GB1390015A - 4-amino-quinazoline compounds - Google Patents
4-amino-quinazoline compoundsInfo
- Publication number
- GB1390015A GB1390015A GB4784974A GB4784974A GB1390015A GB 1390015 A GB1390015 A GB 1390015A GB 4784974 A GB4784974 A GB 4784974A GB 4784974 A GB4784974 A GB 4784974A GB 1390015 A GB1390015 A GB 1390015A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- compounds
- alkoxy
- hydrogen
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/137—Heterocyclic compounds containing two hetero atoms, of which at least one is nitrogen
Abstract
1390015 4-Aminoquinazoline compounds KONINKLIJKE PHARMACEUTISCHE FABRIEKEN NV 5 May 1972 [7 May 1971] 47849/74 Divided out of 1390014 Heading C2C Novel compounds of the Formula I wherein R 3 is a nitrogen-, oxygen-, or sulphurcontaining saturated or unsaturated mononuclear-heterocyclic group attached to the quinazoline nucleus through carbon, which may carry one or more halogens alkyls or alkoxys and/or when it contains an acylatable nitrogen, an N-acyl substituent, and the symbols R 4 to R 7 each are hydrogen, halogen, alkyl or alkoxy, the total number of carbon atoms in alkyl or alkoxy groups, when present, being not more than eight, and in which all alkyl and alkoxy radicals contain up to eight carbon atoms, with the proviso that when all of R 4 to R 7 are hydrogen, R 3 may not be 2-furyl, and acid addition and quaternary ammonium salts thereof may be prepared by the process claimed in Specification 1,390,014. Pharmaceutical compositions of the compounds I or salts thereof when administered orally or parenterally with the usual excipients or mixed in the feedstock show activity against pleuropneumonia-like organisms and other gram negative bacteria and also exert antihypertensive activity.
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1380271A GB1390014A (en) | 1971-05-07 | 1971-05-07 | Process for the preparation of carbocyclic fused pyrimidine derivatives |
GB4784974A GB1390015A (en) | 1971-05-07 | 1971-05-07 | 4-amino-quinazoline compounds |
AU41937/72A AU466496B2 (en) | 1971-05-07 | 1972-05-04 | Pyrimidine derivatives |
BE783119A BE783119A (en) | 1971-05-07 | 1972-05-05 | PROCESS FOR PREPARATION OF PYRIMIDINE DERIVATIVES |
AT391372A AT318620B (en) | 1971-05-07 | 1972-05-05 | Process for the preparation of pyrimidine derivatives and their salts |
FR7216199A FR2139863B1 (en) | 1971-05-07 | 1972-05-05 | |
SE7205960A SE406197B (en) | 1971-05-07 | 1972-05-05 | ANALOGICAL PROCEDURE FOR THE PREPARATION OF 4-AMINOKINAZOLINE DERIVATIVES |
CA141,393A CA974521A (en) | 1971-05-07 | 1972-05-05 | 4-amino quinazolines |
LU65299D LU65299A1 (en) | 1971-05-07 | 1972-05-05 | |
DE19722222231 DE2222231A1 (en) | 1971-05-07 | 1972-05-05 | PROCESS FOR THE MANUFACTURING OF PYRIMIDE DERIVATIVES AND THEIR ACID ADDITION SALTS AND QUARTAR AMMONIUM SALTS AND MEDICINAL PREPARATIONS CONTAINING THESE COMPOUNDS |
CH671672A CH589068A5 (en) | 1971-05-07 | 1972-05-05 | |
NL7206067A NL7206067A (en) | 1971-05-07 | 1972-05-05 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1380271A GB1390014A (en) | 1971-05-07 | 1971-05-07 | Process for the preparation of carbocyclic fused pyrimidine derivatives |
GB4784974A GB1390015A (en) | 1971-05-07 | 1971-05-07 | 4-amino-quinazoline compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1390015A true GB1390015A (en) | 1975-04-09 |
