BG92627A - Метод за пречистване на аминметиленфосфонови киселини - Google Patents

Метод за пречистване на аминметиленфосфонови киселини

Info

Publication number
BG92627A
BG92627A BG092627A BG9262790A BG92627A BG 92627 A BG92627 A BG 92627A BG 092627 A BG092627 A BG 092627A BG 9262790 A BG9262790 A BG 9262790A BG 92627 A BG92627 A BG 92627A
Authority
BG
Bulgaria
Prior art keywords
acid
crystals
temperature
precipitate
maintained
Prior art date
Application number
BG092627A
Other languages
English (en)
Other versions
BG60519B1 (bg
Inventor
Joseph GARLICH
Jaime Simon
Tipton Masterson
Original Assignee
The Dow Chemical Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Dow Chemical Company filed Critical The Dow Chemical Company
Publication of BG92627A publication Critical patent/BG92627A/bg
Publication of BG60519B1 publication Critical patent/BG60519B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/44—Amides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/025—Purification; Separation; Stabilisation; Desodorisation of organo-phosphorus compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C07F9/3817—Acids containing the structure (RX)2P(=X)-alk-N...P (X = O, S, Se)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)

Abstract

Етилендиаминтетра/метиленфосфонова/ киселина и 1,4,7,10-тетраазациклододекан-1,4,7,10-тетра/метиленфосфонов а/ киселина с висока чистота се получават чрез разтваряне на аминметиленфосфоновата киселина във водна база. Разтворът се подкислява с минерална киселина при повишена температура, за да се утаят кристалите, поддържа се при повишена температура в продължение на период от време, достатъчен да осигури кристализирането, и се охлажда при ниска температура. Разтворът се поддържа при тази температура достатъчно продължително време, за да се утаят кристалите. Получените кристали се филтрират при същата температура, промиват се с вода и желаната аминофосфонова киселина се извлича с висока чистота. Етилендиаминтетра/метиленфосфоновата/ киселина се получава в по-чист вид, ако по време на получаването й кристалите се филтрират на горещо. 18 претенции
BG92627A 1989-08-04 1990-08-03 Метод за пречистване на аминметиленфосфонови киселини BG60519B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/389,441 US4937333A (en) 1989-08-04 1989-08-04 Method for purifying aminomethylenephosphonic acids for pharmaceutical use

Publications (2)

Publication Number Publication Date
BG92627A true BG92627A (bg) 1993-12-24
BG60519B1 BG60519B1 (bg) 1995-07-28

Family

ID=23538280

Family Applications (1)

Application Number Title Priority Date Filing Date
BG92627A BG60519B1 (bg) 1989-08-04 1990-08-03 Метод за пречистване на аминметиленфосфонови киселини

Country Status (38)

