SK379690A3 - Method for purifying aminomethylene phosphonic acids - Google Patents
Method for purifying aminomethylene phosphonic acids Download PDFInfo
- Publication number
- SK379690A3 SK379690A3 SK3796-90A SK379690A SK379690A3 SK 379690 A3 SK379690 A3 SK 379690A3 SK 379690 A SK379690 A SK 379690A SK 379690 A3 SK379690 A3 SK 379690A3
- Authority
- SK
- Slovakia
- Prior art keywords
- solution
- acid
- temperature
- precipitate
- water
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 30
- -1 aminomethylene phosphonic acids Chemical class 0.000 title description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 58
- NFDRPXJGHKJRLJ-UHFFFAOYSA-N edtmp Chemical compound OP(O)(=O)CN(CP(O)(O)=O)CCN(CP(O)(O)=O)CP(O)(O)=O NFDRPXJGHKJRLJ-UHFFFAOYSA-N 0.000 claims abstract description 50
- RCXMQNIDOFXYDO-UHFFFAOYSA-N [4,7,10-tris(phosphonomethyl)-1,4,7,10-tetrazacyclododec-1-yl]methylphosphonic acid Chemical compound OP(O)(=O)CN1CCN(CP(O)(O)=O)CCN(CP(O)(O)=O)CCN(CP(O)(O)=O)CC1 RCXMQNIDOFXYDO-UHFFFAOYSA-N 0.000 claims abstract description 39
- 239000002253 acid Substances 0.000 claims abstract description 20
- 239000013078 crystal Substances 0.000 claims abstract description 15
- PTMHPRAIXMAOOB-UHFFFAOYSA-N phosphoramidic acid Chemical compound NP(O)(O)=O PTMHPRAIXMAOOB-UHFFFAOYSA-N 0.000 claims abstract description 15
- 238000001914 filtration Methods 0.000 claims abstract description 6
- 238000001816 cooling Methods 0.000 claims abstract description 5
- 238000005406 washing Methods 0.000 claims abstract description 4
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract 3
- 239000011707 mineral Substances 0.000 claims abstract 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 48
- 238000010992 reflux Methods 0.000 claims description 48
- 239000000203 mixture Substances 0.000 claims description 23
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims description 20
- 239000000908 ammonium hydroxide Substances 0.000 claims description 20
- 238000010438 heat treatment Methods 0.000 claims description 15
- 238000000746 purification Methods 0.000 claims description 11
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 10
- 239000000047 product Substances 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 6
- 239000012429 reaction media Substances 0.000 claims description 6
- ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 claims description 6
- 238000001556 precipitation Methods 0.000 claims description 5
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims description 4
- 229930040373 Paraformaldehyde Natural products 0.000 claims description 3
- 229920002866 paraformaldehyde Polymers 0.000 claims description 3
- 239000007795 chemical reaction product Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 abstract description 2
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 71
- 229940120146 EDTMP Drugs 0.000 description 48
- 238000003756 stirring Methods 0.000 description 46
- 239000002244 precipitate Substances 0.000 description 42
- 239000012535 impurity Substances 0.000 description 25
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 23
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 23
- 239000007787 solid Substances 0.000 description 21
- 238000005481 NMR spectroscopy Methods 0.000 description 19
- 239000000725 suspension Substances 0.000 description 19
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 8
- 238000004458 analytical method Methods 0.000 description 8
- 238000004140 cleaning Methods 0.000 description 8
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical group [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 7
- 238000009835 boiling Methods 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 7
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Substances OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 7
- 229910052698 phosphorus Inorganic materials 0.000 description 7
