FI930049A0 - Kinolon- och naftyridonkarboxylsyraderivat samt deras framstaellning och anvaendning - Google Patents

Kinolon- och naftyridonkarboxylsyraderivat samt deras framstaellning och anvaendning

Info

Publication number
FI930049A0
FI930049A0 FI930049A FI930049A FI930049A0 FI 930049 A0 FI930049 A0 FI 930049A0 FI 930049 A FI930049 A FI 930049A FI 930049 A FI930049 A FI 930049A FI 930049 A0 FI930049 A0 FI 930049A0
Authority
FI
Finland
Prior art keywords
och
naftyridonkarboxylsyraderivat
kinolon
anvaendning
deras framstaellning
Prior art date
Application number
FI930049A
Other languages
English (en)
Other versions
FI930049A (fi
FI104174B (fi
FI104174B1 (fi
Inventor
Uwe Petersen
Andreas Krebs
Thomas Schenke
Thomas Philipps
Klaus Grohe
Klaus-Dieter Bremm
Rainer Endermann
Karl-Georg Metzger
Ingo Haller
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27203290&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI930049(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE4200414A external-priority patent/DE4200414A1/de
Priority claimed from DE4208792A external-priority patent/DE4208792A1/de
Priority claimed from DE4208789A external-priority patent/DE4208789A1/de
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of FI930049A0 publication Critical patent/FI930049A0/fi
Publication of FI930049A publication Critical patent/FI930049A/fi
Priority to FI971012A priority Critical patent/FI971012A0/fi
Application granted granted Critical
Publication of FI104174B publication Critical patent/FI104174B/fi
Publication of FI104174B1 publication Critical patent/FI104174B1/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
FI930049A 1992-01-10 1993-01-07 Menetelmä terapeuttisesti käyttökelpoisten, 1,4-dihydro-4-okso-3-kinoliinikarboksyylihapon 7-[S,S]-2,8-diatsabisyklo[4.3.0]nonaani-isomeeriven valmistamiseksi FI104174B1 (fi)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI971012A FI971012A0 (fi) 1992-01-10 1997-03-11 1,4-dihydro-4-okso-3-kinoliinikarboksyylihappojohdannaiset ja niiden käyttö

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DE4200414 1992-01-10
DE4200414A DE4200414A1 (de) 1992-01-10 1992-01-10 Chinolon- und naphthyridon-carbonsaeure-derivate
DE4208792 1992-03-19
DE4208789 1992-03-19
DE4208792A DE4208792A1 (de) 1992-03-19 1992-03-19 Enantiomerenreine chinolincarbonsaeure-derivate
DE4208789A DE4208789A1 (de) 1992-03-19 1992-03-19 Enantiomerenreine chinolincarbonsaeure-derivate

Publications (4)

Publication Number Publication Date
FI930049A0 true FI930049A0 (fi) 1993-01-07
FI930049A FI930049A (fi) 1993-07-11
FI104174B FI104174B (fi) 1999-11-30
FI104174B1 FI104174B1 (fi) 1999-11-30

Family

ID=27203290

Family Applications (3)

Application Number Title Priority Date Filing Date
FI930049A FI104174B1 (fi) 1992-01-10 1993-01-07 Menetelmä terapeuttisesti käyttökelpoisten, 1,4-dihydro-4-okso-3-kinoliinikarboksyylihapon 7-[S,S]-2,8-diatsabisyklo[4.3.0]nonaani-isomeeriven valmistamiseksi
FI990207A FI110943B (fi) 1992-01-10 1999-02-03 Enantiomeeripuhtaat 2,8-diatsabisyklo[4.3.0]nonaanijohdannaiset
FI20020059A FI113771B (fi) 1992-01-10 2002-01-11 Enantiomeeripuhdas (1S,6S) -2-oksa-5,8-diatsabisyklo[4.3.0]nonaani

Family Applications After (2)

Application Number Title Priority Date Filing Date
FI990207A FI110943B (fi) 1992-01-10 1999-02-03 Enantiomeeripuhtaat 2,8-diatsabisyklo[4.3.0]nonaanijohdannaiset
FI20020059A FI113771B (fi) 1992-01-10 2002-01-11 Enantiomeeripuhdas (1S,6S) -2-oksa-5,8-diatsabisyklo[4.3.0]nonaani

Country Status (16)

Country Link
EP (1) EP0550903A1 (fi)
JP (3) JPH05271229A (fi)
KR (1) KR100251886B1 (fi)
CN (3) CN1043142C (fi)
AU (1) AU669502B2 (fi)
CA (1) CA2086914C (fi)
CZ (1) CZ289076B6 (fi)
FI (3) FI104174B1 (fi)
HU (1) HU219488B (fi)
MX (1) MX9207604A (fi)
MY (1) MY115416A (fi)
NO (1) NO301420B1 (fi)
NZ (1) NZ245640A (fi)
PL (1) PL174853B1 (fi)
SK (3) SK285223B6 (fi)
TW (1) TW209865B (fi)

