SK78598A3 - Complementary adenoviral vector systems and cell lines - Google Patents
Complementary adenoviral vector systems and cell lines Download PDFInfo
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- SK78598A3 SK78598A3 SK785-98A SK78598A SK78598A3 SK 78598 A3 SK78598 A3 SK 78598A3 SK 78598 A SK78598 A SK 78598A SK 78598 A3 SK78598 A3 SK 78598A3
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/572,126 US5851806A (en) | 1994-06-10 | 1995-12-14 | Complementary adenoviral systems and cell lines |
| PCT/US1996/019839 WO1997021826A2 (en) | 1995-12-14 | 1996-12-12 | Complementary adenoviral vector systems and cell lines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK78598A3 true SK78598A3 (en) | 1998-12-02 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK785-98A SK78598A3 (en) | 1995-12-14 | 1996-12-12 | Complementary adenoviral vector systems and cell lines |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5851806A (pt) |
| EP (1) | EP0870049B1 (pt) |
| JP (2) | JP3299761B2 (pt) |
| AT (1) | ATE320503T1 (pt) |
| AU (1) | AU711366B2 (pt) |
| BG (1) | BG62739B1 (pt) |
| BR (1) | BR9612677A (pt) |
| CA (1) | CA2238295C (pt) |
| CZ (1) | CZ182798A3 (pt) |
| DE (1) | DE69635931T2 (pt) |
| EA (1) | EA199800566A1 (pt) |
| EE (1) | EE9800185A (pt) |
| GE (1) | GEP20012559B (pt) |
| HU (1) | HUP9902310A3 (pt) |
| IL (1) | IL124797A0 (pt) |
| IS (1) | IS4762A (pt) |
| NO (1) | NO982687L (pt) |
| NZ (1) | NZ325627A (pt) |
| PL (1) | PL327984A1 (pt) |
| SK (1) | SK78598A3 (pt) |
| WO (1) | WO1997021826A2 (pt) |
Families Citing this family (168)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995034671A1 (en) * | 1994-06-10 | 1995-12-21 | Genvec, Inc. | Complementary adenoviral vector systems and cell lines |
| CN100569297C (zh) | 1995-02-28 | 2009-12-16 | 加利福尼亚大学董事会 | 基因转移介导的血管形成疗法 |
| US20030148968A1 (en) * | 1995-02-28 | 2003-08-07 | Hammond H. Kirk | Techniques and compositions for treating cardiovascular disease by in vivo gene delivery |
| US6281010B1 (en) * | 1995-06-05 | 2001-08-28 | The Trustees Of The University Of Pennsylvania | Adenovirus gene therapy vehicle and cell line |
| US6783980B2 (en) * | 1995-06-15 | 2004-08-31 | Crucell Holland B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
| US6265212B1 (en) * | 1995-06-15 | 2001-07-24 | Introgene B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
| DK0833934T4 (da) | 1995-06-15 | 2012-11-19 | Crucell Holland Bv | Pakningssystemer til human rekombinant adenovirus til anvendelse ved genterapi |
| US20030027250A1 (en) * | 1995-12-15 | 2003-02-06 | Mitchell Lloyd G. | Methods and compositions for use in spliceosome mediated RNA trans-splicing |
| US20060088938A1 (en) * | 1995-12-15 | 2006-04-27 | Mitchell Lloyd G | Methods and compositions for use in spliceosome mediated RNA trans-splicing in plants |
| US20020193580A1 (en) * | 1995-12-15 | 2002-12-19 | Mitchell Lloyd G. | Methods and compositions for use in spliceosome mediated RNA trans-splicing |
| JP4350800B2 (ja) * | 1996-09-25 | 2009-10-21 | ノバルティス アクチエンゲゼルシャフト | 高キャパシティーアデノウイルスベクターの開発の促進に使用するためのパッケージング細胞系 |
