BRPI9915682B8 - modificação cristalina b de ácido 8-cian-1-ciclopropil-7-(1s, 6s-2,8-diazabiciclo-[4.3.0]nonan-8-il)-6-flúor-1,4-dihidro-4-oxo-3-quinolincarboxílico - Google Patents

modificação cristalina b de ácido 8-cian-1-ciclopropil-7-(1s, 6s-2,8-diazabiciclo-[4.3.0]nonan-8-il)-6-flúor-1,4-dihidro-4-oxo-3-quinolincarboxílico

Info

Publication number
BRPI9915682B8
BRPI9915682B8 BRPI9915682A BR9915682A BRPI9915682B8 BR PI9915682 B8 BRPI9915682 B8 BR PI9915682B8 BR PI9915682 A BRPI9915682 A BR PI9915682A BR 9915682 A BR9915682 A BR 9915682A BR PI9915682 B8 BRPI9915682 B8 BR PI9915682B8
Authority
BR
Brazil
Prior art keywords
nonan
diazabicyclo
cyclopropyl
dihydro
acid
Prior art date
Application number
BRPI9915682A
Other languages
English (en)
Other versions
BR9915682A (pt
BRPI9915682B1 (pt
Inventor
Rast Hubert
Himmler Thomas
Hallenbach Werner
Original Assignee
Bayer Animal Health Gmbh
Bayer Ip Gmbh
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Animal Health Gmbh, Bayer Ip Gmbh, Bayer Ag filed Critical Bayer Animal Health Gmbh
Publication of BR9915682A publication Critical patent/BR9915682A/pt
Publication of BRPI9915682B1 publication Critical patent/BRPI9915682B1/pt
Publication of BRPI9915682B8 publication Critical patent/BRPI9915682B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

Patente de Invenção: <B>"MODIFICAÇÃO CRISTALINA B DE ÁCIDO 8-CIAN-1-CICLOPROPIL-7-(1S, 6S-2,8-DIAZABICICLO-[4.3.0]NONAN-8-IL)-6-FLÚOR - 1,4-DIHIDRO-4-OXO-3-QUINOLIN CARBOXÍLICO"<D>. A presente invenção refere-se a uma modificação cristalina definida de ácido 8-ciano-1-ciclopropil-7-(1S,6S-2,8-diazabiciclo[4.3.0]nonan-8-il)-6-flúor-1,4-dihidro-4-oxo-3-quinolincarboxílico da fórmula (I), processo para sua preparação assim como seu emprego em preparações farmacêuticas. A modificação cristalina é diferenciável de outras modificações cristalina de ácido 8-ciano-1-ciclopropil-7-(1S,6S-2,8-diazabiciclo[4.3.0]nonan-8-il)-6-flúor -1,4- dihidro-4-oxo-3-quinolincarboxílico da fórmula (I), por seu difractograma de pó com raio x característico e seu termodiagrama diferencial.
BRPI9915682A 1998-11-25 1999-11-15 modificação cristalina b de ácido 8-cian-1-ciclopropil-7-(1s, 6s-2,8-diazabiciclo-[4.3.0]nonan-8-il)-6-flúor-1,4-dihidro-4-oxo-3-quinolincarboxílico BRPI9915682B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19854355A DE19854355A1 (de) 1998-11-25 1998-11-25 Kristallmodifikation B von 8-Cyan-1-cyclopropyl-7-(1S, 6S-2,8-diazabicyclo-/4.3.O/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
PCT/EP1999/008776 WO2000031076A1 (de) 1998-11-25 1999-11-15 Kristallmodifikation b von 8-cyan- 1-cyclopropyl -7-(1s,6s-2, 8-diazabicyclo -[4.3.0]nonan -8-yl)-6- fluor-1, 4-dihydro- 4-oxo-3- chinolincarbonsaure

Publications (3)

Publication Number Publication Date
BR9915682A BR9915682A (pt) 2001-08-14
BRPI9915682B1 BRPI9915682B1 (pt) 2017-02-21
BRPI9915682B8 true BRPI9915682B8 (pt) 2021-05-25

Family

ID=7888959

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9915682A BRPI9915682B8 (pt) 1998-11-25 1999-11-15 modificação cristalina b de ácido 8-cian-1-ciclopropil-7-(1s, 6s-2,8-diazabiciclo-[4.3.0]nonan-8-il)-6-flúor-1,4-dihidro-4-oxo-3-quinolincarboxílico

