IL99906A0 - Quinazoline derivatives for enhancing antitumor activity - Google Patents
Quinazoline derivatives for enhancing antitumor activityInfo
- Publication number
- IL99906A0 IL99906A0 IL99906A IL9990691A IL99906A0 IL 99906 A0 IL99906 A0 IL 99906A0 IL 99906 A IL99906 A IL 99906A IL 9990691 A IL9990691 A IL 9990691A IL 99906 A0 IL99906 A0 IL 99906A0
- Authority
- IL
- Israel
- Prior art keywords
- antitumor activity
- quinazoline derivatives
- enhancing antitumor
- pct
- sec
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Preventing Corrosion Or Incrustation Of Metals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60998690A | 1990-11-06 | 1990-11-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL99906A0 true IL99906A0 (en) | 1992-08-18 |
Family
ID=24443149
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL99906A IL99906A0 (en) | 1990-11-06 | 1991-10-30 | Quinazoline derivatives for enhancing antitumor activity |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5444062A (xx) |
| EP (1) | EP0556310B1 (xx) |
| JP (1) | JPH05507290A (xx) |
| KR (1) | KR930702292A (xx) |
| CN (1) | CN1061411A (xx) |
| AT (1) | ATE124694T1 (xx) |
| BR (1) | BR9107070A (xx) |
| CA (1) | CA2095213A1 (xx) |
| CZ (1) | CZ400992A3 (xx) |
| DE (2) | DE69111077T2 (xx) |
| DK (1) | DK0556310T3 (xx) |
| ES (1) | ES2074867T3 (xx) |
| FI (1) | FI932032A (xx) |
| GR (1) | GR3017122T3 (xx) |
| HU (1) | HUT64533A (xx) |
| IE (1) | IE913854A1 (xx) |
| IL (1) | IL99906A0 (xx) |
| MX (1) | MX9101913A (xx) |
| NO (1) | NO931635L (xx) |
| NZ (1) | NZ240476A (xx) |
| PT (1) | PT99415A (xx) |
| SK (1) | SK400992A3 (xx) |
| WO (1) | WO1992007844A1 (xx) |
| YU (1) | YU47993B (xx) |
| ZA (1) | ZA918767B (xx) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993010116A1 (en) * | 1991-11-12 | 1993-05-27 | Pfizer Inc. | Triazine derivatives for enhancing antitumor activity |
| KR0144833B1 (ko) | 1992-12-28 | 1998-07-15 | 김태훈 | 신규의 퀴나졸린 유도체 및 그의 제조방법 |
| IL112249A (en) | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
| IL112248A0 (en) | 1994-01-25 | 1995-03-30 | Warner Lambert Co | Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them |
| CN1058265C (zh) * | 1994-05-16 | 2000-11-08 | 株式会社柳韩洋行 | 喹唑啉衍生物,其制备方法及包含该物质的组合物 |
| CA2197298C (en) * | 1994-08-13 | 1999-10-19 | Jong Wook Lee | Novel pyrimidine derivatives and processes for the preparation thereof |
| EP0794178A4 (en) * | 1994-11-25 | 1998-02-25 | Nippon Chemiphar Co | CHINAZOLIN DERIVATIVES |
| TW334434B (en) * | 1995-05-16 | 1998-06-21 | Kanebo Ltd | Novel quinazoline compound and anti-tumor agent |
| WO1997020823A2 (en) * | 1995-12-01 | 1997-06-12 | Novartis Ag | 2-amino quinazoline derivatives as npy receptor antagonists |
| AU7692896A (en) * | 1995-12-01 | 1997-06-27 | Novartis Ag | Quinazolin-2,4-diazirines as NPY receptor antagonist |
| IL126351A0 (en) * | 1996-04-12 | 1999-05-09 | Warner Lambert Co | Irreversible inhibitors of tyrosine kinases |
| IN188411B (xx) | 1997-03-27 | 2002-09-21 | Yuhan Corp | |
| US6184226B1 (en) | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
| KR100272471B1 (ko) | 1998-11-17 | 2000-11-15 | 김선진 | 신규의 피리미딘 유도체 및 그의 제조방법 |
| DE60006618T2 (de) * | 1999-08-06 | 2004-09-23 | F. Hoffmann-La Roche Ag | Tetrahydro-benzo(d)azepine und deren Verwendung als metabotrope Glutamatrezeptor-Antagonisten |
| US6608053B2 (en) * | 2000-04-27 | 2003-08-19 | Yamanouchi Pharmaceutical Co., Ltd. | Fused heteroaryl derivatives |