| US7232899B2 (en) | 1996-09-25 | 2007-06-19 | The Scripps Research Institute | Adenovirus vectors, packaging cell lines, compositions, and methods for preparation and use |
| IL131021A0 (en) * | 1997-01-29 | 2001-01-28 | Cornell Res Foundation Inc | Multiple site delivery of adenoviral vector for the induction of angiogenesis |
| US6706693B1 (en) | 1997-08-13 | 2004-03-16 | The Uab Research Foundation | Vaccination by topical application of genetic vectors |
| US6716823B1 (en) | 1997-08-13 | 2004-04-06 | The Uab Research Foundation | Noninvasive genetic immunization, expression products therefrom, and uses thereof |
| US6348450B1 (en) * | 1997-08-13 | 2002-02-19 | The Uab Research Foundation | Noninvasive genetic immunization, expression products therefrom and uses thereof |
| US6696423B1 (en) | 1997-08-29 | 2004-02-24 | Biogen, Inc. | Methods and compositions for therapies using genes encoding secreted proteins such as interferon-beta |
| IL141403A0 (en) | 1998-08-28 | 2002-03-10 | Univ Duke | Deleted adenoviruses and methods of making and administering the same |
| US6303362B1 (en) * | 1998-11-19 | 2001-10-16 | The Board Of Trustees Of The Leland Stanford Junior University | Adenoviral vector and methods for making and using the same |
| WO2001007571A1 (en) * | 1999-04-23 | 2001-02-01 | Introgene B.V. | Means and methods for nucleic acid transfer |
| US20040009936A1 (en) * | 1999-05-03 | 2004-01-15 | Tang De-Chu C. | Vaccine and drug delivery by topical application of vectors and vector extracts |
| US6793926B1 (en) | 1999-05-27 | 2004-09-21 | Genovo, Inc. | Methods for production of a recombinant adeno-associated virus |
| US6627190B2 (en) * | 1999-07-12 | 2003-09-30 | Saint Louis University | Recombinant adenovirus vectors that are replication-competent in tert-expressing cells |
| US6613516B1 (en) * | 1999-10-30 | 2003-09-02 | Affymetrix, Inc. | Preparation of nucleic acid samples |
| US6867022B1 (en) | 2000-01-21 | 2005-03-15 | Regents Of The University Of Michigan | Replication deficient adenovirus vectors and methods of making and using them |
| US6821775B1 (en) * | 2000-02-11 | 2004-11-23 | Genvec, Inc. | Viral vector encoding pigment epithelium-derived factor |
| US7653769B2 (en) * | 2006-12-14 | 2010-01-26 | International Business Machines Corporation | Management of devices connected to infiniband ports |
| US6591543B2 (en) * | 2000-04-14 | 2003-07-15 | Kenneth P. Sabine | Top water lure with highly active propeller |
| AU5882801A (en) | 2000-05-26 | 2001-12-03 | Sumitomo Pharmaceuticals Company, Limited | Novel recombinant adenovirus vector with relieved side effects |
| US6579522B1 (en) | 2000-06-27 | 2003-06-17 | Genvec, Inc. | Replication deficient adenoviral TNF vector |
| EP1203819A3 (en) | 2000-10-06 | 2002-08-07 | Transgene S.A. | Anti-inflammatory vectors |
| US6573092B1 (en) * | 2000-10-10 | 2003-06-03 | Genvec, Inc. | Method of preparing a eukaryotic viral vector |
| US20040126774A1 (en) * | 2001-01-08 | 2004-07-01 | Mitchell Lioyd G. | Correction of factor VIII genetic defects using spliceosome mediated RNA trans splicing |
| WO2003025161A1 (en) | 2001-09-18 | 2003-03-27 | Clontech Laboratories, Inc. | Site-specific recombinase based method for producing adenoviral vectors |
