DE69027818D1 - Verfahren zur Reinigung von Aminomethylenphosphonsäuren - Google Patents

Verfahren zur Reinigung von Aminomethylenphosphonsäuren

Info

Publication number
DE69027818D1
DE69027818D1 DE69027818T DE69027818T DE69027818D1 DE 69027818 D1 DE69027818 D1 DE 69027818D1 DE 69027818 T DE69027818 T DE 69027818T DE 69027818 T DE69027818 T DE 69027818T DE 69027818 D1 DE69027818 D1 DE 69027818D1
Authority
DE
Germany
Prior art keywords
purification
aminomethylenephosphonic acids
aminomethylenephosphonic
acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69027818T
Other languages
English (en)
Other versions
DE69027818T2 (de
Inventor
Joseph R Garlich
Tipton T Masterson
Jaime Simon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dow Chemical Co
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Application granted granted Critical
Publication of DE69027818D1 publication Critical patent/DE69027818D1/de
Publication of DE69027818T2 publication Critical patent/DE69027818T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/44—Amides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/025—Purification; Separation; Stabilisation; Desodorisation of organo-phosphorus compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C07F9/3817—Acids containing the structure (RX)2P(=X)-alk-N...P (X = O, S, Se)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69027818T 1989-08-04 1990-08-02 Verfahren zur Reinigung von Aminomethylenphosphonsäuren Expired - Lifetime DE69027818T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/389,441 US4937333A (en) 1989-08-04 1989-08-04 Method for purifying aminomethylenephosphonic acids for pharmaceutical use

Publications (2)

Publication Number Publication Date
DE69027818D1 true DE69027818D1 (de) 1996-08-22
DE69027818T2 DE69027818T2 (de) 1996-11-21

Family

ID=23538280

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69027818T Expired - Lifetime DE69027818T2 (de) 1989-08-04 1990-08-02 Verfahren zur Reinigung von Aminomethylenphosphonsäuren

Country Status (38)

Country Link
US (1) US4937333A (de)
EP (1) EP0411941B1 (de)
JP (1) JP2922263B2 (de)
KR (2) KR0178779B1 (de)
CN (2) CN1031191C (de)
AP (1) AP163A (de)
AT (1) ATE140459T1 (de)
AU (1) AU634267B2 (de)
BG (1) BG60519B1 (de)
BR (2) BR9003694A (de)
CA (1) CA2020950C (de)
CZ (1) CZ290556B6 (de)
DD (1) DD297414A5 (de)
DE (1) DE69027818T2 (de)
DK (1) DK0411941T3 (de)
DZ (1) DZ1436A1 (de)
EG (1) EG19250A (de)
ES (1) ES2090105T3 (de)
FI (1) FI105033B (de)
GR (1) GR3020932T3 (de)
HK (1) HK1007558A1 (de)
HU (1) HU205128B (de)
IE (1) IE902812A1 (de)
IL (3) IL110861A (de)
LV (1) LV10718B (de)
MA (1) MA21922A1 (de)
NO (2) NO178196C (de)
NZ (2) NZ247888A (de)
OA (1) OA09300A (de)
PH (1) PH26901A (de)
PL (2) PL166453B1 (de)
PT (1) PT94188B (de)
RO (1) RO105967B1 (de)
RU (1) RU1838321C (de)
SA (1) SA90110175B1 (de)
SK (1) SK379690A3 (de)
YU (1) YU47368B (de)
ZA (1) ZA905564B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4937333A (en) * 1989-08-04 1990-06-26 The Dow Chemical Company Method for purifying aminomethylenephosphonic acids for pharmaceutical use
MC2260A1 (fr) * 1990-06-18 1993-04-26 Dow Chemical Co Formulations de produits radiopharmaceutiques,leur methode d'administration et leur procede de preparation
EP0494603A3 (en) * 1991-01-10 1993-10-20 Hoechst Ag Process for extractive separation of phospho- and sulphobetaines from acidic reaction solutions
US5410043A (en) * 1991-12-06 1995-04-25 Schering Aktiengesellschaft Process for the production of mono-N-substituted tetraaza macrocycles
US5320829A (en) * 1991-12-10 1994-06-14 The Dow Chemical Company Oral compositions for inhibiting plaque formation
DE4218744C2 (de) * 1992-06-04 1997-11-06 Schering Ag Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe
US5495042A (en) * 1993-11-04 1996-02-27 Cytogen Corporation Non-alkaline purification of aminophosphonic acids
JP2003501488A (ja) * 1999-06-11 2003-01-14 ネオルックス コーポレイション 骨髄抑制のための高投与量放射性核種錯体
US7094885B2 (en) * 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
EP1225903A2 (de) * 1999-10-18 2002-07-31 The Dow Chemical Company Aminoalkylenephosphonaten zur behandlung von knochenstörungen
US6794371B1 (en) * 1999-10-18 2004-09-21 The Dow Chemical Company Aminoalkylenephosphonates for treatment of bone disorders
CA2434302A1 (en) * 2001-01-08 2002-08-15 Neorx Corporation Therapeutic and diagnostic compounds, compositions, and methods
CN100368047C (zh) * 2002-12-27 2008-02-13 住友化学株式会社 结晶方法和结晶装置
US20060210479A1 (en) * 2004-08-10 2006-09-21 Dow Global Technologies Inc. Targeting chelants and chelates
CN101381377B (zh) * 2008-10-23 2011-05-04 山东省泰和水处理有限公司 一种适用于电子级固体己二胺四亚甲基膦酸的制备工艺
JP5581832B2 (ja) * 2010-06-11 2014-09-03 三菱瓦斯化学株式会社 高純度アミノメチレンホスホン酸の製造方法
CN103724373A (zh) * 2014-01-02 2014-04-16 山东省泰和水处理有限公司 多聚甲醛生产氨基三亚甲基膦酸的方法
DE102014210378B4 (de) 2014-06-02 2018-10-04 Zschimmer & Schwarz Mohsdorf GmbH &Co.KG. Verfahren zur Herstellung hochreiner Aminoalkylenphosphonsäuren
US10590153B2 (en) 2014-06-02 2020-03-17 Zschimmer & Schwarz Mohsdorf GmbH & Co. KG Process for producing crystalline DTPMP
CN113263580A (zh) * 2021-04-23 2021-08-17 广东工业大学 一种多功能床头柜制造设备