| US6369222B1 (en) * | 2000-07-18 | 2002-04-09 | Hoffmann-La Roche Inc. | mGluR antagonists and a method for their synthesis |
| US6900226B2 (en) * | 2000-09-06 | 2005-05-31 | Hoffman-La Roche Inc. | Neuropeptide Y antagonists |
| PE20030008A1 (es) | 2001-06-19 | 2003-01-22 | Bristol Myers Squibb Co | Inhibidores duales de pde 7 y pde 4 |
| CA2460594A1 (en) | 2001-10-01 | 2003-04-10 | Taisho Pharmaceutical Co., Ltd. | Mch receptor antagonists |
| GB0130341D0 (en) * | 2001-12-19 | 2002-02-06 | Smithkline Beecham Plc | Compounds |
| AU2002361846A1 (en) * | 2001-12-21 | 2003-07-15 | Bayer Pharmaceuticals Corporation | Quinazoline and quinoline derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents |
| BR0312461A (pt) * | 2002-07-05 | 2005-04-26 | Hoffmann La Roche | Compostos, processo para a preparação de um composto, composição farmacêutica que compreende o mesmo, sua utilização e métodos para tratamento e profilaxia |
| FR2845994B1 (fr) * | 2002-10-18 | 2006-05-19 | Servier Lab | Nouveaux derives de benzo[e][1,4]oxazino[3,2-g]isoindole substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| MXPA05011103A (es) * | 2003-04-16 | 2005-12-12 | Hoffmann La Roche | Compuestos de quinazolina. |
| KR100557093B1 (ko) * | 2003-10-07 | 2006-03-03 | 한미약품 주식회사 | 다약제 내성 저해 활성을 갖는 테트라졸 유도체 및 그의제조방법 |
| AU2006233867A1 (en) * | 2005-04-11 | 2006-10-19 | F. Hoffmann-La Roche Ag | (3,4-dihydro-quinazolin-2-yl)-indan-1-yl-amines |
| CN101100466B (zh) | 2006-07-05 | 2013-12-25 | 天津和美生物技术有限公司 | 不可逆蛋白质酪氨酸磷酰化酶抑制剂及其制备和应用 |
| CN102803227B (zh) | 2010-03-16 | 2016-01-20 | 默克专利有限公司 | 吗啉基喹唑啉 |
| DE102010025786A1 (de) | 2010-07-01 | 2012-01-05 | Merck Patent Gmbh | Pyrazolochinoline |
| DE102010035744A1 (de) | 2010-08-28 | 2012-03-01 | Merck Patent Gmbh | Imidazolonylchinoline |
| US8673914B2 (en) | 2011-03-28 | 2014-03-18 | St. John's University | Use of phosphodiesterase inhibitors for treating multidrug resistance |
| DE102011118830A1 (de) | 2011-11-18 | 2013-05-23 | Merck Patent Gmbh | Morpholinylbenzotriazine |
| DE102013008118A1 (de) | 2013-05-11 | 2014-11-13 | Merck Patent Gmbh | Arylchinazoline |
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| CN108245521B (zh) * | 2018-01-24 | 2020-01-03 | 浙江工业大学 | 二丙氨基乙酰氨基苯并氮杂*基喹唑啉类化合物在制备治疗白血病药物中的应用 |
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| DE958197C (de) * | 1952-04-18 | 1957-02-14 | Dr Siegfried Skraup | Verfahren zur Herstellung von 2, 4-Diaminochinazolin |
| CH457460A (fr) * | 1966-06-20 | 1968-06-15 | Parke Davis & Co | Procédé de préparation de quinazolines |
| US3511836A (en) * | 1967-12-13 | 1970-05-12 | Pfizer & Co C | 2,4,6,7-tetra substituted quinazolines |
| US3635979A (en) * | 1969-09-29 | 1972-01-18 | Pfizer | Certain 6- and/or 7-alkoxy-substituted-2 4-bis(disubstituted amino) quinazolines |
| GB1390015A (en) * | 1971-05-07 | 1975-04-09 | Koninklijke Pharma Fab Nv | 4-amino-quinazoline compounds |
| GB1383409A (en) * | 1972-09-09 | 1974-02-12 | Pfizer Ltd | Derivatives of 2-amino- and 4-amino-quinazoline and pharmaceutical compositions containing them |
| US3956495A (en) * | 1973-10-30 | 1976-05-11 | Eli Lilly And Company | 2,4-Diaminoquinazolines as antithrombotic agents |
| FR2389614A1 (en) * | 1977-05-05 | 1978-12-01 | Synthelabo | Antihypertensive 2,4-di:amino-quinazoline(s) - prepd. from a 2-halo-4-amino-quinazoline and a secondary amine |
| US4098788A (en) * | 1977-06-20 | 1978-07-04 | Bristol-Myers Company | Process for preparing quinazolines |
| US4287341A (en) * | 1979-11-01 | 1981-09-01 | Pfizer Inc. | Alkoxy-substituted-6-chloro-quinazoline-2,4-diones |