Country Link
US (1) US4937333A (bg)
EP (1) EP0411941B1 (bg)
JP (1) JP2922263B2 (bg)
KR (2) KR0178779B1 (bg)
CN (2) CN1024196C (bg)
AP (1) AP163A (bg)
AT (1) ATE140459T1 (bg)
AU (1) AU634267B2 (bg)
BG (1) BG60519B1 (bg)
BR (2) BR9003694A (bg)
CA (1) CA2020950C (bg)
CZ (1) CZ290556B6 (bg)
DD (1) DD297414A5 (bg)
DE (1) DE69027818T2 (bg)
DK (1) DK0411941T3 (bg)
DZ (1) DZ1436A1 (bg)
EG (1) EG19250A (bg)
ES (1) ES2090105T3 (bg)
FI (1) FI105033B (bg)
GR (1) GR3020932T3 (bg)
HK (1) HK1007558A1 (bg)
HU (1) HU205128B (bg)
IE (1) IE902812A1 (bg)
IL (3) IL110861A (bg)
LV (1) LV10718B (bg)
MA (1) MA21922A1 (bg)
NO (2) NO178196C (bg)
NZ (2) NZ247888A (bg)
OA (1) OA09300A (bg)
PH (1) PH26901A (bg)
PL (2) PL166453B1 (bg)
PT (1) PT94188B (bg)
RO (1) RO105967B1 (bg)
RU (1) RU1838321C (bg)
SA (1) SA90110175B1 (bg)
SK (1) SK279107B6 (bg)
YU (1) YU47368B (bg)
ZA (1) ZA905564B (bg)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4937333A (en) * 1989-08-04 1990-06-26 The Dow Chemical Company Method for purifying aminomethylenephosphonic acids for pharmaceutical use
MC2260A1 (fr) * 1990-06-18 1993-04-26 Dow Chemical Co Formulations de produits radiopharmaceutiques,leur methode d'administration et leur procede de preparation
EP0494603A3 (en) * 1991-01-10 1993-10-20 Hoechst Ag Process for extractive separation of phospho- and sulphobetaines from acidic reaction solutions
US5410043A (en) * 1991-12-06 1995-04-25 Schering Aktiengesellschaft Process for the production of mono-N-substituted tetraaza macrocycles
US5320829A (en) * 1991-12-10 1994-06-14 The Dow Chemical Company Oral compositions for inhibiting plaque formation
DE4218744C2 (de) * 1992-06-04 1997-11-06 Schering Ag Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe
US5495042A (en) * 1993-11-04 1996-02-27 Cytogen Corporation Non-alkaline purification of aminophosphonic acids
EP1191948A2 (en) 1999-06-11 2002-04-03 Neorx Corporation High dose radionuclide complexes for bone marrow suppression
US7094885B2 (en) * 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
AU1092601A (en) * 1999-10-18 2001-04-30 Dow Global Technologies Inc. Aminoalkylenephosphonates for treatment of bone disorders
US6794371B1 (en) * 1999-10-18 2004-09-21 The Dow Chemical Company Aminoalkylenephosphonates for treatment of bone disorders
JP2004536034A (ja) 2001-01-08 2004-12-02 ネオルクス コーポレイション 治療的および診断的化合物、組成物および方法
CN100368047C (zh) * 2002-12-27 2008-02-13 住友化学株式会社 结晶方法和结晶装置
EP1778699A4 (en) * 2004-08-10 2009-02-25 Dow Global Technologies Inc TARGETING OF CHELANTS AND CHELATES
CN101381377B (zh) * 2008-10-23 2011-05-04 山东省泰和水处理有限公司 一种适用于电子级固体己二胺四亚甲基膦酸的制备工艺
JP5581832B2 (ja) * 2010-06-11 2014-09-03 三菱瓦斯化学株式会社 高純度アミノメチレンホスホン酸の製造方法
CN103724373A (zh) * 2014-01-02 2014-04-16 山东省泰和水处理有限公司 多聚甲醛生产氨基三亚甲基膦酸的方法
DE102014210378B4 (de) * 2014-06-02 2018-10-04 Zschimmer & Schwarz Mohsdorf GmbH &Co.KG. Verfahren zur Herstellung hochreiner Aminoalkylenphosphonsäuren
DE102015210145A1 (de) 2014-06-02 2015-12-03 Zschimmer & Schwarz Mohsdorf GmbH &Co.KG. Verfahren zur Herstellung kristalliner DTPMP
CN113263580A (zh) * 2021-04-23 2021-08-17 广东工业大学 一种多功能床头柜制造设备

