SK286439B6 - MCP-2 skrátený na aminokonci, DNA molekuly, expresný vektor, hostiteľská bunka, rekombinantný spôsob jeho prípravy, farmaceutický prostriedok s jeho obsahom a jeho použitie - Google Patents

MCP-2 skrátený na aminokonci, DNA molekuly, expresný vektor, hostiteľská bunka, rekombinantný spôsob jeho prípravy, farmaceutický prostriedok s jeho obsahom a jeho použitie Download PDF

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Publication number
SK286439B6
SK286439B6 SK450-2000A SK4502000A SK286439B6 SK 286439 B6 SK286439 B6 SK 286439B6 SK 4502000 A SK4502000 A SK 4502000A SK 286439 B6 SK286439 B6 SK 286439B6
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SK
Slovakia
Prior art keywords
mcp
amino
cells
protein
truncated
Prior art date
Application number
SK450-2000A
Other languages
English (en)
Slovak (sk)
Other versions
SK4502000A3 (en
Inventor
Paul Proost
Sofie Struyf
Damme Jo Van
Original Assignee
Laboratoires Serono Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8227408&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK286439(B6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Laboratoires Serono Sa filed Critical Laboratoires Serono Sa
Publication of SK4502000A3 publication Critical patent/SK4502000A3/sk
Publication of SK286439B6 publication Critical patent/SK286439B6/sk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4813—Exopeptidases (3.4.11. to 3.4.19)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • AIDS & HIV (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
SK450-2000A 1997-09-29 1998-09-28 MCP-2 skrátený na aminokonci, DNA molekuly, expresný vektor, hostiteľská bunka, rekombinantný spôsob jeho prípravy, farmaceutický prostriedok s jeho obsahom a jeho použitie SK286439B6 (sk)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP97116863A EP0906954A1 (de) 1997-09-29 1997-09-29 Aminoterminalen verkürzten C-C Chemokine als Chemokine Antagonist
EP97122471A EP0905240A1 (de) 1997-09-29 1997-12-19 Aminoterminalen verkürzten C-C-chemokine and als chemokine Antagonist
EP98104216A EP0905241A1 (de) 1997-09-29 1998-03-10 Aminoterminalen verkürzten C-C Chemokine und als Chemokine Antagonist
PCT/EP1998/006142 WO1999016876A1 (en) 1997-09-29 1998-09-28 Amino-terminally truncated mcp-2 as chemokine antagonists

Publications (2)

Publication Number Publication Date
SK4502000A3 SK4502000A3 (en) 2000-09-12
SK286439B6 true SK286439B6 (sk) 2008-10-07

Family

ID=8227408

Family Applications (2)

Application Number Title Priority Date Filing Date
SK451-2000A SK286495B6 (sk) 1997-09-29 1998-09-28 RANTES skrátené na aminokonci, DNA molekuly, expresný vektor, hostiteľská bunka, rekombinantný spôsob jeho prípravy, farmaceutický prostriedok s jehoobsahom a jeho použitie
SK450-2000A SK286439B6 (sk) 1997-09-29 1998-09-28 MCP-2 skrátený na aminokonci, DNA molekuly, expresný vektor, hostiteľská bunka, rekombinantný spôsob jeho prípravy, farmaceutický prostriedok s jeho obsahom a jeho použitie

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SK451-2000A SK286495B6 (sk) 1997-09-29 1998-09-28 RANTES skrátené na aminokonci, DNA molekuly, expresný vektor, hostiteľská bunka, rekombinantný spôsob jeho prípravy, farmaceutický prostriedok s jehoobsahom a jeho použitie

Country Status (29)

