SK287046B6 - Spôsob prípravy oxazolidínového medziproduktu na syntézu taxánových derivátov - Google Patents

Spôsob prípravy oxazolidínového medziproduktu na syntézu taxánových derivátov Download PDF

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Publication number
SK287046B6
SK287046B6 SK5033-2009A SK50332009A SK287046B6 SK 287046 B6 SK287046 B6 SK 287046B6 SK 50332009 A SK50332009 A SK 50332009A SK 287046 B6 SK287046 B6 SK 287046B6
Authority
SK
Slovakia
Prior art keywords
boc
carboxylic acid
solution
process according
acid
Prior art date
Application number
SK5033-2009A
Other languages
English (en)
Slovak (sk)
Inventor
Ezio Bombardelli
Bruno Gabetta
Alessandro Pontiroli
Original Assignee
Indena S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena S.P.A. filed Critical Indena S.P.A.
Publication of SK287046B6 publication Critical patent/SK287046B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
SK5033-2009A 1999-07-06 2000-07-03 Spôsob prípravy oxazolidínového medziproduktu na syntézu taxánových derivátov SK287046B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1999MI001483A ITMI991483A1 (it) 1999-07-06 1999-07-06 Derivati tassanici e procedimenti per la loro preparazione
PCT/EP2000/006185 WO2001002407A2 (en) 1999-07-06 2000-07-03 Taxane derivatives and processes for the preparation thereof

Publications (1)

Publication Number Publication Date
SK287046B6 true SK287046B6 (sk) 2009-10-07

Family

ID=11383284

Family Applications (2)

Application Number Title Priority Date Filing Date
SK5033-2009A SK287046B6 (sk) 1999-07-06 2000-07-03 Spôsob prípravy oxazolidínového medziproduktu na syntézu taxánových derivátov
SK1-2002A SK287045B6 (sk) 1999-07-06 2000-07-03 Taxánový derivát, spôsob jeho prípravy, farmaceutický prostriedok s jeho obsahom, jeho použitie a medziprodukty

Family Applications After (1)

Application Number Title Priority Date Filing Date
SK1-2002A SK287045B6 (sk) 1999-07-06 2000-07-03 Taxánový derivát, spôsob jeho prípravy, farmaceutický prostriedok s jeho obsahom, jeho použitie a medziprodukty

Country Status (22)

Country Link
US (2) US6906101B1 (cs)
EP (2) EP1192162B1 (cs)
JP (1) JP4823456B2 (cs)
KR (1) KR100778156B1 (cs)
CN (3) CN100418958C (cs)
AT (2) ATE350372T1 (cs)
AU (1) AU771737B2 (cs)
CA (2) CA2676424C (cs)
CZ (1) CZ301764B6 (cs)
DE (2) DE60014374T2 (cs)
DK (2) DK1192162T3 (cs)
ES (2) ES2278254T3 (cs)
HU (1) HUP0202016A3 (cs)
IL (3) IL147445A0 (cs)
IT (1) ITMI991483A1 (cs)
NO (2) NO328150B1 (cs)
PL (1) PL205921B1 (cs)
PT (2) PT1192162E (cs)
RU (1) RU2245882C2 (cs)
SI (2) SI1529777T1 (cs)
SK (2) SK287046B6 (cs)
WO (1) WO2001002407A2 (cs)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1318678B1 (it) * 2000-08-10 2003-08-27 Indena Spa Procedimento per la preparazione di derivati della baccatina iii.
IT1320107B1 (it) * 2000-11-28 2003-11-18 Indena Spa Procedimento per la preparazione di derivati tassanici.
ITMI20021921A1 (it) * 2002-09-10 2004-03-11 Indena Spa Funzionalizzazione della posizione 14 dei nuclei tassanici e sintesi di nuovi derivati antitumorali.
US8557861B2 (en) * 2004-09-28 2013-10-15 Mast Therapeutics, Inc. Low oil emulsion compositions for delivering taxoids and other insoluble drugs
TWI376239B (en) * 2006-02-01 2012-11-11 Andrew Xian Chen Vitamin e succinate stabilized pharmaceutical compositions, methods for the preparation and the use thereof
US7232916B1 (en) 2006-05-11 2007-06-19 Indena S.P.A. Process for the preparation of a taxane derivative
DE602006021546D1 (de) * 2006-05-12 2011-06-09 Indena Spa Verfahren zur Herstellung eines Taxanderivats
ITMI20062479A1 (it) * 2006-12-21 2008-06-22 Indena Spa Processo per la preparazione di secotassani
EP2080763A1 (en) 2008-01-18 2009-07-22 INDENA S.p.A. Crystalline form I of ortataxel
ES2389518T3 (es) 2008-01-18 2012-10-26 Indena S.P.A. Formas sólidas de ortataxel
RU2428175C2 (ru) * 2008-06-02 2011-09-10 Закрытое Акционерное Общество "Биокад" Способ получения парентерального фармацевтического раствора
CN104650109B (zh) 2013-11-22 2019-01-01 江苏天士力帝益药业有限公司 紫杉烷类化合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
US5698712A (en) * 1992-03-06 1997-12-16 Indena S.P.A. Baccatine III derivatives
FR2688499B1 (fr) * 1992-03-10 1994-05-06 Rhone Poulenc Rorer Sa Procede de preparation de la beta-phenylisoserine et de ses analogues.
FR2696460B1 (fr) 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
US5475011A (en) * 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
US5750508A (en) 1993-06-16 1998-05-12 Glycomed Incorporated Sialic acid/fucose based medicaments
IT1275936B1 (it) * 1995-03-17 1997-10-24 Indena Spa Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni

Also Published As

Publication number Publication date
SI1529777T1 (sl) 2007-04-30
DK1192162T3 (da) 2005-01-17
CA2373530A1 (en) 2001-01-11
KR20020022759A (ko) 2002-03-27
WO2001002407A3 (en) 2001-06-28
SI1192162T1 (en) 2005-02-28
PT1192162E (pt) 2004-12-31
DE60032827D1 (de) 2007-02-15
ES2278254T3 (es) 2007-08-01
JP4823456B2 (ja) 2011-11-24
SK12002A3 (en) 2002-04-04
AU771737B2 (en) 2004-04-01
NO332194B1 (no) 2012-07-23
DE60014374D1 (de) 2004-11-04
CN100418958C (zh) 2008-09-17
DE60014374T2 (de) 2006-02-16
PT1529777E (pt) 2007-01-31
EP1192162B1 (en) 2004-09-29
KR100778156B1 (ko) 2007-11-27
ITMI991483A1 (it) 2001-01-06
JP2003503502A (ja) 2003-01-28
DE60032827T2 (de) 2007-11-08
CN1359384A (zh) 2002-07-17
IL172973A (en) 2010-11-30
NO20093014L (no) 2002-02-27
IL147445A (en) 2006-07-05
WO2001002407A2 (en) 2001-01-11
CA2676424A1 (en) 2001-01-11
EP1192162A2 (en) 2002-04-03
PL352278A1 (en) 2003-08-11
NO20020017L (no) 2002-02-27
EP1529777A3 (en) 2005-05-18
CA2676424C (en) 2011-09-27
PL205921B1 (pl) 2010-06-30
HK1089158A1 (zh) 2006-11-24
US6906101B1 (en) 2005-06-14
EP1529777A2 (en) 2005-05-11
ATE277932T1 (de) 2004-10-15
CN1539831A (zh) 2004-10-27
ATE350372T1 (de) 2007-01-15
NO20020017D0 (no) 2002-01-03
AU5823500A (en) 2001-01-22
CN1234696C (zh) 2006-01-04
NO328150B1 (no) 2009-12-21
DK1529777T3 (da) 2007-05-14
CA2373530C (en) 2010-06-29
CZ200222A3 (cs) 2002-05-15
SK287045B6 (sk) 2009-10-07
IL147445A0 (en) 2002-08-14
CN1158286C (zh) 2004-07-21
ITMI991483A0 (it) 1999-07-06
HK1068879A1 (en) 2005-05-06
USRE40901E1 (en) 2009-09-01
EP1529777B1 (en) 2007-01-03
CN1769275A (zh) 2006-05-10
IL172973A0 (en) 2006-06-11
HUP0202016A3 (en) 2005-02-28
ES2228560T3 (es) 2005-04-16
HUP0202016A2 (en) 2002-10-28
RU2245882C2 (ru) 2005-02-10
HK1047096A1 (en) 2003-02-07
CZ301764B6 (cs) 2010-06-16

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Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20100703