DK1529777T3 - Fremgangsmåde og oxazolidin-mellemprodukt til syntese af taxaner - Google Patents

Fremgangsmåde og oxazolidin-mellemprodukt til syntese af taxaner

Info

Publication number
DK1529777T3
DK1529777T3 DK04022031T DK04022031T DK1529777T3 DK 1529777 T3 DK1529777 T3 DK 1529777T3 DK 04022031 T DK04022031 T DK 04022031T DK 04022031 T DK04022031 T DK 04022031T DK 1529777 T3 DK1529777 T3 DK 1529777T3
Authority
DK
Denmark
Prior art keywords
synthesis
taxanes
oxazolidine intermediate
oxazolidine
baccatines
Prior art date
Application number
DK04022031T
Other languages
English (en)
Inventor
Ezio Bombardelli
Alessandro Pontiroli
Bruno Gabetta
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Application granted granted Critical
Publication of DK1529777T3 publication Critical patent/DK1529777T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK04022031T 1999-07-06 2000-07-03 Fremgangsmåde og oxazolidin-mellemprodukt til syntese af taxaner DK1529777T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1999MI001483A ITMI991483A1 (it) 1999-07-06 1999-07-06 Derivati tassanici e procedimenti per la loro preparazione
PCT/EP2000/006185 WO2001002407A2 (en) 1999-07-06 2000-07-03 Taxane derivatives and processes for the preparation thereof

Publications (1)

Publication Number Publication Date
DK1529777T3 true DK1529777T3 (da) 2007-05-14

Family

ID=11383284

Family Applications (2)

Application Number Title Priority Date Filing Date
DK00943970T DK1192162T3 (da) 1999-07-06 2000-07-03 Taxanderivater og fremgangsmåder til fremstilling deraf
DK04022031T DK1529777T3 (da) 1999-07-06 2000-07-03 Fremgangsmåde og oxazolidin-mellemprodukt til syntese af taxaner

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK00943970T DK1192162T3 (da) 1999-07-06 2000-07-03 Taxanderivater og fremgangsmåder til fremstilling deraf

Country Status (23)

Country Link
US (2) USRE40901E1 (da)
EP (2) EP1192162B1 (da)
JP (1) JP4823456B2 (da)
KR (1) KR100778156B1 (da)
CN (3) CN1234696C (da)
AT (2) ATE277932T1 (da)
AU (1) AU771737B2 (da)
CA (2) CA2676424C (da)
CZ (1) CZ301764B6 (da)
DE (2) DE60032827T2 (da)
DK (2) DK1192162T3 (da)
ES (2) ES2278254T3 (da)
HK (3) HK1047096A1 (da)
HU (1) HUP0202016A3 (da)
IL (3) IL147445A0 (da)
IT (1) ITMI991483A1 (da)
NO (2) NO328150B1 (da)
PL (1) PL205921B1 (da)
PT (2) PT1529777E (da)
RU (1) RU2245882C2 (da)
SI (2) SI1529777T1 (da)
SK (2) SK287045B6 (da)
WO (1) WO2001002407A2 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1318678B1 (it) * 2000-08-10 2003-08-27 Indena Spa Procedimento per la preparazione di derivati della baccatina iii.
IT1320107B1 (it) * 2000-11-28 2003-11-18 Indena Spa Procedimento per la preparazione di derivati tassanici.
ITMI20021921A1 (it) * 2002-09-10 2004-03-11 Indena Spa Funzionalizzazione della posizione 14 dei nuclei tassanici e sintesi di nuovi derivati antitumorali.
US8557861B2 (en) * 2004-09-28 2013-10-15 Mast Therapeutics, Inc. Low oil emulsion compositions for delivering taxoids and other insoluble drugs
TWI376239B (en) * 2006-02-01 2012-11-11 Andrew Xian Chen Vitamin e succinate stabilized pharmaceutical compositions, methods for the preparation and the use thereof
US7232916B1 (en) 2006-05-11 2007-06-19 Indena S.P.A. Process for the preparation of a taxane derivative
DE602006021546D1 (de) * 2006-05-12 2011-06-09 Indena Spa Verfahren zur Herstellung eines Taxanderivats
ITMI20062479A1 (it) * 2006-12-21 2008-06-22 Indena Spa Processo per la preparazione di secotassani
EP2080763A1 (en) 2008-01-18 2009-07-22 INDENA S.p.A. Crystalline form I of ortataxel
EP2080764B1 (en) * 2008-01-18 2012-08-22 INDENA S.p.A. Solid forms of ortataxel
CN104650109B (zh) * 2013-11-22 2019-01-01 江苏天士力帝益药业有限公司 紫杉烷类化合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
US5698712A (en) * 1992-03-06 1997-12-16 Indena S.P.A. Baccatine III derivatives
FR2688499B1 (fr) * 1992-03-10 1994-05-06 Rhone Poulenc Rorer Sa Procede de preparation de la beta-phenylisoserine et de ses analogues.
FR2696460B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
US5475011A (en) * 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
US5750508A (en) 1993-06-16 1998-05-12 Glycomed Incorporated Sialic acid/fucose based medicaments
IT1275936B1 (it) * 1995-03-17 1997-10-24 Indena Spa Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni

Also Published As

Publication number Publication date
CN1769275A (zh) 2006-05-10
HUP0202016A3 (en) 2005-02-28
USRE40901E1 (en) 2009-09-01
CN1158286C (zh) 2004-07-21
HK1089158A1 (en) 2006-11-24
HUP0202016A2 (en) 2002-10-28
NO20093014L (no) 2002-02-27
IL147445A (en) 2006-07-05
IL172973A0 (en) 2006-06-11
SI1529777T1 (sl) 2007-04-30
PL205921B1 (pl) 2010-06-30
ATE277932T1 (de) 2004-10-15
PT1529777E (pt) 2007-01-31
KR100778156B1 (ko) 2007-11-27
EP1529777A3 (en) 2005-05-18
PL352278A1 (en) 2003-08-11
EP1529777A2 (en) 2005-05-11
ATE350372T1 (de) 2007-01-15
AU5823500A (en) 2001-01-22
DK1192162T3 (da) 2005-01-17
EP1192162B1 (en) 2004-09-29
CN100418958C (zh) 2008-09-17
WO2001002407A3 (en) 2001-06-28
PT1192162E (pt) 2004-12-31
DE60032827D1 (de) 2007-02-15
ITMI991483A1 (it) 2001-01-06
CA2373530C (en) 2010-06-29
DE60014374D1 (de) 2004-11-04
RU2245882C2 (ru) 2005-02-10
CA2676424C (en) 2011-09-27
ES2278254T3 (es) 2007-08-01
CZ200222A3 (cs) 2002-05-15
SI1192162T1 (en) 2005-02-28
KR20020022759A (ko) 2002-03-27
SK12002A3 (en) 2002-04-04
NO20020017D0 (no) 2002-01-03
CA2676424A1 (en) 2001-01-11
JP4823456B2 (ja) 2011-11-24
SK287045B6 (sk) 2009-10-07
DE60032827T2 (de) 2007-11-08
US6906101B1 (en) 2005-06-14
CZ301764B6 (cs) 2010-06-16
CN1359384A (zh) 2002-07-17
EP1192162A2 (en) 2002-04-03
CN1234696C (zh) 2006-01-04
NO332194B1 (no) 2012-07-23
DE60014374T2 (de) 2006-02-16
SK287046B6 (sk) 2009-10-07
IL172973A (en) 2010-11-30
EP1529777B1 (en) 2007-01-03
IL147445A0 (en) 2002-08-14
AU771737B2 (en) 2004-04-01
ITMI991483A0 (it) 1999-07-06
HK1047096A1 (en) 2003-02-07
JP2003503502A (ja) 2003-01-28
NO20020017L (no) 2002-02-27
NO328150B1 (no) 2009-12-21
CA2373530A1 (en) 2001-01-11
ES2228560T3 (es) 2005-04-16
WO2001002407A2 (en) 2001-01-11
CN1539831A (zh) 2004-10-27
HK1068879A1 (en) 2005-05-06

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