SK285223B6 - Deriváty kyseliny chinolónkarboxylovej a naftyridónkarboxylovej, spôsob ich výroby, liečivá tieto látky obsahujúce a ich použitie - Google Patents

Deriváty kyseliny chinolónkarboxylovej a naftyridónkarboxylovej, spôsob ich výroby, liečivá tieto látky obsahujúce a ich použitie Download PDF

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Publication number
SK285223B6
SK285223B6 SK223-2000A SK2232000A SK285223B6 SK 285223 B6 SK285223 B6 SK 285223B6 SK 2232000 A SK2232000 A SK 2232000A SK 285223 B6 SK285223 B6 SK 285223B6
Authority
SK
Slovakia
Prior art keywords
group
diazabicyclo
carboxylic acid
carbon atoms
cyclopropyl
Prior art date
Application number
SK223-2000A
Other languages
English (en)
Slovak (sk)
Other versions
SK2232000A3 (sk
Inventor
Uwe Petersen
Andreas Krebs
Thomas Schenke
Thomas Philipps
Klaus Grohe
Klaus-Dieter Bremm
Rainer Endermann
Karl-Georg Metzger
Ingo Haller
Original Assignee
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27203290&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK285223(B6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE4200414A external-priority patent/DE4200414A1/de
Priority claimed from DE4208792A external-priority patent/DE4208792A1/de
Priority claimed from DE4208789A external-priority patent/DE4208789A1/de
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Publication of SK2232000A3 publication Critical patent/SK2232000A3/sk
Publication of SK285223B6 publication Critical patent/SK285223B6/sk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Fodder In General (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
SK223-2000A 1992-01-10 1992-12-29 Deriváty kyseliny chinolónkarboxylovej a naftyridónkarboxylovej, spôsob ich výroby, liečivá tieto látky obsahujúce a ich použitie SK285223B6 (sk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4200414A DE4200414A1 (de) 1992-01-10 1992-01-10 Chinolon- und naphthyridon-carbonsaeure-derivate
DE4208792A DE4208792A1 (de) 1992-03-19 1992-03-19 Enantiomerenreine chinolincarbonsaeure-derivate
DE4208789A DE4208789A1 (de) 1992-03-19 1992-03-19 Enantiomerenreine chinolincarbonsaeure-derivate

Publications (2)

Publication Number Publication Date
SK2232000A3 SK2232000A3 (sk) 2006-05-04
SK285223B6 true SK285223B6 (sk) 2006-09-07

Family

ID=27203290

Family Applications (3)

Application Number Title Priority Date Filing Date
SK221-2000A SK285155B6 (sk) 1992-01-10 1992-12-29 Enantiomérne čisté deriváty kyseliny chinolónkarboxylovej a naftyridónkarboxylovej, spôsob ich výroby, liečivá tieto látky obsahujúce a ich použitie
SK223-2000A SK285223B6 (sk) 1992-01-10 1992-12-29 Deriváty kyseliny chinolónkarboxylovej a naftyridónkarboxylovej, spôsob ich výroby, liečivá tieto látky obsahujúce a ich použitie
SK3966-92A SK282971B6 (sk) 1992-01-10 1992-12-29 Deriváty kyseliny chinolónkarboxylovej a naftyridónkarboxylovej

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SK221-2000A SK285155B6 (sk) 1992-01-10 1992-12-29 Enantiomérne čisté deriváty kyseliny chinolónkarboxylovej a naftyridónkarboxylovej, spôsob ich výroby, liečivá tieto látky obsahujúce a ich použitie

Family Applications After (1)

Application Number Title Priority Date Filing Date
SK3966-92A SK282971B6 (sk) 1992-01-10 1992-12-29 Deriváty kyseliny chinolónkarboxylovej a naftyridónkarboxylovej

Country Status (16)

Country Link
EP (1) EP0550903A1 (fi)
JP (3) JPH05271229A (fi)
KR (1) KR100251886B1 (fi)
CN (3) CN1043142C (fi)
AU (1) AU669502B2 (fi)
CA (1) CA2086914C (fi)
CZ (1) CZ289076B6 (fi)
FI (3) FI104174B1 (fi)
HU (1) HU219488B (fi)
MX (1) MX9207604A (fi)
MY (1) MY115416A (fi)
NO (1) NO301420B1 (fi)
NZ (1) NZ245640A (fi)
PL (1) PL174853B1 (fi)
SK (3) SK285155B6 (fi)
TW (1) TW209865B (fi)

