SK287069B6 - Deriváty aminotiazolu, spôsob ich prípravy a farmaceutické kompozície, ktoré ich obsahujú, a ich použitie - Google Patents
Deriváty aminotiazolu, spôsob ich prípravy a farmaceutické kompozície, ktoré ich obsahujú, a ich použitie Download PDFInfo
- Publication number
- SK287069B6 SK287069B6 SK38-2002A SK382002A SK287069B6 SK 287069 B6 SK287069 B6 SK 287069B6 SK 382002 A SK382002 A SK 382002A SK 287069 B6 SK287069 B6 SK 287069B6
- Authority
- SK
- Slovakia
- Prior art keywords
- carbon atoms
- methylphenyl
- group
- methoxy
- methylthiazol
- Prior art date
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- 238000002360 preparation method Methods 0.000 title claims abstract description 29
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 10
- RAIPHJJURHTUIC-UHFFFAOYSA-N 1,3-thiazol-2-amine Chemical compound NC1=NC=CS1 RAIPHJJURHTUIC-UHFFFAOYSA-N 0.000 title description 9
- 229950003476 aminothiazole Drugs 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 187
- 238000000034 method Methods 0.000 claims abstract description 26
- -1 2-chloro-4-methoxy-5-methylphenyl Chemical group 0.000 claims description 75
- 125000004432 carbon atom Chemical group C* 0.000 claims description 66
- 125000000217 alkyl group Chemical group 0.000 claims description 50
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 45
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 24
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- 208000035475 disorder Diseases 0.000 claims description 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 11
- 125000003545 alkoxy group Chemical group 0.000 claims description 9
- 125000005843 halogen group Chemical group 0.000 claims description 9
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 7
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- XNLZVDGMPUXCEL-BQAIUKQQSA-N 4-(2-chloro-4-methoxy-5-methylphenyl)-n-[(1s)-1-(4-fluorophenyl)pentyl]-5-methyl-n-prop-2-ynyl-1,3-thiazol-2-amine;hydrochloride Chemical compound Cl.C#CCN([C@@H](CCCC)C=1C=CC(F)=CC=1)C(SC=1C)=NC=1C1=CC(C)=C(OC)C=C1Cl XNLZVDGMPUXCEL-BQAIUKQQSA-N 0.000 claims description 2
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- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 62
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Classifications
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- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
Landscapes
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9909144A FR2796380B3 (fr) | 1999-07-15 | 1999-07-15 | Nouveaux derives d'aminothiazoles, leur preparation et les compositions pharmaceutiques les contenant |
PCT/FR2000/001995 WO2001005776A1 (fr) | 1999-07-15 | 2000-07-11 | Derives d'aminothiazole et leur utilisation comme ligands des recepteurs crf |
Publications (2)
Publication Number | Publication Date |
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SK382002A3 SK382002A3 (en) | 2002-07-02 |
SK287069B6 true SK287069B6 (sk) | 2009-11-05 |
Family
ID=9548107
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK38-2002A SK287069B6 (sk) | 1999-07-15 | 2000-07-11 | Deriváty aminotiazolu, spôsob ich prípravy a farmaceutické kompozície, ktoré ich obsahujú, a ich použitie |
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US (2) | US6586456B1 (cs) |
EP (1) | EP1200419B1 (cs) |
JP (1) | JP4949582B2 (cs) |
KR (1) | KR100707320B1 (cs) |
CN (1) | CN1167692C (cs) |
AR (1) | AR024747A1 (cs) |
AT (1) | ATE264315T1 (cs) |
AU (1) | AU772683B2 (cs) |
BR (1) | BR0012478B1 (cs) |
CA (1) | CA2378792C (cs) |
CO (1) | CO5200792A1 (cs) |
CZ (1) | CZ300937B6 (cs) |
DE (1) | DE60009911T2 (cs) |
DK (1) | DK1200419T3 (cs) |