| US20030086903A1 (en) * | 2001-11-02 | 2003-05-08 | Genvec, Inc. | Therapeutic regimen for treating cancer |
| US20030087438A1 (en) * | 2001-11-02 | 2003-05-08 | Genvec, Inc. | E1-revertant-free adenoviral composition |
| US20030158112A1 (en) * | 2002-02-15 | 2003-08-21 | Johns Hopkins University School Of Medicine | Selective induction of apoptosis to treat ocular disease |
| US7399753B2 (en) * | 2002-02-25 | 2008-07-15 | Virxsys Corporation | Trans-splicing mediated photodynamic therapy |
| WO2004050680A2 (en) * | 2002-05-08 | 2004-06-17 | Intronn, Inc. | Use of spliceosome mediated rna trans-splicing to confer cell selective replication to adenoviruses |
| WO2004038380A2 (en) * | 2002-10-23 | 2004-05-06 | Intronn, Inc. | Screening methods for identification of efficient pre-trans-splicing molecules |
| AU2003297607A1 (en) * | 2002-12-02 | 2004-06-23 | Genvec, Inc | Materials and methods for treating ocular-related disorders |
| US20040166091A1 (en) * | 2003-02-24 | 2004-08-26 | Genvec, Inc. | Materials and methods for treating disorders of the ear |
| US20050118676A1 (en) * | 2003-03-19 | 2005-06-02 | Yan Qi | Gene therapy vectors having reduced immunogenicity |
| WO2005012537A2 (en) * | 2003-07-25 | 2005-02-10 | Genvec, Inc. | Adenoviral vector-based vaccines |
| DE602004025726D1 (de) * | 2003-11-14 | 2010-04-08 | Genvec Inc | Pharmazeutische verbindung zur behandlung von lokal fortgeschrittenem primär inoperablen pankreaskarzinom (lapc). |
| CN101507822B (zh) * | 2003-11-24 | 2012-06-06 | 坎吉有限公司 | 皮肤瘢痕形成的减少 |
| US8053232B2 (en) | 2004-01-23 | 2011-11-08 | Virxsys Corporation | Correction of alpha-1-antitrypsin genetic defects using spliceosome mediated RNA trans splicing |
| US7968334B2 (en) * | 2004-01-23 | 2011-06-28 | Virxsys Corporation | Expression of apoAI and variants thereof using spliceosome mediated RNA trans-splicing |
| WO2005070023A2 (en) * | 2004-01-23 | 2005-08-04 | Intronn, Inc. | Expression of apoa-1 and variants thereof using spliceosome mediated rna trans-splicing |
| DE602005015332D1 (de) * | 2004-02-23 | 2009-08-20 | Crucell Holland Bv | Verfahren zur Reinigung von Viren |
| WO2005089811A1 (en) * | 2004-03-12 | 2005-09-29 | Genvec, Inc. | Materials for treating vascular leakage in the eye |
| CN1972958B (zh) | 2004-04-12 | 2013-01-23 | 美国政府卫生与公共服务部 | 应用腺病毒载体诱导免疫应答的方法 |
| CN101068574B (zh) * | 2004-07-20 | 2012-07-18 | 伊索格尼斯股份有限公司 | 与自身抗原有关的自身免疫和疾病的特异性抑制 |
| US20060094110A1 (en) * | 2004-07-30 | 2006-05-04 | Mcgarrity Gerard J | Use of spliceosome mediated RNA trans-splicing for immunotherapy |
| US20060134658A1 (en) * | 2004-08-09 | 2006-06-22 | Garcia-Blanco Mariano A | Use of RNA trans-splicing for generation of interfering RNA molecules |
| JP2008511336A (ja) * | 2004-09-01 | 2008-04-17 | アメリカ合衆国 | 免疫原性が増加したアデノウイルスベクターをインビボで用いる方法 |
| DE102004047492B4 (de) * | 2004-09-23 | 2006-07-20 | Jost-Werke Gmbh & Co. Kg | Verfahren zum Übertragen von elektrischer, pneumatischer oder hydraulischer Energie sowie ein Energieübertragungssystem |
| US7871795B2 (en) | 2004-10-08 | 2011-01-18 | Virxsys Corporation | Targeted trans-splicing of highly abundant transcripts for in vivo production of recombinant proteins |