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JPH04445A (ja) 1990-04-17 1992-01-06 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料の処理方法
DE69131509T2 (de) 1990-05-09 1999-11-25 Fuji Photo Film Co Ltd Photographische Verarbeitungszusammensetzung und diese verwendendes Verarbeitungsverfahren
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DE4301246A1 (de) * 1993-01-19 1994-07-21 Bayer Ag Chinolon- und Naphthyridoncarbonsäurederivate
JP3372994B2 (ja) 1993-06-11 2003-02-04 富士写真フイルム株式会社 ハロゲン化銀カラー写真感光材料の処理方法
DE4329600A1 (de) * 1993-09-02 1995-03-09 Bayer Ag Pyrido [1,2,3-d,e] [1,3,4] benzoxadiazinderivate
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DE4342186A1 (de) * 1993-12-10 1995-06-14 Bayer Ag Eintopfverfahren zur Herstellung von 3-Chinoloncarbonsäurederivaten
DE4418510A1 (de) * 1994-05-27 1995-11-30 Bayer Ag 1,9-überbrückte Thiazolol[3,4-a]chinolinderivate
AU6221296A (en) * 1995-06-07 1996-12-30 Bayer Aktiengesellschaft Testing device for determining the susceptibility of microor ganisms to inhibitory agents
DE19546249A1 (de) * 1995-12-12 1997-06-19 Bayer Ag Neue Kristallmodifikation des 1-Cyclopropyl-7-([S,S]-2,8-diazabicyclo[4,3,0]non-8-yl)-6-fluor-1,4-dihydro-8-methoxy-4-oxo-3-chinolincarbonsäure Hydrochlorid (CDCH), Verfahren zu dessen Herstellung und diese enthaltende pharmazeutische Zubereitungen
DE19652239A1 (de) 1996-12-16 1998-06-18 Bayer Ag Verwendung von 7-(2-Oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-chinolon- und -naphthyridoncarbonsäure-Derivaten zur Therapie von Helicobacter-pylori-Infektionen und den damit assoziierten gastroduodenalen Erkrankungen
DE19735198A1 (de) * 1997-08-14 1999-02-18 Bayer Ag Verfahren zur Racematspaltung von cis- und trans-Pyrrolopiperidin
CN1623533A (zh) * 1997-09-25 2005-06-08 拜尔公司 控释活性化合物的药物制剂
DE19751948A1 (de) * 1997-11-24 1999-05-27 Bayer Ag Verfahren zur Herstellung von 8-Methoxy-Chinoloncarbonsäuren
DE19821039A1 (de) * 1998-05-11 1999-11-18 Bayer Ag Verfahren zur Herstellung von (S,S)-Benzyl-2,8-diazabicyclo[4.3.0]nonan
US6395746B1 (en) 1998-09-30 2002-05-28 Alcon Manufacturing, Ltd. Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
AR020661A1 (es) * 1998-09-30 2002-05-22 Alcon Lab Inc Una composicion farmaceutica topica oftalmica, otica o nasal y el uso de la misma para la manufactura de un medicamento
US6716830B2 (en) 1998-09-30 2004-04-06 Alcon, Inc. Ophthalmic antibiotic compositions containing moxifloxacin
US6509327B1 (en) 1998-09-30 2003-01-21 Alcon Manufacturing, Ltd. Compositions and methods for treating otic, ophthalmic and nasal infections
ID29089A (id) * 1998-11-10 2001-07-26 Bayer Ag Sediaan farmasi moksifloksasin
WO2000054811A1 (fr) 1999-03-17 2000-09-21 Daiichi Pharmaceutical Co., Ltd. Compositions medicamenteuses
DE19927412A1 (de) * 1999-06-16 2000-12-21 Bayer Ag Verfahren zur Enantiomerenanreicherung von cis-8-Benzyl-7,9-dioxo-2,8-diazabicyclo [4.3.0]nonan
DE19931115A1 (de) * 1999-07-06 2001-01-11 Bayer Ag Racemisierung von R, S-Dioxo-Benzylpyrrolopiperidin
DE19962470A1 (de) * 1999-12-22 2001-07-12 Schulz Hans Herrmann Verwendung von Chemotherapeutika
DE10226923A1 (de) * 2002-06-17 2003-12-24 Bayer Ag Verfahren zur Enantiomerenanreicherung von cis-8-Benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonan
ITMI20032259A1 (it) 2003-11-20 2005-05-21 Chemi Spa Nuovo polimorfo dell'acido 1-ciclopropil-7-(s,s-2,8-diazabciclo-4.3.0-non-8-il)-6-fluoro-1,4-diidro-8-metossi-4-oxo-chinolin carbossilico cloridrato e metodi per la sua preparazione
DE602004018370D1 (de) * 2003-11-20 2009-01-22 Chemi Spa Polymorphe von 1-cyclopropyl-7-(äs,sü - 2,8-diazadicyclo ä4.3.0ü non-8-yl) -6-fluor-1,4-dihydro-8-methoxy-4-oxo-3-chinolincarbonsäurehydrochlorid und verfahren zu deren herstellung
CN1244582C (zh) * 2004-04-21 2006-03-08 中国医学科学院医药生物技术研究所 喹诺酮羧酸类化合物及其制备方法和医药用途