EA (1) | EA005159B1 (cs) |
EE (1) | EE05004B1 (cs) |
ES (1) | ES2220504T3 (cs) |
FR (1) | FR2796380B3 (cs) |
HK (1) | HK1045692B (cs) |
HU (1) | HU229069B1 (cs) |
IL (2) | IL147282A0 (cs) |
IS (1) | IS2314B (cs) |
ME (1) | MEP26608A (cs) |
MX (1) | MXPA02000545A (cs) |
NO (1) | NO324352B1 (cs) |
NZ (1) | NZ516397A (cs) |
PL (1) | PL206515B1 (cs) |
PT (1) | PT1200419E (cs) |
RS (1) | RS50443B (cs) |
SI (1) | SI1200419T1 (cs) |
SK (1) | SK287069B6 (cs) |
TR (1) | TR200200125T2 (cs) |
TW (1) | TWI278453B (cs) |
UA (1) | UA73125C2 (cs) |
WO (1) | WO2001005776A1 (cs) |
ZA (1) | ZA200200221B (cs) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
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AU9625501A (en) * | 2000-09-21 | 2002-04-02 | Bristol Myers Squibb Co | Substituted azole derivatives as inhibitors of corticotropin releasing factor |
WO2003015777A1 (en) * | 2001-08-13 | 2003-02-27 | Lion Bioscience Ag | Nr1h4 nuclear receptor binding compounds |
AU2002334772A1 (en) | 2001-10-12 | 2003-04-28 | Duke University | Methods for image analysis of high-density synthetic dna microarrays |
CN102453763A (zh) | 2004-06-03 | 2012-05-16 | 阿什洛米克斯控股有限公司 | 诊断应激的药物和方法 |
AU2005272815A1 (en) * | 2004-08-13 | 2006-02-23 | Genentech, Inc. | Thiazole based inhibitors of ATP-utilizing enzymes |
EP1834641A1 (en) * | 2006-03-16 | 2007-09-19 | Sanofi-Aventis | Use of CRF1 receptor antagonists for preparing a drug for treating metabolic syndrome and/or obesity and/or dyslipoproteinemia |
HUP0900267A2 (en) * | 2009-04-30 | 2011-03-28 | Sanofi Aventis | Process for preparing of thiazole amines and intermediates thereof |
WO2013160317A2 (en) * | 2012-04-23 | 2013-10-31 | Holsboermaschmeyer Neurochemie Gmbh | Crhr1 antagonists for use in the treatment of patients having crh overactivity |
GB201210686D0 (en) | 2012-06-15 | 2012-08-01 | Holsboermaschmeyer Neurochemie Gmbh | V1B receptor antagonist for use in the treatment of patients having an elevated AVP level and/or an elevated copeptin level |
GB201310782D0 (en) | 2013-06-17 | 2013-07-31 | Max Planck Innovation Gmbh | Method for predicting a treatment response to a CRHR1 antagonist and/or V1B antagonist in a patient with depressive and/or anxiety symptoms |
CN111228274A (zh) | 2014-01-21 | 2020-06-05 | 纽罗克里生物科学有限公司 | 治疗先天性肾上腺增生的crf1受体拮抗剂 |
JP7532328B2 (ja) * | 2018-12-07 | 2024-08-13 | ニューロクライン バイオサイエンシーズ,インコーポレイテッド | 先天性副腎過形成を処置するためのcrf1受容体アンタゴニスト、その医薬製剤および固体形態 |
CA3121920A1 (en) | 2018-12-07 | 2020-06-11 | Neurocrine Biosciences, Inc. | Crf1 receptor antagonist, pharmaceutical formulations and solid forms thereof for the treatment of congenital adrenal hyperplasia |
CN118252829A (zh) * | 2019-09-27 | 2024-06-28 | 纽罗克里生物科学有限公司 | Crf受体拮抗剂及使用方法 |
BR112022024875A2 (pt) | 2020-06-10 | 2022-12-27 | Neurocrine Biosciences Inc | Antagonista de receptor crf1 para o tratamento de hiperplasia adrenal congênita |
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FR2692893B1 (fr) * | 1992-06-24 | 1994-09-02 | Sanofi Elf | Dérivés alkylamino ramifiés du thiazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent. |
FR2714059B1 (fr) | 1993-12-21 | 1996-03-08 | Sanofi Elf | Dérivés amino ramifiés du thiazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent. |
FR2735777B1 (fr) * | 1995-06-21 | 1997-09-12 | Sanofi Sa | Derives de 4-phenylaminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant |
FR2754258B1 (fr) * | 1996-10-08 | 1998-12-31 | Sanofi Sa | Derives d'aminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant |
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MM4A | Patent lapsed due to non-payment of maintenance fees |
Effective date: 20160711 |