| WO2006083331A2 (en) * | 2004-10-08 | 2006-08-10 | Intronn, Inc | Use of rna trans-splicing for antibody gene transfer and antibody polypeptide production |
| US20060188481A1 (en) * | 2005-02-22 | 2006-08-24 | Saitama Medical School | Methods for prophylactically or therapeutically treating an animal for an ocular-related disorder |
| WO2006091722A2 (en) | 2005-02-23 | 2006-08-31 | Uab Research Foundation | Alkyl-glycoside enhanced vaccination |
| ES2317517T5 (es) * | 2005-04-11 | 2016-01-21 | Crucell Holland B.V. | Purificación de virus usando ultrafiltración |
| US8450055B2 (en) * | 2005-08-31 | 2013-05-28 | The United States Of America As Represented By The Secretary Of The Navy | Malaria antigen screening method |
| US9651543B2 (en) | 2005-08-31 | 2017-05-16 | The United States Of America As Represented By The Secretary Of The Navy | Malaria antigen screening method |
| AU2006284756B2 (en) * | 2005-08-31 | 2012-06-07 | Genvec, Inc. | Adenoviral vector-based malaria vaccines |
| CA2629163C (en) * | 2005-11-10 | 2017-03-21 | Genvec, Inc. | Adenoviral vector-based foot-and-mouth disease vaccine |
| WO2008086386A2 (en) * | 2007-01-09 | 2008-07-17 | Genvec, Inc. | Adenoviral vector-based malaria vaccines |
| WO2008112540A2 (en) * | 2007-03-09 | 2008-09-18 | Vectorlogics, Inc. | Cells for adenovirus vector and protein production |
| US20100263066A1 (en) * | 2007-04-30 | 2010-10-14 | Medtronic, Inc | Inert dna sequences for efficient viral packaging and methods of use |
| US20090202492A1 (en) * | 2008-01-25 | 2009-08-13 | University Of South Florida | Adenovirus vaccine utilizing ikk as adjuvant |
| US8871515B2 (en) | 2008-09-17 | 2014-10-28 | Isogenis, Inc. | Construction of fully-deleted adenovirus-based gene delivery vectors and uses thereof |
| DK2350268T3 (en) * | 2008-11-03 | 2015-03-23 | Crucell Holland Bv | PROCEDURE FOR PRODUCING ADENOVIRUS VECTORS |
| PL2488636T3 (pl) | 2009-10-15 | 2014-07-31 | Crucell Holland Bv | Sposób oczyszczania cząsteczek adenowirusów z hodowli o wysokim zagęszczeniu komórkowym |
| JP5465331B2 (ja) | 2009-10-15 | 2014-04-09 | クルセル ホランド ベー ヴェー | 高細胞密度の培養物からのアデノウイルスの精製方法 |
| US20120219583A1 (en) | 2009-10-16 | 2012-08-30 | Los Alamos National Security, Llc | Nucleic acid sequences encoding expandable hiv mosaic proteins |
| EP2853266B1 (en) | 2009-11-09 | 2018-01-31 | Genvec, Inc. | Method of propagating monkey adenoviral vectors |
| WO2011057254A2 (en) | 2009-11-09 | 2011-05-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Simian adenoviral vector-based vaccines |
| EA023816B1 (ru) | 2010-02-15 | 2016-07-29 | Круселл Холланд Б.В. | СПОСОБ ПРОДУЦИРОВАНИЯ ВИРУСНЫХ ЧАСТИЦ Ad26 |
| US9682133B2 (en) | 2010-03-17 | 2017-06-20 | Cornell University | Disrupted adenovirus-based vaccine against drugs of abuse |
| CN103038343A (zh) | 2010-03-23 | 2013-04-10 | 英特瑞克斯顿股份有限公司 | 条件表达治疗蛋白的载体，包含所述载体的宿主细胞，及其应用 |
| WO2012021730A2 (en) | 2010-08-11 | 2012-02-16 | Genvec, Inc. | Respiratory syncytial virus (rsv) vaccine |
| CA2808556A1 (en) | 2010-09-20 | 2012-03-29 | Crucell Holland B.V. | Therapeutic vaccination against active tuberculosis |