Family
ID=26250021
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1380271A Expired GB1390014A (en) | 1971-05-07 | 1971-05-07 | Process for the preparation of carbocyclic fused pyrimidine derivatives |
GB4784974A Expired GB1390015A (en) | 1971-05-07 | 1971-05-07 | 4-amino-quinazoline compounds |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1380271A Expired GB1390014A (en) | 1971-05-07 | 1971-05-07 | Process for the preparation of carbocyclic fused pyrimidine derivatives |
Country Status (11)
Country | Link |
---|---|
AT (1) | AT318620B (en) |
AU (1) | AU466496B2 (en) |
BE (1) | BE783119A (en) |
CA (1) | CA974521A (en) |
CH (1) | CH589068A5 (en) |
DE (1) | DE2222231A1 (en) |
FR (1) | FR2139863B1 (en) |
GB (2) | GB1390014A (en) |
LU (1) | LU65299A1 (en) |
NL (1) | NL7206067A (en) |
SE (1) | SE406197B (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2377399A1 (en) * | 1977-01-17 | 1978-08-11 | Warner Lambert Co | NEW COMPOUNDS OF THE QUINAZOLINE FAMILY AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS |
WO1994005628A1 (en) * | 1992-08-31 | 1994-03-17 | Acic (Canada) Inc. | Synthesis of 2-substituted quinazoline compounds (such as terazosin) and meobentine and bethanidine and intermediates therefor |
WO1999032460A1 (en) * | 1997-12-18 | 1999-07-01 | Aventis Pharma Deutschland Gmbh | Substituted 2-aryl-4-amino-chinazolines, method for the production and use thereof as medicaments |
WO2013003586A1 (en) * | 2011-06-29 | 2013-01-03 | Otsuka Pharmaceutical Co., Ltd. | Quinazolines as therapeutic compounds and related methods of use |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5461194A (en) | 1977-10-21 | 1979-05-17 | Takeda Chem Ind Ltd | Preparation of n22substituted 2*66diaminonebularin |
AU5118979A (en) | 1978-10-16 | 1980-04-24 | Takeda Chemical Industries Ltd. | 2,6-diaminoebularines |
FI67699C (en) * | 1979-01-31 | 1985-05-10 | Orion Yhtymae Oy | PROCEDURE FOR THE FRAMSTATION OF AV 6,7-DIMETOXY-4-AMINO-2- (4- (2-FUROYL) -1-PIPERAZINYL) QUINAZOLINE HYDROCHLORIDE WITH BLODTRYCKSSAENKANDE VERKAN |
AU572585B2 (en) * | 1983-09-29 | 1988-05-12 | Akzo N.V. | Quinazoline and isoquinoline derivatives |
US5380841A (en) * | 1985-09-12 | 1995-01-10 | The Upjohn Company | Pyridinylpiperazinyl steroids |
WO1987001706A2 (en) * | 1985-09-12 | 1987-03-26 | The Upjohn Company | C20 through c26 amino steroids |
AU593284B2 (en) * | 1985-09-12 | 1990-02-08 | Pharmacia & Upjohn Company | C20 to c26 amino steroids |
IL88507A (en) * | 1987-12-03 | 1993-02-21 | Smithkline Beckman Intercredit | 2,4-diaminoquinazolines, process for their preparation and pharmaceutical compositions comprising them |
EP0360936A1 (en) * | 1988-09-29 | 1990-04-04 | Siemens Aktiengesellschaft Österreich | Method for the conversion of a sampled analog input signal |
GB8910722D0 (en) * | 1989-05-10 | 1989-06-28 | Smithkline Beckman Intercredit | Compounds |
SK400992A3 (en) * | 1990-11-06 | 1995-08-09 | Pfizer | Quinazolines derivatives for enhancing antitumor activity |
US5536725A (en) * | 1993-08-25 | 1996-07-16 | Fmc Corporation | Insecticidal substituted-2,4-diamino-5,6,7,8-tetrahydroquinazolines |
GB2295387A (en) * | 1994-11-23 | 1996-05-29 | Glaxo Inc | Quinazoline antagonists of alpha 1c adrenergic receptors |
GB9700504D0 (en) * | 1997-01-11 | 1997-02-26 | Pfizer Ltd | Pharmaceutical compounds |
