SK286428B6 - Analógy povrchovo aktívnej látky typu C, syntetická povrchovo aktívna látka a použitie analógov povrchovo aktívnej látky typu C - Google Patents
Analógy povrchovo aktívnej látky typu C, syntetická povrchovo aktívna látka a použitie analógov povrchovo aktívnej látky typu C Download PDFInfo
- Publication number
- SK286428B6 SK286428B6 SK1144-2001A SK11442001A SK286428B6 SK 286428 B6 SK286428 B6 SK 286428B6 SK 11442001 A SK11442001 A SK 11442001A SK 286428 B6 SK286428 B6 SK 286428B6
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- Prior art keywords
- surfactant
- analogs
- lks
- formula
- gallmgl
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- ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 claims description 38
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999MI000275A IT1308180B1 (it) | 1999-02-12 | 1999-02-12 | Peptidi sintetici aventi la capacita' di diminuire la tensionesuperficiale e loro impiego nella preparazione di un surfattante |
| PCT/EP2000/001044 WO2000047623A1 (en) | 1999-02-12 | 2000-02-09 | Artificial peptides having surface activity and the use thereof in the preparation of artificial surfactant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK11442001A3 SK11442001A3 (sk) | 2001-12-03 |
| SK286428B6 true SK286428B6 (sk) | 2008-09-05 |
Family
ID=11381859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1144-2001A SK286428B6 (sk) | 1999-02-12 | 2000-02-09 | Analógy povrchovo aktívnej látky typu C, syntetická povrchovo aktívna látka a použitie analógov povrchovo aktívnej látky typu C |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US7053044B1 (de) |
| EP (1) | EP1151008B1 (de) |
| JP (1) | JP4754073B2 (de) |
| KR (1) | KR100645145B1 (de) |
| CN (1) | CN1221570C (de) |
| AR (1) | AR022578A1 (de) |
| AT (1) | ATE280181T1 (de) |
| AU (1) | AU758735B2 (de) |
| BG (1) | BG65196B1 (de) |
| BR (1) | BR0009964A (de) |
| CA (1) | CA2362507C (de) |
| CO (1) | CO5241361A1 (de) |
| CZ (1) | CZ301108B6 (de) |
| DE (1) | DE60015082T2 (de) |
| EA (1) | EA004058B1 (de) |
| EE (1) | EE04879B1 (de) |
| ES (1) | ES2228473T3 (de) |
| GE (1) | GEP20032976B (de) |
| HK (1) | HK1042500A1 (de) |
| HU (1) | HU228997B1 (de) |
| IL (1) | IL144842A0 (de) |
| IT (1) | IT1308180B1 (de) |
| MA (1) | MA25381A1 (de) |
| NO (1) | NO20013888L (de) |
| NZ (1) | NZ513451A (de) |
| PL (1) | PL201084B1 (de) |
| PT (1) | PT1151008E (de) |
| SK (1) | SK286428B6 (de) |
| TR (1) | TR200102308T2 (de) |
| UA (1) | UA72751C2 (de) |
| WO (1) | WO2000047623A1 (de) |
| YU (1) | YU57701A (de) |
| ZA (1) | ZA200106530B (de) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1308180B1 (it) * | 1999-02-12 | 2001-12-07 | Chiesi Farma Spa | Peptidi sintetici aventi la capacita' di diminuire la tensionesuperficiale e loro impiego nella preparazione di un surfattante |
| JP2003522138A (ja) * | 2000-02-11 | 2003-07-22 | アルタナ ファルマ アクチエンゲゼルシャフト | 慢性肺疾患の予防および治療のための肺表面活性剤の新規使用 |
| DE60217060T2 (de) * | 2002-03-01 | 2007-06-21 | Chiesi Farmaceutici S.P.A. | Pharmazeutische Zusammensetzungen, die Lungensurfactants und ein Polymyxin umfassen und verbesserte Oberflächenspannung-senkende Eigenschaften haben |
| ITMI20021058A1 (it) | 2002-05-17 | 2003-11-17 | Chiesi Farma Spa | Miscele di lipidi sintetici ottimizzate per la preparazione di un surfattante ricostituito |
| CN100401896C (zh) * | 2002-12-09 | 2008-07-16 | 儿童医院医疗中心 | 诊断和治疗间质性肺病的方法 |
| EP1481665A1 (de) * | 2003-05-30 | 2004-12-01 | CHIESI FARMACEUTICI S.p.A. | Neue Lipidmischungen für synthetische Tenside |
| US20090011978A1 (en) * | 2003-08-28 | 2009-01-08 | Atlanta Pharma Ag | Use of Surfactant Preparations for the Treatment of Surgical Adhesions |
| US20060004185A1 (en) * | 2004-07-01 | 2006-01-05 | Leese Richard A | Peptide antibiotics and peptide intermediates for their prepartion |
| US8337815B2 (en) * | 2004-12-23 | 2012-12-25 | Discovery Laboratories, Inc. | Pulmonary surfactant formulations |
| WO2008011559A2 (en) | 2006-07-20 | 2008-01-24 | University Of Rochester | Synthetic lung surfactant and use thereof |
| UA94477C2 (ru) * | 2006-10-13 | 2011-05-10 | КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. | Воспроизведенные сурфактанты, которые имеют улучшенные свойства |