| MX354752B (es) | 2010-09-27 | 2018-03-20 | Janssen Vaccines & Prevention Bv | Regimen de vacunacion de sensibilizacion y refuerzo heterologo contra malaria. |
| WO2012083297A2 (en) | 2010-12-17 | 2012-06-21 | Genvec, Inc. | Adenoviral vectors with modified hexon regions |
| EP2654786B1 (en) | 2010-12-20 | 2019-02-20 | GenVec, Inc. | Adenoviral vector-based dengue fever vaccine |
| CA2828411A1 (en) | 2011-03-04 | 2012-09-13 | Intrexon Corporation | Vectors conditionally expressing protein |
| WO2012162428A1 (en) | 2011-05-23 | 2012-11-29 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Prime-boost vaccination for viral infection |
| EP2764014B1 (en) | 2011-10-05 | 2022-02-09 | GenVec, Inc. | Adenoviral vectors and methods of use |
| WO2013052859A2 (en) | 2011-10-05 | 2013-04-11 | Genvec, Inc. | Adenoviral vector-based respiratory syncytial virus (rsv) vaccine |
| CA2850629C (en) | 2011-10-05 | 2024-05-21 | Genvec, Inc. | Affenadenovirus (gorilla) or adenoviral vectors and methods of use |
| US9629906B2 (en) | 2011-10-05 | 2017-04-25 | Genvec, Inc. | Affenadenovirus (gorilla) or adenoviral vectors and methods of use |
| EP2780034A1 (en) | 2011-11-14 | 2014-09-24 | Crucell Holland B.V. | Heterologous prime-boost immunization using measles virus-based vaccines |
| EP2809346A1 (en) | 2012-02-02 | 2014-12-10 | GenVec, Inc. | Adenoviral vector-based malaria vaccine |
| SG11201405228VA (en) | 2012-03-12 | 2014-11-27 | Crucell Holland Bv | Batches of recombinant adenovirus with altered terminal ends |
| US8932607B2 (en) | 2012-03-12 | 2015-01-13 | Crucell Holland B.V. | Batches of recombinant adenovirus with altered terminal ends |
| CN105431169B (zh) | 2012-03-22 | 2019-04-02 | 扬森疫苗与预防公司 | 抗rsv疫苗 |
| US9125870B2 (en) | 2012-03-22 | 2015-09-08 | Crucell Holland B.V. | Vaccine against RSV |
| EP2855669B1 (en) | 2012-05-29 | 2018-10-10 | GenVec, Inc. | Modified serotype 28 adenoviral vectors |
| US9676824B2 (en) | 2012-05-29 | 2017-06-13 | Genvec, Inc. | Herpes simplex virus vaccine |
| US10017543B2 (en) | 2013-03-13 | 2018-07-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Prefusion RSV F proteins and their use |
| EA035522B1 (ru) | 2013-04-25 | 2020-06-29 | Янссен Вэксинс Энд Превеншн Б.В. | Стабильные растворимые f-полипептиды rsv в конформации "до слияния" |
| CN105408348B (zh) | 2013-06-17 | 2021-07-06 | 扬森疫苗与预防公司 | 稳定化的可溶性融合前rsv f多肽 |
| PT3046536T (pt) | 2013-09-19 | 2019-02-25 | Janssen Vaccines & Prevention Bv | Formulações de adenovírus melhoradas |
| WO2016037154A1 (en) | 2014-09-04 | 2016-03-10 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Recombinant hiv-1 envelope proteins and their use |
| TWI710635B (zh) * | 2014-10-09 | 2020-11-21 | 美商珍維克公司 | 編碼人類無調同源物-1(hath1)之腺病毒載體 |
| HUE040440T2 (hu) | 2014-11-04 | 2019-03-28 | Janssen Vaccines & Prevention Bv | Terápiás HPV16-oltóanyagok |
| EP3236998A1 (en) | 2014-12-24 | 2017-11-01 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Recombinant metapneumovirus f proteins and their use |
| CN107406835A (zh) | 2015-01-20 | 2017-11-28 | 美利坚合众国,由健康及人类服务部部长代表 | 表达嵌合rsv/bpiv3f蛋白的重组人/牛副流感病毒3(b/hpiv3)及其用途 |
| KR20170140180A (ko) | 2015-02-24 | 2017-12-20 | 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 | 중동 호흡기 증후군 코로나 바이러스 면역원, 항체 및 그 용도 |