US7176314B2 (en) | 2001-12-05 | 2007-02-13 | Amgen, Inc. | Inflammation modulators |
-
1971
- 1971-05-07 GB GB1380271A patent/GB1390014A/en not_active Expired
- 1971-05-07 GB GB4784974A patent/GB1390015A/en not_active Expired
-
1972
- 1972-05-04 AU AU41937/72A patent/AU466496B2/en not_active Expired
- 1972-05-05 CA CA141,393A patent/CA974521A/en not_active Expired
- 1972-05-05 CH CH671672A patent/CH589068A5/xx not_active IP Right Cessation
- 1972-05-05 DE DE19722222231 patent/DE2222231A1/en not_active Ceased
- 1972-05-05 AT AT391372A patent/AT318620B/en not_active IP Right Cessation
- 1972-05-05 NL NL7206067A patent/NL7206067A/xx not_active Application Discontinuation
- 1972-05-05 LU LU65299D patent/LU65299A1/xx unknown
- 1972-05-05 FR FR7216199A patent/FR2139863B1/fr not_active Expired
- 1972-05-05 BE BE783119A patent/BE783119A/en not_active IP Right Cessation
- 1972-05-05 SE SE7205960A patent/SE406197B/en unknown
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2377399A1 (en) * | 1977-01-17 | 1978-08-11 | Warner Lambert Co | NEW COMPOUNDS OF THE QUINAZOLINE FAMILY AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS |
WO1994005628A1 (en) * | 1992-08-31 | 1994-03-17 | Acic (Canada) Inc. | Synthesis of 2-substituted quinazoline compounds (such as terazosin) and meobentine and bethanidine and intermediates therefor |
US5675006A (en) * | 1992-08-31 | 1997-10-07 | Brantford Chemicals Inc. | Methods of making ureas and guanidines, including, terazosin, prazosin, doxazosin, tiodazosin, trimazosin, quinazosin, and bunazosin (exemplary of 2- substituted quinazoline compounds), and meobentine, and bethanidine and intermediates therefor |
US5686612A (en) * | 1992-08-31 | 1997-11-11 | Brantford Chemicals Inc. | Methods of making ureas and guanidines, including terazosin, prazosin, doxazosin, tiodazosin, trimazosin, quinazosin, and bunazosin (exemplary of 2-substituted quinazoline compounds), and meobentine, and bethanidine and intermediates thereof |
US6080860A (en) * | 1992-08-31 | 2000-06-27 | Brantford Chemicalss Inc. | Methods of making ureas and guanidines including, terazosin, prazosin, doxazosin, tiodazosin, trimazosin, quinazosin and bunazosin (exemplary of 2-substituted quinazoline compounds), and meobentine, and bethanidine and intermediates therefor |
WO1999032460A1 (en) * | 1997-12-18 | 1999-07-01 | Aventis Pharma Deutschland Gmbh | Substituted 2-aryl-4-amino-chinazolines, method for the production and use thereof as medicaments |
US6613772B1 (en) | 1997-12-18 | 2003-09-02 | Aventis Pharma Deutschland Gmbh | Substituted 2-aryl-4-amino-chinazolines, method for the production and use thereof as medicaments |
WO2013003586A1 (en) * | 2011-06-29 | 2013-01-03 | Otsuka Pharmaceutical Co., Ltd. | Quinazolines as therapeutic compounds and related methods of use |
Also Published As
Publication number | Publication date |
---|---|
AU4193772A (en) | 1973-11-08 |
GB1390014A (en) | 1975-04-09 |
NL7206067A (en) | 1972-11-09 |
DE2222231A1 (en) | 1974-06-27 |
FR2139863B1 (en) | 1975-10-31 |
LU65299A1 (en) | 1972-08-23 |
BE783119A (en) | 1972-11-06 |
AU466496B2 (en) | 1975-10-30 |
AT318620B (en) | 1974-11-11 |
CH589068A5 (en) | 1977-06-30 |
FR2139863A1 (en) | 1973-01-12 |
SE406197B (en) | 1979-01-29 |
CA974521A (en) | 1975-09-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |