SK338092A3 - Substituted biphenylpyridones, method for their producing, pharmaceutical composition containing the same and their use - Google Patents

Substituted biphenylpyridones, method for their producing, pharmaceutical composition containing the same and their use Download PDF

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Publication number
SK338092A3
SK338092A3 SK3380-92A SK338092A SK338092A3 SK 338092 A3 SK338092 A3 SK 338092A3 SK 338092 A SK338092 A SK 338092A SK 338092 A3 SK338092 A3 SK 338092A3
Authority
SK
Slovakia
Prior art keywords
group
carbon atoms
straight
branched alkyl
atom
Prior art date
Application number
SK3380-92A
Other languages
English (en)
Slovak (sk)
Other versions
SK279433B6 (sk
Inventor
Matthias Muller-Gliemann
Martin Beuck
Stanislav Kazda
Johannes-Peter Stasch
Andreas Knorr
Stefan Wohlfeil
Walter Hubsch
Jurgen Dressel
Peter Fey
Rudolf Hanko
Thomas Kramer
Ulrich E Muller
Siegfried Zaiss
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of SK338092A3 publication Critical patent/SK338092A3/sk
Publication of SK279433B6 publication Critical patent/SK279433B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
SK3380-92A 1991-11-12 1992-11-12 Substituované bifenylpyridóny, spôsob ich výroby, SK279433B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4137151 1991-11-12
DE4221583A DE4221583A1 (de) 1991-11-12 1992-07-01 Substituierte biphenylpyridone

Publications (2)

Publication Number Publication Date
SK338092A3 true SK338092A3 (en) 1998-11-04
SK279433B6 SK279433B6 (sk) 1998-11-04

Family

ID=25909023

Family Applications (1)

Application Number Title Priority Date Filing Date
SK3380-92A SK279433B6 (sk) 1991-11-12 1992-11-12 Substituované bifenylpyridóny, spôsob ich výroby,

Country Status (23)

Country Link
US (2) US5356911A (no)
EP (1) EP0542059B1 (no)
JP (1) JPH05255258A (no)
KR (1) KR930010030A (no)
CN (1) CN1038935C (no)
AT (1) ATE135700T1 (no)
AU (1) AU659235B2 (no)
CA (1) CA2082306A1 (no)
CZ (1) CZ281937B6 (no)
DE (2) DE4221583A1 (no)
DK (1) DK0542059T3 (no)
ES (1) ES2086046T3 (no)
FI (1) FI925100A (no)
GR (1) GR3019398T3 (no)
HU (1) HUT67018A (no)
IL (1) IL103688A (no)
MX (1) MX9206305A (no)
MY (1) MY109880A (no)
NO (1) NO303541B1 (no)
NZ (1) NZ245073A (no)
RU (1) RU2100350C1 (no)
SK (1) SK279433B6 (no)
TW (1) TW218874B (no)

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GB0420722D0 (en) * 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
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DE102005030522A1 (de) * 2005-06-30 2007-01-04 Bayer Healthcare Ag Salz des Embusartans
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US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MY152078A (en) 2007-09-14 2014-08-15 Ortho Mcneil Janssen Pharm 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h,1'h-[1,4']bipyridinyl-2'-ones
CN101848893B (zh) 2007-09-14 2012-06-06 奥梅-杨森制药有限公司 1,3-二取代的4-(芳基-x-苯基)-1h-吡啶-2-酮
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JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
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JP5547194B2 (ja) 2008-09-02 2014-07-09 ジャンセン ファーマシューティカルズ， インコーポレイテッド． 代謝型グルタミン酸受容体の調節因子としての３−アザビシクロ［３．１．０］ヘキシル誘導体
EP2346505B1 (en) 2008-10-16 2014-04-23 Janssen Pharmaceuticals, Inc. Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
CN102232074B (zh) 2008-11-28 2014-12-03 奥梅-杨森制药有限公司 作为代谢性谷氨酸盐受体调节剂的吲哚和苯并噁嗪衍生物
AU2010246607B2 (en) 2009-05-12 2012-09-27 Addex Pharma S.A. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
MX2011011964A (es) 2009-05-12 2012-02-23 Janssen Pharmaceuticals Inc Derivados de 1,2,3-triazolo[4,3-a]piridina y su uso para el tratamiento o prevencion de trastornos neurologicos y psiquiatricos.
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PL2649069T3 (pl) 2010-11-08 2016-01-29 Janssen Pharmaceuticals Inc Pochodne 1,2,4-triazolo[4,3-a]pirydyny i ich zastosowanie jako dodatnich allosterycznych modulatorów receptorów mGluR2
WO2013093484A1 (en) * 2011-12-21 2013-06-27 Ono Pharmaceutical Co., Ltd. Pyridinone and pyrimidinone derivatives as factor xia inhibitors
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JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
HUE045610T2 (hu) 2014-01-21 2020-01-28 Janssen Pharmaceutica Nv 2-es altípusú metabotróp glutamáterg receptor pozitív allosztérikus modulátorait vagy ortosztérikus agonistáit tartalmazó kombinációk és alkalmazásuk
EA033889B1 (ru) 2014-01-21 2019-12-05 Янссен Фармацевтика Нв Комбинация на основе лиганда sv2a и положительного аллостерического модулятора метаботропного глутаматергического рецептора 2 подтипа
WO2016093285A1 (ja) 2014-12-10 2016-06-16 小野薬品工業株式会社 ジヒドロインドリジノン誘導体

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EP0407342A3 (en) 1989-07-06 1991-07-10 Ciba-Geigy Ag Pyrimidine derivatives
US5100897A (en) * 1989-08-28 1992-03-31 Merck & Co., Inc. Substituted pyrimidinones as angiotensin ii antagonists
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Also Published As

Publication number Publication date
DE4221583A1 (de) 1993-05-13
ES2086046T3 (es) 1996-06-16
GR3019398T3 (en) 1996-06-30
CA2082306A1 (en) 1993-05-12
FI925100A0 (fi) 1992-11-10
NO924172L (no) 1993-05-14
HU9203552D0 (en) 1993-01-28
DE59205752D1 (de) 1996-04-25
ATE135700T1 (de) 1996-04-15
MY109880A (en) 1997-09-30
CZ281937B6 (cs) 1997-04-16
SK279433B6 (sk) 1998-11-04
FI925100A (fi) 1993-05-13
HUT67018A (en) 1995-01-30
CN1072180A (zh) 1993-05-19
IL103688A0 (en) 1993-04-04
US5356911A (en) 1994-10-18
RU2100350C1 (ru) 1997-12-27
EP0542059A1 (de) 1993-05-19
CN1038935C (zh) 1998-07-01
NO303541B1 (no) 1998-07-27
AU2823292A (en) 1993-05-13
NZ245073A (en) 1996-02-27
DK0542059T3 (da) 1996-07-22
TW218874B (no) 1994-01-11
MX9206305A (es) 1993-05-01
IL103688A (en) 1997-02-18
JPH05255258A (ja) 1993-10-05
EP0542059B1 (de) 1996-03-20
KR930010030A (ko) 1993-06-21
AU659235B2 (en) 1995-05-11
US5599823A (en) 1997-02-04
NO924172D0 (no) 1992-10-29
CZ338092A3 (en) 1993-09-15

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