| HUE051897T2 (hu) | 2015-03-18 | 2021-03-29 | Janssen Vaccines & Prevention Bv | Vizsgálatok rekombináns expressziós rendszerekre |
| EP3283634B1 (en) | 2015-04-14 | 2019-05-22 | Janssen Vaccines & Prevention B.V. | Recombinant adenovirus expressing two transgenes with a bidirectional promoter |
| EP3821906A1 (en) | 2015-07-07 | 2021-05-19 | Janssen Vaccines & Prevention B.V. | Vaccine against rsv comprising modified f polypeptide |
| US10457708B2 (en) | 2015-07-07 | 2019-10-29 | Janssen Vaccines & Prevention B.V. | Stabilized soluble pre-fusion RSV F polypeptides |
| CA2995740A1 (en) | 2015-08-20 | 2017-02-23 | Janssen Vaccines & Prevention B.V. | Therapeutic hpv18 vaccines |
| EP3359132B1 (en) | 2015-10-06 | 2023-08-16 | Janssen Vaccines & Prevention B.V. | Methods for preventing plastic-induced degradation of biologicals |
| WO2017139392A1 (en) | 2016-02-08 | 2017-08-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Recombinant hiv-1 envelope proteins and their use |
| EP3426291A1 (en) | 2016-03-09 | 2019-01-16 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Recombinant hiv-1 envelope proteins and their use |
| PE20190420A1 (es) | 2016-04-05 | 2019-03-19 | Janssen Vaccines And Prevention B V | Proteinas f de prefusion del virus respiratorio sincicial (vrs) solubles y estabilizadas |
| IL262109B2 (en) | 2016-04-05 | 2023-04-01 | Janssen Vaccines Prevention B V | vaccine against rsv |
| BR112018072372A2 (pt) | 2016-05-02 | 2019-02-19 | Janssen Vaccines & Prevention B.V. | combinações de vacina terapêutica contra o hpv |
| MY194419A (en) | 2016-05-30 | 2022-11-30 | Janssen Vaccines & Prevention Bv | Stabilized pre-fusion rsv f proteins |
| US11001858B2 (en) | 2016-06-20 | 2021-05-11 | Janssen Vaccines & Prevention B.V. | Potent and balanced bidirectional promoter |
| EP3484506A1 (en) | 2016-07-14 | 2019-05-22 | Janssen Vaccines & Prevention B.V. | Hpv vaccines |
| US11155832B2 (en) | 2016-09-30 | 2021-10-26 | Genvec, Inc. | Adenovectors for delivery of therapeutic genetic material into T cells |
| EP4070815A1 (en) | 2016-10-03 | 2022-10-12 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Hiv-1 env fusion peptide immunogens and their use |
| US10960070B2 (en) | 2016-10-25 | 2021-03-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Prefusion coronavirus spike proteins and their use |
| WO2018109220A2 (en) | 2016-12-16 | 2018-06-21 | Institute For Research In Biomedicine | Novel recombinant prefusion rsv f proteins and uses thereof |
| CN110268061B (zh) | 2017-02-09 | 2024-07-16 | 扬森疫苗与预防公司 | 用于表达异源基因的有效的短启动子 |
| EP3600405A1 (en) | 2017-03-24 | 2020-02-05 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Glycan-masked engineered outer domains of hiv-1 gp120 and their use |
| BR112019023477A2 (pt) | 2017-05-08 | 2020-06-30 | Gritstone Oncology, Inc. | vetores de neoantígeno de alfavírus |
| EP3624844A1 (en) | 2017-05-17 | 2020-03-25 | Janssen Vaccines & Prevention B.V. | Methods and compositions for inducing protective immunity against rsv infection |
| MX2020002876A (es) | 2017-09-15 | 2020-07-22 | Janssen Vaccines & Prevention Bv | Metodo para la induccion segura de inmunidad contra el vsr. |