US7759362B2 (en) 2004-04-21 2010-07-20 Institut Of Medicinal Biotechnology Chinese Academy Of Medical Sciences Quinolonecarboxylic acid compounds, preparation methods and pharmaceutical uses thereof
ES2284380B1 (es) * 2006-03-10 2008-11-01 Quimica Sintetica S.A. Procedimiento para la preparacion de moxifloxacino y moxifloxacino clorhidrato.
EP2436381A1 (en) 2006-06-27 2012-04-04 Sandoz AG Crystallization of hydrohalides of pharmaceutical compounds
JP2010509305A (ja) 2006-11-13 2010-03-25 シプラ・リミテッド モキシフロキサシン塩酸塩の合成方法
WO2008059521A2 (en) * 2006-11-14 2008-05-22 Msn Laboratories Limited Novel process for the preparation of moxifloxacin hydrochloride and a novel polymorph of moxifloxacin
US7692015B2 (en) 2007-01-05 2010-04-06 Zheqing Wang Economical process for preparing (S, S)-2, 8-diazabicyclo[4.3.0]nonane and its enantiomer
WO2008102188A1 (en) 2007-02-22 2008-08-28 Tibor Nagy Procedure to manufacture and use beer and other types liquids treated with neodimium magnet
EP2083010A1 (en) 2008-01-08 2009-07-29 Chemo Ibérica, S.A. Polymorphic Forms of Moxifloxacin hydrochloride and processes for preparation thereof
EP2154137A1 (en) 2008-08-04 2010-02-17 Chemo Ibérica, S.A. Crystalline form of moxifloxacin base
IT1393337B1 (it) * 2009-03-06 2012-04-20 Italiana Sint Spa Sintesi di (4as, 7as)-ottaidro-1h-pirrolo[3,4-b]piridina
EP2423211B1 (en) * 2009-04-20 2014-04-16 Kaneka Corporation Processes for producing (1s,6s)- or (1r,6r)-cis-2,8-diazabicyclo[4.3.0]nonane and intermediate thereof
IT1398952B1 (it) * 2010-03-19 2013-03-28 F S I Fabbrica Italiana Sint Processo di preparazione della moxifloxacina e suoi sali
CN101941969B (zh) * 2010-09-30 2012-05-23 江苏正大丰海制药有限公司 盐酸莫西沙星的制备方法
CN102675308A (zh) * 2011-03-17 2012-09-19 苏州中科天马肽工程中心有限公司 一种制备8-苄基-2,8-二氮杂二环[4.3.0]壬烷的方法
CN102675307A (zh) * 2011-03-17 2012-09-19 苏州中科天马肽工程中心有限公司 一种制备手性化合物8-苯乙基-2,8-二氮杂二环[4.3.0]壬烷的方法
ITTO20110705A1 (it) 2011-07-29 2013-01-30 Italiana Sint Spa Procedimento di preparazione della moxifloxacina cloridrato e relativi intermedi
CN102964346B (zh) * 2011-09-01 2015-04-22 中国中化股份有限公司 一种制备(S,S)-八氢-6H-吡咯并[3,4-b]吡啶的方法
CN103044418B (zh) * 2011-10-14 2015-02-04 上海朴颐化学科技有限公司 (s,s)-2,8-二氮杂双环[4,3,0]壬烷的不对称合成方法、相关原料及制备方法
CN102408427B (zh) * 2011-10-22 2012-12-12 浙江普洛康裕制药有限公司 莫西沙星中间体〔1s，6r〕—8—苄基—7，9—二氧—2，8—二氮杂双环［4．3．0］壬烷的制备方法
BRPI1106900A2 (pt) 2011-12-26 2013-11-05 Ems Sa Composição farmacêutica sólida compreendendo antibótico da familia das quinolonas e processo de sua obtenção
FR2992218B1 (fr) 2012-06-22 2015-01-23 Rivopharm Sa Composition pharmaceutique de chlorhydrate de moxifloxacine et procede de preparation
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CN103012452B (zh) * 2012-12-25 2015-12-02 浙江新和成股份有限公司 一种莫西沙星及其盐酸盐的制备方法
UA106556C2 (uk) * 2013-05-13 2014-09-10 Наталья Николаевна Деркач СПОСІБ ОДЕРЖАННЯ (1-ЦИКЛОПРОПІЛ-6-ФТОР-1,4-ДИГІДРО-8-МЕТОКСІ-7-[(4aS,7aS)-ОКТАГІДРО-6Н-ПІРОЛО[3,4-b]-4-ОКСО-3-ХІНОЛІНКАРБОНОВОЇ КИСЛОТИ
CN103724262B (zh) * 2013-12-10 2016-05-18 广东省第二人民医院 一种氟喹诺酮银化合物及其制备方法和用途
CN104860944A (zh) * 2015-06-09 2015-08-26 内蒙古东北六药集团有限公司 盐酸莫西沙星的生产方法
CN108872413B (zh) * 2018-04-27 2021-06-08 山东齐都药业有限公司 检测(s,s)-2,8-二氮杂双环[4,3,0]壬烷中对映异构体含量的方法
CN110627768B (zh) * 2018-06-22 2021-11-09 扬子江药业集团有限公司 一种莫西沙星降解杂质j的制备方法
CN110183445B (zh) * 2019-06-28 2021-08-24 昆明学院 莫西沙星及其衍生物的合成方法
RU2713932C1 (ru) * 2019-10-31 2020-02-11 федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) Соединения фторхинолонового ряда на основе производных пиридоксина, обладающие антибактериальными свойствами
CN112939849B (zh) * 2019-12-11 2022-05-03 浙江新和成股份有限公司 一种(s,s)-2,8-二氮杂双环[4.3.0]壬烷中间体及其制备方法和应用
CN110981874A (zh) * 2020-03-05 2020-04-10 北京四环生物制药有限公司 一种盐酸莫西沙星的制备方法
CN112409352B (zh) * 2020-11-20 2022-05-24 华南理工大学 一类莫西沙星类药物衍生物及其制备方法和应用
CN112574197B (zh) * 2020-12-07 2021-12-31 泰安汉威集团有限公司 一种化合物c的手性纯化方法

