxadiazole compounds
WO1993013083A1 (en) * 1991-12-31 1993-07-08 Fujisawa Pharmaceutical Co., Ltd. Oxadiazole derivatives having acetylcholinesterase-inhibitory and muscarinic agonist activity
US20060019976A1 (en) * 2004-07-22 2006-01-26 Karp Gary M Methods for treating Hepatitis C

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008525524A (en) * 2004-12-28 2008-07-17 アストラゼネカ・アクチエボラーグ Arylsulfonamide modulator
ATE477253T1 (en) * 2005-04-26 2010-08-15 Neurosearch As NOVEL OXADIAZOLE DERIVATIVES AND THEIR MEDICAL USE
EP2083921A2 (en) * 2006-09-04 2009-08-05 Neurosearch A/S Pharmaceutical combinations of a nicotine receptor modulator and a cognitive enhancer
US20080167286A1 (en) * 2006-12-12 2008-07-10 Abbott Laboratories Pharmaceutical compositions and their methods of use

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4022901A (en) * 1975-03-05 1977-05-10 E. R. Squibb & Sons, Inc. 3-Pyridinyl-5-isothiocyanophenyl oxadiazoles
US4122257A (en) * 1976-06-04 1978-10-24 Hoechst Aktiengesellschaft Benzofuran-oxadiazole compounds
WO1993013083A1 (en) * 1991-12-31 1993-07-08 Fujisawa Pharmaceutical Co., Ltd. Oxadiazole derivatives having acetylcholinesterase-inhibitory and muscarinic agonist activity
US20060019976A1 (en) * 2004-07-22 2006-01-26 Karp Gary M Methods for treating Hepatitis C
WO2006019832A1 (en) * 2004-07-22 2006-02-23 Ptc Therapeutics, Inc. Thienopyridines for treating hepatitis c

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
KOCEVAR ET AL.: "Ring transformations of some 4-aminopteridine-3-oxides and derivatives", TETRAHEDRON, vol. 39, no. 5, 1982, pages 823 - 829, XP002671613 *
POULAIN R F ET AL: "Parallel synthesis of 1,2,4-oxadiazoles from carboxylic acids using an improved, uronium-based, activation", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 42, no. 8, 1 January 2001 (2001-01-01), pages 1495 - 1498, XP002427070, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(00)02293-0 *
See also references of WO2009148452A1 *
STREET L J ET AL: "SYNTHESIS AND SEROTONERGIC ACTIVITY OF 5-(OXADIAZOLYL)TRYPTAMINES: POTENT AGONISTS FOR 5-HT 1D RECEPTORS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 36, no. 11, 11 May 1993 (1993-05-11), pages 1529 - 1538, XP002058071, ISSN: 0022-2623, DOI: 10.1021/JM00063A003 *

Also Published As

Publication number Publication date
MX2010013399A (en) 2010-12-21
EP2297140A1 (en) 2011-03-23
WO2009148452A1 (en) 2009-12-10
CA2725573A1 (en) 2009-12-10
JP2011522818A (en) 2011-08-04
CN102089297A (en) 2011-06-08

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