| WO2019079337A1 (en) | 2017-10-16 | 2019-04-25 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | RECOMBINANT HIV-1 ENVELOPE PROTEINS AND THEIR USE |
| CA3077630A1 (en) | 2017-10-31 | 2019-05-09 | Janssen Vaccines & Prevention B.V. | Adenovirus vectors and uses thereof |
| KR20200083510A (ko) | 2017-10-31 | 2020-07-08 | 얀센 백신스 앤드 프리벤션 비.브이. | 아데노바이러스 및 이의 용도 |
| KR20200074987A (ko) | 2017-10-31 | 2020-06-25 | 얀센 백신스 앤드 프리벤션 비.브이. | 아데노바이러스 및 이의 용도 |
| EA202091074A1 (ru) | 2017-10-31 | 2020-07-22 | Янссен Вэксинс Энд Превеншн Б.В. | Аденовирус и его применения |
| PL3743106T3 (pl) | 2018-01-23 | 2022-11-14 | Janssen Vaccines & Prevention B.V. | Szczepionki przeciwko wirusowi grypy i ich zastosowanie |
| WO2019173463A1 (en) | 2018-03-06 | 2019-09-12 | Intrexon Corporation | Hepatitis b vaccines and uses of the same |
| US20210340188A1 (en) | 2018-10-22 | 2021-11-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic | Recombinant gp120 protein with v1-loop deletion |
| CN113573729A (zh) | 2019-01-10 | 2021-10-29 | 詹森生物科技公司 | 前列腺新抗原及其用途 |
| KR20220005002A (ko) | 2019-04-25 | 2022-01-12 | 얀센 백신스 앤드 프리벤션 비.브이. | 재조합 인플루엔자 항원 |
| CN113924113A (zh) | 2019-05-15 | 2022-01-11 | 扬森疫苗与预防公司 | 季节性流感疫苗与基于腺病毒的呼吸道合胞病毒疫苗的共同施用 |
| WO2020229579A1 (en) | 2019-05-15 | 2020-11-19 | Janssen Vaccines & Prevention B.V. | Prophylactic treatment of respiratory syncytial virus infection with an adenovirus based vaccine |
| MX2021014525A (es) | 2019-05-30 | 2022-03-17 | Gritstone Bio Inc | Adenovirus modificados. |
| JP2022547107A (ja) | 2019-09-05 | 2022-11-10 | ヤンセン ファッシンズ アンド プリベンション ベーフェー | インフルエンザウイルスワクチン及びその使用 |
| CN114710957A (zh) | 2019-10-03 | 2022-07-05 | 扬森疫苗与预防公司 | 腺病毒载体及其用途 |
| CN114761546A (zh) | 2019-10-08 | 2022-07-15 | 波士顿学院董事会 | 含有多个不同非天然氨基酸的蛋白质以及制备和使用此类蛋白质的方法 |
| IL293051A (en) | 2019-11-18 | 2022-07-01 | Janssen Biotech Inc | calr and jak2 mutant-based vaccines and their uses |
| CN118767143A (zh) | 2019-12-12 | 2024-10-15 | 听治疗有限责任公司 | 用于预防和治疗听力损失的组合物和方法 |
| WO2021163365A1 (en) | 2020-02-11 | 2021-08-19 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Sars-cov-2 vaccine |
| TW202144389A (zh) | 2020-02-14 | 2021-12-01 | 美商健生生物科技公司 | 在多發性骨髓瘤中表現之新抗原及其用途 |
| TW202144388A (zh) | 2020-02-14 | 2021-12-01 | 美商健生生物科技公司 | 在卵巢癌中表現之新抗原及其用途 |
| CN115484978A (zh) | 2020-03-05 | 2022-12-16 | 尼奥克斯医疗有限公司 | 使用免疫细胞治疗癌症的方法和组合物 |
| US11213482B1 (en) | 2020-03-05 | 2022-01-04 | University of Pittsburgh—Of the Commonwealth System of Higher Educat | SARS-CoV-2 subunit vaccine and microneedle array delivery system |
| US11773391B2 (en) | 2020-04-01 | 2023-10-03 | University of Pittsburgh—of the Commonwealth System of Higher Education | Therapeutic and diagnostic target for SARS-CoV-2 and COVID-19 |
| WO2021209897A1 (en) | 2020-04-13 | 2021-10-21 | Janssen Biotech, Inc. | Psma and steap1 vaccines and their uses |
| EP4142785A2 (en) | 2020-04-29 | 2023-03-08 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Recombinant human metapneumovirus f proteins and their use |
| US20230024133A1 (en) | 2020-07-06 | 2023-01-26 | Janssen Biotech, Inc. | Prostate Neoantigens And Their Uses |