| EP1997502A1 (de) | 2007-06-01 | 2008-12-03 | CHIESI FARMACEUTICI S.p.A. | Rekonstituierte Tenside mit verbesserten Eigenschaften |
| US8048043B2 (en) | 2007-06-08 | 2011-11-01 | Chiesi Farmaceutici S. P. A. | Method of administration of a pulmonary surfactant |
| EP2022798A1 (de) * | 2007-08-09 | 2009-02-11 | CHIESI FARMACEUTICI S.p.A. | Synthetische Lungensurfactant-Peptide |
| US8343912B2 (en) | 2008-12-23 | 2013-01-01 | Biosource Pharm, Inc. | Antibiotic compositions for the treatment of gram negative infections |
| CN102470150B (zh) | 2009-09-08 | 2013-12-11 | 奇斯药制品公司 | 包含肺表面活性物质和抗氧化酶的治疗组合物 |
| US8415307B1 (en) | 2010-06-23 | 2013-04-09 | Biosource Pharm, Inc. | Antibiotic compositions for the treatment of gram negative infections |
| SG11201406628RA (en) * | 2012-04-23 | 2014-11-27 | Chiesi Farma Spa | Method and system for the administration of a pulmonary surfactant by atomization |
| CA2891933C (en) | 2012-11-21 | 2022-07-05 | Chiesi Farmaceutici S.P.A. | Recombinant pulmonary surfactants comprising sp-b and sp-c analogues and a phospholipid mixture |
| EP3106090A1 (de) | 2015-06-15 | 2016-12-21 | CHIESI FARMACEUTICI S.p.A. | System zur effektiven und atemsynchronisierten abgabe eines medikaments in die lungen |
| EP3285645B1 (de) | 2015-04-22 | 2020-08-12 | Chiesi Farmaceutici S.p.A. | System zur effektiven und atemsynchronisierten abgabe eines medikaments in die lungen |
| US11311691B2 (en) | 2015-04-28 | 2022-04-26 | Chiesi Farmaceutici S.P.A | Device for facilitating the administration of a medicament to the lung by a catheter |
| US20180147262A1 (en) | 2015-04-30 | 2018-05-31 | University Of Bremen | Novel skin medical and cosmetic care product |
| MA45772A (fr) | 2016-07-28 | 2021-04-28 | Chiesi Farm Spa | Procédé et système d'administration d'un médicament sous forme d'aérosol |
| BR112019008169A2 (pt) | 2016-10-26 | 2019-07-09 | Chiesi Farm Spa | dispositivo para facilitar o posicionamento de um cateter, sistema para entrega de um medicamento em aerossol por meio de um cateter, método para utilização de um dispositivo e kit |
| PL3558376T3 (pl) | 2016-12-22 | 2022-02-14 | Chiesi Farmaceutici S.P.A. | Kombinacja terapeutyczna zawierająca surfaktant płucny i steroid do leczenia rozwijającej się BPD |
| TW201927286A (zh) | 2017-12-15 | 2019-07-16 | 義大利商凱西製藥公司 | 用於噴霧投藥之包含肺表面張力素的藥學調配物 |
| WO2019115771A1 (en) | 2017-12-15 | 2019-06-20 | Pari Pharma Gmbh | Nebuliser system, holding system, combination comprising nebuliser system and holding system, and aerosol administration method |
| MX2020011127A (es) | 2018-04-23 | 2021-01-15 | Chiesi Farm Spa | Combinacion terapeutica que comprende agente tensioactivo pulmonar y esteroide para la profilaxis de displasia broncopulmonar (bpd). |
| EP3666316A1 (de) | 2018-12-14 | 2020-06-17 | PARI Pharma GmbH | Aerosolabgabevorrichtung und verfahren zum betrieb der aerosolabgabevorrichtung |
| EP3666315A1 (de) | 2018-12-14 | 2020-06-17 | PARI Pharma GmbH | Aerosolabgabevorrichtung und verfahren zum betrieb der aerosolabgabevorrichtung |
| EP3843105A1 (de) | 2019-12-23 | 2021-06-30 | PARI Pharma GmbH | Steuerungsvorrichtung für aerosolzerstäubersystem |
| EP4097128A1 (de) | 2020-01-28 | 2022-12-07 | Chiesi Farmaceutici S.p.A. | Polypeptide mit verbesserten eigenschaften |
| CN114159546A (zh) * | 2021-12-20 | 2022-03-11 | 双鹤药业(海南)有限责任公司 | 新一代合成肺表面活性物质制剂及其临床应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5104853A (en) * | 1984-12-11 | 1992-04-14 | California Biotechnology Inc. | Alveolar surfactant proteins having cys to ser mutations |
| SE8803713D0 (sv) * | 1988-10-18 | 1988-10-18 | Kabigen Ab | Biologically active lipoprotein and its use |
| DK0733645T3 (da) * | 1993-12-08 | 2003-07-14 | Mitsubishi Pharma Corp | Syntetisk peptid, lungeoverfladeaktivt stof indeholdende dette og præparat mod respiratory distress syndrome |
| DE4418936A1 (de) * | 1994-05-31 | 1996-02-08 | Byk Gulden Lomberg Chem Fab | Polypeptid |
| IT1308180B1 (it) * | 1999-02-12 | 2001-12-07 | Chiesi Farma Spa | Peptidi sintetici aventi la capacita' di diminuire la tensionesuperficiale e loro impiego nella preparazione di un surfattante |
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| MK4A | Patent expired |
Expiry date: 20200209 |