Country Status (29)

Country Link
US (1) US6664268B1 (pt)
EP (1) EP1133497B1 (pt)
JP (2) JP5127094B2 (pt)
KR (1) KR100740950B1 (pt)
CN (1) CN1150193C (pt)
AR (1) AR028467A1 (pt)
AT (1) ATE289606T1 (pt)
AU (1) AU767890B2 (pt)
BR (1) BRPI9915682B8 (pt)
CA (1) CA2351707C (pt)
CZ (1) CZ300012B6 (pt)
DE (2) DE19854355A1 (pt)
DK (1) DK1133497T3 (pt)
ES (1) ES2237186T3 (pt)
HK (1) HK1042705B (pt)
HU (1) HU229071B1 (pt)
IL (2) IL142695A0 (pt)
NO (1) NO318065B1 (pt)
NZ (1) NZ511862A (pt)
PL (1) PL196078B1 (pt)
PT (1) PT1133497E (pt)
RU (1) RU2248355C2 (pt)
SK (1) SK285554B6 (pt)
TR (1) TR200101444T2 (pt)
TW (1) TWI245767B (pt)
UA (1) UA67873C2 (pt)
UY (1) UY25818A (pt)
WO (1) WO2000031076A1 (pt)
ZA (1) ZA200103187B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19854356A1 (de) 1998-11-25 2000-05-31 Bayer Ag Kristallmodifikation A von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo-/4.3.0/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19854355A1 (de) * 1998-11-25 2000-05-31 Bayer Ag Kristallmodifikation B von 8-Cyan-1-cyclopropyl-7-(1S, 6S-2,8-diazabicyclo-/4.3.O/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19908448A1 (de) 1999-02-26 2000-08-31 Bayer Ag Kristallmodifikation D von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicylo[4.3.0)nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chino incarbonsäure
DE19908449A1 (de) 1999-02-26 2000-08-31 Bayer Ag Kristallmodifikation C von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicylo-[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chino/incarbonsäure
DE102004015981A1 (de) * 2004-04-01 2005-10-20 Bayer Healthcare Ag Neue kirstalline Form von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE102005055385A1 (de) * 2004-12-09 2006-06-14 Bayer Healthcare Ag Arzneimittel zur hygienischen Applikation im Ohr
DE102006049520A1 (de) * 2006-10-20 2008-04-24 Bayer Healthcare Ag Verfahren zur Herstellung von Pradofloxacin
DE102007026550A1 (de) 2007-06-08 2008-12-11 Bayer Healthcare Ag Extrudate mit verbesserter Geschmacksmaskierung
WO2018146194A1 (en) 2017-02-13 2018-08-16 Bayer Animal Health Gmbh Liquid composition containing pradofloxacin

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA25898A1 (uk) * 1987-02-02 1999-02-26 Пфайзер Інк. Спосіб одержаhhя кристалічhої hатрієвої солі 5-хлор-3-(2-теhоїл)-2-оксііhдол-1-карбоксаміду
JP2676521B2 (ja) * 1988-03-22 1997-11-17 北陸製薬株式会社 キノロンカルボン酸化合物ｉ型結晶の製造法
DE3906365A1 (de) * 1988-07-15 1990-01-18 Bayer Ag 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe
DE3910663A1 (de) * 1989-04-03 1990-10-04 Bayer Ag 5-alkylchinoloncarbonsaeuren
JP2832848B2 (ja) * 1989-10-21 1998-12-09 株式会社林原生物化学研究所 結晶２―Ｏ―α―Ｄ―グルコピラノシル―Ｌ―アスコルビン酸とその製造方法並びに用途
BR9509688A (pt) * 1994-11-18 1997-09-30 Upjohn Co Composto e composição farmacêutica
DE19546249A1 (de) * 1995-12-12 1997-06-19 Bayer Ag Neue Kristallmodifikation des 1-Cyclopropyl-7-([S,S]-2,8-diazabicyclo[4,3,0]non-8-yl)-6-fluor-1,4-dihydro-8-methoxy-4-oxo-3-chinolincarbonsäure Hydrochlorid (CDCH), Verfahren zu dessen Herstellung und diese enthaltende pharmazeutische Zubereitungen
DE19633805A1 (de) * 1996-02-23 1997-08-28 Bayer Ag Gegenenenfalls substituierte 8-Cyan-l-cyclopropyl-7-(2,8-diazabicyclo-[4.3.0]-nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäuren und ihre Derivate
DK0882049T3 (da) * 1996-02-23 2003-03-03 Bayer Ag Eventuelt substituerede 8-cyan-1-cyclopropyl-7-(2,8-diazabicyclo-[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-quinolincarboxylsyrer og deres derivater
DE19649681A1 (de) * 1996-11-29 1998-06-04 Basf Ag Verfahren zur Herstellung eines kristallinen Feststoffes aus Glycin-N,N-diessigsäure-Derivaten mit hinreichend geringer Hygroskopizität
DE19854356A1 (de) 1998-11-25 2000-05-31 Bayer Ag Kristallmodifikation A von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo-/4.3.0/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19854355A1 (de) * 1998-11-25 2000-05-31 Bayer Ag Kristallmodifikation B von 8-Cyan-1-cyclopropyl-7-(1S, 6S-2,8-diazabicyclo-/4.3.O/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19908449A1 (de) 1999-02-26 2000-08-31 Bayer Ag Kristallmodifikation C von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicylo-[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chino/incarbonsäure
DE19908448A1 (de) 1999-02-26 2000-08-31 Bayer Ag Kristallmodifikation D von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicylo[4.3.0)nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chino incarbonsäure