| WO2022009051A1 (en) | 2020-07-06 | 2022-01-13 | Janssen Biotech, Inc. | A method for determining responsiveness to prostate cancer treatment |
| EP4175664A2 (en) | 2020-07-06 | 2023-05-10 | Janssen Biotech, Inc. | Prostate neoantigens and their uses |
| WO2022035860A2 (en) | 2020-08-10 | 2022-02-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Replication-competent adenovirus type 4-hiv env vaccines and their use |
| US20240228549A1 (en) | 2021-04-29 | 2024-07-11 | The U.S.A., As Represented By The Secretary, Department Of Health And Human Services | Prefusion-stabilized lassa virus glycoprotein complex and its use |
| AU2022323509A1 (en) | 2021-08-03 | 2024-02-08 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Hiv-1 vaccination and samt-247 microbicide to prevent hiv-1 infection |
| WO2023091696A1 (en) | 2021-11-19 | 2023-05-25 | Christiana Care Gene Editing Institute, Inc. | Adenovirus delivery system for cancer treatment |
| WO2023192835A1 (en) | 2022-03-27 | 2023-10-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Base-covered hiv-1 envelope ectodomains and their use |
| WO2023196898A1 (en) | 2022-04-07 | 2023-10-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Beta globin mimetic peptides and their use |
| EP4338727A1 (en) | 2022-09-14 | 2024-03-20 | Roquette Freres | Adenovirus formulations |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4405712A (en) * | 1981-07-01 | 1983-09-20 | The United States Of America As Represented By The Department Of Health And Human Services | LTR-Vectors |
| US5585362A (en) * | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| WO1994008026A1 (en) * | 1992-09-25 | 1994-04-14 | Rhone-Poulenc Rorer S.A. | Adenovirus vectors for the transfer of foreign genes into cells of the central nervous system, particularly in brain |
| EP0957172B1 (en) * | 1992-11-18 | 2005-10-19 | Arch Development Corporation | Adenovirus-mediated gene transfer to cardiac and vascular smooth muscle |
| AU680459B2 (en) * | 1992-12-03 | 1997-07-31 | Genzyme Corporation | Gene therapy for cystic fibrosis |
| FR2705686B1 (fr) * | 1993-05-28 | 1995-08-18 | Transgene Sa | Nouveaux adénovirus défectifs et lignées de complémentation correspondantes. |
| CA2166118C (en) * | 1993-06-24 | 2007-04-17 | Frank L. Graham | Adenovirus vectors for gene therapy |
| FR2707664B1 (fr) * | 1993-07-13 | 1995-09-29 | Centre Nat Rech Scient | Vecteurs viraux et utilisation en thérapie génique. |
| RU2219241C2 (ru) * | 1993-07-13 | 2003-12-20 | Рон-Пуленк Роре С.А. | Дефектный рекомбинантный аденовирусный вектор (варианты) |
| LU88429A1 (fr) * | 1993-11-23 | 1995-07-10 | Wurth Paul Sa | Dispositif de chargement d'un four à cuve |
| CA2117668C (en) * | 1994-03-09 | 2005-08-09 | Izumu Saito | Recombinant adenovirus and process for producing the same |
| US5872005A (en) * | 1994-11-03 | 1999-02-16 | Cell Genesys Inc. | Packaging cell lines for adeno-associated viral vectors |
-
1995
- 1995-12-14 US US08/572,126 patent/US5851806A/en not_active Expired - Lifetime
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1996
- 1996-12-12 SK SK785-98A patent/SK78598A3/sk unknown
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