SK400992A3 - Quinazolines derivatives for enhancing antitumor activity - Google Patents
Quinazolines derivatives for enhancing antitumor activity Download PDFInfo
- Publication number
- SK400992A3 SK400992A3 SK4009-92A SK400992A SK400992A3 SK 400992 A3 SK400992 A3 SK 400992A3 SK 400992 A SK400992 A SK 400992A SK 400992 A3 SK400992 A3 SK 400992A3
- Authority
- SK
- Slovakia
- Prior art keywords
- methoxy
- carbon atoms
- hydrogen
- alkoxy
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preventing Corrosion Or Incrustation Of Metals (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60998690A | 1990-11-06 | 1990-11-06 | |
| PCT/US1991/007254 WO1992007844A1 (en) | 1990-11-06 | 1991-10-10 | Quinazolines derivatives for enhancing antitumor activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK400992A3 true SK400992A3 (en) | 1995-08-09 |
Family
ID=24443149
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK4009-92A SK400992A3 (en) | 1990-11-06 | 1991-10-10 | Quinazolines derivatives for enhancing antitumor activity |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5444062A (el) |
| EP (1) | EP0556310B1 (el) |
| JP (1) | JPH05507290A (el) |
| KR (1) | KR930702292A (el) |
| CN (1) | CN1061411A (el) |
| AT (1) | ATE124694T1 (el) |
| BR (1) | BR9107070A (el) |
| CA (1) | CA2095213A1 (el) |
| CZ (1) | CZ400992A3 (el) |
| DE (2) | DE9190155U1 (el) |
| DK (1) | DK0556310T3 (el) |
| ES (1) | ES2074867T3 (el) |
| FI (1) | FI932032A0 (el) |
| GR (1) | GR3017122T3 (el) |
| HU (1) | HUT64533A (el) |
| IE (1) | IE913854A1 (el) |
| IL (1) | IL99906A0 (el) |
| MX (1) | MX9101913A (el) |
| NO (1) | NO931635L (el) |
| NZ (1) | NZ240476A (el) |
| PT (1) | PT99415A (el) |
| SK (1) | SK400992A3 (el) |
| WO (1) | WO1992007844A1 (el) |
| YU (1) | YU47993B (el) |
| ZA (1) | ZA918767B (el) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2599992A (en) * | 1991-11-12 | 1993-06-15 | Pfizer Inc. | Triazine derivatives for enhancing antitumor activity |
| KR0144833B1 (ko) | 1992-12-28 | 1998-07-15 | 김태훈 | 신규의 퀴나졸린 유도체 및 그의 제조방법 |
| IL112249A (en) | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
| IL112248A0 (en) | 1994-01-25 | 1995-03-30 | Warner Lambert Co | Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them |
| CN1058265C (zh) * | 1994-05-16 | 2000-11-08 | 株式会社柳韩洋行 | 喹唑啉衍生物,其制备方法及包含该物质的组合物 |
| DE69530989T2 (de) * | 1994-08-13 | 2004-05-19 | Yuhan Corp. | Neue pyrimidinderivate und verfahren zu ihrer herstellung |
| AU3578595A (en) * | 1994-11-25 | 1996-06-19 | Nippon Chemiphar Co. Ltd. | Quinazoline derivative |
| TW334434B (en) * | 1995-05-16 | 1998-06-21 | Kanebo Ltd | Novel quinazoline compound and anti-tumor agent |
| WO1997020822A1 (en) * | 1995-12-01 | 1997-06-12 | Novartis Ag | Quinazolin-2,4-diazirines as npy receptor antagonist |
| WO1997020823A2 (en) * | 1995-12-01 | 1997-06-12 | Novartis Ag | 2-amino quinazoline derivatives as npy receptor antagonists |
| SI0892789T2 (sl) * | 1996-04-12 | 2010-03-31 | Warner Lambert Co | Ireverzibilni inhibitorji tirozin kinaz |
| IN188411B (el) | 1997-03-27 | 2002-09-21 | Yuhan Corp | |
| US6184226B1 (en) | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
| KR100272471B1 (ko) | 1998-11-17 | 2000-11-15 | 김선진 | 신규의 피리미딘 유도체 및 그의 제조방법 |
| DE60006618T2 (de) * | 1999-08-06 | 2004-09-23 | F. Hoffmann-La Roche Ag | Tetrahydro-benzo(d)azepine und deren Verwendung als metabotrope Glutamatrezeptor-Antagonisten |
| US6608053B2 (en) * | 2000-04-27 | 2003-08-19 | Yamanouchi Pharmaceutical Co., Ltd. | Fused heteroaryl derivatives |