Also Published As

Publication number Publication date
TWI245767B (en) 2005-12-21
ZA200103187B (en) 2002-06-26
UY25818A (es) 2016-06-30
BR9915682A (pt) 2001-08-14
PT1133497E (pt) 2005-07-29
WO2000031076A1 (de) 2000-06-02
SK6832001A3 (en) 2001-12-03
CZ300012B6 (cs) 2009-01-14
EP1133497A1 (de) 2001-09-19
NO20012461L (no) 2001-05-18
TR200101444T2 (tr) 2002-01-21
CZ20011857A3 (cs) 2001-09-12
CA2351707C (en) 2011-02-01
IL142695A (en) 2006-04-10
ATE289606T1 (de) 2005-03-15
RU2248355C2 (ru) 2005-03-20
EP1133497B1 (de) 2005-02-23
US6664268B1 (en) 2003-12-16
KR100740950B1 (ko) 2007-07-19
NO318065B1 (no) 2005-01-31
UA67873C2 (uk) 2004-07-15
HK1042705B (zh) 2005-03-11
PL196078B1 (pl) 2007-12-31
DE59911666D1 (de) 2005-03-31
JP2002530407A (ja) 2002-09-17
JP2012236841A (ja) 2012-12-06
KR20010080927A (ko) 2001-08-25
HK1042705A1 (en) 2002-08-23
IL142695A0 (en) 2002-03-10
HU229071B1 (en) 2013-07-29
CN1150193C (zh) 2004-05-19
DK1133497T3 (da) 2005-05-17
SK285554B6 (sk) 2007-03-01
JP5127094B2 (ja) 2013-01-23
AU1651700A (en) 2000-06-13
NZ511862A (en) 2003-08-29
BRPI9915682B1 (pt) 2017-02-21
HUP0104713A3 (en) 2002-12-28
DE19854355A1 (de) 2000-05-31
AR028467A1 (es) 2003-05-14
CN1328556A (zh) 2001-12-26
PL347785A1 (en) 2002-04-22
HUP0104713A2 (hu) 2002-04-29
NO20012461D0 (no) 2001-05-18
CA2351707A1 (en) 2000-06-02
ES2237186T3 (es) 2005-07-16
AU767890B2 (en) 2003-11-27

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Legal Events

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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
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Owner name: BAYER ANIMAL HEALTH GMBH (DE)

Free format text: TRANSFERIDO DE: BAYER AKTIENGESELLSCHAFT

B09B Patent application refused [chapter 9.2 patent gazette]

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B12B Appeal against refusal [chapter 12.2 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B25A Requested transfer of rights approved

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B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

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B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]
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Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/11/1999 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

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Free format text: RETIFICACAO REF. RPI 2407, DE 21/02/2017. PRAZO DE VALIDADE: 10 ANOS CONTADOS A PARTIR DE 21/02/2017, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME A ADI 5.529/DF, COM APOSTILAMENTO DO PRAZO DE VALIDADE DA PROTECAO DA MATERIA RELATIVA A PRODUTOS E PROCESSOS FARMACEUTICOS E EQUIPAMENTOS E/OU MATERIAIS DE USO EM SAUDE, PARA APLICACAO EM HUMANOS.