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2599807A (en) * 1950-06-01 1952-06-10 Frederick C Bersworth Alkylene polyamine methylene phosphonic acids
CA775575A (en) * 1961-11-13 1968-01-09 R. Irani Riyad Organic phosphorus compounds
US3738937A (en) * 1970-05-08 1973-06-12 Textilana Corp Polyalkylene polyamino polykis methylene phosphonic acids and salts thereof and methods for producing same
NL7903500A (nl) * 1979-05-04 1980-11-06 Philips Nv Verbrandingsflitslamp en flitsinrichting voorzien van verscheidene verbrandingsflitslampen.
JPS5775990A (en) * 1980-10-27 1982-05-12 Mitsubishi Gas Chem Co Inc Preparation of n,n,n',n'-tetra(phosphonomethyl) diaminoalkane
EP0225409A1 (de) * 1985-12-02 1987-06-16 The Dow Chemical Company Organoaminophosphonische Säurekomplexe für die Behandlung von Kalktumoren
US4937333A (en) * 1989-08-04 1990-06-26 The Dow Chemical Company Method for purifying aminomethylenephosphonic acids for pharmaceutical use
GB8903023D0 (en) * 1989-02-10 1989-03-30 Parker David Chemical compounds
DE3911816A1 (de) * 1989-04-11 1990-10-25 Hoechst Ag Substituierte 1,4,7,10-tetraazacyclotridecane, verfahren zu deren herstellung sowie verwendung derselben zur markierung von substanzen mit radionukliden

Also Published As

Publication number Publication date
JP2922263B2 (ja) 1999-07-19
DD297414A5 (de) 1992-01-09
DE69027818T2 (de) 1996-11-21
BG92627A (bg) 1993-12-24
FI903864A0 (fi) 1990-08-03
AP163A (en) 1992-01-11
CZ379690A3 (cs) 2000-08-16
YU145390A (sh) 1992-09-07
LV10718B (en) 1996-04-20
NO178196B (no) 1995-10-30
PT94188B (pt) 1996-12-31
EP0411941B1 (de) 1996-07-17
NO178196C (no) 1996-02-07
ZA905564B (en) 1992-03-25
IL110861A (en) 1999-07-14
JPH0366697A (ja) 1991-03-22
KR910004642A (ko) 1991-03-29
EP0411941A2 (de) 1991-02-06
ES2090105T3 (es) 1996-10-16
PL164908B1 (pl) 1994-10-31
KR0178779B1 (ko) 1999-05-15
CN1091744A (zh) 1994-09-07
NZ234464A (en) 1994-06-27
DK0411941T3 (da) 1996-11-11
HU205128B (en) 1992-03-30
LV10718A (lv) 1995-06-20
NO903419D0 (no) 1990-08-03
AP9000202A0 (en) 1990-10-31
EP0411941A3 (en) 1992-04-15
NO970653L (no) 1991-02-05
HU904890D0 (en) 1991-01-28
CA2020950C (en) 2000-04-11
EG19250A (en) 1994-09-29
IL95094A (en) 1995-05-26
IE902812A1 (en) 1991-02-27
RU1838321C (ru) 1993-08-30
BR1101174A (pt) 2000-08-08
HUT54698A (en) 1991-03-28
SK279107B6 (sk) 1998-06-03
PL286349A1 (en) 1991-05-20
IL110861A0 (en) 1994-11-28
RO105967B1 (ro) 1993-01-30
BR9003694A (pt) 1991-09-03
AU6023790A (en) 1991-02-07
HK1007558A1 (en) 2003-07-10
ATE140459T1 (de) 1996-08-15
CN1049351A (zh) 1991-02-20
NZ247888A (en) 1994-07-26
CN1031191C (zh) 1996-03-06
BG60519B1 (bg) 1995-07-28
IL95094A0 (en) 1991-06-10
DZ1436A1 (fr) 2004-09-13
OA09300A (en) 1992-09-15
CZ290556B6 (cs) 2002-08-14
GR3020932T3 (en) 1996-12-31
PH26901A (en) 1992-12-03
MA21922A1 (fr) 1991-04-01
CA2020950A1 (en) 1991-02-05
NO970653D0 (no) 1997-02-12
KR0178877B1 (ko) 1999-05-15
CN1024196C (zh) 1994-04-13
FI105033B (fi) 2000-05-31
NO903419L (no) 1991-02-05
SA90110175B1 (ar) 2004-03-09
AU634267B2 (en) 1993-02-18
YU47368B (sh) 1995-01-31
US4937333A (en) 1990-06-26
PT94188A (pt) 1991-04-18
PL166453B1 (pl) 1995-05-31
SK379690A3 (en) 1998-06-03

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Legal Events

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8364 No opposition during term of opposition