| IL88507A (en) * | 1987-12-03 | 1993-02-21 | Smithkline Beckman Intercredit | 2,4-diaminoquinazolines, process for their preparation and pharmaceutical compositions comprising them |
| IL89027A (en) * | 1988-01-29 | 1993-01-31 | Lilly Co Eli | Quinazoline derivatives, process for their preparation and fungicidal, insecticidal and miticidal compositions containing them |
| GB8910722D0 (en) * | 1989-05-10 | 1989-06-28 | Smithkline Beckman Intercredit | Compounds |
-
1991
- 1991-10-10 KR KR1019930701349A patent/KR930702292A/ko not_active Application Discontinuation
- 1991-10-10 BR BR9107070A patent/BR9107070A/pt not_active Application Discontinuation
- 1991-10-10 EP EP92900750A patent/EP0556310B1/en not_active Expired - Lifetime
- 1991-10-10 DE DE69111077T patent/DE69111077T2/de not_active Expired - Fee Related
- 1991-10-10 JP JP92501815A patent/JPH05507290A/ja active Pending
- 1991-10-10 WO PCT/US1991/007254 patent/WO1992007844A1/en not_active Application Discontinuation
- 1991-10-10 AT AT92900750T patent/ATE124694T1/de active
- 1991-10-10 DK DK92900750.8T patent/DK0556310T3/da active
- 1991-10-10 HU HU9301314A patent/HUT64533A/hu unknown
- 1991-10-10 US US08/050,047 patent/US5444062A/en not_active Expired - Lifetime
- 1991-10-10 SK SK4009-92A patent/SK400992A3/sk unknown
- 1991-10-10 ES ES92900750T patent/ES2074867T3/es not_active Expired - Lifetime
- 1991-10-10 CZ CS924009A patent/CZ400992A3/cs unknown
- 1991-10-10 DE DE9190155U patent/DE9190155U1/de not_active Expired - Lifetime
- 1991-10-10 CA CA002095213A patent/CA2095213A1/en not_active Abandoned
- 1991-10-30 IL IL99906A patent/IL99906A0/xx unknown
- 1991-11-04 MX MX9101913A patent/MX9101913A/es unknown
- 1991-11-04 PT PT99415A patent/PT99415A/pt not_active Application Discontinuation
- 1991-11-05 NZ NZ240476A patent/NZ240476A/en unknown
- 1991-11-05 IE IE385491A patent/IE913854A1/en unknown
- 1991-11-05 YU YU176191A patent/YU47993B/sh unknown
- 1991-11-05 ZA ZA918767A patent/ZA918767B/xx unknown
- 1991-11-05 CN CN91108479A patent/CN1061411A/zh active Pending
-
1993
- 1993-05-05 NO NO93931635A patent/NO931635L/no unknown
- 1993-05-05 FI FI932032A patent/FI932032A/fi not_active Application Discontinuation
-
1995
- 1995-08-16 GR GR950402241T patent/GR3017122T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0556310A1 (en) | 1993-08-25 |
| BR9107070A (pt) | 1994-05-31 |
| HUT64533A (en) | 1994-01-28 |
| FI932032A0 (fi) | 1993-05-05 |
| YU47993B (sh) | 1996-08-13 |
| CZ400992A3 (en) | 1993-12-15 |
| US5444062A (en) | 1995-08-22 |
| GR3017122T3 (en) | 1995-11-30 |
| JPH05507290A (ja) | 1993-10-21 |
| MX9101913A (es) | 1992-07-08 |
| EP0556310B1 (en) | 1995-07-05 |
| WO1992007844A1 (en) | 1992-05-14 |
| ZA918767B (en) | 1993-05-05 |
| DE69111077D1 (de) | 1995-08-10 |
| DE9190155U1 (de) | 1993-10-07 |
| IE913854A1 (en) | 1992-05-22 |
| PT99415A (pt) | 1992-09-30 |
| AU644035B2 (en) | 1993-12-02 |
| ATE124694T1 (de) | 1995-07-15 |
| DE69111077T2 (de) | 1995-11-02 |
| NZ240476A (en) | 1994-04-27 |
| KR930702292A (ko) | 1993-09-08 |
| CA2095213A1 (en) | 1992-05-07 |
| ES2074867T3 (es) | 1995-09-16 |
| HU9301314D0 (en) | 1993-09-28 |
| CN1061411A (zh) | 1992-05-27 |
| SK400992A3 (en) | 1995-08-09 |
| AU9059291A (en) | 1992-05-26 |
| FI932032A (fi) | 1993-05-05 |
| NO931635D0 (no) | 1993-05-05 |
| DK0556310T3 (da) | 1995-08-21 |
| YU176191A (sh) | 1994-01-20 |
| NO931635L (no) | 1993-05-05 |
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