| US6369222B1 (en) * | 2000-07-18 | 2002-04-09 | Hoffmann-La Roche Inc. | mGluR antagonists and a method for their synthesis |
| US6900226B2 (en) * | 2000-09-06 | 2005-05-31 | Hoffman-La Roche Inc. | Neuropeptide Y antagonists |
| PE20030008A1 (es) | 2001-06-19 | 2003-01-22 | Bristol Myers Squibb Co | Inhibidores duales de pde 7 y pde 4 |
| JP2005523237A (ja) | 2001-10-01 | 2005-08-04 | 大正製薬株式会社 | Ｍｃｈ受容体アンタゴニスト |
| GB0130341D0 (en) * | 2001-12-19 | 2002-02-06 | Smithkline Beecham Plc | Compounds |
| WO2003055866A1 (en) * | 2001-12-21 | 2003-07-10 | Bayer Pharmaceuticals Corporation | Quinazoline and quinoline derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents |
| CN1665791A (zh) | 2002-07-05 | 2005-09-07 | 霍夫曼-拉罗奇有限公司 | 喹唑啉衍生物 |
| FR2845994B1 (fr) * | 2002-10-18 | 2006-05-19 | Servier Lab | Nouveaux derives de benzo[e][1,4]oxazino[3,2-g]isoindole substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| JP2006523638A (ja) | 2003-04-16 | 2006-10-19 | エフ．ホフマン−ラ ロシュ アーゲー | キナゾリン化合物 |
| KR100557093B1 (ko) * | 2003-10-07 | 2006-03-03 | 한미약품 주식회사 | 다약제 내성 저해 활성을 갖는 테트라졸 유도체 및 그의제조방법 |
| JP4796622B2 (ja) * | 2005-04-11 | 2011-10-19 | エフ．ホフマン−ラ ロシュ アーゲー | （３，４−ジヒドロ−キナゾリン−２−イル）−インダン−１−イル−アミン |
| CN101100466B (zh) | 2006-07-05 | 2013-12-25 | 天津和美生物技术有限公司 | 不可逆蛋白质酪氨酸磷酰化酶抑制剂及其制备和应用 |
| CA2793299A1 (en) | 2010-03-16 | 2011-09-22 | Merck Patent Gmbh | Morpholinylquinazolines |
| DE102010025786A1 (de) | 2010-07-01 | 2012-01-05 | Merck Patent Gmbh | Pyrazolochinoline |
| DE102010035744A1 (de) | 2010-08-28 | 2012-03-01 | Merck Patent Gmbh | Imidazolonylchinoline |
| US8673914B2 (en) | 2011-03-28 | 2014-03-18 | St. John's University | Use of phosphodiesterase inhibitors for treating multidrug resistance |
| DE102011118830A1 (de) | 2011-11-18 | 2013-05-23 | Merck Patent Gmbh | Morpholinylbenzotriazine |
| DE102013008118A1 (de) | 2013-05-11 | 2014-11-13 | Merck Patent Gmbh | Arylchinazoline |
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| CN108324717B (zh) * | 2018-01-24 | 2020-08-21 | 浙江工业大学 | 特戊酰氨基氯代苯并[d]氮杂*基喹唑啉类化合物在制备治疗宫颈癌药物中的应用 |
| CN108078993B (zh) * | 2018-01-24 | 2020-02-21 | 浙江工业大学 | 6-硝基喹唑啉类化合物在制备治疗肺癌药物中的应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE958197C (de) * | 1952-04-18 | 1957-02-14 | Dr Siegfried Skraup | Verfahren zur Herstellung von 2, 4-Diaminochinazolin |
| CH457460A (fr) * | 1966-06-20 | 1968-06-15 | Parke Davis & Co | Procédé de préparation de quinazolines |
| US3511836A (en) * | 1967-12-13 | 1970-05-12 | Pfizer & Co C | 2,4,6,7-tetra substituted quinazolines |
| US3635979A (en) * | 1969-09-29 | 1972-01-18 | Pfizer | Certain 6- and/or 7-alkoxy-substituted-2 4-bis(disubstituted amino) quinazolines |
| GB1390015A (en) * | 1971-05-07 | 1975-04-09 | Koninklijke Pharma Fab Nv | 4-amino-quinazoline compounds |
| GB1383409A (en) * | 1972-09-09 | 1974-02-12 | Pfizer Ltd | Derivatives of 2-amino- and 4-amino-quinazoline and pharmaceutical compositions containing them |
| US3956495A (en) * | 1973-10-30 | 1976-05-11 | Eli Lilly And Company | 2,4-Diaminoquinazolines as antithrombotic agents |
| FR2389614A1 (en) * | 1977-05-05 | 1978-12-01 | Synthelabo | Antihypertensive 2,4-di:amino-quinazoline(s) - prepd. from a 2-halo-4-amino-quinazoline and a secondary amine |
| US4098788A (en) * | 1977-06-20 | 1978-07-04 | Bristol-Myers Company | Process for preparing quinazolines |
| US4287341A (en) * | 1979-11-01 | 1981-09-01 | Pfizer Inc. | Alkoxy-substituted-6-chloro-quinazoline-2,4-diones |