- 239000011574 phosphorus Substances 0.000 description 7
- 239000012266 salt solution Substances 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 150000007513 acids Chemical class 0.000 description 6
- 150000001412 amines Chemical class 0.000 description 6
- 239000006227 byproduct Substances 0.000 description 6
- 239000011521 glass Substances 0.000 description 6
- 238000001953 recrystallisation Methods 0.000 description 6
- DUYCTCQXNHFCSJ-UHFFFAOYSA-N dtpmp Chemical compound OP(=O)(O)CN(CP(O)(O)=O)CCN(CP(O)(=O)O)CCN(CP(O)(O)=O)CP(O)(O)=O DUYCTCQXNHFCSJ-UHFFFAOYSA-N 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 5
- QBPPRVHXOZRESW-UHFFFAOYSA-N 1,4,7,10-tetraazacyclododecane Chemical compound C1CNCCNCCNCCN1 QBPPRVHXOZRESW-UHFFFAOYSA-N 0.000 description 4
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 239000008367 deionised water Substances 0.000 description 4
- 229910021641 deionized water Inorganic materials 0.000 description 4
- 239000000706 filtrate Substances 0.000 description 4
- 239000008098 formaldehyde solution Substances 0.000 description 4
- 239000011541 reaction mixture Substances 0.000 description 4
- YDONNITUKPKTIG-UHFFFAOYSA-N [Nitrilotris(methylene)]trisphosphonic acid Chemical compound OP(O)(=O)CN(CP(O)(O)=O)CP(O)(O)=O YDONNITUKPKTIG-UHFFFAOYSA-N 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 238000000354 decomposition reaction Methods 0.000 description 3
- 239000012065 filter cake Substances 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- 239000007858 starting material Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 239000004809 Teflon Substances 0.000 description 2
- 229920006362 Teflon® Polymers 0.000 description 2
- 125000003277 amino group Chemical group 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- YVPJCJLMRRTDMQ-UHFFFAOYSA-N ethyl diazoacetate Chemical compound CCOC(=O)C=[N+]=[N-] YVPJCJLMRRTDMQ-UHFFFAOYSA-N 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 150000002739 metals Chemical class 0.000 description 2
- 150000002825 nitriles Chemical class 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- FAIAAWCVCHQXDN-UHFFFAOYSA-N phosphorus trichloride Chemical compound ClP(Cl)Cl FAIAAWCVCHQXDN-UHFFFAOYSA-N 0.000 description 2
- 239000012217 radiopharmaceutical Substances 0.000 description 2
- 229940121896 radiopharmaceutical Drugs 0.000 description 2
- 230000002799 radiopharmaceutical effect Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241000255969 Pieris brassicae Species 0.000 description 1
- 239000003929 acidic solution Substances 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical compound [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 229920000768 polyamine Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000012498 ultrapure water Substances 0.000 description 1
- 239000011345 viscous material Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/025—Purification; Separation; Stabilisation; Desodorisation of organo-phosphorus compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
- C07F9/3817—Acids containing the structure (RX)2P(=X)-alk-N...P (X = O, S, Se)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/389,441 US4937333A (en) | 1989-08-04 | 1989-08-04 | Method for purifying aminomethylenephosphonic acids for pharmaceutical use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK279107B6 SK279107B6 (sk) | 1998-06-03 |
| SK379690A3 true SK379690A3 (en) | 1998-06-03 |
Family
ID=23538280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK3796-90A SK379690A3 (en) | 1989-08-04 | 1990-07-31 | Method for purifying aminomethylene phosphonic acids |
Country Status (38)
| Country | Link |
|---|---|
| US (1) | US4937333A (lv) |
| EP (1) | EP0411941B1 (lv) |
| JP (1) | JP2922263B2 (lv) |
| KR (2) | KR0178779B1 (lv) |
| CN (2) | CN1024196C (lv) |
| AP (1) | AP163A (lv) |
| AT (1) | ATE140459T1 (lv) |
| AU (1) | AU634267B2 (lv) |
| BG (1) | BG60519B1 (lv) |