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2599807A (en) * 1950-06-01 1952-06-10 Frederick C Bersworth Alkylene polyamine methylene phosphonic acids
NL285361A (bg) * 1961-11-13 1900-01-01
US3738937A (en) * 1970-05-08 1973-06-12 Textilana Corp Polyalkylene polyamino polykis methylene phosphonic acids and salts thereof and methods for producing same
NL7903500A (nl) * 1979-05-04 1980-11-06 Philips Nv Verbrandingsflitslamp en flitsinrichting voorzien van verscheidene verbrandingsflitslampen.
JPS5775990A (en) * 1980-10-27 1982-05-12 Mitsubishi Gas Chem Co Inc Preparation of n,n,n',n'-tetra(phosphonomethyl) diaminoalkane
EP0225409A1 (en) * 1985-12-02 1987-06-16 The Dow Chemical Company Organic amine phosphonic acid complexes for the treatment of calcific tumors
US4937333A (en) * 1989-08-04 1990-06-26 The Dow Chemical Company Method for purifying aminomethylenephosphonic acids for pharmaceutical use
GB8903023D0 (en) * 1989-02-10 1989-03-30 Parker David Chemical compounds
DE3911816A1 (de) * 1989-04-11 1990-10-25 Hoechst Ag Substituierte 1,4,7,10-tetraazacyclotridecane, verfahren zu deren herstellung sowie verwendung derselben zur markierung von substanzen mit radionukliden

Also Published As

Publication number Publication date
GR3020932T3 (en) 1996-12-31
PT94188B (pt) 1996-12-31
RO105967B1 (ro) 1993-01-30
DZ1436A1 (fr) 2004-09-13
YU145390A (sh) 1992-09-07
PH26901A (en) 1992-12-03
NZ247888A (en) 1994-07-26
IL95094A0 (en) 1991-06-10
BR1101174A (pt) 2000-08-08
ES2090105T3 (es) 1996-10-16
FI903864A0 (fi) 1990-08-03
HUT54698A (en) 1991-03-28
OA09300A (en) 1992-09-15
CN1091744A (zh) 1994-09-07
NO178196C (no) 1996-02-07
CZ379690A3 (cs) 2000-08-16
BR9003694A (pt) 1991-09-03
PL286349A1 (en) 1991-05-20
BG60519B1 (bg) 1995-07-28
NO970653L (no) 1991-02-05
YU47368B (sh) 1995-01-31
DE69027818D1 (de) 1996-08-22
AP9000202A0 (en) 1990-10-31
KR0178779B1 (ko) 1999-05-15
CN1049351A (zh) 1991-02-20
NO903419D0 (no) 1990-08-03
FI105033B (fi) 2000-05-31
CZ290556B6 (cs) 2002-08-14
DE69027818T2 (de) 1996-11-21
HU904890D0 (en) 1991-01-28
NO903419L (no) 1991-02-05
NO178196B (no) 1995-10-30
NZ234464A (en) 1994-06-27
IE902812A1 (en) 1991-02-27
SK379690A3 (en) 1998-06-03
JPH0366697A (ja) 1991-03-22
US4937333A (en) 1990-06-26
MA21922A1 (fr) 1991-04-01
IL95094A (en) 1995-05-26
HK1007558A1 (en) 2003-07-10
DK0411941T3 (da) 1996-11-11
EP0411941A3 (en) 1992-04-15
EP0411941B1 (en) 1996-07-17
PL166453B1 (pl) 1995-05-31
AU634267B2 (en) 1993-02-18
LV10718B (en) 1996-04-20
KR910004642A (ko) 1991-03-29
DD297414A5 (de) 1992-01-09
AP163A (en) 1992-01-11
EG19250A (en) 1994-09-29
LV10718A (lv) 1995-06-20
JP2922263B2 (ja) 1999-07-19
CN1024196C (zh) 1994-04-13
EP0411941A2 (en) 1991-02-06
IL110861A (en) 1999-07-14
HU205128B (en) 1992-03-30
AU6023790A (en) 1991-02-07
PT94188A (pt) 1991-04-18
NO970653D0 (no) 1997-02-12
IL110861A0 (en) 1994-11-28
RU1838321C (ru) 1993-08-30
PL164908B1 (pl) 1994-10-31
ATE140459T1 (de) 1996-08-15
CA2020950A1 (en) 1991-02-05
CN1031191C (zh) 1996-03-06
CA2020950C (en) 2000-04-11
SK279107B6 (sk) 1998-06-03
KR0178877B1 (ko) 1999-05-15
ZA905564B (en) 1992-03-25
SA90110175B1 (ar) 2004-03-09

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