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DE4301246A1 (de) * 1993-01-19 1994-07-21 Bayer Ag Chinolon- und Naphthyridoncarbonsäurederivate
JP3372994B2 (ja) 1993-06-11 2003-02-04 富士写真フイルム株式会社 ハロゲン化銀カラー写真感光材料の処理方法
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ITMI20032259A1 (it) * 2003-11-20 2005-05-21 Chemi Spa Nuovo polimorfo dell'acido 1-ciclopropil-7-(s,s-2,8-diazabciclo-4.3.0-non-8-il)-6-fluoro-1,4-diidro-8-metossi-4-oxo-chinolin carbossilico cloridrato e metodi per la sua preparazione
CN1244582C (zh) * 2004-04-21 2006-03-08 中国医学科学院医药生物技术研究所 喹诺酮羧酸类化合物及其制备方法和医药用途
US7759362B2 (en) 2004-04-21 2010-07-20 Institut Of Medicinal Biotechnology Chinese Academy Of Medical Sciences Quinolonecarboxylic acid compounds, preparation methods and pharmaceutical uses thereof
ES2284380B1 (es) * 2006-03-10 2008-11-01 Quimica Sintetica S.A. Procedimiento para la preparacion de moxifloxacino y moxifloxacino clorhidrato.
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US7692015B2 (en) 2007-01-05 2010-04-06 Zheqing Wang Economical process for preparing (S, S)-2, 8-diazabicyclo[4.3.0]nonane and its enantiomer
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EP2083010A1 (en) 2008-01-08 2009-07-29 Chemo Ibérica, S.A. Polymorphic Forms of Moxifloxacin hydrochloride and processes for preparation thereof
EP2154137A1 (en) 2008-08-04 2010-02-17 Chemo Ibérica, S.A. Crystalline form of moxifloxacin base
IT1393337B1 (it) * 2009-03-06 2012-04-20 Italiana Sint Spa Sintesi di (4as, 7as)-ottaidro-1h-pirrolo[3,4-b]piridina
WO2010122774A1 (ja) * 2009-04-20 2010-10-28 株式会社カネカ (１ｓ,６ｓ)または(１ｒ,６ｒ)-シス-２,８-ジアザビシクロ[４.３.０]ノナンおよびその中間体の製造法
IT1398952B1 (it) 2010-03-19 2013-03-28 F S I Fabbrica Italiana Sint Processo di preparazione della moxifloxacina e suoi sali
CN101941969B (zh) * 2010-09-30 2012-05-23 江苏正大丰海制药有限公司 盐酸莫西沙星的制备方法
CN102675308A (zh) * 2011-03-17 2012-09-19 苏州中科天马肽工程中心有限公司 一种制备8-苄基-2,8-二氮杂二环[4.3.0]壬烷的方法
CN102675307A (zh) * 2011-03-17 2012-09-19 苏州中科天马肽工程中心有限公司 一种制备手性化合物8-苯乙基-2,8-二氮杂二环[4.3.0]壬烷的方法
ITTO20110705A1 (it) 2011-07-29 2013-01-30 Italiana Sint Spa Procedimento di preparazione della moxifloxacina cloridrato e relativi intermedi
CN102964346B (zh) * 2011-09-01 2015-04-22 中国中化股份有限公司 一种制备(S,S)-八氢-6H-吡咯并[3,4-b]吡啶的方法
CN103044418B (zh) * 2011-10-14 2015-02-04 上海朴颐化学科技有限公司 (s,s)-2,8-二氮杂双环[4,3,0]壬烷的不对称合成方法、相关原料及制备方法
CN102408427B (zh) * 2011-10-22 2012-12-12 浙江普洛康裕制药有限公司 莫西沙星中间体〔1s，6r〕—8—苄基—7，9—二氧—2，8—二氮杂双环［4．3．0］壬烷的制备方法
BRPI1106900A2 (pt) 2011-12-26 2013-11-05 Ems Sa Composição farmacêutica sólida compreendendo antibótico da familia das quinolonas e processo de sua obtenção
FR2992218B1 (fr) 2012-06-22 2015-01-23 Rivopharm Sa Composition pharmaceutique de chlorhydrate de moxifloxacine et procede de preparation
CA2893534A1 (en) 2012-12-04 2014-06-12 Mankind Research Centre An improved process for the preparation of moxifloxacin hydrochloride
CN103012452B (zh) * 2012-12-25 2015-12-02 浙江新和成股份有限公司 一种莫西沙星及其盐酸盐的制备方法
UA106556C2 (uk) * 2013-05-13 2014-09-10 Наталья Николаевна Деркач СПОСІБ ОДЕРЖАННЯ (1-ЦИКЛОПРОПІЛ-6-ФТОР-1,4-ДИГІДРО-8-МЕТОКСІ-7-[(4aS,7aS)-ОКТАГІДРО-6Н-ПІРОЛО[3,4-b]-4-ОКСО-3-ХІНОЛІНКАРБОНОВОЇ КИСЛОТИ
CN103724262B (zh) * 2013-12-10 2016-05-18 广东省第二人民医院 一种氟喹诺酮银化合物及其制备方法和用途
CN104860944A (zh) * 2015-06-09 2015-08-26 内蒙古东北六药集团有限公司 盐酸莫西沙星的生产方法
CN108872413B (zh) * 2018-04-27 2021-06-08 山东齐都药业有限公司 检测(s,s)-2,8-二氮杂双环[4,3,0]壬烷中对映异构体含量的方法
CN110627768B (zh) * 2018-06-22 2021-11-09 扬子江药业集团有限公司 一种莫西沙星降解杂质j的制备方法
CN110183445B (zh) * 2019-06-28 2021-08-24 昆明学院 莫西沙星及其衍生物的合成方法
RU2713932C1 (ru) * 2019-10-31 2020-02-11 федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) Соединения фторхинолонового ряда на основе производных пиридоксина, обладающие антибактериальными свойствами
CN112939849B (zh) * 2019-12-11 2022-05-03 浙江新和成股份有限公司 一种(s,s)-2,8-二氮杂双环[4.3.0]壬烷中间体及其制备方法和应用
CN110981874A (zh) * 2020-03-05 2020-04-10 北京四环生物制药有限公司 一种盐酸莫西沙星的制备方法
CN112409352B (zh) * 2020-11-20 2022-05-24 华南理工大学 一类莫西沙星类药物衍生物及其制备方法和应用
CN112574197B (zh) * 2020-12-07 2021-12-31 泰安汉威集团有限公司 一种化合物c的手性纯化方法