| BR (2) | BR9003694A (lv) |
| CA (1) | CA2020950C (lv) |
| CZ (1) | CZ290556B6 (lv) |
| DD (1) | DD297414A5 (lv) |
| DE (1) | DE69027818T2 (lv) |
| DK (1) | DK0411941T3 (lv) |
| DZ (1) | DZ1436A1 (lv) |
| EG (1) | EG19250A (lv) |
| ES (1) | ES2090105T3 (lv) |
| FI (1) | FI105033B (lv) |
| GR (1) | GR3020932T3 (lv) |
| HK (1) | HK1007558A1 (lv) |
| HU (1) | HU205128B (lv) |
| IE (1) | IE902812A1 (lv) |
| IL (3) | IL110861A (lv) |
| LV (1) | LV10718B (lv) |
| MA (1) | MA21922A1 (lv) |
| NO (2) | NO178196C (lv) |
| NZ (2) | NZ247888A (lv) |
| OA (1) | OA09300A (lv) |
| PH (1) | PH26901A (lv) |
| PL (2) | PL166453B1 (lv) |
| PT (1) | PT94188B (lv) |
| RO (1) | RO105967B1 (lv) |
| RU (1) | RU1838321C (lv) |
| SA (1) | SA90110175B1 (lv) |
| SK (1) | SK379690A3 (lv) |
| YU (1) | YU47368B (lv) |
| ZA (1) | ZA905564B (lv) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4937333A (en) * | 1989-08-04 | 1990-06-26 | The Dow Chemical Company | Method for purifying aminomethylenephosphonic acids for pharmaceutical use |
| MC2260A1 (fr) * | 1990-06-18 | 1993-04-26 | Dow Chemical Co | Formulations de produits radiopharmaceutiques,leur methode d'administration et leur procede de preparation |
| EP0494603A3 (en) * | 1991-01-10 | 1993-10-20 | Hoechst Ag | Process for extractive separation of phospho- and sulphobetaines from acidic reaction solutions |
| US5410043A (en) * | 1991-12-06 | 1995-04-25 | Schering Aktiengesellschaft | Process for the production of mono-N-substituted tetraaza macrocycles |
| US5320829A (en) * | 1991-12-10 | 1994-06-14 | The Dow Chemical Company | Oral compositions for inhibiting plaque formation |
| DE4218744C2 (de) * | 1992-06-04 | 1997-11-06 | Schering Ag | Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe |
| US5495042A (en) * | 1993-11-04 | 1996-02-27 | Cytogen Corporation | Non-alkaline purification of aminophosphonic acids |
| EP1191948A2 (en) * | 1999-06-11 | 2002-04-03 | Neorx Corporation | High dose radionuclide complexes for bone marrow suppression |
| US7094885B2 (en) * | 1999-07-11 | 2006-08-22 | Neorx Corporation | Skeletal-targeted radiation to treat bone-associated pathologies |
| JP2003512331A (ja) * | 1999-10-18 | 2003-04-02 | ザ ダウ ケミカル カンパニー | 骨障害治療用アミノアルキレンホスホネート |
| US6794371B1 (en) * | 1999-10-18 | 2004-09-21 | The Dow Chemical Company | Aminoalkylenephosphonates for treatment of bone disorders |
| EP1390081A2 (en) * | 2001-01-08 | 2004-02-25 | Neorx Corporation | Therapeutic and diagnostic compounds, compositions, and methods |
| AU2003296117A1 (en) * | 2002-12-27 | 2004-07-29 | Sumitomo Chemical Company, Limited | Method and apparatus for crystallization |
| EP1778699A4 (en) * | 2004-08-10 | 2009-02-25 | Dow Global Technologies Inc | TARGETING OF CHELANTS AND CHELATES |
| CN101381377B (zh) * | 2008-10-23 | 2011-05-04 | 山东省泰和水处理有限公司 | 一种适用于电子级固体己二胺四亚甲基膦酸的制备工艺 |
| JP5581832B2 (ja) * | 2010-06-11 | 2014-09-03 | 三菱瓦斯化学株式会社 | 高純度アミノメチレンホスホン酸の製造方法 |
| CN103724373A (zh) * | 2014-01-02 | 2014-04-16 | 山东省泰和水处理有限公司 | 多聚甲醛生产氨基三亚甲基膦酸的方法 |
| US10590153B2 (en) | 2014-06-02 | 2020-03-17 | Zschimmer & Schwarz Mohsdorf GmbH & Co. KG | Process for producing crystalline DTPMP |
| DE102014210378B4 (de) | 2014-06-02 | 2018-10-04 | Zschimmer & Schwarz Mohsdorf GmbH &Co.KG. | Verfahren zur Herstellung hochreiner Aminoalkylenphosphonsäuren |
| CN113263580A (zh) * | 2021-04-23 | 2021-08-17 | 广东工业大学 | 一种多功能床头柜制造设备 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2599807A (en) * | 1950-06-01 | 1952-06-10 | Frederick C Bersworth | Alkylene polyamine methylene phosphonic acids |
| NL285361A (lv) * | 1961-11-13 | 1900-01-01 | ||
| US3738937A (en) * | 1970-05-08 | 1973-06-12 | Textilana Corp | Polyalkylene polyamino polykis methylene phosphonic acids and salts thereof and methods for producing same |
| NL7903500A (nl) * | 1979-05-04 | 1980-11-06 | Philips Nv | Verbrandingsflitslamp en flitsinrichting voorzien van verscheidene verbrandingsflitslampen. |