Country Link
US (5) US6977071B2 (de)
EP (6) EP0906954A1 (de)
JP (2) JP4230659B2 (de)
KR (2) KR100542934B1 (de)
CN (3) CN1148447C (de)
AR (2) AR013529A1 (de)
AT (3) ATE263242T1 (de)
AU (2) AU750341B2 (de)
BG (2) BG64757B1 (de)
BR (2) BR9812565A (de)
CA (2) CA2305017A1 (de)
CY (1) CY1110927T1 (de)
CZ (2) CZ299478B6 (de)
DE (3) DE69823218T2 (de)
DK (3) DK1439231T3 (de)
EA (2) EA003942B1 (de)
EE (2) EE200000152A (de)
ES (3) ES2215324T3 (de)
HK (3) HK1032425A1 (de)
HU (2) HU226468B1 (de)
IL (2) IL135352A (de)
NO (2) NO20001584L (de)
NZ (3) NZ503234A (de)
PL (2) PL196427B1 (de)
PT (3) PT1019507E (de)
SK (2) SK286495B6 (de)
UA (2) UA73080C2 (de)
WO (2) WO1999016877A1 (de)
ZA (2) ZA988675B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7067117B1 (en) 1997-09-11 2006-06-27 Cambridge University Technical Services, Ltd. Compounds and methods to inhibit or augment an inflammatory response
US6989435B2 (en) 1997-09-11 2006-01-24 Cambridge University Technical Services Ltd. Compounds and methods to inhibit or augment an inflammatory response
AU1616499A (en) * 1997-12-01 1999-06-16 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Chemokine variants and methods of use
US7238711B1 (en) 1999-03-17 2007-07-03 Cambridge University Technical Services Ltd. Compounds and methods to inhibit or augment an inflammatory response
AU1259501A (en) * 1999-10-25 2001-05-08 Euroscreen S.A. Processed human chemokines phc-1 and phc-2
EP1167527A1 (de) * 2000-06-22 2002-01-02 Euroscreen S.A. Prozessierte Menschliche Chemokine: PHC-1 und PHC-2
AU2505601A (en) * 1999-11-15 2001-05-30 Wolf-Georg Forssmann Novel use of hcc-2
CA2316405A1 (en) * 2000-05-26 2001-11-26 Ian Clark-Lewis Modulation of inflammation by protease products
EP1176200A3 (de) 2000-06-20 2005-01-12 Switch Biotech Aktiengesellschaft Verwendung von Polypeptiden oder diese kodierende Nukleinsäuren zur Diagnose oder Behandlung von Hauterkrankung oder Wundheilung sowie ihre Verwendung zur Indentifizierung von pharmakologisch aktiven Substanzen
UA77950C2 (en) * 2000-10-04 2007-02-15 Applied Research Systems Use of mutants of cc chemokines for treatment of multiple sclerosis
GB2373785A (en) * 2001-03-28 2002-10-02 Rega Inst For Medical Res Truncating chemokines using dipeptidyl peptidase IV
ATE421974T1 (de) 2001-12-17 2009-02-15 Serono Lab Chemokine mutanten, die als chemokine antagonisten wirken
WO2004104216A2 (en) * 2003-05-21 2004-12-02 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with dipeptidylpeptidase iv (dpp4)
DE102005049637A1 (de) * 2005-10-14 2007-04-26 Rheinisch-Westfälische Technische Hochschule Aachen Antagonisten gegen die Interaktion von PF4 und RANTES
ES2453592T3 (es) 2007-08-02 2014-04-08 Novimmune Sa Anticuerpos anti-RANTES y métodos de uso de los mismos
US20130053257A1 (en) * 2010-02-08 2013-02-28 Paul E. Oran RANTES Multiplexed Assay, RANTES Variants Related to Disease, and RANTES Variants Related to Enzymatice Activity
CN102884194B (zh) 2010-03-11 2015-07-22 健康研究股份有限公司 含增强免疫应答的Fc融合蛋白的方法和组合物
TW201718851A (zh) * 2015-09-18 2017-06-01 通用醫院公司 具有抗化學排斥(anti-fugetactic)性質之經修飾自然殺手細胞及其用途
EP3813869B1 (de) 2018-05-28 2023-10-18 Université de Genève Ccr5-inhibitor zur verwendung bei der behandlung einer neuroinflammatorischen erkrankung, die eine gehirnentzündung beinhaltet
US11629196B2 (en) 2020-04-27 2023-04-18 Incelldx, Inc. Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions
US11402391B2 (en) 2020-12-21 2022-08-02 Incelldx, Inc. Methods of treating a long-hauler subject for chronic COVID-19 by administering a CCR5 or CCL5 antagonist

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01265099A (ja) 1987-10-08 1989-10-23 Stichting Rega Vzw 抗ｈｉｖ活性をもつ３’，−フルオロプリン−２’，３’−ジデオキシリボシド類
US5739103A (en) * 1993-11-12 1998-04-14 Dana-Farber Cancer Institute Chemokine N-terminal deletion mutations
NZ296570A (en) * 1994-12-08 1998-11-25 Glaxo Group Ltd Anti-inflammatory peptides related to rantes
AU1532697A (en) * 1996-01-12 1997-08-01 Genetics Institute Inc. Beta-chemokine, h1305 (mcp-2)
EP0889961A2 (de) * 1996-03-27 1999-01-13 Icos Corporation Monozyte chemotaktisches protein-5 stoffe und verfahren
FR2748938B1 (fr) * 1996-05-22 1998-07-31 Pasteur Institut Utilisation de molecules antagonistes de chemokines pour leur activite antivirale notamment contre un retrovirus de type vih
US6168784B1 (en) * 1997-09-03 2001-01-02 Gryphon Sciences N-terminal modifications of RANTES and methods of use

