SK285554B6 - Kryštalická modifikácia B kyseliny 8-kyano-1-cyklopropyl-7-(1S, 6S-2,8-diazabicyklo-[4.3.0]nonan-8-yl) -6-fluór-1,4-dihydro-4- oxo-3-chinolínkarboxylovej, spôsob prípravy a jej použitie vo farmaceutických prípravkoch - Google Patents

Kryštalická modifikácia B kyseliny 8-kyano-1-cyklopropyl-7-(1S, 6S-2,8-diazabicyklo-[4.3.0]nonan-8-yl) -6-fluór-1,4-dihydro-4- oxo-3-chinolínkarboxylovej, spôsob prípravy a jej použitie vo farmaceutických prípravkoch Download PDF

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Publication number
SK285554B6
SK285554B6 SK683-2001A SK6832001A SK285554B6 SK 285554 B6 SK285554 B6 SK 285554B6 SK 6832001 A SK6832001 A SK 6832001A SK 285554 B6 SK285554 B6 SK 285554B6
Authority
SK
Slovakia
Prior art keywords
cyclopropyl
fluoro
cyano
dihydro
oxo
Prior art date
Application number
SK683-2001A
Other languages
English (en)
Slovak (sk)
Other versions
SK6832001A3 (en
Inventor
Thomas Himmler
Werner Hallenbach
Hubert Rast
Original Assignee
Bayer Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Aktiengesellschaft filed Critical Bayer Aktiengesellschaft
Publication of SK6832001A3 publication Critical patent/SK6832001A3/sk
Publication of SK285554B6 publication Critical patent/SK285554B6/sk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SK683-2001A 1998-11-25 1999-11-15 Kryštalická modifikácia B kyseliny 8-kyano-1-cyklopropyl-7-(1S, 6S-2,8-diazabicyklo-[4.3.0]nonan-8-yl) -6-fluór-1,4-dihydro-4- oxo-3-chinolínkarboxylovej, spôsob prípravy a jej použitie vo farmaceutických prípravkoch SK285554B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19854355A DE19854355A1 (de) 1998-11-25 1998-11-25 Kristallmodifikation B von 8-Cyan-1-cyclopropyl-7-(1S, 6S-2,8-diazabicyclo-/4.3.O/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
PCT/EP1999/008776 WO2000031076A1 (de) 1998-11-25 1999-11-15 Kristallmodifikation b von 8-cyan- 1-cyclopropyl -7-(1s,6s-2, 8-diazabicyclo -[4.3.0]nonan -8-yl)-6- fluor-1, 4-dihydro- 4-oxo-3- chinolincarbonsaure

Publications (2)

Publication Number Publication Date
SK6832001A3 SK6832001A3 (en) 2001-12-03
SK285554B6 true SK285554B6 (sk) 2007-03-01

Family

ID=7888959

Family Applications (1)

Application Number Title Priority Date Filing Date
SK683-2001A SK285554B6 (sk) 1998-11-25 1999-11-15 Kryštalická modifikácia B kyseliny 8-kyano-1-cyklopropyl-7-(1S, 6S-2,8-diazabicyklo-[4.3.0]nonan-8-yl) -6-fluór-1,4-dihydro-4- oxo-3-chinolínkarboxylovej, spôsob prípravy a jej použitie vo farmaceutických prípravkoch

Country Status (29)

Country Link
US (1) US6664268B1 (ja)
EP (1) EP1133497B1 (ja)
JP (2) JP5127094B2 (ja)
KR (1) KR100740950B1 (ja)
CN (1) CN1150193C (ja)
AR (1) AR028467A1 (ja)
AT (1) ATE289606T1 (ja)
AU (1) AU767890B2 (ja)
BR (1) BRPI9915682B8 (ja)
CA (1) CA2351707C (ja)
CZ (1) CZ300012B6 (ja)
DE (2) DE19854355A1 (ja)
DK (1) DK1133497T3 (ja)
ES (1) ES2237186T3 (ja)
HK (1) HK1042705B (ja)
HU (1) HU229071B1 (ja)
IL (2) IL142695A0 (ja)
NO (1) NO318065B1 (ja)
NZ (1) NZ511862A (ja)
PL (1) PL196078B1 (ja)
PT (1) PT1133497E (ja)
RU (1) RU2248355C2 (ja)
SK (1) SK285554B6 (ja)
TR (1) TR200101444T2 (ja)
TW (1) TWI245767B (ja)
UA (1) UA67873C2 (ja)
UY (1) UY25818A (ja)
WO (1) WO2000031076A1 (ja)
ZA (1) ZA200103187B (ja)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19854356A1 (de) 1998-11-25 2000-05-31 Bayer Ag Kristallmodifikation A von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo-/4.3.0/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19854355A1 (de) * 1998-11-25 2000-05-31 Bayer Ag Kristallmodifikation B von 8-Cyan-1-cyclopropyl-7-(1S, 6S-2,8-diazabicyclo-/4.3.O/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19908449A1 (de) 1999-02-26 2000-08-31 Bayer Ag Kristallmodifikation C von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicylo-[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chino/incarbonsäure
DE19908448A1 (de) 1999-02-26 2000-08-31 Bayer Ag Kristallmodifikation D von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicylo[4.3.0)nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chino incarbonsäure
DE102004015981A1 (de) * 2004-04-01 2005-10-20 Bayer Healthcare Ag Neue kirstalline Form von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE102005055385A1 (de) * 2004-12-09 2006-06-14 Bayer Healthcare Ag Arzneimittel zur hygienischen Applikation im Ohr
DE102006049520A1 (de) * 2006-10-20 2008-04-24 Bayer Healthcare Ag Verfahren zur Herstellung von Pradofloxacin
DE102007026550A1 (de) * 2007-06-08 2008-12-11 Bayer Healthcare Ag Extrudate mit verbesserter Geschmacksmaskierung
UA124124C2 (uk) 2017-02-13 2021-07-21 Баєр Енімал Хелс Гмбх Рідка композиція, що містить прадофлоксацин

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5036099A (en) * 1987-02-02 1991-07-30 Pfizer Inc. Anhydrous, crystalline sodium salt of 5-chloro-3-(2-thenoyl)-2-oxindole-1-carboxamide
JP2676521B2 (ja) * 1988-03-22 1997-11-17 北陸製薬株式会社 キノロンカルボン酸化合物ｉ型結晶の製造法
DE3906365A1 (de) * 1988-07-15 1990-01-18 Bayer Ag 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe
DE3910663A1 (de) * 1989-04-03 1990-10-04 Bayer Ag 5-alkylchinoloncarbonsaeuren
JP2832848B2 (ja) * 1989-10-21 1998-12-09 株式会社林原生物化学研究所 結晶２―Ｏ―α―Ｄ―グルコピラノシル―Ｌ―アスコルビン酸とその製造方法並びに用途
AU709057B2 (en) 1994-11-18 1999-08-19 Pharmacia & Upjohn Company A new physically stable solid form of a fluoroquinolone
DE19546249A1 (de) * 1995-12-12 1997-06-19 Bayer Ag Neue Kristallmodifikation des 1-Cyclopropyl-7-([S,S]-2,8-diazabicyclo[4,3,0]non-8-yl)-6-fluor-1,4-dihydro-8-methoxy-4-oxo-3-chinolincarbonsäure Hydrochlorid (CDCH), Verfahren zu dessen Herstellung und diese enthaltende pharmazeutische Zubereitungen
CZ291251B6 (cs) * 1996-02-23 2003-01-15 Bayer Aktiengesellschaft Popřípadě substituované 8-kyan-1-cyklopropyl-7-(2,8-diazabicyklo-[4,3,0]-nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolinkarboxylové kyseliny a jejich deriváty, způsob jejich výroby, léčiva tyto látka obsahující a jejich pouľití
DE19633805A1 (de) * 1996-02-23 1997-08-28 Bayer Ag Gegenenenfalls substituierte 8-Cyan-l-cyclopropyl-7-(2,8-diazabicyclo-[4.3.0]-nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäuren und ihre Derivate
DE19649681A1 (de) * 1996-11-29 1998-06-04 Basf Ag Verfahren zur Herstellung eines kristallinen Feststoffes aus Glycin-N,N-diessigsäure-Derivaten mit hinreichend geringer Hygroskopizität
DE19854356A1 (de) 1998-11-25 2000-05-31 Bayer Ag Kristallmodifikation A von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo-/4.3.0/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19854355A1 (de) * 1998-11-25 2000-05-31 Bayer Ag Kristallmodifikation B von 8-Cyan-1-cyclopropyl-7-(1S, 6S-2,8-diazabicyclo-/4.3.O/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19908449A1 (de) 1999-02-26 2000-08-31 Bayer Ag Kristallmodifikation C von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicylo-[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chino/incarbonsäure
DE19908448A1 (de) 1999-02-26 2000-08-31 Bayer Ag Kristallmodifikation D von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicylo[4.3.0)nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chino incarbonsäure

Also Published As

Publication number Publication date
TWI245767B (en) 2005-12-21
US6664268B1 (en) 2003-12-16
TR200101444T2 (tr) 2002-01-21
NO318065B1 (no) 2005-01-31
CN1150193C (zh) 2004-05-19
SK6832001A3 (en) 2001-12-03
NZ511862A (en) 2003-08-29
BR9915682A (pt) 2001-08-14
HUP0104713A3 (en) 2002-12-28
KR100740950B1 (ko) 2007-07-19
PL196078B1 (pl) 2007-12-31
HU229071B1 (en) 2013-07-29
CA2351707A1 (en) 2000-06-02
PT1133497E (pt) 2005-07-29
UA67873C2 (uk) 2004-07-15
NO20012461D0 (no) 2001-05-18
ATE289606T1 (de) 2005-03-15
BRPI9915682B1 (pt) 2017-02-21
ES2237186T3 (es) 2005-07-16
UY25818A (es) 2016-06-30
AU1651700A (en) 2000-06-13
HUP0104713A2 (hu) 2002-04-29
RU2248355C2 (ru) 2005-03-20
AR028467A1 (es) 2003-05-14
WO2000031076A1 (de) 2000-06-02
JP2012236841A (ja) 2012-12-06
EP1133497B1 (de) 2005-02-23
HK1042705B (zh) 2005-03-11
HK1042705A1 (en) 2002-08-23
IL142695A0 (en) 2002-03-10
JP2002530407A (ja) 2002-09-17
PL347785A1 (en) 2002-04-22
CN1328556A (zh) 2001-12-26
NO20012461L (no) 2001-05-18
DE59911666D1 (de) 2005-03-31
CZ300012B6 (cs) 2009-01-14
CZ20011857A3 (cs) 2001-09-12
BRPI9915682B8 (pt) 2021-05-25
KR20010080927A (ko) 2001-08-25
IL142695A (en) 2006-04-10
EP1133497A1 (de) 2001-09-19
CA2351707C (en) 2011-02-01
JP5127094B2 (ja) 2013-01-23
DK1133497T3 (da) 2005-05-17
ZA200103187B (en) 2002-06-26
DE19854355A1 (de) 2000-05-31
AU767890B2 (en) 2003-11-27

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Legal Events

Date Code Title Description
PC4A Assignment and transfer of rights

Owner name: BAYER INTELLECTUAL PROPERTY GMBH, MONHEIM AM R, DE

Free format text: FORMER OWNER: BAYER ANIMAL HEALTH GMBH, LEVERKUSEN, DE

Effective date: 20121011

MK4A Expiry of patent

Expiry date: 20191115