| JPS5775990A (en) * | 1980-10-27 | 1982-05-12 | Mitsubishi Gas Chem Co Inc | Preparation of n,n,n',n'-tetra(phosphonomethyl) diaminoalkane |
| EP0225409A1 (en) * | 1985-12-02 | 1987-06-16 | The Dow Chemical Company | Organic amine phosphonic acid complexes for the treatment of calcific tumors |
| US4937333A (en) * | 1989-08-04 | 1990-06-26 | The Dow Chemical Company | Method for purifying aminomethylenephosphonic acids for pharmaceutical use |
| GB8903023D0 (en) * | 1989-02-10 | 1989-03-30 | Parker David | Chemical compounds |
| DE3911816A1 (de) * | 1989-04-11 | 1990-10-25 | Hoechst Ag | Substituierte 1,4,7,10-tetraazacyclotridecane, verfahren zu deren herstellung sowie verwendung derselben zur markierung von substanzen mit radionukliden |
-
1989
- 1989-08-04 US US07/389,441 patent/US4937333A/en not_active Expired - Lifetime
-
1990
- 1990-05-29 PT PT94188A patent/PT94188B/pt not_active IP Right Cessation
- 1990-07-11 NZ NZ24788890A patent/NZ247888A/en unknown
- 1990-07-11 NZ NZ234464A patent/NZ234464A/en unknown
- 1990-07-11 CA CA002020950A patent/CA2020950C/en not_active Expired - Lifetime
- 1990-07-16 IL IL11086190A patent/IL110861A/xx active IP Right Grant
- 1990-07-16 ZA ZA905564A patent/ZA905564B/xx unknown
- 1990-07-16 IL IL9509490A patent/IL95094A/en active IP Right Grant
- 1990-07-24 JP JP2194121A patent/JP2922263B2/ja not_active Expired - Lifetime
- 1990-07-24 BR BR909003694A patent/BR9003694A/pt not_active Application Discontinuation
- 1990-07-25 YU YU145390A patent/YU47368B/sh unknown
- 1990-07-26 PH PH40907A patent/PH26901A/en unknown
- 1990-07-28 CN CN90104982A patent/CN1024196C/zh not_active Expired - Lifetime
- 1990-07-28 CN CN93108500A patent/CN1031191C/zh not_active Expired - Fee Related
- 1990-07-31 DZ DZ900139A patent/DZ1436A1/fr active
- 1990-07-31 CZ CZ19903796A patent/CZ290556B6/cs not_active IP Right Cessation
- 1990-07-31 SK SK3796-90A patent/SK379690A3/sk unknown
- 1990-08-02 ES ES90308524T patent/ES2090105T3/es not_active Expired - Lifetime
- 1990-08-02 DE DE69027818T patent/DE69027818T2/de not_active Expired - Lifetime
- 1990-08-02 RO RO145690A patent/RO105967B1/ro unknown
- 1990-08-02 AT AT90308524T patent/ATE140459T1/de not_active IP Right Cessation
- 1990-08-02 DK DK90308524.9T patent/DK0411941T3/da active
- 1990-08-02 MA MA22192A patent/MA21922A1/fr unknown
- 1990-08-02 EP EP90308524A patent/EP0411941B1/en not_active Expired - Lifetime
- 1990-08-03 IE IE281290A patent/IE902812A1/en not_active IP Right Cessation
- 1990-08-03 FI FI903864A patent/FI105033B/fi active IP Right Grant
- 1990-08-03 PL PL90286349A patent/PL166453B1/pl unknown
- 1990-08-03 RU SU904830923A patent/RU1838321C/ru active
- 1990-08-03 KR KR1019900011923A patent/KR0178779B1/ko not_active IP Right Cessation
- 1990-08-03 PL PL90300181A patent/PL164908B1/pl unknown
- 1990-08-03 NO NO903419A patent/NO178196C/no not_active IP Right Cessation
- 1990-08-03 BG BG92627A patent/BG60519B1/bg unknown
- 1990-08-03 AP APAP/P/1990/000202A patent/AP163A/en active
- 1990-08-03 OA OA59828A patent/OA09300A/xx unknown
- 1990-08-03 HU HU904890A patent/HU205128B/hu unknown
- 1990-08-03 DD DD90343237A patent/DD297414A5/de unknown
- 1990-08-04 EG EG46290A patent/EG19250A/xx active
- 1990-08-06 AU AU60237/90A patent/AU634267B2/en not_active Expired
- 1990-12-18 SA SA90110175A patent/SA90110175B1/ar unknown
-
1993
- 1993-06-30 LV LVP-93-934A patent/LV10718B/lv unknown
-
1994
- 1994-09-05 IL IL11086194A patent/IL110861A0/xx unknown
-
1996
- 1996-09-03 GR GR960402289T patent/GR3020932T3/el unknown
-
1997
- 1997-02-12 NO NO970653A patent/NO970653D0/no unknown
- 1997-05-14 BR BR1101174-2A patent/BR1101174A/pt active IP Right Grant
-
1998
- 1998-06-25 HK HK98106634A patent/HK1007558A1/xx not_active IP Right Cessation
- 1998-06-29 KR KR1019980024928A patent/KR0178877B1/ko not_active IP Right Cessation
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