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JPH0754229B2 (ja) * 1987-09-28 1995-06-07 松下冷機株式会社 冷蔵庫
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JPH03188080A (ja) * 1989-12-15 1991-08-16 Banyu Pharmaceut Co Ltd ピリドンカルボン酸誘導体

Also Published As

Publication number Publication date
FI930049A (fi) 1993-07-11
FI990207A0 (fi) 1999-02-03
NO301420B1 (no) 1997-10-27
CZ396692A3 (en) 1993-08-11
JP2003026574A (ja) 2003-01-29
MX9207604A (es) 1993-10-01
HU219488B (hu) 2001-04-28
CN1043142C (zh) 1999-04-28
JPH05271229A (ja) 1993-10-19
SK285223B6 (sk) 2006-09-07
AU669502B2 (en) 1996-06-13
CN1192440A (zh) 1998-09-09
CN1212256A (zh) 1999-03-31
KR100251886B1 (ko) 2000-07-01
FI104174B (fi) 1999-11-30
JP4111431B2 (ja) 2008-07-02
FI113771B (fi) 2004-06-15
FI20020059A (fi) 2002-01-11
HU9300034D0 (en) 1993-04-28
TW209865B (fi) 1993-07-21
PL174853B1 (pl) 1998-09-30
CZ289076B6 (cs) 2001-10-17
NO924978L (no) 1993-07-12
SK2232000A3 (sk) 2006-05-04
JP2003048890A (ja) 2003-02-21
CN1075499C (zh) 2001-11-28
FI990207A (fi) 1999-02-03
FI104174B1 (fi) 1999-11-30
SK2212000A3 (sk) 2006-05-04
CN1074218A (zh) 1993-07-14
AU3105493A (en) 1993-07-15
CN1061351C (zh) 2001-01-31
EP0550903A1 (de) 1993-07-14
CA2086914C (en) 2005-03-15
PL297338A1 (en) 1993-09-06
HUT64065A (en) 1993-11-29
KR930016421A (ko) 1993-08-26
SK285155B6 (sk) 2006-07-07
MY115416A (en) 2003-06-30
FI110943B (fi) 2003-04-30
SK282971B6 (sk) 2003-01-09
SK396692A3 (en) 2002-09-10
NZ245640A (en) 1995-03-28
CA2086914A1 (en) 1993-07-11
NO924978D0 (no) 1992-12-22

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