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Also Published As

Publication number Publication date
AU669502B2 (en) 1996-06-13
KR100251886B1 (ko) 2000-07-01
CZ289076B6 (cs) 2001-10-17
FI20020059A (fi) 2002-01-11
FI990207A0 (fi) 1999-02-03
MY115416A (en) 2003-06-30
CN1043142C (zh) 1999-04-28
JP2003026574A (ja) 2003-01-29
JPH05271229A (ja) 1993-10-19
NO924978D0 (no) 1992-12-22
FI113771B (fi) 2004-06-15
CN1074218A (zh) 1993-07-14
SK396692A3 (en) 2002-09-10
JP4111431B2 (ja) 2008-07-02
NZ245640A (en) 1995-03-28
FI110943B (fi) 2003-04-30
NO301420B1 (no) 1997-10-27
EP0550903A1 (de) 1993-07-14
CN1061351C (zh) 2001-01-31
FI930049A (fi) 1993-07-11
FI104174B (fi) 1999-11-30
CN1212256A (zh) 1999-03-31
KR930016421A (ko) 1993-08-26
SK2212000A3 (sk) 2006-05-04
NO924978L (no) 1993-07-12
FI930049A0 (fi) 1993-01-07
CZ396692A3 (en) 1993-08-11
FI104174B1 (fi) 1999-11-30
SK282971B6 (sk) 2003-01-09
JP2003048890A (ja) 2003-02-21
CA2086914C (en) 2005-03-15
HUT64065A (en) 1993-11-29
CN1192440A (zh) 1998-09-09
PL174853B1 (pl) 1998-09-30
PL297338A1 (en) 1993-09-06
CN1075499C (zh) 2001-11-28
MX9207604A (es) 1993-10-01
FI990207A (fi) 1999-02-03
SK2232000A3 (sk) 2006-05-04
CA2086914A1 (en) 1993-07-11
TW209865B (fi) 1993-07-21
AU3105493A (en) 1993-07-15
HU9300034D0 (en) 1993-04-28
HU219488B (hu) 2001-04-28
SK285155B6 (sk) 2006-07-07

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