| IL88507A (en) * | 1987-12-03 | 1993-02-21 | Smithkline Beckman Intercredit | 2,4-diaminoquinazolines, process for their preparation and pharmaceutical compositions comprising them |
| IL89027A (en) * | 1988-01-29 | 1993-01-31 | Lilly Co Eli | Quinazoline derivatives, process for their preparation and fungicidal, insecticidal and miticidal compositions containing them |
| GB8910722D0 (en) * | 1989-05-10 | 1989-06-28 | Smithkline Beckman Intercredit | Compounds |
-
1991
- 1991-10-10 HU HU9301314A patent/HUT64533A/hu unknown
- 1991-10-10 EP EP92900750A patent/EP0556310B1/en not_active Expired - Lifetime
- 1991-10-10 DE DE9190155U patent/DE9190155U1/de not_active Expired - Lifetime
- 1991-10-10 WO PCT/US1991/007254 patent/WO1992007844A1/en not_active Application Discontinuation
- 1991-10-10 AT AT92900750T patent/ATE124694T1/de active
- 1991-10-10 SK SK4009-92A patent/SK400992A3/sk unknown
- 1991-10-10 KR KR1019930701349A patent/KR930702292A/ko not_active Application Discontinuation
- 1991-10-10 ES ES92900750T patent/ES2074867T3/es not_active Expired - Lifetime
- 1991-10-10 CA CA002095213A patent/CA2095213A1/en not_active Abandoned
- 1991-10-10 US US08/050,047 patent/US5444062A/en not_active Expired - Lifetime
- 1991-10-10 CZ CS924009A patent/CZ400992A3/cs unknown
- 1991-10-10 DK DK92900750.8T patent/DK0556310T3/da active
- 1991-10-10 BR BR9107070A patent/BR9107070A/pt not_active Application Discontinuation
- 1991-10-10 JP JP92501815A patent/JPH05507290A/ja active Pending
- 1991-10-10 DE DE69111077T patent/DE69111077T2/de not_active Expired - Fee Related
- 1991-10-30 IL IL99906A patent/IL99906A0/xx unknown
- 1991-11-04 PT PT99415A patent/PT99415A/pt not_active Application Discontinuation
- 1991-11-04 MX MX9101913A patent/MX9101913A/es unknown
- 1991-11-05 ZA ZA918767A patent/ZA918767B/xx unknown
- 1991-11-05 IE IE385491A patent/IE913854A1/en unknown
- 1991-11-05 NZ NZ240476A patent/NZ240476A/en unknown
- 1991-11-05 YU YU176191A patent/YU47993B/sh unknown
- 1991-11-05 CN CN91108479A patent/CN1061411A/zh active Pending
-
1993
- 1993-05-05 FI FI932032A patent/FI932032A0/fi not_active Application Discontinuation
- 1993-05-05 NO NO93931635A patent/NO931635L/no unknown
-
1995
- 1995-08-16 GR GR950402241T patent/GR3017122T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2095213A1 (en) | 1992-05-07 |
| EP0556310A1 (en) | 1993-08-25 |
| IL99906A0 (en) | 1992-08-18 |
| ES2074867T3 (es) | 1995-09-16 |
| HUT64533A (en) | 1994-01-28 |
| CN1061411A (zh) | 1992-05-27 |
| ATE124694T1 (de) | 1995-07-15 |
| US5444062A (en) | 1995-08-22 |
| MX9101913A (es) | 1992-07-08 |
| KR930702292A (ko) | 1993-09-08 |
| HU9301314D0 (en) | 1993-09-28 |
| FI932032A (fi) | 1993-05-05 |
| YU176191A (sh) | 1994-01-20 |
| NZ240476A (en) | 1994-04-27 |
| DE69111077T2 (de) | 1995-11-02 |
| PT99415A (pt) | 1992-09-30 |
| JPH05507290A (ja) | 1993-10-21 |
| NO931635D0 (no) | 1993-05-05 |
| AU644035B2 (en) | 1993-12-02 |
| FI932032A0 (fi) | 1993-05-05 |
| AU9059291A (en) | 1992-05-26 |
| ZA918767B (en) | 1993-05-05 |
| IE913854A1 (en) | 1992-05-22 |
| DE69111077D1 (de) | 1995-08-10 |
| WO1992007844A1 (en) | 1992-05-14 |
| DE9190155U1 (de) | 1993-10-07 |
| BR9107070A (pt) | 1994-05-31 |
| DK0556310T3 (da) | 1995-08-21 |
| NO931635L (no) | 1993-05-05 |
| EP0556310B1 (en) | 1995-07-05 |
| GR3017122T3 (en) | 1995-11-30 |
| YU47993B (sh) | 1996-08-13 |
| CZ400992A3 (en) | 1993-12-15 |
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