Also Published As

Publication number Publication date
AU9442098A (en) 1999-04-23
NZ503235A (en) 2002-08-28
EP0905241A1 (de) 1999-03-31
EP0906954A1 (de) 1999-04-07
EA200000379A1 (ru) 2000-10-30
NO20001609L (no) 2000-03-28
DE69838188T2 (de) 2007-11-22
NO20001609D0 (no) 2000-03-28
ZA988675B (en) 1999-11-24
DK1439231T3 (da) 2007-11-05
HK1032426A1 (en) 2001-07-20
HUP0003563A2 (hu) 2001-02-28
US20050164936A1 (en) 2005-07-28
EP0905240A1 (de) 1999-03-31
EE200000152A (et) 2001-02-15
ATE368742T1 (de) 2007-08-15
JP4230659B2 (ja) 2009-02-25
ATE263242T1 (de) 2004-04-15
KR20010024213A (ko) 2001-03-26
UA73081C2 (en) 2005-06-15
WO1999016877A1 (en) 1999-04-08
US20050220790A1 (en) 2005-10-06
CZ299478B6 (cs) 2008-08-06
CN1490049A (zh) 2004-04-21
DK1019507T3 (da) 2004-07-19
WO1999016876A1 (en) 1999-04-08
EA200000378A1 (ru) 2000-10-30
EA003940B1 (ru) 2003-10-30
EP1021541A1 (de) 2000-07-26
CN1271385A (zh) 2000-10-25
DK1021541T3 (da) 2004-08-02
DE69822856T2 (de) 2004-08-19
BG64679B1 (bg) 2005-11-30
NO20001584D0 (no) 2000-03-27
EP1021541B1 (de) 2004-04-14
HU226414B1 (en) 2008-11-28
SK4502000A3 (en) 2000-09-12
HK1032425A1 (en) 2001-07-20
DE69823218T2 (de) 2004-08-26
AU9747498A (en) 1999-04-23
ES2215324T3 (es) 2004-10-01
HU226468B1 (en) 2008-12-29
BG64757B1 (bg) 2006-02-28
AU750606B2 (en) 2002-07-25
PT1019507E (pt) 2004-06-30
HUP0003505A3 (en) 2005-11-28
CA2305017A1 (en) 1999-04-08
US20030124677A1 (en) 2003-07-03
ATE264390T1 (de) 2004-04-15
DE69823218D1 (de) 2004-05-19
CN1233415C (zh) 2005-12-28
US6977071B2 (en) 2005-12-20
PL339545A1 (en) 2000-12-18
CY1110927T1 (el) 2015-06-10
CZ20001146A3 (cs) 2000-09-13
PT1439231E (pt) 2007-08-20
UA73080C2 (en) 2005-06-15
CN1145693C (zh) 2004-04-14
CZ299479B6 (cs) 2008-08-06
AU750341B2 (en) 2002-07-18
KR100542934B1 (ko) 2006-01-11
NZ503234A (en) 2002-06-28
IL135351A (en) 2006-08-20
KR100560275B1 (ko) 2006-03-10
CN1148447C (zh) 2004-05-05
ES2218860T3 (es) 2004-11-16
JP2001518297A (ja) 2001-10-16
BR9812565A (pt) 2000-08-01
JP2001518296A (ja) 2001-10-16
US6905676B2 (en) 2005-06-14
ES2287601T3 (es) 2007-12-16
BG104267A (en) 2000-11-30
PL196427B1 (pl) 2008-01-31
EP1439231B1 (de) 2007-08-01
HUP0003505A2 (hu) 2001-02-28
EP1019507A1 (de) 2000-07-19
NO20001584L (no) 2000-03-27
DE69838188D1 (de) 2007-09-13
BR9812394A (pt) 2000-09-12
HK1062637A1 (en) 2004-11-19
EP1019507B1 (de) 2004-03-31
CZ20001147A3 (cs) 2000-09-13
HUP0003563A3 (en) 2005-11-28
EP1439231A2 (de) 2004-07-21
NZ516027A (en) 2003-05-30
PL197569B1 (pl) 2008-04-30
EP1439231A3 (de) 2004-12-22
US20050201977A1 (en) 2005-09-15
ZA988676B (en) 1999-12-03
PT1021541E (pt) 2004-07-30
EE200000151A (et) 2001-02-15
AR013528A1 (es) 2000-12-27
JP4233214B2 (ja) 2009-03-04
KR20010024214A (ko) 2001-03-26
EA003942B1 (ru) 2003-10-30
BG104266A (en) 2000-11-30
US20030119148A1 (en) 2003-06-26
SK286495B6 (sk) 2008-11-06
PL339559A1 (en) 2000-12-18
CN1271386A (zh) 2000-10-25
IL135352A (en) 2006-08-20
AR013529A1 (es) 2000-12-27
DE69822856D1 (de) 2004-05-06
US7326411B2 (en) 2008-02-05
US7338653B2 (en) 2008-03-04
CA2304827A1 (en) 1999-04-08
SK4512000A3 (en) 2000-09-12

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Effective date: 20090928